Fig. 3

Allelic expression imbalance (AEI) analysis. A Left, allelic (C/T) ratios in the synovium samples from knee OA patients heterozygous for rs11583641 (n = 15, numbers on the x-axis are patient sample IDs). In each sample, the ratio of values for cDNA and DNA between the C (OA risk) allele and T allele was plotted; each symbol represents the average of three technical repeats. Right, the mean DNA and cDNA values in the presence of the C allele versus the T allele in the 15 heterozygous patients. Values are shown as a box plot, with the lines inside the box representing the median, the box showing the interquartile range and the whiskers showing the minimum and maximum values. B Left, allelic (C/G) ratios in the synovium samples from knee OA patients heterozygous for rs114661926 (n = 10). In each sample, the ratio of values for cDNA and DNA between the C (OA risk) allele and G allele was plotted; each symbol represents the average of three technical repeats. Right, the mean DNA and cDNA values in the presence of the C allele versus the G allele in the 10 heterozygous patients. Values are shown as a box plot, as above. P values were calculated by Wilcoxon matched-pairs signed rank test