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  1. Content type: Review

    Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked endogenous class II mo...

    Authors: Veena Taneja and Chella S David

    Citation: Arthritis Research & Therapy 2000 2:205

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  2. Content type: Review

    The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the 'initiators' of RA (if ...

    Authors: Raimund W Kinne, Rolf Bräuer, Bruno Stuhlmüller, Ernesta Palombo-Kinne and Gerd-R Burmester

    Citation: Arthritis Research & Therapy 2000 2:189

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  3. Content type: Commentary

    Results and new hypotheses in animal models often stimulate development of new paradigms in how we view rheumatoid arthritis (RA). The complexity of RA does, however, eventually lead to the rejection of these ...

    Authors: Rikard Holmdahl

    Citation: Arthritis Research & Therapy 2000 2:169

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  4. Content type: Research article

    An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine the clinical significance of a ...

    Authors: Raphaela Goldbach-Mansky, Jennifer Lee, Angela McCoy, Joseph Hoxworth, Cheryl Yarboro, Josef S Smolen, Günter Steiner, Antony Rosen, Cindy Zhang, Henri A Ménard, Zhi Jie Zhou, Timo Palosuo, Walther J Van Venrooij, Ronald L Wilder, John H Klippel, H Ralph Schumacher Jr…

    Citation: Arthritis Research & Therapy 2000 2:236

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  5. Content type: Research article

    The kinetics of apoptosis and the apoptosis-regulating gene p53 in adjuvant arthritis (AA) were investigated to assess the value of the AA rat model for testing apoptosis-inducing therapies. Very few terminal deo...

    Authors: Paul P Tak, Maartje S Klapwijk, Sophie FM Broersen, Deliana A van de Geest, Marieke Overbeek and Gary S Firestein

    Citation: Arthritis Research & Therapy 2000 2:229

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  6. Content type: Research article

    Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA express...

    Authors: Rosemary O'Hara, Evelyn P Murphy, Alexander S Whitehead, Oliver FitzGerald and Barry Bresnihan

    Citation: Arthritis Research & Therapy 2000 2:142

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  7. Content type: Review

    Normally the immune response is restricted to the peripheral secondary lymphoid organs. However, additional ectopic lymphoid tissue may develop at chronic sites of inflammation. In the synovium of rheumatoid a...

    Authors: Hye-Jung Kim and Claudia Berek

    Citation: Arthritis Research & Therapy 2000 2:126

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  8. Content type: Commentary

    Osteoarthritis is complex in genetics, pathogenesis, monitoring and treatment. Current treatment of osteoarthritis does not influence progression. Much could be gained by more effective 'low-tech-low-cost' tre...

    Authors: L Stefan Lohmander

    Citation: Arthritis Research & Therapy 2000 2:95

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  9. Content type: Research article

    Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy...

    Authors: Raphaela Goldbach-Mansky, Jennifer M Lee, Joseph M Hoxworth, David Smith II, Paul Duray, H Ralph Schumacher Jr, Cheryl H Yarboro, John Klippel, David Kleiner and Hani S El-Gabalawy

    Citation: Arthritis Research & Therapy 2000 2:145

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  10. Content type: Review

    Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The me...

    Authors: Paul J Utz,, Timothy J Gensler and Paul Anderson

    Citation: Arthritis Research & Therapy 2000 2:101

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  11. Content type: Commentary

    A chance observation has led to the development of a new murine model for inflammatory arthritis. Arthritis is induced, and transferred, by T-cell-dependent antibodies to glucose-6-phosphate isomerase. This en...

    Authors: Hugh McDevitt

    Citation: Arthritis Research & Therapy 2000 2:85

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