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Expression of cytokine mRNA and protein in joints and lymphoid organs during the course of rat antigen-induced arthritis

Cytokine expression was assessed during antigen-induced arthritis (AIA) in synovial membrane (SM), inguinal lymph node (LN), and spleen using competitive RT-PCR and sandwich ELISA. In the SM, early elevations ...

Authors: Dirk Pohlers, Angela Siegling, Eberhard Buchner, Carsten B Schmidt-Weber, Ernesta Palombo-Kinne, Frank Emmrich, Rolf Bräuer and Raimund W Kinne

Citation: Arthritis Research & Therapy 2005 7:R445

Content type: Research article Published on: 17 February 2005
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Pharmacokinetic study of oral prednisolone compared with intravenous methylprednisolone in patients with vasculitis of rheumatic disease

Authors: KA Rouster-Stevens, JA Daru, LM Pachman, B Javonovic and K-L Ngai

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P165

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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A role for CD8 cells in cell-contact-mediated inflammation

Authors: SE Robertson, A Crilly, JA Gracie, P Life and IB McInnes

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P163

Content type: Poster presentation Published on: 17 February 2005

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A revised assay for the measurement of T-cell receptor excision circles as a quantitative measure of thymic function in systemic lupus erythematosus

Authors: AR Lorenzi, AM Patterson and JD Isaacs

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P158

Content type: Poster presentation Published on: 17 February 2005

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Bystander-activated CD4⁺memory lymphocytes: a role in the pathology of rheumatoid arthritis?

Authors: JT Beech, SH Owen, P Green, P Amjadi and FM Brennan

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P145

Content type: Poster presentation Published on: 17 February 2005

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Binding properties of anti-histone H1 antibodies suggest that nuclei of necrotic cells rather than cells undergoing apoptosis are engulfed in the LE cell phenomenon

Authors: E Feierl, JS Smolen, T Karonitsch, GH Stummvoll, H Ekhart, CW Steiner and M Aringer

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P132

Content type: Poster presentation Published on: 17 February 2005

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Synovial monocytes mediate Rap1-dependent oxidative stress in rheumatoid arthritis T lymphocytes

Authors: PH Remans, JM van Laar, ME Sanders, P-P Tak and KA Reedquist

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P130

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Antibodies to ferritin in rheumatoid arthritis are associated with disease severity

Authors: D Mewar, DJ Moore, PF Watson and AG Wilson

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P128

Content type: Poster presentation Published on: 17 February 2005

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The effect of B-cell depletion with an anti-CD20 antibody on the immunoglobulin heavy-chain repertoire in a patient with rheumatoid arthritis

Authors: A-S Rouzière, C Kneitz, T Dörner and H-P Tony

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P126

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Noggin haploinsufficiency influences severity of arthritis in different mouse models

Authors: M Daans, RJU Lories, I Derese, P Tylzanowski and FP Luyten

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P118

Content type: Poster presentation Published on: 17 February 2005

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Association of FCGR2A and Fc gamma receptor haplotypes with Spanish polymyalgia rheumatica and giant cell arteritis

Authors: AW Morgan, MA Gonzalez-Gay, JI Robinson, SJ Babbage, L Haroon-Rashid, AH Hajeer, WER Ollier and JD Isaacs

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P117

Content type: Poster presentation Published on: 17 February 2005

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Tryptase as a PAR-2 activator in joint inflammation

Authors: EB Kelso, L Dunning, JC Lockhart, WR Ferrell, R Plevin and CP Sommerhoff

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P99

Content type: Poster presentation Published on: 17 February 2005

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Type 1 regulatory T cells in treatment of murine lupus

Authors: R Undeutsch, J Humrich, BH Hahn, F Hiepe, G Burmester, A Radbruch and G Riemekasten

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P95

Content type: Poster presentation Published on: 17 February 2005

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Efficient IL-18 and IL-18BPc adenoviral gene transfer to cultured murine submandibular gland epithelial cells and successful murine retrograde submandibular duct cannulation to modulate IL-18 function in the salivary gland of animal models of Sjogren's syndrome

Authors: M Bombardieri, F Barone, G Proctor, FA van de Loo, WB van den Berg, G Valesini, IB McInnes and C Pitzalis

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P94

Content type: Poster presentation Published on: 17 February 2005

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Quantifying the contribution of the second HLA-DRB1 susceptibility allele to the risk of rheumatoid arthritis: a meta-analysis

Authors: IA van Rossum, AH Zwinderman, PP Tak and N de Vries

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P93

Content type: Poster presentation Published on: 17 February 2005

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Intracellular IL-1 receptor antagonist (icIL-1Ra1) does not antagonize growth inhibitory effects of pre-IL-1α in SaOS-2 cells

Authors: G Palmer, S Trolliet, D Talabot-Ayer, F Mézin, D Magne and C Gabay

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P91

Content type: Poster presentation Published on: 17 February 2005

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Mitogen-activated kinases in psoriatic arthritis: differences in activation and distinct regulation by etanercept therapy

Authors: RJU Lories, I Derese, FP Luyten and K de Vlam

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P88

Content type: Poster presentation Published on: 17 February 2005

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Effects of anti-rheumatic treatments on the prostaglandin E₂ biosynthetic pathway in synovial tissue and synovial fluid cells from patients with rheumatoid arthritis

Authors: M Korotkova, M Westman, KR Gheorghe, E af Klint, C Trollmo, A-K Ulfgren, L Klareskog and P-J Jakobsson

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P87

Content type: Poster presentation Published on: 17 February 2005

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Inhibition of tumour necrosis factor alpha production by activated T cells of rheumatoid arthritis patients by novel anti-folate drugs: an ex vivopilot study

Authors: JW van der Heijden, AH Gerards, R Oerlemans, WF Lems, RJ Scheper, LA Aarden, BAC Dijkmans and G Jansen

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P84

Content type: Poster presentation Published on: 17 February 2005

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Proinflammatory role for AT₁receptors in the rat synovium

Authors: AG Price, JC Lockhart, JS McLean and WR Ferrell

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P74

Content type: Poster presentation Published on: 17 February 2005

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Influence of HLA-DR genes on the production of rheumatoid arthritis-specific autoantibodies to citrullinated fibrin

Authors: I Auger, M Sebag, C Vincent, S Guis, L Nogueira, B Svensson, A Cantagrel, G Serre and J Roudier

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P63

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Oncostatin M in rheumatoid arthritis: a key cytokine acts synergistically with other proinflammatory cytokines to promote human cartilage loss

Authors: U Fearon, R Mullan, R Poole, T Markham, O FitzGerald, B Bresnihan and DJ Veale

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P61

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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A link between complement activation and anti-SSA in immune complex-induced cytokine production in systemic lupus erythematosus

Authors: L Mathsson, E Åhlin, H Storfors and J Rönnelid

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P59

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Expression of IL-18 in muscle tissue of patients with treatment-resistant idiopathic inflammatory myopathies

Authors: IE Lundberg, S Barbasso, AK Ulfgren, JA Gracie and IB McInnes

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P57

Content type: Poster presentation Published on: 17 February 2005

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BiP induces IL-4-dependent regulatory cells

Authors: R Brownlie, LK Myers, VM Corrigall, MD Bodman-Smith, SJ Thompson and GS Panayi

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P55

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Abstract withdrawn

Authors:

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P49

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Results of the Consensus Finding Study Group on Autoantibodies (March 2003–March 2004)

Authors: D Hamann, P Charles, M Renz, HP Seelig, A Wiik and RJT Smeenk

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P44

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Activation of antigen-presenting cells by endogenous retroviral RNA

Authors: D Moyes, S Sacre, N Temperton, A Lundberg, B Foxwell and P Venables

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P24

Content type: Poster presentation Published on: 17 February 2005

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Intra-articular gene therapy blocking NF-κB using adeno-associated virus type 5 ameliorates adjuvant arthritis in rats

Authors: J Adriaansen, SW Tas, N Hajji, A Bakker, MJ Vervoordeldonk and PP Tak

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P22

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Citrullinated α enolase, a novel citrullinated autoantigen in rheumatoid arthritis, upregulated by chronic inflammation

Authors: A Kinloch, V Tatzer, R Wait, D Peston, S Sacre, P Donatien, D Moyes, P Taylor and PJ Venables

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P20

Content type: Poster presentation Published on: 17 February 2005

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T-bet expression in rheumatoid arthritis patients with early, disease-modifying anti-rheumatic drug naïve disease is low and correlates with low levels of IL-7 and T-cell dysfunctions

Authors: F Ponchel, AK Brown, SL Field, M Quinn, P Conaghan, P Emery and JD Isaacs

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P18

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Human type II collagen is processed in lysosomal compartments of macrophages for presentation of the glycosylated arthritogenic epitope hCII_259–273to CD4 T cells in HLA-DR1 transgenic mice

Authors: A von Delwig, DM Altmann, JD Isaacs, R Holmdahl, N McKie and JH Robinson

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):P14

Content type: Poster presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Molecular signatures of rheumatoid arthritis characterized by transcriptome and proteome analysis

Authors: MO Glocker, J Kekow and H-J Thiesen

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S7

Content type: Oral presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Tracking immune responses in vivo

Authors: MK Jenkins

Citation: Arthritis Research & Therapy 2005 7(Suppl 1):S5

Content type: Oral presentation Published on: 17 February 2005

This article is part of a Supplement: Volume 7 Supplement 1
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Natural killer T cells and rheumatoid arthritis: friend or foe?

Authors: Dirk Elewaut

Citation: Arthritis Research & Therapy 2005 7:88

Content type: Viewpoint Published on: 14 February 2005
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Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal?

The anti-double-stranded DNA (anti-dsDNA) antibody test incorporated in the 1982 revised American College of Rheumatology criteria for the classification of systemic lupus erythematosus needs updating to refle...

Authors: Hans C Nossent and Ole Petter Rekvig

Citation: Arthritis Research & Therapy 2005 7:85

Content type: Commentary Published on: 10 February 2005
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Amplification of autoimmune disease by infection

Reports of infection with certain chronic persistent microbes (herpesviruses or Chlamydiae) in human autoimmune diseases are consistent with the hypothesis that these microbes are reactivated in the setting of...

Authors: David N Posnett and Dmitry Yarilin

Citation: Arthritis Research & Therapy 2005 7:74

Content type: Review Published on: 10 February 2005
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Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis

It is well known that cytokines are highly involved in the disease process of rheumatoid arthritis (RA). Recently, targeting of neuropeptides has been suggested to have potential therapeutic effects in RA. The...

Authors: Ola Grimsholm, Solbritt Rantapää-Dahlqvist and Sture Forsgren

Citation: Arthritis Research & Therapy 2005 7:R416

Content type: Research article Published on: 7 February 2005
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Defective CD4⁺CD25⁺regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ

Mice with a deficiency in IFN-γ or IFN-γ receptor (IFN-γR) are more susceptible to collagen-induced arthritis (CIA), an experimental autoimmune disease that relies on the use of complete Freund's adjuvant (CFA...

Authors: Hilde Kelchtermans, Bert De Klerck, Tania Mitera, Maarten Van Balen, Dominique Bullens, Alfons Billiau, Georges Leclercq and Patrick Matthys

Citation: Arthritis Res Ther 2005 7:R402

Content type: Research article Published on: 28 January 2005
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Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation

During immune-complex-mediated arthritis (ICA), severe cartilage destruction is mediated by Fcγ receptors (FcγRs) (mainly FcγRI), cytokines (e.g. IL-1), and enzymes (matrix metalloproteinases (MMPs)). IL-13, a...

Authors: Karin CAM Nabbe, Peter LEM van Lent, Astrid EM Holthuysen, Annet W Sloëtjes, Alisa E Koch, Timothy RDJ Radstake and Wim B van den Berg

Citation: Arthritis Res Ther 2005 7:R392

Content type: Research article Published on: 26 January 2005
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Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function

Oxidative stress leads to increased risk for osteoarthritis (OA) but the precise mechanism remains unclear. We undertook this study to clarify the impact of oxidative stress on the progression of OA from the v...

Authors: Kazuo Yudoh, Nguyen van Trieu, Hiroshi Nakamura, Kayo Hongo-Masuko, Tomohiro Kato and Kusuki Nishioka

Citation: Arthritis Res Ther 2005 7:R380

Content type: Research article Published on: 26 January 2005
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Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options

Apart from complete and incomplete congenital heart block (CHB), new cardiac manifestations related to anti-SSA/Ro antibodies have been reported in children born to mothers bearing these antibodies. These mani...

Authors: Nathalie Costedoat-Chalumeau, Zahir Amoura, Elisabeth Villain, Laurence Cohen and Jean-Charles Piette

Citation: Arthritis Res Ther 2005 7:69

Content type: Review Published on: 25 January 2005
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Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases

Naturally occurring CD4⁺CD25⁺ regulatory T cells mediate immune suppression to limit immunopathogenesis associated with chronic inflammation, persistent infections and autoimmune diseases. Their mode of suppressi...

Authors: Sharon M Wahl and Wanjun Chen

Citation: Arthritis Res Ther 2005 7:62

Content type: Review Published on: 24 January 2005
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TLR2 modulates inflammation in zymosan-induced arthritis in mice

The interplay between the innate and acquired immune systems in chronic inflammation is not well documented. We have investigated the mechanisms of inflammation in murine zymosan-induced arthritis (ZIA) in the...

Authors: Matthias E Frasnelli, David Tarussio, Veronique Chobaz-Péclat, Nathalie Busso and Alexander So

Citation: Arthritis Res Ther 2005 7:R370

Content type: Research article Published on: 21 January 2005
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Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy

Considering the relation between synovial inflammation and global disease activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA) synovitis, the present ...

Authors: Dominique Baeten, Elli Kruithof, Leen De Rycke, Anemieke M Boots, Herman Mielants, Eric M Veys and Filip De Keyser

Citation: Arthritis Res Ther 2005 7:R359

Content type: Research article Published on: 21 January 2005
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Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis

Rheumatoid arthritis (RA) is a highly heterogeneous disease with respect to its joint destructivity. The reasons underlying this heterogeneity are unknown. Deficient apoptosis in rheumatoid synovial tissue has...

Authors: Maria Bokarewa, Sofia Lindblad, Dmitriy Bokarew and Andrej Tarkowski

Citation: Arthritis Res Ther 2005 7:R349

Content type: Research article Published on: 21 January 2005
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Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases?

Pleiotropic effects are now described for the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (or statins) that might have utility in the context of chronic inflammatory autoimmune disease. Here we ...

Authors: David W McCarey, Naveed Sattar and Iain B McInnes

Citation: Arthritis Res Ther 2005 7:55

Content type: Review Published on: 21 January 2005
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Multilevel examination of minor salivary gland biopsy for Sjögren's syndrome significantly improves diagnostic performance of AECG classification criteria

The recently observed low reproducibility of focus score (FS) assessment at different section depths in a series of single minor salivary gland biopsies highlighted the need for a standardized protocol of exte...

Authors: Patrizia Morbini, Antonio Manzo, Roberto Caporali, Oscar Epis, Chiara Villa, Carmine Tinelli, Enrico Solcia and Carlomaurizio Montecucco

Citation: Arthritis Res Ther 2005 7:R343

Content type: Research article Published on: 17 January 2005
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Prescription channeling of COX-2 inhibitors and traditional nonselective nonsteroidal anti-inflammatory drugs: a population-based case–control study

This pharmacoepidemiologic study was conducted to determine whether risk factors for upper gastrointestinal bleeding influenced the prescription of cyclo-oxygenase (COX)-2 inhibitors and traditional nonselecti...

Authors: Yola Moride, Thierry Ducruet, Jean-François Boivin, Nicholas Moore, Sylvie Perreault and Sean Zhao

Citation: Arthritis Res Ther 2005 7:R333

Content type: Research article Published on: 17 January 2005
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High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery

This study demonstrates the first real-time imaging in vivo of human cartilage in normal and osteoarthritic knee joints at a resolution of micrometers, using optical coherence tomography (OCT). This recently deve...

Authors: Xingde Li, Scott Martin, Costas Pitris, Ravi Ghanta, Debra L Stamper, Michelle Harman, James G Fujimoto and Mark E Brezinski

Citation: Arthritis Res Ther 2005 7:R318

Content type: Research article Published on: 17 January 2005
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