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  1. Osteoarthritis (OA) is mainly characterized by the progressive destruction of articular cartilage. Mounting studies have revealed that disruption of extracellular matrix (ECM) homeostasis, aberrant chondrocyte...

    Authors: Kaibo Sun, Yuangang Wu, Yi Zeng, Jiawen Xu, Limin Wu, Mingyang Li and Bin Shen
    Citation: Arthritis Research & Therapy 2022 24:286
    Content type: Review Published on:

  2. Sugiyama et al. recently described in “Latent class analysis of 216 patients with adult-onset Still’s disease,” baseline characteristics, laboratory tests, treatment, relapse, and death of adult-onset Still’s ...

    Authors: Marion Delplanque, Arsène Mekinian and Sophie Georgin-Lavialle
    Citation: Arthritis Research & Therapy 2022 24:285
    Content type: Correspondence Published on:

  3. Lupus nephritis (LN) is the most common and serious complication of systemic lupus erythematosus (SLE). LN pathogenesis is not fully understood. Axl receptor tyrosine kinase is upregulated and contributes to t...

    Authors: Yuxuan Zhen, Yan Ren, Mario Medvedovic, David E. Adams, Diping Wang and Wen-Hai Shao
    Citation: Arthritis Research & Therapy 2022 24:284
    Content type: Research Published on:

  4. Psoriatic arthritis (PsA) patient data from two phase 3 secukinumab trials (FUTURE 1, 5) were analysed to quantify the prevalence and extent of pre-existing radiographic damage (RD) at baseline; investigate th...

    Authors: Philip Mease, Désirée van der Heijde, Bruce Kirkham, Georg Schett, Ana-Maria Orbai, Christopher Ritchlin, Joseph F. Merola, Luminita Pricop, David A. James, Xuan Zhu and Gregory Ligozio
    Citation: Arthritis Research & Therapy 2022 24:283
    Content type: Research Published on:

  5. The infrapatellar fat pad (IFP) is the largest adipose deposit in the knee; however, its contributions to the homeostasis of this organ remain undefined. To determine the influence of the IFP and its associate...

    Authors: Maryam F. Afzali, Lauren B. Radakovich, Madeline M. Sykes, Margaret A. Campbell, Kayley M. Patton, Joseph L. Sanford, Nicole Vigon, Ryan Ek, Gerardo E. Narez, Angela J. Marolf, Katie J. Sikes, Tammy L. Haut Donahue and Kelly S. Santangelo
    Citation: Arthritis Research & Therapy 2022 24:282
    Content type: Research Published on:

  6. Uncontrolled/refractory gout patients are recalcitrant/intolerant to oral urate-lowering therapies (ULTs), experiencing frequent gout flares, functionally limiting tophi, and low quality of life. Pegloticase l...

    Authors: John K. Botson, Katie Obermeyer, Brian LaMoreaux, Lin Zhao, Michael E. Weinblatt and Jeff Peterson
    Citation: Arthritis Research & Therapy 2022 24:281
    Content type: Research Published on:

  7. Interstitial lung disease, a common extra-articular complication of connective tissue disease, is characterized by progressive and irreversible pulmonary inflammation and fibrosis, which causes significant mor...

    Authors: Ziye Qu, Wencan Dou, Kexin Zhang, Lili Duan, Dongmei Zhou and Songlou Yin
    Citation: Arthritis Research & Therapy 2022 24:280
    Content type: Research Published on:

  8. In axial spondyloarthritis (axSpA) inflammation of the sacroiliac joints and spine is associated with local extracellular matrix (ECM) remodeling of affected tissues. We aimed to investigate the association of...

    Authors: Signe Holm Nielsen, Shu Sun, Anne C. Bay-Jensen, Morten Karsdal, Inge Juul Sørensen, Ulrich Weber, Anne Gitte Loft, Gina Kollerup, Gorm Thamsborg, Ole Rintek Madsen, Jakob Møller, Mikkel Østergaard and Susanne Juhl Pedersen
    Citation: Arthritis Research & Therapy 2022 24:279
    Content type: Research Published on:

  9. In patients affected by connective tissue diseases (CTDs), the identification of wide autoantibody profiles may prove useful in early diagnosis, in the evaluation of prognosis (risk stratification), and in pre...

    Authors: Nicola Bizzaro, Danilo Villalta, Vittorio Bini, Paola Migliorini, Franco Franceschini, Silvia Piantoni, Emirena Garrafa, Valeria Riccieri, Antonella Fioravanti, Francesca Bellisai, Marilina Tampoia, Marco Fornaro, Florenzo Iannone, Anna Ghirardello, Margherita Zen, Boaz Palterer…
    Citation: Arthritis Research & Therapy 2022 24:278
    Content type: Research Published on:

  10. Rheumatoid arthritis patients usually suffer from arthritic chronic pain. However, due to an incomplete understanding of the mechanisms underlying autoimmune disorders, the management of arthritic pain is unsa...

    Authors: Yue-Peng Jiang, Song Wang, Wei-Dong Lai, Xue-Qing Wu, Yan Jin, Zheng-Hao Xu, Aubin Moutal, Rajesh Khanna, Ki Duk Park, Zhi-Ming Shan, Cheng-Ping Wen and Jie Yu
    Citation: Arthritis Research & Therapy 2022 24:277
    Content type: Research Published on:

  11. To evaluate the effects of tumor necrosis factor inhibitors (TNFi), interleukin-6 receptor inhibitors (IL-6Ri), and Janus kinase inhibitors (JAKi) on hemoglobin (Hb) and C-reactive protein (CRP) levels in adul...

    Authors: Anthony S. Padula, Dimitrios A. Pappas, Stefano Fiore, Taylor S. Blachley, Kerri Ford, Kelechi Emeanuru and Joel M. Kremer
    Citation: Arthritis Research & Therapy 2022 24:276
    Content type: Research Published on:

    The Research to this article has been published in Arthritis Research & Therapy 2022 24:207

  13. Neutrophil extracellular traps (NETs) are critically involved in microscopic polyangiitis (MPA) pathogenesis, and some patients with MPA possess anti-NET antibody (ANETA). Anti-myosin light chain 6 (MYL6) anti...

    Authors: Miku Yoshinari, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Yoshihiro Arimura, Koichi Amano, Yukio Yuzawa, Ken-Ei Sada, Tatsuya Atsumi, Hiroaki Dobashi, Hitoshi Hasegawa, Masayoshi Harigai, Seiichi Matsuo, Hirofumi Makino and Akihiro Ishizu
    Citation: Arthritis Research & Therapy 2022 24:274
    Content type: Research Published on:

  14. Bone marrow-derived mesenchymal stem cells (BMSCs) are general progenitor cells of osteoblasts and adipocytes and they are characterized as a fundamental mediator for bone formation. The current research studi...

    Authors: Lixia Fan, Kaiyun Yang, Ruixuan Yu, Houde Hui and Wenliang Wu
    Citation: Arthritis Research & Therapy 2022 24:273
    Content type: Research Published on:

  15. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13075-022-02973-w.

    Authors: Gianluca Bagnato, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Donatella Sangari, Maurizio Cinquegrani, William Neal Roberts, Marco Atteritano, Domenica Altavilla, Francesco Squadrito, Gianfilippo Bagnato and Antonino Saitta
    Citation: Arthritis Research & Therapy 2022 24:272
    Content type: Retraction Note Published on:

  16. To analyze therapy adherence, safety, and outcome in adult patients with juvenile idiopathic arthritis (JIA) treated with the etanercept biosimilar Benepali® (Biogen Inc, Cambridge, USA).

    Authors: Kristina Vollbach, Klaus Tenbrock, Nobert Wagner, Gerd Horneff, Ariane Klein, Ivan Foeldvari, Johannes-Peter Haas, Peer Aries, Georg Gauler, Frank Striesow, Paula Hoff, Christine Scholz, Stefanie Tatsis, Eva Seipelt, Jens Klotsche and Kirsten Minden
    Citation: Arthritis Research & Therapy 2022 24:271
    Content type: Research Published on:

  17. The associations of rheumatoid arthritis (RA) with risk of site-specific cancers beyond lymphohematopoietic cancer have been scarcely explored. We conducted a Mendelian randomization investigation of the assoc...

    Authors: Shuai Yuan, Jie Chen, Xixian Ruan, Mathew Vithayathil, Siddhartha Kar, Xue Li, Amy M. Mason, Stephen Burgess and Susanna C. Larsson
    Citation: Arthritis Research & Therapy 2022 24:270
    Content type: Research Published on:

  18. Although cross-sectional and cohort data suggest that higher serum blood glucose levels in patients with knee osteoarthritis (KOA) are associated with more severe knee symptoms, little is known about the longi...

    Authors: Daisuke Chiba, Tetsushi Ohyama, Eiji Sasaki, Makoto Daimon, Shigeyuki Nakaji and Yasuyuki Ishibashi
    Citation: Arthritis Research & Therapy 2022 24:269
    Content type: Research Published on:

  19. Rheumatoid arthritis is an autoimmune condition that predominantly affects the synovial joints, causing joint destruction, pain, and disability. Historically, the standard for measuring the long-term efficacy ...

    Authors: Alix Bird, Lauren Oakden-Rayner, Christopher McMaster, Luke A. Smith, Minyan Zeng, Mihir D. Wechalekar, Shonket Ray, Susanna Proudman and Lyle J. Palmer
    Citation: Arthritis Research & Therapy 2022 24:268
    Content type: Review Published on:

  20. Lupus nephritis (LN) is an inflammatory disease of the kidneys affecting patients with systemic lupus erythematosus. Current immunosuppressive and cytotoxic therapies are associated with serious side effects a...

    Authors: Justin Knapp, Marsela Braunstein, Spencer Iner Thomas Berg and Cody Shirriff
    Citation: Arthritis Research & Therapy 2022 24:267
    Content type: Research Published on:

  21. Takayasu arteritis (TAK) is characterized by pro-inflammatory M1 macrophage infiltration and increased interferon (IFN)-γ expression in vascular lesions. IFN-γ is a key cytokine involved in M1 polarization. Ma...

    Authors: Rongyi Chen, Jinghua Wang, Xiaojuan Dai, Sifan Wu, Qingrong Huang, Lindi Jiang and Xiufang Kong
    Citation: Arthritis Research & Therapy 2022 24:266
    Content type: Research Published on:

  22. Loss of bone is a common medical problem and, while it can be treated with available therapies, some of these therapies have critical side effects. We have previously demonstrated that CGS21680, a selective A2A a...

    Authors: Ane Larrañaga-Vera, Kiran S. Toti, James S. Flatow, Alexandra J. Haraczy, Eugene Warnick, Harsha Rao, Zhan-Guo Gao, Sarah M. Sussman, Aranzazu Mediero, Philipp Leucht, Kenneth A. Jacobson and Bruce N. Cronstein
    Citation: Arthritis Research & Therapy 2022 24:265
    Content type: Research Published on:

  23. This exploratory study compared the inhibition of bone erosion progression in rheumatoid arthritis (RA) patients treated with a conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) plus denos...

    Authors: Naoki Iwamoto, Ko Chiba, Shuntaro Sato, Kazuteru Shiraishi, Kounosuke Watanabe, Nozomi Oki, Akitomo Okada, Tomohiro Koga, Shin-ya Kawashiri, Mami Tamai, Naoki Hosogaya, Masako Furuyama, Makiko Kobayashi, Kengo Saito, Naoki Okubo, Masataka Uetani…
    Citation: Arthritis Research & Therapy 2022 24:264
    Content type: Research Published on:

  24. The autoimmune exocrinopathy, Sjögren’s syndrome (SjS), is associated with secretory defects in salivary glands. The cystic fibrosis transmembrane conductance regulator (CFTR) of the chloride channel is a mast...

    Authors: Qi Zhang, Xiuying Lv, Ying Wang, Bin Wang, Yan He, Chubing Chen, Guixiu Shi and Yan Li
    Citation: Arthritis Research & Therapy 2022 24:263
    Content type: Research Published on:

  25. Psoriatic Arthritis (PsA) is an immune-mediated disease with heterogenous symptoms indicating differences in the underlying immunopathogenesis. The primary objective of the study explored the dynamic mechanism...

    Authors: Marie Skougaard, Sisse B. Ditlev, Zara R. Stisen, Laura C. Coates, Karen Ellegaard and Lars Erik Kristensen
    Citation: Arthritis Research & Therapy 2022 24:262
    Content type: Research Published on:

  26. Numerous potential therapeutic alternatives for intervertebral disc degeneration (IDD) have been investigated, the most promising of which are based on biological variables such as microRNAs (miRNAs). Therefor...

    Authors: Zhonghui Chen, Jianghua Ming, Yajing Liu, Geliang Hu and Qi Liao
    Citation: Arthritis Research & Therapy 2022 24:261
    Content type: Research Published on:

  27. Intra-articular injection is indicated for mild or moderate osteoarthritis (OA). However, the superiority of cell-based injection and the role of diverse cell sources are still unclear. This study aimed to com...

    Authors: Yijian Zhang, Huilin Yang, Fan He and Xuesong Zhu
    Citation: Arthritis Research & Therapy 2022 24:260
    Content type: Review Published on:

  28. Non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) has been confirmed to have subtle changes in brain structure before the appearance of obvious neuropsychiatric symptoms. Previous literature mainly...

    Authors: Shu Li, Ru Bai, Yifan Yang, Ruotong Zhao, Bibhuti Upreti, Xiangyu Wang, Shuang Liu, Yuqi Cheng and Jian Xu
    Citation: Arthritis Research & Therapy 2022 24:259
    Content type: Research Published on:

  29. Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell therapy (HSCT) can be a rescue therapy for patients with rapidly progressive SSc.

    Authors: Norbert Blank, Marc Schmalzing, Pia Moinzadeh, Max Oberste, Elise Siegert, Ulf Müller-Ladner, Gabriela Riemekasten, Claudia Günther, Ina Kötter, Gabriele Zeidler, Christiane Pfeiffer, Aaron Juche, Ilona Jandova, Jan Ehrchen, Laura Susok, Tim Schmeiser…
    Citation: Arthritis Research & Therapy 2022 24:258
    Content type: Research Published on:

  30. To investigate the occurrence and frequency of anti-citrullinated protein antibodies (ACPA) to cyclic citrullinated type II collagen (COL2) epitope with a capacity to bind joint cartilage.

    Authors: Qixing Li, Yanpeng Li, Bibo Liang, Rui Xu, Bingze Xu, Erik Lönnblom, Hui Feng, Jing’an Bai, Roma Stawikowska, Changrong Ge, Aiping Lu, Gregg B. Fields, Lianbo Xiao and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2022 24:257
    Content type: Research Published on:

  31. Dysbiotic intestinal and oral microbiota have been implicated in the pathogenesis of rheumatoid arthritis (RA), but the mechanisms how microbiota could impact disease activity have remained elusive. The aim of...

    Authors: J. Parantainen, G. Barreto, R. Koivuniemi, H. Kautiainen, D. Nordström, E. Moilanen, M. Hämäläinen, M. Leirisalo-Repo, K. Nurmi and K. K. Eklund
    Citation: Arthritis Research & Therapy 2022 24:256
    Content type: Research Published on:

  32. The prevalence of rheumatoid arthritis (RA) in persons 60 years or older is estimated to be 2%. Late-onset rheumatoid arthritis (LORA) is traditionally defined as the onset of RA after the age of 60 years. Com...

    Authors: Xiuying Li, Angela Cesta, Mohammad Movahedi and Claire Bombardier
    Citation: Arthritis Research & Therapy 2022 24:255
    Content type: Research Published on:

  33. EC-18, a synthetic monoacetyldiaglyceride, exhibits protective effects against lung inflammation, allergic asthma, and abdominal sepsis. However, there have been no investigations to determine whether EC-18 ha...

    Authors: Jin-Sil Park, Seung Cheon Yang, Ha Yeon Jeong, Seon-Young Lee, Jun-Geol Ryu, Jeong Won Choi, Hye Yeon Kang, Sung-Min Kim, Sun-Hee Hwang, Mi-La Cho and Sung-Hwan Park
    Citation: Arthritis Research & Therapy 2022 24:254
    Content type: Research Published on:

  34. This study aimed to investigate the trajectory of damage accrual, associated factors, and impact on health-related quality of life (HR-QoL) in a multicenter cohort of patients with Behçet’s syndrome (BS) over ...

    Authors: Alberto Floris, Matteo Piga, Riccardo Laconi, Gerard Espinosa, Giuseppe Lopalco, Luisa Serpa Pinto, Nikolaos Kougkas, Jurgen Sota, Andrea Lo Monaco, Marcello Govoni, Luca Cantarini, George Bertsias, João Correia, Florenzo Iannone, Ricard Cervera, Carlos Vasconcelos…
    Citation: Arthritis Research & Therapy 2022 24:253
    Content type: Research Published on:

  35. Pain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common feature. However, sensitization can be originally related to the periphe...

    Authors: Jesus Pujol, Laura Blanco-Hinojo, Andrea Doreste, Fabiola Ojeda, Gerard Martínez-Vilavella, Víctor Pérez-Sola, Joan Deus and Jordi Monfort
    Citation: Arthritis Research & Therapy 2022 24:252
    Content type: Research Published on:

  36. To evaluate the levels of periostin in patients with systemic sclerosis (SSc) and their association with features of systemic sclerosis.

    Authors: Fatima El-Adili, Justin K. Lui, Mortada Najem, Giuseppina Farina, Maria Trojanowska, Flora Sam and Andreea M. Bujor
    Citation: Arthritis Research & Therapy 2022 24:251
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:11

  37. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s13075-022-02950-3.

    Authors: Yanhong Li, Jing Wang, Yanchao Ma, Wenjia Du, Haijun Feng, Kai Feng, Guangjie Li and Shuanke Wang
    Citation: Arthritis Research & Therapy 2022 24:250
    Content type: Retraction Note Published on:

  38. Macrophages are key innate immune cells implicated in the pathogenesis of Behçet’s disease (BD), and macrophage polarization plays a pivotal role in inflammatory response. This study aimed to investigate the r...

    Authors: Xiuhua Wu, Zhimian Wang, Jing Shi, Xin Yu, Chaoran Li, Jinjing Liu, Fengchun Zhang, Hua Chen and Wenjie Zheng
    Citation: Arthritis Research & Therapy 2022 24:249
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:275

  39. Authors: Martin Bergman, Namita Tundia, Naomi Martin, Jessica L. Suboticki, Jayeshkumar Patel, Debbie Goldschmidt, Yan Song and Grace C. Wright
    Citation: Arthritis Research & Therapy 2022 24:248
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:155

  40. The cytoskeletal protein, PSTPIP2, is associated with inflammation and is predominantly expressed in macrophages. Previous data have shown that PSTPIP2 inhibits articular bone damage in arthritic rats. The aim...

    Authors: Yao Yao, Xiaoyu Cai, Meng Zhang, Xiao Zhang, Fujia Ren, Yan Zheng, Weidong Fei, Mengdan Zhao and Caihong Zheng
    Citation: Arthritis Research & Therapy 2022 24:247
    Content type: Research Published on:

  41. Authors: Thales R. Hein, Leonardo Peterson, Barbara J. Bartikoski, Juliana Portes, Rafaela C. Espirito Santo and Ricardo M. Xavier
    Citation: Arthritis Research & Therapy 2022 24:246
    Content type: Letter Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:245

  42. We read with great interest the article by Hein et al., which described the meta-analysis study on the impact of disease-modifying anti-rheumatic drugs (DMARDs) therapy on skeletal muscle mass in rheumatoid ar...

    Authors: Hiroto Minamino, Mie Torii, Masao Katsushima, Yoshihito Fujita and Motomu Hashimoto
    Citation: Arthritis Research & Therapy 2022 24:245
    Content type: Comment Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:171

    The Letter to this article has been published in Arthritis Research & Therapy 2022 24:246

  43. Authors: Koichiro Komiya, Hiroyuki Enomoto, Isao Inoki, Satoko Okazaki, Yoshinari Fujita, Eiji Ikeda, Eiko Ohuchi, Hideo Matsumoto, Yoshiaki Toyama and Yasunori Okada
    Citation: Arthritis Research & Therapy 2022 24:244
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2005 7:R1158

  44. Observational studies have demonstrated associations between gout and hypertension, but whether they are causal remains unclear. Our work aims to assess the causal relationship between gout and hypertension.

    Authors: Benjamin Lai, Huang-Ping Yu, Yu-Jing Chang, Liang-Chin Wang, Che-Kai Chen, Weiya Zhang, Michael Doherty, Shang-Hung Chang, Jun-Te Hsu, Kuang-Hui Yu and Chang-Fu Kuo
    Citation: Arthritis Research & Therapy 2022 24:243
    Content type: Research Published on:

  45. Clustering is an important clinical feature of Behçet’s syndrome (BS) and may have pathogenetic and therapeutic implications. Recent and previous studies on BS phenotype differ substantially in terms of method...

    Authors: Ufuk İlgen
    Citation: Arthritis Research & Therapy 2022 24:242
    Content type: Commentary Published on:

  46. In patients with tracheobronchial involvement, the differential diagnosis between granulomatosis with polyangiitis (GPA) and relapsing polychondritis (RP) can be challenging. The aim of this study was to descr...

    Authors: Carole Jalaber, Xavier Puéchal, Ines Saab, Emma Canniff, Benjamin Terrier, Luc Mouthon, Eglantine Cabanne, Sandra Mghaieth, Marie-Pierre Revel and Guillaume Chassagnon
    Citation: Arthritis Research & Therapy 2022 24:241
    Content type: Research Published on:

  47. We compared the treatment effectiveness between guselkumab and adalimumab in patients with pustulotic arthro-osteitis (PAO). In addition, we performed peripheral blood immunophenotyping to elucidate the immuno...

    Authors: Masanobu Ueno, Ippei Miyagawa, Yusuke Miyazaki, Kentaro Hanami, Shunsuke Fukuyo, Satoshi Kubo, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:240
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:24

  48. Authors: Jingjing Zhu, Zheng Niu, Lars Alfredsson, Lars Klareskog, Leonid Padyukov and Xia Jiang
    Citation: Arthritis Research & Therapy 2022 24:239
    Content type: Letter Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:237

  50. With great interest, we have read the recent article “Age at menarche, age at natural menopause, and risk of rheumatoid arthritis — a Mendelian randomization study” by Zhu et al. While we have a great apprecia...

    Authors: Zhenqian Wang and Jiawen Lu
    Citation: Arthritis Research & Therapy 2022 24:237
    Content type: Correspondence Published on:

    The original article was published in Arthritis Research & Therapy 2021 23:108

    The Letter to this article has been published in Arthritis Research & Therapy 2022 24:239

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