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  1. Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked endogenous class II mo...

    Authors: Veena Taneja and Chella S David

    Citation: Arthritis Research & Therapy 2000 2:205

    Content type: Review

    Published on:

  2. The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the 'initiators' of RA (if ...

    Authors: Raimund W Kinne, Rolf Bräuer, Bruno Stuhlmüller, Ernesta Palombo-Kinne and Gerd-R Burmester

    Citation: Arthritis Research & Therapy 2000 2:189

    Content type: Review

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  3. Results and new hypotheses in animal models often stimulate development of new paradigms in how we view rheumatoid arthritis (RA). The complexity of RA does, however, eventually lead to the rejection of these ...

    Authors: Rikard Holmdahl

    Citation: Arthritis Research & Therapy 2000 2:169

    Content type: Commentary

    Published on:

  4. An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine the clinical significance of a ...

    Authors: Raphaela Goldbach-Mansky, Jennifer Lee, Angela McCoy, Joseph Hoxworth, Cheryl Yarboro, Josef S Smolen, Günter Steiner, Antony Rosen, Cindy Zhang, Henri A Ménard, Zhi Jie Zhou, Timo Palosuo, Walther J Van Venrooij, Ronald L Wilder, John H Klippel, H Ralph Schumacher Jr…

    Citation: Arthritis Research & Therapy 2000 2:236

    Content type: Research article

    Published on:

  5. The kinetics of apoptosis and the apoptosis-regulating gene p53 in adjuvant arthritis (AA) were investigated to assess the value of the AA rat model for testing apoptosis-inducing therapies. Very few terminal deo...

    Authors: Paul P Tak, Maartje S Klapwijk, Sophie FM Broersen, Deliana A van de Geest, Marieke Overbeek and Gary S Firestein

    Citation: Arthritis Research & Therapy 2000 2:229

    Content type: Research article

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  6. Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA express...

    Authors: Rosemary O'Hara, Evelyn P Murphy, Alexander S Whitehead, Oliver FitzGerald and Barry Bresnihan

    Citation: Arthritis Research & Therapy 2000 2:142

    Content type: Research article

    Published on:

  7. Normally the immune response is restricted to the peripheral secondary lymphoid organs. However, additional ectopic lymphoid tissue may develop at chronic sites of inflammation. In the synovium of rheumatoid a...

    Authors: Hye-Jung Kim and Claudia Berek

    Citation: Arthritis Research & Therapy 2000 2:126

    Content type: Review

    Published on:

  8. Osteoarthritis is complex in genetics, pathogenesis, monitoring and treatment. Current treatment of osteoarthritis does not influence progression. Much could be gained by more effective 'low-tech-low-cost' tre...

    Authors: L Stefan Lohmander

    Citation: Arthritis Research & Therapy 2000 2:95

    Content type: Commentary

    Published on:

  9. Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy...

    Authors: Raphaela Goldbach-Mansky, Jennifer M Lee, Joseph M Hoxworth, David Smith II, Paul Duray, H Ralph Schumacher Jr, Cheryl H Yarboro, John Klippel, David Kleiner and Hani S El-Gabalawy

    Citation: Arthritis Research & Therapy 2000 2:145

    Content type: Research article

    Published on:

  10. Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The me...

    Authors: Paul J Utz,, Timothy J Gensler and Paul Anderson

    Citation: Arthritis Research & Therapy 2000 2:101

    Content type: Review

    Published on:

  11. A chance observation has led to the development of a new murine model for inflammatory arthritis. Arthritis is induced, and transferred, by T-cell-dependent antibodies to glucose-6-phosphate isomerase. This en...

    Authors: Hugh McDevitt

    Citation: Arthritis Research & Therapy 2000 2:85

    Content type: Commentary

    Published on:

  12. CD8+ T cells dominate the lymphocyte population insynovial fluid in chronic inflammatory arthritis. It is known that theseCD8+ T cells are often clonally or oligoclonally expanded, but theirspecificity and their ...

    Authors: Linda C Tan, Alastair G Mowat, Chrysoula Fazou, Tim Rostron, Helen Roskell, P Rod Dunbar, Claire Tournay, François Romagné, Marie-Alix Peyrat, Elisabeth Houssaint, Marc Bonneville, Alan B Rickinson, Andrew J McMichael and Margaret FC Callan

    Citation: Arthritis Research & Therapy 2000 2:154

    Content type: Research article

    Published on:

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