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  1. In the present study 55 IgVH genes amplified from three different anatomical regions of a rheumatoid arthritis (RA) patient were analyzed, adding further information on synovial B-cell maturation and recircula...

    Authors: Maria M Souto-Carneiro, Veit Krenn, Ralph Hermann, Achim König and Hans-Konrad Müller-Hermelink

    Citation: Arthritis Research & Therapy 2000 2:303

    Content type: Research article

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  2. Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds. The levels of both se...

    Authors: William P Arend and Cem Gabay

    Citation: Arthritis Research & Therapy 2000 2:245

    Content type: Commentary

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  3. Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked endogenous class II mo...

    Authors: Veena Taneja and Chella S David

    Citation: Arthritis Research & Therapy 2000 2:205

    Content type: Review

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  4. The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the 'initiators' of RA (if ...

    Authors: Raimund W Kinne, Rolf Bräuer, Bruno Stuhlmüller, Ernesta Palombo-Kinne and Gerd-R Burmester

    Citation: Arthritis Research & Therapy 2000 2:189

    Content type: Review

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  5. Results and new hypotheses in animal models often stimulate development of new paradigms in how we view rheumatoid arthritis (RA). The complexity of RA does, however, eventually lead to the rejection of these ...

    Authors: Rikard Holmdahl

    Citation: Arthritis Research & Therapy 2000 2:169

    Content type: Commentary

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  6. An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine the clinical significance of a ...

    Authors: Raphaela Goldbach-Mansky, Jennifer Lee, Angela McCoy, Joseph Hoxworth, Cheryl Yarboro, Josef S Smolen, Günter Steiner, Antony Rosen, Cindy Zhang, Henri A Ménard, Zhi Jie Zhou, Timo Palosuo, Walther J Van Venrooij, Ronald L Wilder, John H Klippel, H Ralph Schumacher Jr…

    Citation: Arthritis Research & Therapy 2000 2:236

    Content type: Research article

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  7. The kinetics of apoptosis and the apoptosis-regulating gene p53 in adjuvant arthritis (AA) were investigated to assess the value of the AA rat model for testing apoptosis-inducing therapies. Very few terminal deo...

    Authors: Paul P Tak, Maartje S Klapwijk, Sophie FM Broersen, Deliana A van de Geest, Marieke Overbeek and Gary S Firestein

    Citation: Arthritis Research & Therapy 2000 2:229

    Content type: Research article

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  8. Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA express...

    Authors: Rosemary O'Hara, Evelyn P Murphy, Alexander S Whitehead, Oliver FitzGerald and Barry Bresnihan

    Citation: Arthritis Research & Therapy 2000 2:142

    Content type: Research article

    Published on:

  9. Normally the immune response is restricted to the peripheral secondary lymphoid organs. However, additional ectopic lymphoid tissue may develop at chronic sites of inflammation. In the synovium of rheumatoid a...

    Authors: Hye-Jung Kim and Claudia Berek

    Citation: Arthritis Research & Therapy 2000 2:126

    Content type: Review

    Published on:

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