Variable | Secukinumab 150 mg with loading (n = 185) | Secukinumab 150 mg without loading (n = 184) | Secukinumab pooled (n = 369) | Placebo (n = 186) |
---|---|---|---|---|
Radiographs | ||||
Total sacroiliitis score, mean (SD) (range, 0–8) | 1.40 (1.47) | 1.44 (1.50) | 1.42 (1.48) | 1.51 (1.58) |
mSASSS score, mean (SD) (range, 0–72) | 0.80 (2.70) | 0.75 (2.59) | 0.77 (2.64) | 0.84 (2.43) |
Patients with syndesmophytes, n (%) | 29 (15.7) | 33 (17.9) | 62 (16.8) | 27 (14.7) |
MRI | ||||
SI joint bone marrow edema score, mean (SD) (0–24) | 2.14 (3.52) | 1.94 (3.39) | 2.04 (3.45) | 2.26 (3.69) |
Spinal inflammation, Berlin score, mean (SD) (0–69) | 0.78 (1.70) | 0.86 (1.81) | 0.82 (1.75) | 1.07 (2.28) |