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Table 3 High-resolution respirometry using permeabilized skeletal muscle fibers of RA and control participants

From: Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case–control study

 

Weight standardized

Max complex IV standardized

CS activity standardized

Variablea

Mean difference

(95% CI)

p-value

Mean difference

(95% CI)

p-value

Mean difference

(95% CI)

p-value

Leak rate with fatty acid substrate (PC)

 − 3.19 (− 4.50, − 1.89)

 < 0.01

0.01 (− 0.004, 0.02)

0.17

 − 0.06 (− 0.26, 0.14)

0.59

OXPHOS capacity

 − 6.69 (− 22.18, 8.80)

0.41

0.14 (0.02, 0.26)

0.03

0.82 (− 0.91, 2.55)

0.36

Maximal rate of uncoupler-stimulated respiration

 − 17.27 (− 32.28, − 2.25)

0.03

0.09 (− 0.04, 0.22)

0.17

 − 0.18 (− 1.76, 1.39)

0.82

Max complex IV activity (mitochondrial content)b

 − 74.45 (− 108.90, − 40.01)

 < 0.01

  

 − 3.01 (− 6.79, 0.77)

0.13

  1. aControls are the reference group in all cases. Negative values indicate that the variable is lower in the RA group
  2. bAs this variable was used to standardize the mitochondrial content, it is only reported for the weight standardized values