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  1. The substantial progress in our understanding of molecular and cellular biology has allowed us to design biological therapeutics ('biologicals') with defined targets and effector functions. These biologicals h...

    Authors: Hendrik Schulze-Koops and Joachim R Kalden
    Citation: Arthritis Research & Therapy 2000 2:337
  2. Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes an...

    Authors: Allan Wiik
    Citation: Arthritis Research & Therapy 2000 2:252
  3. Fibroblast-like cells in the synovial lining (type B lining cells), stroma and pannus tissue are targeted by many signals, such as the following: ligands binding to cell surface receptors; lipid soluble, small...

    Authors: Yrjö T Konttinen, Tian-Fang Li, Mika Hukkanen, Jian Ma, Jing-Wen Xu and Ismo Virtanen
    Citation: Arthritis Research & Therapy 2000 2:348
  4. Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete remissions can be achieved in refractory polychondr...

    Authors: Oliver Rosen, Andreas Thiel, Gero Massenkeil, Falk Hiepe, Thomas Häupl, Hartmut Radtke, Gerd R Burmester, Erika Gromnica-Ihle, Andreas Radbruch and Renate Arnold
    Citation: Arthritis Research & Therapy 2000 2:327
  5. The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 2...

    Authors: Vivianne Malmström, Johan Bäcklund, Liselotte Jansson, Jan Kihlberg and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2000 2:315
  6. Studies on immunological reconstitution after immune ablation and stem-cell therapy may yield important clues to our understanding of the pathogenesis of human autoimmune disease, due to the profound effects o...

    Authors: Jacob M van Laar
    Citation: Arthritis Research & Therapy 2000 2:270
  7. To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mIL-4) was used for periarticular injection into...

    Authors: Seon Hee Kim, Christopher H Evans, Sunyoung Kim, Thomas Oligino, Steven C Ghivizzani and Paul D Robbins
    Citation: Arthritis Research & Therapy 2000 2:293
  8. In the present study 55 IgVH genes amplified from three different anatomical regions of a rheumatoid arthritis (RA) patient were analyzed, adding further information on synovial B-cell maturation and recircula...

    Authors: Maria M Souto-Carneiro, Veit Krenn, Ralph Hermann, Achim König and Hans-Konrad Müller-Hermelink
    Citation: Arthritis Research & Therapy 2000 2:303
  9. Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds. The levels of both se...

    Authors: William P Arend and Cem Gabay
    Citation: Arthritis Research & Therapy 2000 2:245
  10. Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked endogenous class II mo...

    Authors: Veena Taneja and Chella S David
    Citation: Arthritis Research & Therapy 2000 2:205

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