Comparison of two doses of leucovorin in severe low-dose methotrexate toxicity – a randomized controlled trial

Table 2 Primary and secondary outcomes

	Leucovorin 15 mg (n = 19)	Leucovorin 25 mg (n = 19)	p-value^#	Unadjusted odds (hazard) ratio^a	Adjusted odds (hazard) ratio^b
Primary Outcome
Death by 30 days	8	9
Mortality % (95% CI)	42 (23–64)	47 (27–68)	0.74	1.2 (0.3–4.5)	1.3 (0.3–4.9)
Secondary outcomes
Time to Hematological recovery, days, median (95% CI)	7 (4–10)	6 (4–8)	0.90	1 (0.4–2.7)	0.8 (0.3–2.1)
Time to Oral ulcer recovery, days, median (95% CI)	5 (2–8)	4 (3–5)	0.59	1.5 (0.6–3.7)	1.4 (0.6–3.5)

Abbreviations: CI Confidence interval
^#p-value obtained from univariable analysis by Chi-square for primary and log-rank test for secondary outcome
^aComparing 25 mg group to 15 mg group
^bAdjusted for baseline serum creatinine, Values depict Odds-ratio for the primary outcome and hazard-ratio for the secondary outcomes

ISSN: 1478-6362