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  1. Systemic sclerosis (SSc) is a connective tissue disease with a significant morbidity and reduced survival of patients. Effective treatment and clinical control of the disease remain challenging. In particular,...

    Authors: Jakob Einhaus, Ann-Christin Pecher, Elisa Asteriti, Hannes Schmid, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Reinhild Klein, Corina Schneidawind, Joerg Henes and Dominik Schneidawind

    Citation: Arthritis Research & Therapy 2020 22:66

    Content type: Research article

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  2. Iguratimod, a novel immunomodulatory agent for rheumatoid arthritis, has been shown to be effective against murine lupus. The aim of this study was to make a preliminary evaluation of the efficacy and safety o...

    Authors: Yuening Kang, Qingran Yan, Qiong Fu, Ran Wang, Min Dai, Fang Du, Qing Dai, Ping Ye, Chunmei Wu, Liangjing Lu and Chunde Bao

    Citation: Arthritis Research & Therapy 2020 22:65

    Content type: Research article

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  3. Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) competes with CD28 for binding CD80/CD86 on antigen-presenting cells (APCs) to limit T cell activation. B cells are believed to be important APCs in t...

    Authors: Po-Chun Liu, Chih-Tai Ssu, Yen-Po Tsao, Teh-Ling Liou, Chang-Youh Tsai, Chung-Tei Chou, Ming-Han Chen and Chuen-Miin Leu

    Citation: Arthritis Research & Therapy 2020 22:64

    Content type: Research article

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  4. Innate lymphoid cells (ILCs) play an essential role in maintaining homeostasis; however, they can also cause chronic inflammation and autoimmune disease. This study aimed to identify the role of ILCs in the pa...

    Authors: Seungwon Ryu, Eun Young Lee, Dong Ki Kim, Yon Su Kim, Doo Hyun Chung, Ji Hyung Kim, Hajeong Lee and Hye Young Kim

    Citation: Arthritis Research & Therapy 2020 22:63

    Content type: Research article

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  5. Although increasing studies have demonstrated that chondrogenic progenitor cells (CPCs) remain present in human osteoarthritic cartilage, the biological alterations of the CPCs from the less diseased lateral t...

    Authors: Yu-Xing Wang, Zhi-Dong Zhao, Qian Wang, Zhong-Li Li, Ya Huang, Sen Zhao, Wei Hu, Jia-Wu Liang, Pei-Lin Li, Hua Wang, Ning Mao, Chu-Tse Wu and Heng Zhu

    Citation: Arthritis Research & Therapy 2020 22:62

    Content type: Research article

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  6. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint stiffness, finally leading to tissue destruction. Connective tissue growth factor (CTGF) is a critical factor i...

    Authors: Weiwei Sun, Jinglan Ma, Han Zhao, Chipeng Xiao, Hao Zhong, Hanzhi Ling, Zhen Xie, Qingqing Tian, Huaijun Chen, Tingting Zhang, Mu Chen, Shengwei Jin and Jianguang Wang

    Citation: Arthritis Research & Therapy 2020 22:61

    Content type: Research article

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  7. ABP 710 is being developed as a biosimilar to infliximab reference product (RP). Analytical similarity and pharmacokinetic equivalence between the two have been previously demonstrated. Here we report results ...

    Authors: Mark C. Genovese, Juan Sanchez-Burson, MyungShin Oh, Eva Balazs, Jeffrey Neal, Andrea Everding, Tomas Hala, Rafal Wojciechowski, Gary Fanjiang and Stanley Cohen

    Citation: Arthritis Research & Therapy 2020 22:60

    Content type: Research article

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  8. To investigate the effect of ACE inhibitors (ACEi) on the incidence of scleroderma renal crisis (SRC) when given prior to SRC in the prospectively collected cohort from the European Scleroderma Trial and Resea...

    Authors: Lukas Bütikofer, Pierre A. Varisco, O. Distler, O. Kowal-Bielecka, Y. Allanore, G. Riemekasten, P. M. Villiger and S. Adler

    Citation: Arthritis Research & Therapy 2020 22:59

    Content type: Research article

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  9. The SPARCC sacroiliac joint inflammation (SIS) and structural (SSS) scores are reliable measures to quantify abnormalities in the pediatric sacroiliac joint. We aimed to evaluate the utility of online calibrat...

    Authors: Pamela F. Weiss, Walter P. Maksymowych, Rui Xiao, David M. Biko, Michael L. Francavilla, Robert G. Lambert, Jacob L. Jaremko, Merav Heshin-Bekenstein, Timothy G. Brandon and Nancy A. Chauvin

    Citation: Arthritis Research & Therapy 2020 22:58

    Content type: Research article

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  10. Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the inciden...

    Authors: Li-Juan Wang, Ni Zeng, Zhi-Peng Yan, Jie-Ting Li and Guo-Xin Ni

    Citation: Arthritis Research & Therapy 2020 22:57

    Content type: Review

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  11. European data indicate that systemic sclerosis (SSc)-related death rates are increasing, thus raising concerns about SSc’s optimal management. Herein, we describe current treatment modalities and drug survival...

    Authors: S. Panopoulos, Κ. Chatzidionysiou, M. G. Tektonidou, V. K. Bournia, A. A. Drosos, Stamatis-Nick C. Liossis, T. Dimitroulas, L. Sakkas, D. Boumpas, P. V. Voulgari, D. Daoussis, K. Thomas, G. Georgiopoulos, G. Vosvotekas, Α. Garyfallos, P. Sidiropoulos…

    Citation: Arthritis Research & Therapy 2020 22:56

    Content type: Research article

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  12. Citation: Arthritis Research & Therapy 2020 22:55

    Content type: Letter

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    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:101

    The original article was published in Arthritis Research & Therapy 2020 22:17

  13. The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research...

    Authors: W. E. van Spil, S. M. A. Bierma-Zeinstra, L. A. Deveza, N. K. Arden, A.-C. Bay-Jensen, V. Byers Kraus, L. Carlesso, R. Christensen, M. Van Der Esch, P. Kent, J. Knoop, C. Ladel, C. B. Little, R. F. Loeser, E. Losina, K. Mills…

    Citation: Arthritis Research & Therapy 2020 22:54

    Content type: Research article

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  14. The evaluation of quality of care in juvenile idiopathic arthritis (JIA) is critical for advancing patient outcomes but is not currently part of routine care across all centers in Canada. The study objective i...

    Authors: Claire E. H. Barber, Marinka Twilt, Tram Pham, Gillian R. Currie, Susanne Benseler, Rae S. M. Yeung, Michelle Batthish, Nicholas Blanchette, Jaime Guzman, Bianca Lang, Claire LeBlanc, Deborah M. Levy, Christine O’Brien, Heinrike Schmeling, Gordon Soon, Lynn Spiegel…

    Citation: Arthritis Research & Therapy 2020 22:53

    Content type: Research article

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  15. Lupus patients are at risk for pregnancy loss, and it has been generally accepted that women with SLE should have low disease activity prior to conception. However, there are conflicting results regarding the ...

    Authors: Julia Davis-Porada, Mimi Y. Kim, Marta M. Guerra, Carl A. Laskin, Michelle Petri, Michael D. Lockshin, Lisa R. Sammaritano, D. Ware Branch, Allen Sawitzke, Joan T. Merrill, Jill P. Buyon and Jane E. Salmon

    Citation: Arthritis Research & Therapy 2020 22:52

    Content type: Research article

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  16. Little is known about the mechanisms underlying the clinical overlap between gut inflammation and joint ankylosis, as exemplified by the concurrence of inflammatory bowel diseases (IBD) and ankylosing spondyli...

    Authors: Aifeng Lin, Robert D. Inman, Catherine J. Streutker, Zhenbo Zhang, Kenneth P. H. Pritzker, Hing Wo Tsui and Florence W. L. Tsui

    Citation: Arthritis Research & Therapy 2020 22:51

    Content type: Research article

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  17. Measurement of skin involvement is essential for the diagnosis and assessment of prognosis and disease progression in systemic sclerosis (SSc). The modified Rodnan skin score (mRSS) is the gold standard measur...

    Authors: T. Santiago, M. Santiago, M. Coutinho, M. J. Salvador and J. A. P. Da Silva

    Citation: Arthritis Research & Therapy 2020 22:50

    Content type: Research article

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  18. Osteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood. The gasotransmitter hydrogen sulfide (H2S...

    Authors: Sonia Nasi, Driss Ehirchiou, Athanasia Chatzianastasiou, Noriyuki Nagahara, Andreas Papapetropoulos, Jessica Bertrand, Giuseppe Cirino, Alexander So and Nathalie Busso

    Citation: Arthritis Research & Therapy 2020 22:49

    Content type: Research article

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  19. Skin fibrosis is the clinical hallmark of systemic sclerosis (SSc), where collagen deposition and remodeling of the dermis occur over time. The most widely used outcome measure in SSc clinical trials is the mo...

    Authors: Chase Correia, Seamus Mawe, Shane Lofgren, Roberta G. Marangoni, Jungwha Lee, Rana Saber, Kathleen Aren, Michelle Cheng, Shannon Teaw, Aileen Hoffmann, Isaac Goldberg, Shawn E. Cowper, Purvesh Khatri, Monique Hinchcliff and J. Matthew Mahoney

    Citation: Arthritis Research & Therapy 2020 22:48

    Content type: Research article

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  20. Peficitinib (ASP015K), a novel oral Janus kinase inhibitor, has demonstrated efficacy and safety for the treatment of rheumatoid arthritis (RA) in randomized, controlled trials of up to 52 weeks’ duration. How...

    Authors: Tsutomu Takeuchi, Yoshiya Tanaka, Sakae Tanaka, Atsushi Kawakami, Yeong-Wook Song, Yi-Hsing Chen, Mitsuhiro Rokuda, Hiroyuki Izutsu, Satoshi Ushijima, Yuichiro Kaneko, Yoshihiro Nakashima, Teruaki Shiomi and Emi Yamada

    Citation: Arthritis Research & Therapy 2020 22:47

    Content type: Research article

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    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:155

  21. Abatacept (ABA) is a biological disease-modifying antirheumatic drug (bDMARD) for rheumatoid arthritis (RA). The aim of this study was to identify molecules that are associated with therapeutic responses to AB...

    Authors: Waka Yokoyama-Kokuryo, Hayato Yamazaki, Tsutomu Takeuchi, Koichi Amano, Jun Kikuchi, Tsuneo Kondo, Seiji Nakamura, Ryoko Sakai, Fumio Hirano, Toshihiro Nanki, Ryuji Koike and Masayoshi Harigai

    Citation: Arthritis Research & Therapy 2020 22:46

    Content type: Research article

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  22. The ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9, yet the effect size on gout is greater. We tested the h...

    Authors: Rebekah Wrigley, Amanda J. Phipps-Green, Ruth K. Topless, Tanya J. Major, Murray Cadzow, Philip Riches, Anne-Kathrin Tausche, Matthijs Janssen, Leo A. B. Joosten, Tim L. Jansen, Alexander So, Jennie Harré Hindmarsh, Lisa K. Stamp, Nicola Dalbeth and Tony R. Merriman

    Citation: Arthritis Research & Therapy 2020 22:45

    Content type: Research article

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  23. Although observational epidemiological studies have found that smoking is positively associated with risk of rheumatoid arthritis (RA), assessing the causality of this relationship has remained elusive because...

    Authors: Yu Qian, Lingzhi Zhang, David J. H. Wu, Zhijun Xie, Chengping Wen and Yingying Mao

    Citation: Arthritis Research & Therapy 2020 22:44

    Content type: Research article

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  24. In the GO-VIBRANT trial of intravenous golimumab in psoriatic arthritis (PsA), golimumab significantly inhibited radiographic progression. In post hoc analyses, we evaluated changes in total PsA-modified Sharp...

    Authors: Philip Mease, M. Elaine Husni, Shelly Kafka, Soumya D. Chakravarty, Diane D. Harrison, Kim Hung Lo, Stephen Xu, Elizabeth C. Hsia and Arthur Kavanaugh

    Citation: Arthritis Research & Therapy 2020 22:43

    Content type: Research article

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  25. The pathophysiology of systemic sclerosis (SSc) is closely linked to overactive TGFβ signaling. TGFβ is produced and circulates in latent form, making its activation crucial for signaling. This activation can ...

    Authors: A. van Caam, J. Aarts, T. van Ee, E. Vitters, M. Koenders, F. van de Loo, P. van Lent, F. van den Hoogen, R. Thurlings, M. C. Vonk and P. M. van der Kraan

    Citation: Arthritis Research & Therapy 2020 22:42

    Content type: Research article

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  26. With advancement in the treatment options of rheumatoid arthritis (RA), optimising the outcomes of difficult-to-treat patients has become increasingly important in clinical practice. In particular, insensitivi...

    Authors: Sae Ochi, Kazuyoshi Saito, Fumitaka Mizoguchi, Shigeaki Kato and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2020 22:41

    Content type: Research article

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  27. To evaluate the value of 3 Tesla (T) magnetic resonance imaging (MRI) changes of flexor tendon pulleys for the differentiation of psoriatic (PsA) and rheumatoid arthritis (RA), using a novel 16-channel high-re...

    Authors: Daniel B. Abrar, Christoph Schleich, Sven Nebelung, Miriam Frenken, Karl Ludger Radke, Stefan Vordenbäumen, Ralph Brinks, Matthias Schneider, Benedikt Ostendorf, Dennis McGonagle and Philipp Sewerin

    Citation: Arthritis Research & Therapy 2020 22:40

    Content type: Research article

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  28. To assess the presence of a seasonal effect on fatigue, pain and dryness in primary Sjögren’s syndrome (pSS).

    Authors: Pierre-Marie Duret, Nicolas Meyer, Alain Saraux, Valérie Devauchelle-Pensec, Raphaele Seror, Véronique Le-Guern, Claire Larroche, Aleth Perdriger, Jean Sibilia, Vianney Guardiolle, Xavier Mariette and Jacques-Eric Gottenberg

    Citation: Arthritis Research & Therapy 2020 22:39

    Content type: Research article

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  29. Unstimulated whole saliva (UWS) flow rate is one of the ACR/EULAR 2016 criteria for primary Sjögren’s syndrome (pSS). With a single threshold of ≤ 0.1 mL/min, UWS flow does not take into account the age- and s...

    Authors: Valentin Lacombe, Carole Lacout, Pierre Lozac’h, Alaa Ghali, Aline Gury, Christian Lavigne and Geoffrey Urbanski

    Citation: Arthritis Research & Therapy 2020 22:38

    Content type: Research article

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  30. Hyperuricemia is closely associated with cardiovascular disease (CVD). However, it has not been definitively established whether this association is independent of traditional cardiovascular risk factors (CVRF...

    Authors: Panagiota Drivelegka, Helena Forsblad-d’Elia, Oskar Angerås, Göran Bergström, Caroline Schmidt, Lennart T. H. Jacobsson and Mats Dehlin

    Citation: Arthritis Research & Therapy 2020 22:37

    Content type: Research article

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  31. To explore whether a prime-boost vaccination strategy, i.e., a dose of pneumococcal conjugate vaccine (PCV) and a dose of 23-valent polysaccharide vaccine (PPV23), enhances antibody response compared to single...

    Authors: Per Nived, Göran Jönsson, Bo Settergren, Jon Einarsson, Tor Olofsson, Charlotte Sværke Jørgensen, Lillemor Skattum and Meliha C. Kapetanovic

    Citation: Arthritis Research & Therapy 2020 22:36

    Content type: Research article

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    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:162

  32. Systemic lupus erythematous (SLE) disproportionately impacts patients of color and socioeconomically disadvantaged patients. Similar disparities in HIV were reduced through a World Health Organization-endorsed...

    Authors: Christie M. Bartels, Ann Rosenthal, Xing Wang, Umber Ahmad, Ian Chang, Nnenna Ezeh, Shivani Garg, Maria Schletzbaum and Amy Kind

    Citation: Arthritis Research & Therapy 2020 22:35

    Content type: Research article

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  33. Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin ...

    Authors: Hui Li, Xiang Ding, Robert Terkeltaub, Hang Lin, Yuqing Zhang, Bin Zhou, Ke He, Kun Li, Zhichen Liu, Jie Wei, Yuanheng Yang, Hui Xie, Chao Zeng and Guanghua Lei

    Citation: Arthritis Research & Therapy 2020 22:34

    Content type: Research article

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  34. Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies in addition to IgG/IgM anti-cardiolipin antibodies (aCL)...

    Authors: Tingting Liu, Jieyu Gu, Liyan Wan, Qiongyi Hu, Jialin Teng, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Yue Sun, Jinfeng Zhou, Gary L. Norman, Xuefeng Wang, Chengde Yang and Hui Shi

    Citation: Arthritis Research & Therapy 2020 22:33

    Content type: Research article

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  35. Patients with systemic sclerosis (SSc) complicated by gastrointestinal dysmotility are difficult to treat and have high mortality. To clarify the pathogenesis of gastrointestinal manifestations, we aimed to de...

    Authors: Shunya Nakane, Masataka Umeda, Shin-ya Kawashiri, Akihiro Mukaino, Kunihiro Ichinose, Osamu Higuchi, Yasuhiro Maeda, Hideki Nakamura, Hidenori Matsuo and Atsushi Kawakami

    Citation: Arthritis Research & Therapy 2020 22:32

    Content type: Research article

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  36. Systemic sclerosis (SSc) is a severe and highly heterogeneous disease. The modified Rodnan skin score (mRSS) is a widely used tool for the assessment of the extent and degree of skin thickness. This study aime...

    Authors: Emmanuel Ledoult, David Launay, Hélène Béhal, Luc Mouthon, Grégory Pugnet, Jean-Christophe Lega, Christian Agard, Yannick Allanore, Patrick Jego, Anne-Laure Fauchais, Jean-Robert Harlé, Sabine Berthier, Achille Aouba, Arsène Mekinian, Elisabeth Diot, Marie-Elise Truchetet…

    Citation: Arthritis Research & Therapy 2020 22:30

    Content type: Research article

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  37. Synovitis is implicated in the severity and progression of pain and structural pathology of osteoarthritis (OA). Increases in inflammatory or immune cell subpopulations including macrophages and lymphocytes ha...

    Authors: Cindy C. Shu, Sanaa Zaki, Varshini Ravi, Antonella Schiavinato, Margaret M. Smith and Christopher B. Little

    Citation: Arthritis Research & Therapy 2020 22:29

    Content type: Research article

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  38. Colchicine is a widely used drug to treat inflammatory diseases. Due to its long historical use in medicine, controlled clinical trials have been small and there remains some caution with the use of this drug ...

    Authors: Sarah Stewart, Kevin Chih Kai Yang, Kate Atkins, Nicola Dalbeth and Philip C. Robinson

    Citation: Arthritis Research & Therapy 2020 22:28

    Content type: Research article

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  39. The aim of this study was to evaluate the association between periodontal parameters related with the periodontal disease severity and the presence and levels of anti-citrullinated protein antibodies (ACPAs) i...

    Authors: Jerián González-Febles, Beatriz Rodríguez-Lozano, Carlos Sánchez-Piedra, Jorge Garnier-Rodríguez, Sagrario Bustabad, Martina Hernández-González, Enrique González-Dávila, Mariano Sanz and Federico Díaz-González

    Citation: Arthritis Research & Therapy 2020 22:27

    Content type: Research article

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  40. C-reactive protein (CRP) is often normal in patients with psoriatic disease. Herein, we aimed to define markers of systemic inflammation in patients with monomorphic and polymorphic psoriatic skin, entheseal, ...

    Authors: Maria V. Sokolova, David Simon, Kemal Nas, Mario M. Zaiss, Yubin Luo, Yi Zhao, Jürgen Rech and Georg Schett

    Citation: Arthritis Research & Therapy 2020 22:26

    Content type: Research article

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  41. Aberrant activation and dysregulation of immune system is a common feature of many forms of inflammatory arthritis. Since their identification as a distinctive population of leukocytes, innate lymphoid cells (...

    Authors: Weiting Fang, Yuanyuan Zhang and Zhu Chen

    Citation: Arthritis Research & Therapy 2020 22:25

    Content type: Review

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  42. 14-3-3η is an intracellular protein also detected in the serum and synovial fluid of patients with rheumatoid arthritis (RA). It is closely related to disease activity and anti-cyclic citrullinated peptide ant...

    Authors: Gulzhan Trimova, Kaoru Yamagata, Shigeru Iwata, Shintaro Hirata, Tong Zhang, Fumi Uemura, Minoru Satoh, Norma Biln, Shingo Nakayamada, Walter P. Maksymowych and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2020 22:24

    Content type: Research article

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  43. Citation: Arthritis Research & Therapy 2020 22:22

    Content type: Letter

    Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:179

    The Letter to this article has been published in Arthritis Research & Therapy 2020 22:23

    The Letter to this article has been published in Arthritis Research & Therapy 2020 22:21

  44. Interstitial lung disease (ILD) is a serious complication of connective tissue diseases (CTDs). Although immune dysregulation triggered by genetic and environmental factors is thought to provoke inflammation a...

    Authors: Hiroshi Takei, Hidekata Yasuoka, Keiko Yoshimoto and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2020 22:20

    Content type: Research article

    Published on:

  45. Magnetic resonance imaging (MRI) and ultrasonography (US) are more sensitive than clinical evaluation in assessing inflammation in rheumatoid arthritis (RA). Data is scarce regarding potential link between pat...

    Authors: Dorota Kuettel, Daniel Glinatsi, Mikkel Østergaard, Lene Terslev, Jette Primdahl, Sören Möller, Andreas Pedersen, Randi Petersen, Ulrich Weber and Kim Hørslev-Petersen

    Citation: Arthritis Research & Therapy 2020 22:19

    Content type: Research article

    Published on:

  46. Psoriatic arthritis (PsA) is an immune-mediated, clinically heterogeneous disease characterized by arthritis, enthesitis, dactylitis, spondylitis, and psoriasis of the skin and nails. Persistent articular infl...

    Authors: Désirée van der Heijde, Dafna D. Gladman, Arthur Kavanaugh and Philip J. Mease

    Citation: Arthritis Research & Therapy 2020 22:18

    Content type: Review

    Published on:

  47. Citation: Arthritis Research & Therapy 2020 22:17

    Content type: Letter

    Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:121

    The Letter to this article has been published in Arthritis Research & Therapy 2020 22:55

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