Clinical characteristics and survival of pulmonary arterial hypertension with or without interstitial lung disease in systemic sclerosis

Table 4 Generalised estimating equation (GEE) regression analyses of health-related quality of life measures over time

Variable	Value	N^a	OR	95% CI	p
SHAQ scores^b
Disease group	SSc-only	2943	.	.	.
	ILD-only	1213	1.54	1.27 to 1.87	< 0.001
	PAH	229	2.23	1.56 to 3.17	< 0.001
	PAH-ILD	181	3.41	2.26 to 5.14	< 0.001
Physical component summary scores of the SF-36^c
Disease group	SSc-only	2201	.	.	.
	ILD-only	899	2.13	1.61 to 2.80	< 0.001
	PAH	175	7.05	3.15 to 15.78	< 0.001
	PAH-ILD	132	12.48	4.11 to 37.91	< 0.001
Mental component summary scores of the SF-36^c
Disease group	SSc-only	2201	.	.	.
	ILD-only	899	1.06	0.86 to 1.31	0.586
	PAH	175	0.92	0.63 to 1.34	0.693
	PAH-ILD	132	1.26	0.83 to 1.91	0.248

Abbreviations: CI confidence interval, GEE generalised estimating equation, ILD interstitial lung disease, OR odds ratio, PAH pulmonary arterial hypertension, SF-36 Short Form Survey 36, SSc systemic sclerosis, sHAQ Scleroderma Health Assessment Questionnaire
^aNumber of observations available for longitudinal analysis
^bThe odds of sHAQ score being greater (worse) than median sHAQ for ASCS population [13]
^cThe odds that the physical or mental component summary score being equal to, or below (worse than) the population average of 50

ISSN: 1478-6362