Fig. 4

D2R agonist sumanirole in vitro inhibits CIA-induced bias of CD4⁺ T cells towards Th1 and Th17 phenotypes and D2R antagonist L-741,626 blocks this effect. A Protein expression of the specific transcription factors in CD4⁺ T cells. The left panel represents Western blotting bands and the right panel indicates quantitative data of the left panel. B Gene expression levels of the cytokines in CD4⁺ T cells. C-F Concentrations of the cytokines in supernatants of the activated CD4⁺ T cells. All the data were from five repeated experiments. **P < 0.01, versus control group; ^##P < 0.01, versus CIA group; ^&&P < 0.01, versus CIA + sumanirole 10^–6 M group