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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Multi-omics profiling reveals potential alterations in rheumatoid arthritis with different disease activity levels

Fig. 5

nsSNV of the HLA-DRB1 and HLA-DRB5 gene locus were associated with the disease activity of RA. A PPI analysis of genes with nsSNV mutation rate greater than 10% and genes involved in lipid metabolism pathways. The blue dots represent genes with RA PMBC nsSNV mutation rate greater than 10%, and the yellow dots represent genes associated with lipid metabolism pathways. The size of the point represents the node size of the gene in PPI. B KEGG pathway enrichment analysis bars of related genes in PPI analysis. Color bars indicate enrichment significance. C Mutation rates of nsSNV in related genes in different disease activity groups. nsSNV, non-synonymous single nucleotide variation; RA, rheumatoid arthritis; PPI, protein–protein interaction; PMBC, peripheral mononuclear blood cell

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