Table 3 Hazard ratios (95% CI) of independent variables which are associated with death in patients with MTX toxicity

Leucovorin dose^a

1.1 (0.4–2.9)

0.84

Age

1.0 (1.0–1.1)

0.97

Gender (male by female)

1.3 (0.5–3.3)

0.63

Duration of symptoms

0.9 (0.8–1.1)

0.43

Comorbidity (HT or DM)

0.5 (0.1–1.5)

0.45

Dose cumulative MTX

1.0 (0.98–1.0)

0.84

Hemoglobin at baseline

0.9 (0.7–1.2)

0.52

WBC nadir (× 10^9)

0.4 (0.2–1.0)

0.06

0.7(0.3–1.7)

0.39

WBC at baseline (× 10^9)

0.6 (0.3–1.1)

0.11

Platelet count at baseline (× 10^9)

1.0 (1.0–1.0)

0.97

Platelet count nadir (× 10^9)

1.0 (1.0–1.0)

0.29

Serum albumin at baseline

0.2 (0.1–0.7)

0.01*

0.3 (0.1–0.9)

0.03*

Creatinine at baseline

1.2 (1.0–1.5)

0.06

1.2 (0.9–1.5)

0.23

Bilirubin at baseline

1.1 (0.7 -1.7)

0.64