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  1. The antigenic specificity of an unusual antinuclear antibody pattern in three patient sera was identified after separating HeLa-cell nuclear extracts by two-dimensional (2D) gel electrophoresis and localizing ...

    Authors: Niels HH Heegaard, Martin R Larsen, Terri Muncrief, Allan Wiik and Peter Roepstorff

    Citation: Arthritis Research & Therapy 2000 2:407

    Content type: Research article

    Published on:

  2. IL-10, IL-13, IFN-γ, tumor necrosis factor (TNF)-α, LT-α, CD154, and TNF-related activation-induced cytokine (TRANCE) were expressed by 2-20% of rheumatoid arthritis (RA) synovial tissue CD4+ memory T cells, wher...

    Authors: Toshihiro Nanki and Peter E Lipsky

    Citation: Arthritis Research & Therapy 2000 2:415

    Content type: Research article

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  3. We propose that the phenomenon of X-chromosome inactivation in females may constitute a risk factor for loss of T-cell tolerance; specifically that skewed X-chromosome inactivation in the thymus may lead to in...

    Authors: Smita Chitnis, Joanita Monteiro, David Glass, Brian Apatoff, Jane Salmon, Patrick Concannon and Peter K Gregersen

    Citation: Arthritis Research & Therapy 2000 2:399

    Content type: Research article

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    The Erratum to this article has been published in Arthritis Research & Therapy 2001 3:E001

  4. Leukocyte ingress into the synovium is a key process in the pathogenesis of rheumatoid arthritis and other inflammatory conditions. In this review, the role of endothelial cells in leukocyte extravasation will...

    Authors: Zoltan Szekanecz and Alisa E Koch

    Citation: Arthritis Research & Therapy 2000 2:368

    Content type: Review

    Published on:

  5. The substantial progress in our understanding of molecular and cellular biology has allowed us to design biological therapeutics ('biologicals') with defined targets and effector functions. These biologicals h...

    Authors: Hendrik Schulze-Koops and Joachim R Kalden

    Citation: Arthritis Research & Therapy 2000 2:337

    Content type: Commentary

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  6. Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes an...

    Authors: Allan Wiik

    Citation: Arthritis Research & Therapy 2000 2:252

    Content type: Review

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  7. Fibroblast-like cells in the synovial lining (type B lining cells), stroma and pannus tissue are targeted by many signals, such as the following: ligands binding to cell surface receptors; lipid soluble, small...

    Authors: Yrjö T Konttinen, Tian-Fang Li, Mika Hukkanen, Jian Ma, Jing-Wen Xu and Ismo Virtanen

    Citation: Arthritis Research & Therapy 2000 2:348

    Content type: Review

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  8. Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete remissions can be achieved in refractory polychondr...

    Authors: Oliver Rosen, Andreas Thiel, Gero Massenkeil, Falk Hiepe, Thomas Häupl, Hartmut Radtke, Gerd R Burmester, Erika Gromnica-Ihle, Andreas Radbruch and Renate Arnold

    Citation: Arthritis Research & Therapy 2000 2:327

    Content type: Research article

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  9. The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 2...

    Authors: Vivianne Malmström, Johan Bäcklund, Liselotte Jansson, Jan Kihlberg and Rikard Holmdahl

    Citation: Arthritis Research & Therapy 2000 2:315

    Content type: Research article

    Published on:

  10. Studies on immunological reconstitution after immune ablation and stem-cell therapy may yield important clues to our understanding of the pathogenesis of human autoimmune disease, due to the profound effects o...

    Authors: Jacob M van Laar

    Citation: Arthritis Research & Therapy 2000 2:270

    Content type: Review

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  11. To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mIL-4) was used for periarticular injection into...

    Authors: Seon Hee Kim, Christopher H Evans, Sunyoung Kim, Thomas Oligino, Steven C Ghivizzani and Paul D Robbins

    Citation: Arthritis Research & Therapy 2000 2:293

    Content type: Research article

    Published on:

  12. In the present study 55 IgVH genes amplified from three different anatomical regions of a rheumatoid arthritis (RA) patient were analyzed, adding further information on synovial B-cell maturation and recircula...

    Authors: Maria M Souto-Carneiro, Veit Krenn, Ralph Hermann, Achim König and Hans-Konrad Müller-Hermelink

    Citation: Arthritis Research & Therapy 2000 2:303

    Content type: Research article

    Published on:

  13. Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds. The levels of both se...

    Authors: William P Arend and Cem Gabay

    Citation: Arthritis Research & Therapy 2000 2:245

    Content type: Commentary

    Published on:

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