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Table 2 Causal effects of serum 25(OH)D levels on SS risks in MR analysis

From: Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis

Exposure

Outcome

SNPs (n)

MR method

OR

95% CI

P-value

25(OH)D

SS

81

IVW

0.9824

(0.7130, 1.3538)

0.9137

Weighted median

1.1814

(0.7054, 1.9786)

0.5263

MR-Egger (P for heterogeneity = 0.7221; P for pleiotropy = 0.2787)

0.8955

(0.5209, 1.5394)

0.6908

MR-PRESSO global test

-

-

0.7483

  1. 25(OH)D, 25-hydroxyvitamin D, SS Sjogren’s syndrome, SNPs Single nucleotide polymorphisms, OR Odds ratio, CI Confidence intervals, IVW Inverse-variance weighted