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  1. The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 product...

    Authors: Martine Chabaud, Erik Lubberts, Leo Joosten, Wim van den Berg and Pierre Miossec

    Citation: Arthritis Research & Therapy 2001 3:168

    Content type: Research article

    Published on:

  2. Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P116

    Content type: Meeting abstract

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 2

  3. In our study we characterised the immunophenotype of monocytes that migrated through an endothelial cell (EC) monolayer in vitro. We found that monocyte migration led to an enhanced expression of CD11a, CD33, CD4...

    Authors: Johannes Grisar, Philipp Hahn, Susanne Brosch, Meinrad Peterlik, Josef S Smolen and Peter Pietschmann

    Citation: Arthritis Research & Therapy 2001 3:127

    Content type: Research article

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  4. This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and oxidative str...

    Authors: Georg Schett, Makiyeh Tohidast-Akrad, Günter Steiner and Josef Smolen

    Citation: Arthritis Research & Therapy 2001 3:80

    Content type: Commentary

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  5. Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted i...

    Authors: Kenji Hayashida, Toshihiro Nanki, Hermann Girschick, Sule Yavuz, Takahiro Ochi and Peter E Lipsky

    Citation: Arthritis Research & Therapy 2001 3:118

    Content type: Research article

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  6. The causes of rheumatoid arthritis (RA) are largely unknown. However, RA is most probably a multifactorial disease with contributions from genetic and environmental factors. Searches for genes that influence R...

    Authors: Johan Jirholt, Anna-Karin B Lindqvist and Rikard Holmdahl

    Citation: Arthritis Research & Therapy 2000 3:87

    Content type: Review

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  7. The underlying molecular defect resulting in the abnormal calcification observed in ank/ank mice has been identified. The responsible nonsense mutation affects the protein product of ank, resulting in diminished ...

    Authors: Lawrence M Ryan

    Citation: Arthritis Research & Therapy 2000 3:77

    Content type: Commentary

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  8. Most anti-inflammatory drugs have been associated with an increased risk of serious upper gastrointestinal complications. Epidemiological studies have estimated the magnitude of the risk for specific anti-infl...

    Authors: Luis Alberto García Rodríguez and Sonia Hernández-Díaz

    Citation: Arthritis Research & Therapy 2000 3:98

    Content type: Review

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  9. To reduce culture artifacts by conventional repeated passaging and long-term culture in vitro, the isolation of synovial fibroblasts (SFB) was attempted from rheumatoid arthritis (RA) synovial membranes by trypsi...

    Authors: Thomas Zimmermann, Elke Kunisch, Robert Pfeiffer, Astrid Hirth, Hans-Detlev Stahl, Ulrich Sack, Anke Laube, Eckehard Liesaus, Andreas Roth, Ernesta Palombo-Kinne, Frank Emmrich and Raimund W Kinne

    Citation: Arthritis Research & Therapy 2000 3:72

    Content type: Research article

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  10. Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are considered to be master cytokines in chronic, destructive arthritis. Therapeutic approaches in rheumatoid arthritis (RA) patients have so far focused ma...

    Authors: Wim B van den Berg

    Citation: Arthritis Research & Therapy 2000 3:18

    Content type: Review

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  11. Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from fiv...

    Authors: Maarten C Kraan, Dhavalkumar D Patel, Jasper J Haringman, Malcolm D Smith, Helen Weedon, Michael J Ahern, Ferdinand C Breedveld and Paul P Tak

    Citation: Arthritis Research & Therapy 2000 3:65

    Content type: Research article

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  12. We discuss major topics presented at this recent international workshop, illustrating how recent progress in areas as diverse as free radical biochemistry, developmental biology, molecular genetics and vascula...

    Authors: Frank A Wollheim, Christopher P Denton and David J Abraham

    Citation: Arthritis Research & Therapy 2000 3:34

    Content type: Meeting report

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  13. The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of...

    Authors: Olof H Hultgren, Martin Stenson and Andrzej Tarkowski

    Citation: Arthritis Research & Therapy 2000 3:41

    Content type: Research article

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  14. The contribution of osteoclasts to the process of bone loss in inflammatory arthritis has recently been demonstrated. Studies in osteoclast biology have led to the identification of factors responsible for the...

    Authors: Ellen M Gravallese, Deborah L Galson, Steven R Goldring and Philip E Auron

    Citation: Arthritis Research & Therapy 2000 3:6

    Content type: Review

    Published on:

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