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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Stiffness and axial pain are associated with the progression of calcification in a mouse model of diffuse idiopathic skeletal hyperostosis

Fig. 2

ENT1−/− mice show reduced grip force without signs of axial stretch-induced discomfort in tail suspension. A In the grip force assay, the peak force at the point of release (measured in grams) was recorded during axial stretch. Data are stratified by sex, each animal is represented as a unique symbol, and data are presented as means ± SEM (n = 10 female, 10 male per genotype). Data from two female wild-type mice at 2 months of age are missing due to non-compliance with testing. BD In the 180-second tail suspension assay, spontaneous behavioral responses to axial stretch are recorded: B self-supporting, C rearing, and D immobile. Data are stratified by sex, each animal is represented as a unique symbol, and data are presented as means ± SEM (n = 10 female, 10 male per genotype). *P < 0.05 by two-way-ANOVA or mixed-effects model with Sidak’s multiple comparisons test

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