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  1. The field of gene therapy for bone and joint disorders has grown considerably over the last two and a half years. Investigators have shown that ex vivo or in vivo gene transfer is highly effective in blocking art...

    Authors: Paul D Robbins, Christian Jorgensen and Christopher H Evans
    Citation: Arthritis Research & Therapy 2001 3:289
  2. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to a wide range of self-antigens. Recent genome screens have implicated numerous chromosomal...

    Authors: Robert R Graham, Carl D Langefeld, Patrick M Gaffney, Ward A Ortmann, Scott A Selby, Emily C Baechler, Katherine B Shark, Theresa C Ockenden, Kristine E Rohlf, Kathleen L Moser, William M Brown, Sherine E Gabriel, Ronald P Messner, Richard A King, Pavel Horak, James T Elder…
    Citation: Arthritis Research & Therapy 2001 3:299
  3. Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries. Apart from being ...

    Authors: Maria Luisa Brandi, Luigi Gennari, Marco Matucci Cerinic, Lucia Becherini, Alberto Falchetti, Laura Masi, Carlo Gennari and Jean-Yves Reginster
    Citation: Arthritis Research & Therapy 2001 3:270
  4. T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to analyse objectively ...

    Authors: Mei-Yi Sun and Paul Bowness
    Citation: Arthritis Research & Therapy 2001 3:265
  5. There is mounting evidence for a role of the growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF) in inflammatory disease, including arthritis. In the present study, we examined the effectiv...

    Authors: Andrew D Cook, Emma L Braine, Ian K Campbell, Melissa J Rich and John A Hamilton
    Citation: Arthritis Research & Therapy 2001 3:293
  6. This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An amphotropic retrovirus (MFG-IRAP) was used ex vivo to...

    Authors: Maria A Del Vecchio, Helga I Georgescu, James E McCormack, Paul D Robbins and Christopher H Evans
    Citation: Arthritis Research & Therapy 2001 3:259
  7. The induction of autoantibodies to U1 small nuclear ribonucleoprotein (U1 snRNP) complexes is not well understood. We present evidence that healthy individuals with cytomegalovirus (CMV) infection have an incr...

    Authors: Marianna M Newkirk, Walther J van Venrooij and Gary S Marshall
    Citation: Arthritis Research & Therapy 2001 3:253
  8. Authors: AC Bakker, FAJ van de Loo, OJ Arntz, LAB Joosten, I Dmitriev, V Krasnykh, DT Curiel and WB van den Berg
    Citation: Arthritis Research & Therapy 2001 3(Suppl 1):P19

    This article is part of a Supplement: Volume 3 Supplement 1

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