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  1. The Assessment of SpondyloArthritis international Society (ASAS) has defined core sets for (i) symptom-modifying anti-rheumatic drugs (SM-ARD), (ii) clinical record keeping, and (iii) disease-controlling anti-...

    Authors: Rikke A. Andreasen, Lars E. Kristensen, Xenofon Baraliakos, Vibeke Strand, Philip J. Mease, Maarten de Wit, Torkell Ellingsen, Inger Marie J. Hansen, Jamie Kirkham, George A. Wells, Peter Tugwell, Lara Maxwell, Maarten Boers, Kenneth Egstrup and Robin Christensen

    Citation: Arthritis Research & Therapy 2020 22:177

    Content type: Review

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  2. Histone deacetylase (HDAC) 6 promotes inflammation. We investigated the anti-arthritic effects of CKD-506, a novel HDAC6 inhibitor, in vitro and in a murine model of arthritis as a novel treatment option for r...

    Authors: Jin Kyun Park, Yu Jin Jang, Bo Ram Oh, Jieun Shin, Daekwon Bae, Nina Ha, Young il Choi, Gi Soo Youn, Jinseu Park, Eun Young Lee, Eun Bong Lee and Yeong Wook Song

    Citation: Arthritis Research & Therapy 2020 22:176

    Content type: Research article

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  3. Most patients with systemic lupus erythematosus (SLE) progress to lupus nephritis (LN) within 5 years of their SLE diagnosis, although it is not uncommon for LN to develop at later time points. Here we evaluat...

    Authors: Kunihiro Ichinose, Mineaki Kitamura, Shuntaro Sato, Keita Fujikawa, Yoshiro Horai, Naoki Matsuoka, Masahiko Tsuboi, Fumiaki Nonaka, Toshimasa Shimizu, Remi Sumiyoshi, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Takashi Igawa, Mami Tamai, Hideki Nakamura…

    Citation: Arthritis Research & Therapy 2020 22:175

    Content type: Research article

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  4. The interaction between galectin-9 (Gal-9) and its ligand, T cell immunoglobulin, and mucin-containing-molecule-3 (TIM-3), one of the coinhibitory receptors, transduce the inhibitory signaling to regulate immu...

    Authors: Yuya Fujita, Tomoyuki Asano, Haruki Matsumoto, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Makiko Yashiro Furuya, Eiji Suzuki, Hiroshi Watanabe, Tomohiro Koga, Atsushi Kawakami and Kiyoshi Migita

    Citation: Arthritis Research & Therapy 2020 22:174

    Content type: Research article

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  5. Infiltration of immune cells into the kidney is one of the key features of lupus nephritis (LN). The presence of immune cells in the urine may be used as a non-invasive biomarker of LN. Here, we aimed to analy...

    Authors: Jihye Kim, Jung Sun Lee, Heounjeong Go, Joon Seo Lim, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo and Seokchan Hong

    Citation: Arthritis Research & Therapy 2020 22:173

    Content type: Research article

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  6. Several metabolomics studies have shed substantial light on the pathophysiological pathways underlying multiple diseases including systemic lupus erythematosus (SLE). This review takes stock of our current und...

    Authors: Ting Zhang and Chandra Mohan

    Citation: Arthritis Research & Therapy 2020 22:172

    Content type: Review

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  7. Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rare...

    Authors: Lorenzo Ramos-Mucci, Behzad Javaheri, Rob van ‘t Hof, George Bou-Gharios, Andrew A. Pitsillides, Eithne Comerford and Blandine Poulet

    Citation: Arthritis Research & Therapy 2020 22:171

    Content type: Research article

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  8. Rheumatoid arthritis (RA) is classified as seropositive or seronegative, depending on the presence/absence of rheumatoid factor (RF), primarily IgM RF, and/or anti-citrullinated protein antibodies (ACPA), comm...

    Authors: Evan Reed, Anna Karin Hedström, Monika Hansson, Linda Mathsson-Alm, Boel Brynedal, Saedis Saevarsdottir, Martin Cornillet, Per-Johan Jakobsson, Rikard Holmdahl, Karl Skriner, Guy Serre, Lars Alfredsson, Johan Rönnelid and Karin Lundberg

    Citation: Arthritis Research & Therapy 2020 22:170

    Content type: Research article

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  9. Patients with gout have arterial dysfunction and systemic inflammation, even during intercritical episodes, which may be markers of future adverse cardiovascular outcomes. We conducted a prospective observatio...

    Authors: Michael Toprover, Binita Shah, Cheongeun Oh, Talia F. Igel, Aaron Garza Romero, Virginia C. Pike, Fatmira Curovic, Daisy Bang, Deana Lazaro, Svetlana Krasnokutsky, Stuart D. Katz and Michael H. Pillinger

    Citation: Arthritis Research & Therapy 2020 22:169

    Content type: Research article

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  10. Chondroclasts and osteoclasts have been previously identified as the cells capable of resorbing mineralized cartilage and bone matrices, respectively. While both cell types appear morphologically similar, cont...

    Authors: Nazir M. Khan, Kari B. Clifton, Joseph Lorenzo, Marc F. Hansen and Hicham Drissi

    Citation: Arthritis Research & Therapy 2020 22:168

    Content type: Research article

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  11. The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthritis, and is often associated with T lymphocyte biology. We previously showed that certain lym...

    Authors: Kevin M.-C. Lee, Zihao Zhang, Adrian Achuthan, Andrew J. Fleetwood, Julia E. Smith, John A. Hamilton and Andrew D. Cook

    Citation: Arthritis Research & Therapy 2020 22:123

    Content type: Research article

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  12. To assess the diagnostic potential of IgG antibodies to citrullinated and corresponding native autoantigens in early arthritis.

    Authors: Stefan Vordenbäumen, Ralph Brinks, Patrick Schriek, Angelika Lueking, Jutta G. Richter, Petra Budde, Peter Schulz-Knappe, Hans-Dieter Zucht, Johanna Callhoff and Matthias Schneider

    Citation: Arthritis Research & Therapy 2020 22:167

    Content type: Research article

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  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Paul Emery, Yoshiya Tanaka, Tracy Cardillo, Douglas Schlichting, Terence Rooney, Scott Beattie, Cameron Helt and Josef S. Smolen

    Citation: Arthritis Research & Therapy 2020 22:166

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2020 22:115

  14. Progesterone receptor (PR) affects immunomodulation, and lack of PR in osteoprogenitor cells primarily affects pathways associated with immunomodulation, especially in males. In this study, we selectively dele...

    Authors: Lixian Liu, Junjing Jia, Min Jiang, Xueping Liu, Chenling Dai, Barton L. Wise, Nancy E. Lane and Wei Yao

    Citation: Arthritis Research & Therapy 2020 22:165

    Content type: Research article

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  15. Gout is a heterogeneous inflammatory disease with numerous clinical manifestations. A composite means to assess the impact of therapy on numerous aspects of gout could be useful.

    Authors: Naomi Schlesinger, N. Lawrence Edwards, Anthony E. Yeo and Peter E. Lipsky

    Citation: Arthritis Research & Therapy 2020 22:164

    Content type: Research article

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  16. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Per Nived, Göran Jönsson, Bo Settergren, Jon Einarsson, Tor Olofsson, Charlotte Sværke Jørgensen, Lillemor Skattum and Meliha C. Kapetanovic

    Citation: Arthritis Research & Therapy 2020 22:162

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2020 22:36

  17. Pepsin agglutinators, discovered over 50 years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope. AHAs have different reactivity for each ...

    Authors: Toshiyuki Ota, Shun-ichiro Ota, Ayumi Uchino and Shuji Nagano

    Citation: Arthritis Research & Therapy 2020 22:161

    Content type: Research article

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  18. The Src homology region 2 domain-containing phosphatase-1 (SHP-1) is known to exert negative regulatory effects on immune cell signaling. Mice with mutations in the Shp1 gene develop inflammatory skin disease and...

    Authors: Adrienn Markovics, Daniel M. Toth, Tibor T. Glant and Katalin Mikecz

    Citation: Arthritis Research & Therapy 2020 22:160

    Content type: Research article

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  19. Systemic lupus erythematosus (SLE) is associated with increased risk of cancer and the mechanism remains unclear. Here, we examined the level of auto-antibodies and disease activity index scores in SLE patient...

    Authors: Jinyan Guo, Zhigang Ren, Jianhao Li, Tianfang Li, Shengyun Liu and Zujiang Yu

    Citation: Arthritis Research & Therapy 2020 22:159

    Content type: Research article

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  20. Reliable assessment of remission is important for the optimal management of rheumatoid arthritis (RA) patients. In this study, we used the multi-biomarker disease activity (MBDA) test to explore the role of bi...

    Authors: M. H. Y. Ma, N. Defranoux, W. Li, E. H. Sasso, F. Ibrahim, D. L. Scott and A. P. Cope

    Citation: Arthritis Research & Therapy 2020 22:158

    Content type: Research article

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  21. We reported that the production of BAFF (B cell-activating factor) and IL-6, both of which are involved in survival and differentiation of B cells, is dysregulated in monocytes of patients with primary Sjögren...

    Authors: Keiko Yoshimoto, Katsuya Suzuki, Eriko Takei, Yumi Ikeda and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2020 22:157

    Content type: Research article

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  22. A comprehensive intuition of the systemic lupus erythematosus (SLE), as a complex and multifactorial disease, is a biological challenge. Dealing with this challenge needs employing sophisticated bioinformatics...

    Authors: Samaneh Maleknia, Zahra Salehi, Vahid Rezaei Tabar, Ali Sharifi-Zarchi and Kaveh Kavousi

    Citation: Arthritis Research & Therapy 2020 22:156

    Content type: Research article

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  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Tsutomu Takeuchi, Yoshiya Tanaka, Sakae Tanaka, Atsushi Kawakami, Yeong-Wook Song, Yi-Hsing Chen, Mitsuhiro Rokuda, Hiroyuki Izutsu, Satoshi Ushijima, Yuichiro Kaneko, Yoshihiro Nakashima, Teruaki Shiomi and Emi Yamada

    Citation: Arthritis Research & Therapy 2020 22:155

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2020 22:47

  24. The aim of this study was to identify the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome (pSS) at the transcriptome level.

    Authors: Jun Inamo, Katsuya Suzuki, Masaru Takeshita, Yoshiaki Kassai, Maiko Takiguchi, Rina Kurisu, Yuumi Okuzono, Shinya Tasaki, Akihiko Yoshimura and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2020 22:153

    Content type: Research article

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  25. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expre...

    Authors: Aijing Liu, Fu-Dong Shi, Irun R. Cohen, Giuseppe Castaldo, Giuseppe Matarese, Francisco J. Quintana and Antonio La Cava

    Citation: Arthritis Research & Therapy 2020 22:152

    Content type: Research article

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  26. Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder of unknown aetiology usually affecting young adults. Interestingly, recent evidence from the juvenile counterpart of AOSD suggested the em...

    Authors: Piero Ruscitti, Onorina Berardicurti, Daniela Iacono, Ilenia Pantano, Vasiliki Liakouli, Francesco Caso, Giacomo Emmi, Rosa Daniela Grembiale, Francesco Paolo Cantatore, Fabiola Atzeni, Federico Perosa, Raffaele Scarpa, Giuliana Guggino, Francesco Ciccia, Antonio Barile, Paola Cipriani…

    Citation: Arthritis Research & Therapy 2020 22:151

    Content type: Research article

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  27. There is evidence that the cause of primary osteoarthritis (OA) is related to the changes in subchondral bone; however, the influence of subchondral insufficiency fracture (SIF) of the femoral head on the dege...

    Authors: Tomohiro Shimizu, Shunichi Yokota, Yosuke Kimura, Tsuyoshi Asano, Hirokazu Shimizu, Hotaka Ishizu, Norimasa Iwasaki and Daisuke Takahashi

    Citation: Arthritis Research & Therapy 2020 22:150

    Content type: Research article

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  28. Studies into ankylosing spondylitis (AS) and its relationship with immune imbalance are controversial, and the correlation between the efficacy of TNF-α inhibitor and changes in immune imbalance is unclear.

    Authors: Mingcan Yang, Qing Lv, Qiujing Wei, Yutong Jiang, Jun Qi, Min Xiao, Linkai Fang, Ya Xie, Shuangyan Cao, Zhiming Lin, Yanli Zhang, Liudan Tu, Minjing Zhao, Yunfeng Pan, Ou Jin and Jieruo Gu

    Citation: Arthritis Research & Therapy 2020 22:149

    Content type: Research article

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  29. Gout is the most prevalent inflammatory arthritis in developed countries. A gout flare is mediated by phagocytosis of monosodium urate crystals by macrophages and neutrophils leading to subsequent activation o...

    Authors: D. Vedder, M. Gerritsen, B. Duvvuri, R. F. van Vollenhoven, M. T. Nurmohamed and C. Lood

    Citation: Arthritis Research & Therapy 2020 22:148

    Content type: Research article

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  30. Approximately 50% of systemic lupus erythematosus (SLE) patients develop nephritis, which is among the most severe and frequent complications of the disease and a leading cause of morbidity and mortality. Desp...

    Authors: Orthodoxia Nicolaou, Kleitos Sokratous, Zuzanna Makowska, María Morell, Aurélie De Groof, Pauline Montigny, Andreas Hadjisavvas, Kyriaki Michailidou, Anastasis Oulas, George M. Spyrou, Christiana Demetriou, Marta E. Alarcón-Riquelme, Savvas Psarellis, Andreas Kousios, Bernard Lauwerys and Kyriacos Kyriacou

    Citation: Arthritis Research & Therapy 2020 22:147

    Content type: Research article

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  31. Despite the advances of rheumatoid arthritis (RA) therapeutics, several patients do not receive adequate treatment due to the toxicity and/or insufficient response of drugs. The aim of this study is to design ...

    Authors: You-Jung Ha, Sun-Mi Lee, Chin Hee Mun, Hyung Joon Kim, Yonghee Bae, Ji-Hee Lim, Kyu-Hyung Park, Soo-Kon Lee, Kyung-Hwa Yoo and Yong-Beom Park

    Citation: Arthritis Research & Therapy 2020 22:146

    Content type: Research article

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  32. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease that affects small- to medium-sized blood vessels. Despite treatments having been improved, patients often exper...

    Authors: Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto, Noriyasu Seki, Hideto Tsujimoto, Kenji Chiba and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2020 22:145

    Content type: Research article

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  33. Digital ulcers (DU) present a challenging complication in systemic sclerosis (SSc). The aim of this study was to combine clinical characteristics and imaging methods to a composite score for the prediction of ...

    Authors: S. Friedrich, S. Lüders, J. Klotsche, G. R. Burmester, G. Riemekasten and S. Ohrndorf

    Citation: Arthritis Research & Therapy 2020 22:144

    Content type: Research article

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  34. To assess whether age, at the beginning of biologic treatment, is associated with the time a first adverse event (AE) appears in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriat...

    Authors: Paloma Vela, Carlos Sanchez-Piedra, Carolina Perez-Garcia, María C. Castro-Villegas, Mercedes Freire, Lourdes Mateo, Cesar Díaz-Torné, Cristina Bohorquez, Juan M. Blanco-Madrigal, Inmaculada Ros-Vilamajo, Silvia Gómez, Rocio Caño, Fernando Sánchez-Alonso, Federico Díaz-González and Juan J. Gómez-Reino

    Citation: Arthritis Research & Therapy 2020 22:143

    Content type: Research article

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  35. This multi-center, retrospective study aimed to clarify retention rates and reasons for discontinuation of 7 biological disease-modifying antirheumatic drugs (bDMARDs) and tofacitinib (TOF), one of the janus k...

    Authors: Kosuke Ebina, Toru Hirano, Yuichi Maeda, Wataru Yamamoto, Motomu Hashimoto, Koichi Murata, Tohru Takeuchi, Hideyuki Shiba, Yonsu Son, Hideki Amuro, Akira Onishi, Kengo Akashi, Ryota Hara, Masaki Katayama, Keiichi Yamamoto, Atsushi Kumanogoh…

    Citation: Arthritis Research & Therapy 2020 22:142

    Content type: Research article

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  36. B cell depletion by rituximab (RTX) is an effective treatment for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV). However, peripheral B cell phenotypes and the selection criteria f...

    Authors: Yusuke Miyazaki, Shingo Nakayamada, Satoshi Kubo, Yuichi Ishikawa, Maiko Yoshikawa, Kei Sakata, Shigeru Iwata, Ippei Miyagawa, Kazuhisa Nakano and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2020 22:141

    Content type: Research article

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  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Marta Arévalo, Jordi Gratacós Masmitjà, Mireia Moreno, Joan Calvet, Cristobal Orellana, Desirée Ruiz, Carmen Castro, Pilar Carreto, Marta Larrosa, Eduardo Collantes and Pilar Font

    Citation: Arthritis Research & Therapy 2020 22:140

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2018 20:221

  38. The interleukin-6 receptor inhibitor sarilumab demonstrated efficacy in combination with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or as monotherapy in patients with moderately to...

    Authors: Mark C. Genovese, Roy Fleischmann, Alan Kivitz, Eun-Bong Lee, Hubert van Hoogstraten, Toshio Kimura, Gregory St John, Erin K. Mangan and Gerd R. Burmester

    Citation: Arthritis Research & Therapy 2020 22:139

    Content type: Research article

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  39. To investigate non-histologic factors that can discriminate proliferative lupus nephritis (LN) from membranous LN in patients with systemic lupus erythematosus with renal manifestations.

    Authors: Oh Chan Kwon, Jung Hwan Park, Hyeong-Cheon Park, Seung Min Jung, Sang-Won Lee, Jason Jungsik Song, Yong-Beom Park and Min-Chan Park

    Citation: Arthritis Research & Therapy 2020 22:138

    Content type: Research article

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  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Vibeke Strand, Janet Pope, Namita Tundia, Alan Friedman, Heidi S. Camp, Aileen Pangan, Arijit Ganguli, Mahesh Fuldeore, Debbie Goldschmidt and Michael Schiff

    Citation: Arthritis Research & Therapy 2020 22:137

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:272

  41. The effectiveness and safety of biological disease-modifying antirheumatic drugs (bDMARDs) by age group (< 65, 65–74, and ≥ 75 years) are uncertain. We examined retention rates reflecting the effectiveness and...

    Authors: Akio Kawabe, Kazuhisa Nakano, Satoshi Kubo, Takeshi Asakawa and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2020 22:136

    Content type: Research article

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  42. To measure regional brain microvascular and microstructural changes in childhood-onset SLE (cSLE) using diffusion-weighted imaging (DWI) at multiple b values and investigate relationships of those measures with n...

    Authors: Mark W. DiFrancesco, Gregory Lee, Mekibib Altaye, Dean W. Beebe, Jamie Meyers-Eaton and Hermine I. Brunner

    Citation: Arthritis Research & Therapy 2020 22:135

    Content type: Research article

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  43. Knee osteoarthritis (KOA) is a common joint disease in people over 60 years old. Exercise therapy is one of the most effective non-pharmacological treatments for KOA, but low exercise adherence needs to be imp...

    Authors: Limin Wang, Hongbo Chen, Han Lu, Yunlin Wang, Congying Liu, Xu Dong, Jieru Chen, Nan Liu, Fang Yu, Qiaoqin Wan and Shaomei Shang

    Citation: Arthritis Research & Therapy 2020 22:134

    Content type: Research article

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  44. The mechanisms involved in the pathogenesis of autoimmune disorders, including systemic lupus erythematosus (SLE), have not been fully elucidated. Some of these mechanisms involve epigenetic regulation of gene...

    Authors: Yuxuan Zhen, Roger D. Smith, Fred D. Finkelman and Wen-Hai Shao

    Citation: Arthritis Research & Therapy 2020 22:133

    Content type: Research article

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  45. Outcomes of therapeutic studies in diffuse cutaneous systemic sclerosis (dcSSc) have mainly been measured for specific organs, particularly the skin and lungs. A new composite response index in dcSSc (CRISS) h...

    Authors: Boyang Zheng, Marie Hudson, Mianbo Wang and Murray Baron

    Citation: Arthritis Research & Therapy 2020 22:132

    Content type: Research article

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  46. Takayasu arteritis (TA) is a large vessel vasculitis that can involve pulmonary arteries (PAs). We studied multiple clinical characteristics related to pulmonary artery involvement (PAI) in TA patients.

    Authors: Xiufang Kong, Lili Ma, Peng Lv, Xiaomeng Cui, Rongyi Chen, Zongfei Ji, Huiyong Chen, Jiang Lin and Lindi Jiang

    Citation: Arthritis Research & Therapy 2020 22:131

    Content type: Research article

    Published on:

  47. Patients with systemic lupus erythematosus (SLE) have an ongoing interferon (IFN) production due to an activation of plasmacytoid dendritic cells (pDCs), which can be triggered to type I IFN synthesis by RNA c...

    Authors: Karin Hjorton, Niklas Hagberg, Pascal Pucholt, Maija-Leena Eloranta and Lars Rönnblom

    Citation: Arthritis Research & Therapy 2020 22:130

    Content type: Research article

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  48. Skin fibrosis is a main hallmark of systemic sclerosis (SSc). Clinical assessment is done semi-quantitatively using the modified Rodnan skin score (mRSS). Objective measurements for quantifying skin fibrosis c...

    Authors: Bettina Müller, Lisa Ruby, Suzana Jordan, Marga B. Rominger, Edoardo Mazza and Oliver Distler

    Citation: Arthritis Research & Therapy 2020 22:128

    Content type: Research article

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