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  1. The loss of extracellular matrix macromolecules from the cartilage results in serious impairment of joint function. Metalloproteinases called 'aggrecanases' that cleave the Glu373–Ala374 bond of the aggrecan core...

    Authors: Hideaki Nagase and Masahide Kashiwagi
    Citation: Arthritis Res Ther 2003 5:94
  2. Scleroderma (systemic sclerosis) is associated with several autoantibodies, each of which is useful in the diagnosis of affected patients and in determining their prognosis. Anti-centromere antibodies (ACA) an...

    Authors: Khanh T Ho and John D Reveille
    Citation: Arthritis Res Ther 2003 5:80
  3. Patients with systemic lupus erythematosus (SLE) have ongoing interferon-α (IFN-α) production and serum IFN-α levels are correlated with both disease activity and severity. Recent studies of patients with SLE ...

    Authors: Lars Rönnblom and Gunnar V Alm
    Citation: Arthritis Res Ther 2003 5:68
  4. The systematic analysis of polymorphisms across large parts of the human genome has begun to provide the first information on haplotypes and the problem of linkage disequilibrium across large genomic regions. ...

    Authors: John I Bell
    Citation: Arthritis Res Ther 2003 5:51
  5. The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues, including bone marrow stroma and a number of connective tissues, has provided exciting prospects for cell-ba...

    Authors: Rocky S Tuan, Genevieve Boland and Richard Tuli
    Citation: Arthritis Res Ther 2002 5:32
  6. Cyclooxygenase (COX)-2 selective inhibitors have been shown to have comparable efficacy to nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of patients with osteoarthritis (OA) and r...

    Authors: Marc C Hochberg
    Citation: Arthritis Res Ther 2002 5:28
  7. We are pleased to announce a number of changes to the journal that will take effect from the start of 2003.

    Authors: Peter E Lipsky and Ravinder N Maini
    Citation: Arthritis Res Ther 2002 5:1
  8. Primary Sjögren's syndrome (pSS) is an autoimmune disorder characterized by specific pathologic features and the production of typical autoantibodies. In addition, characteristic changes in the distribution of...

    Authors: Thomas Dörner and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2002 4:360
  9. Sjögren's syndrome is a multisystem inflammatory rheumatic disease that is classified into primary and secondary forms, with cardinal features in the eye (keratoconjunctivitis sicca) and mouth (xerostomia). Th...

    Authors: Anne Isine Bolstad and Roland Jonsson
    Citation: Arthritis Research & Therapy 2002 4:353
  10. IFN-β treatment is emerging as a potentially effective form of therapy in various immune-mediated conditions. The present review addresses the possible role of IFN-β in immune-mediated diseases such as multipl...

    Authors: Judith van Holten, Christine Plater-Zyberk and Paul P Tak
    Citation: Arthritis Research & Therapy 2002 4:346
  11. Therapeutic options for patients with more severe forms of spondyloarthritis (SpA) have been rather limited in recent decades. There is accumulating evidence that anti-tumor-necrosis-factor (anti-TNF) therapy ...

    Authors: Juergen Braun and Joachim Sieper
    Citation: Arthritis Research & Therapy 2002 4:307
  12. The chronic arthropathies of childhood share clinical and pathological features with rheumatoid arthritis (RA) in adults. Both are autoimmune diseases characterized by a destructive arthropathy. Both are likel...

    Authors: Sampath Prahalad and David N Glass
    Citation: Arthritis Research & Therapy 2002 4(Suppl 3):303

    This article is part of a Supplement: Volume 4 Supplement 3

  13. T-cell responses to antigens are classified on the basis of the cytokines they produce as either Th1 (IFN-γ, IL-2) or Th2 (IL-4, IL-10), with these Th types being indicative of either cell-mediated or antibody...

    Authors: Edward F Rosloniec, Kary Latham and Yajaira B Guedez
    Citation: Arthritis Research & Therapy 2002 4:333
  14. Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is affected by a chr...

    Authors: Ann-Sofie Hansson and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2002 4:296
  15. Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine that has been implicated in a variety of rheumatic and inflammatory diseases. New understanding of the importance of TNF-α in the pathophysiology...

    Authors: Joachim R Kalden
    Citation: Arthritis Research & Therapy 2002 4(Suppl 2):S34

    This article is part of a Supplement: Volume 4 Supplement 2

  16. Several groups have documented the expression of cytokines in rheumatoid arthritis synovial tissue over the past 15 years or so. These studies have indicated that most cytokines examined are expressed at the m...

    Authors: Fionula Mary Brennan and Andrew David Foey
    Citation: Arthritis Research & Therapy 2002 4(Suppl 3):S177

    This article is part of a Supplement: Volume 4 Supplement 3

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