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  1. Destruction of cartilage and bone are hallmarks of human rheumatoid arthritis (RA), and controlling these erosive processes is the most challenging objective in the treatment of RA. Systemic interleukin-4 trea...

    Authors: Leo AB Joosten, Erik Lubberts, Monique MA Helsen, Tore Saxne, Christina JJ Coenen-de Roo, Dick Heinegård and Wim B van den Berg

    Citation: Arthritis Research & Therapy 1999 1:81

    Content type: Research article

    Published on:

  2. Our aim was to identify specifically expressed genes using RNA arbitrarily primed (RAP)-polymerase chain reaction (PCR) for differential display in patients with rheumatoid arthritis (RA). In RA, amplification...

    Authors: Frank Kullmann, Martin Judex, Wibke Ballhorn, Hans-Peter Jüsten, Dieter Wessinghage, John Welsh, Tim J Yen, Bernhard Lang, Jim C Hittle, Michael McClelland, Steffen Gay, Jürgen Schölmerich and Ulf Müller-Ladner

    Citation: Arthritis Research & Therapy 1999 1:71

    Content type: Research article

    Published on:

  3. The genetic basis for rheumatoid arthritis (RA) is likely to be extremely complex. Even the role of MHC genes remains to be fully defined, and may involve interactive genetic effects. The difficulty of precise...

    Authors: Peter K Gregersen

    Citation: Arthritis Research & Therapy 1999 1:37

    Content type: Review

    Published on:

  4. The biologically active metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], acts through vitamin D receptors, which were found in rheumatoid tissues in the present study. IL-1β-activated rheumatoi...

    Authors: Lynne C Tetlow and David E Woolley

    Citation: Arthritis Research & Therapy 1999 1:63

    Content type: Research article

    Published on:

  5. Recent technological advances allow the transfer of genes to the synovial lining of joints. As well as opening novel opportunities for therapy, these techniques provide valuable new tools for the study of syno...

    Authors: Christopher H Evans, Steven C Ghivizzani, Eric R Lechman, Zhebao Mi, Daniel Jaffurs and Paul D Robbins

    Citation: Arthritis Research & Therapy 1999 1:21

    Content type: Review

    Published on:

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