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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Multi-omics profiling reveals potential alterations in rheumatoid arthritis with different disease activity levels

Fig. 4

Transcriptome analysis of RA suggests changes in lipid metabolism pathways. A Volcano plots showing DEGs in RA with different disease activity, respectively. Red indicated upregulated genes, and green indicated downregulated genes. B Venn diagram showing 162 DEGs in common across RA with different disease activity. C Fold change of DAS28-related genes in RA with different disease activity. D, E Bar graphs showing the top 10 most significant pathways of DAS28-related genes in Gene ontology term (D) and Kyoto Encyclopedia of Genes and Genomes (E) enrichment analysis. F, G GSEA analysis showing DEGs of RA vs. HC were upregulated in the chemokine signaling pathway (F) and downregulated in the linoleic acid metabolism pathway (G). H, J Expression of PLA2G6 (H), PTGS1 (I), and GDE1 (J) gene in lipid metabolism pathway in RA progression. The bar chart shows the mean value of each group. Error bars represent standard error of the mean values. RA, rheumatoid arthritis; HC, healthy controls; DEGs, differentially expressed genes; P-value, *p < 0.05, **p < 0.01, ***p < 0.001

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