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  1. Content type: Research article

    This study aimed to explore the molecular mechanism and clinical relevance of iguratimod in the regulation of human B cell terminal differentiation.

    Authors: Yan Ye, Mei Liu, Longhai Tang, Fang Du, Yuanhua Liu, Pei Hao, Qiong Fu, Qiang Guo, Qingran Yan, Xiaoming Zhang and Chunde Bao

    Citation: Arthritis Research & Therapy 2019 21:92

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  2. Content type: Editorial

    Rheumatoid arthritis is an immune-mediated inflammatory disease of the synovium. Yet we still lack robust tissue-specific (synovial) biomarkers that are able to guide clinical decisions and stratify patients a...

    Authors: Helen Michelle McGettrick

    Citation: Arthritis Research & Therapy 2019 21:90

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    The original article was published in Arthritis Research & Therapy 2018 20:265

  3. Content type: Research article

    Final data are presented for the ORAL Sequel long-term extension (LTE) study evaluating the safety and efficacy of tofacitinib 5 mg and 10 mg twice daily (BID) for up to 9.5 years in patients with rheumatoid a...

    Authors: Jürgen Wollenhaupt, Eun-Bong Lee, Jeffrey R. Curtis, Joel Silverfield, Ketti Terry, Koshika Soma, Chris Mojcik, Ryan DeMasi, Sander Strengholt, Kenneth Kwok, Irina Lazariciu, Lisy Wang and Stanley Cohen

    Citation: Arthritis Research & Therapy 2019 21:89

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  4. Content type: Research article

    Recent data suggest that anti-TNF doses can be reduced in ankylosing spondylitis (AS) patients. Some authors even propose withdrawing treatment in patients in clinical remission; however, at present there is n...

    Authors: Mireia Moreno, Jordi Gratacós, Vicenç Torrente-Segarra, Raimon Sanmarti, Rosa Morlà, Caridad Pontes, Maria Llop and Xavier Juanola

    Citation: Arthritis Research & Therapy 2019 21:88

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  5. Content type: Research article

    Abnormal glycolytic metabolism contributes to joint inflammation and destruction in rheumatoid arthritis (RA). We examine the expression and function of hexokinases in RA and evaluate the potential of their sp...

    Authors: Guanhua Song, Qiqi Lu, Hua Fan, Xiumei Zhang, Luna Ge, Ruisong Tian, Shiguan Wang, Tingting Feng, Jihong Pan, Jingjing Feng, Yabo Xiao, Xin Yi, Ningxin Ren and Lin Wang

    Citation: Arthritis Research & Therapy 2019 21:87

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  6. Content type: Research article

    Data on survival and prognosis factors in incident cohorts are scarce in systemic sclerosis (SStc). To describe survival, standardized mortality ratio (SMR), and prognosis factors in systemic sclerosis (SSc), ...

    Authors: M. R. Pokeerbux, J. Giovannelli, L. Dauchet, L. Mouthon, C. Agard, J. C. Lega, Y. Allanore, P. Jego, B. Bienvenu, S. Berthier, A. Mekinian, E. Hachulla and D. Launay

    Citation: Arthritis Research & Therapy 2019 21:86

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  7. Content type: Research article

    Systemic sclerosis (SSc) is a female-predominant disease, characterized by excessive extracellular matrix deposition (ECM) with dermal and internal organ fibrosis. Considering the sex-based disparity in diseas...

    Authors: DeAnna Baker Frost, Bethany Wolf, Christine Peoples, Jessica Fike, Katherine Silver, Maureen Laffoon, Thomas A. Medsger Jr and Carol Feghali-Bostwick

    Citation: Arthritis Research & Therapy 2019 21:85

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  8. Content type: Research article

    ABP 501 was evaluated in a phase 3 single-arm, open-label extension (OLE) study to collect additional safety and efficacy data in patients with rheumatoid arthritis (RA).

    Authors: Stanley Cohen, Jose L. Pablos, Karel Pavelka, Gerard Anton Müller, Alan Matsumoto, Alan Kivitz, Hui Wang and Eswar Krishnan

    Citation: Arthritis Research & Therapy 2019 21:84

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  9. Content type: Review

    Obesity is associated with numerous comorbidities including some rheumatic conditions. Through adipose-derived inflammation, obesity has been shown to induce increased initiation, progression, and worse respon...

    Authors: Eric Lespessailles, Emneh Hammoud, Hechmi Toumi and Nada Ibrahim-Nasser

    Citation: Arthritis Research & Therapy 2019 21:83

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  10. Content type: Research article

    No population-based study has investigated the cumulative incidence of pulmonary arterial hypertension (PAH) in patients with newly diagnosed systemic lupus erythematosus (SLE) or the survival impact of PAH in...

    Authors: Hung-An Chen, Tsai-Ching Hsu, Su-Ching Yang, Chia-Tse Weng, Chun-Hsin Wu, Chien-Yao Sun and Chun-Yu Lin

    Citation: Arthritis Research & Therapy 2019 21:82

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  11. Content type: Editorial

    Systemic sclerosis (SSc) is an immune-mediated fibrotic disease affecting skin, lung and gut which are all sites with an established microbiome. Altered microbial flora may occur and contribute to the initiati...

    Authors: Christopher P. Denton and Charles Murray

    Citation: Arthritis Research & Therapy 2019 21:81

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    The original article was published in Arthritis Research & Therapy 2019 21:49

  12. Content type: Research article

    The vast majority of patients with systemic lupus erythematosus (SLE) complain about fatigue. They also report fatigue as one of their most debilitating symptoms. Yet, in clinical practice, fatigue is only rar...

    Authors: Alice Horisberger, Delphine Courvoisier and Camillo Ribi

    Citation: Arthritis Research & Therapy 2019 21:80

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  13. Content type: Research

    Sarilumab is a human immunoglobulin G1 anti-interleukin-6 (IL-6) receptor monoclonal antibody that blocks IL-6 from binding to membrane-bound and soluble IL-6 receptor α. This bridging study assessed the effic...

    Authors: Yoshiya Tanaka, Kazuteru Wada, Yoshinori Takahashi, Owen Hagino, Hubert van Hoogstraten, Neil M. H. Graham and Hideto Kameda

    Citation: Arthritis Research & Therapy 2019 21:79

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    The Correction to this article has been published in Arthritis Research & Therapy 2019 21:99

  14. Content type: Research article

    Hypoxia plays an important role in the proliferation of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), leading to pathology of RA. This study was conducted to evaluate hypoxia-induced microRNAs (h...

    Authors: Shanshan Yu, Ying Lu, Ming Zong, Qi Tan and Lieying Fan

    Citation: Arthritis Research & Therapy 2019 21:78

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  15. Content type: Research article

    ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout ...

    Authors: Blanka Stiburkova, Katerina Pavelcova, Marketa Pavlikova, Pavel Ješina and Karel Pavelka

    Citation: Arthritis Research & Therapy 2019 21:77

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  16. Content type: Research article

    The role of the complement system in the pathogenesis of systemic sclerosis (SSc) is controversial. This study investigated the role of the lectin pathway of complement as a mediator of ischemia/reperfusion in...

    Authors: Michael Osthoff, Veronika K. Jaeger, Ingmar A. F. M. Heijnen, Marten Trendelenburg, Suzana Jordan, Oliver Distler and Ulrich A. Walker

    Citation: Arthritis Research & Therapy 2019 21:76

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  17. Content type: Research article

    The 17DD-yellow fever (YF) vaccine induces a long-lasting protective immunity, resulting from humoral and cellular immunological memory. The treatment of rheumatoid arthritis (RA) patients with disease-modifyi...

    Authors: Clarissa de Castro Ferreira, Ana Carolina Campi-Azevedo, Vanessa Peruhype-Magalhāes, Jordana Grazziela Coelho-dos-Reis, Lis Ribeiro do Valle Antonelli, Karen Torres, Larissa Chaves Freire, Ismael Artur da Costa-Rocha, Ana Cristina Vanderley Oliveira, Maria de Lourdes de Sousa Maia, Sheila Maria Barbosa de Lima, Carla Magda Domingues, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho and Lícia Maria Henrique da Mota

    Citation: Arthritis Research & Therapy 2019 21:75

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  18. Content type: Research article

    Tendon disease is a significant global healthcare burden whereby patients experience pain and disability; however, the mechanisms that underlie inflammation and pain are poorly understood. Herein, we investiga...

    Authors: Filip Bergqvist, Andrew J. Carr, Kim Wheway, Bridget Watkins, Udo Oppermann, Per-Johan Jakobsson and Stephanie G. Dakin

    Citation: Arthritis Research & Therapy 2019 21:74

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  19. Content type: Research article

    Resolvin D1 (RvD1), an important member of resolvins, exerts a wide spectrum of biological effects, including resolution of inflammation, tissue repair, and preservation of cell viability. The aim of the present ...

    Authors: Houda Abir Benabdoun, Merve Kulbay, Elsa-Patricia Rondon, Francis Vallières, Qin Shi, Julio Fernandes, Hassan Fahmi and Mohamed Benderdour

    Citation: Arthritis Research & Therapy 2019 21:72

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  20. Content type: Research article

    A retrospective study was performed to investigate the clinical features and associated factors of invasive mycoses (IM) in patients with connective tissue disease (CTD) from Southern China.

    Authors: Minxi Lao, Zhongping Zhan, Fan Su, Hao Li, Zheng Yang, Haihong Chen, Liuqin Liang and Dongying Chen

    Citation: Arthritis Research & Therapy 2019 21:71

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  21. Content type: Research article

    The specific function of long noncoding RNAs (lncRNAs) in systemic lupus erythematosus (SLE) and the mechanism of their involvement in related pathological changes remain to be elucidated, so, in this study, w...

    Authors: Hui Ye, Xue Wang, Lei Wang, Xiaoying Chu, Xuanxuan Hu, Li Sun, Minghua Jiang, Hong Wang, Zihan Wang, Han Zhao, Xinyu Yang and Jianguang Wang

    Citation: Arthritis Research & Therapy 2019 21:70

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  22. Content type: Correction

    Following publication of the original article [1], the authors reported an error in the spelling of Lorenzo Dagna’s name.

    Authors: Giulio Cavalli, Alessandro Tomelleri, Giacomo De Luca, Corrado Campochiaro, Charles A. Dinarello, Elena Baldissera and Lorenzo Dagna

    Citation: Arthritis Research & Therapy 2019 21:69

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    The original article was published in Arthritis Research & Therapy 2019 21:54

  23. Content type: Research article

    Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammati...

    Authors: Anna Katri, Aneta Dąbrowska, Henrik Löfvall, Ming Ding, Morten A. Karsdal, Kim V. Andreassen, Christian S. Thudium and Kim Henriksen

    Citation: Arthritis Research & Therapy 2019 21:68

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  24. Content type: Research article

    Multisite pain and falls are common in older people, and isolated studies have identified multisite pain as a potential falls risk factor. This study aims to synthesise published literature to further explore ...

    Authors: Victoria K. Welsh, Lorna E. Clarson, Christian D. Mallen and John McBeth

    Citation: Arthritis Research & Therapy 2019 21:67

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  25. Content type: Research article

    The aim of our study was to investigate the influence of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and body mass index (BMI) on circulating drug levels and clinical response to t...

    Authors: Borja Hernández-Breijo, Chamaida Plasencia-Rodríguez, Victoria Navarro-Compán, Ana Martínez-Feito, Andrea Jochems, Eva L. Kneepkens, Gerrit J. Wolbink, Theo Rispens, Cristina Diego, Dora Pascual-Salcedo and Alejandro Balsa

    Citation: Arthritis Research & Therapy 2019 21:66

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  26. Content type: Research article

    Patients with giant cell arteritis (GCA) treated with tocilizumab (TCZ) every week or every other week and prednisone tapering achieved superior rates of sustained remission to patients treated with placebo an...

    Authors: Vibeke Strand, Sophie Dimonaco, Katie Tuckwell, Micki Klearman, Neil Collinson and John H. Stone

    Citation: Arthritis Research & Therapy 2019 21:64

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  27. Content type: Research article

    Health-related quality of life (HRQoL) is a priority for patients. The objectives were to describe the changes in HRQoL over 5–8 years in patients with early arthritis (EA) or early inflammatory back pain (IBP...

    Authors: Déborah Puyraimond-Zemmour, Benjamin Granger, Anna Molto, Cécile Gaujoux-Viala, Francis Guillemin, Adeline Ruyssen-Witrand, Maxime Dougados, Bruno Fautrel and Laure Gossec

    Citation: Arthritis Research & Therapy 2019 21:63

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  28. Content type: Research article

    Previous studies and own clinical observations of patients with systemic lupus erythematosus (SLE) suggest that SLE harbors distinct immunophenotypes. This heterogeneity might result in differences in response...

    Authors: Helena Idborg, Arash Zandian, Ann-Sofi Sandberg, Bo Nilsson, Kerstin Elvin, Lennart Truedsson, Azita Sohrabian, Johan Rönnelid, John Mo, Giorgia Grosso, Marika Kvarnström, Iva Gunnarsson, Janne Lehtiö, Peter Nilsson, Elisabet Svenungsson and Per-Johan Jakobsson

    Citation: Arthritis Research & Therapy 2019 21:62

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  29. Content type: Research article

    Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis of the skin and the involvement of multiple internal organs. Previous studies reported poorer health-related quality of life (HRQ...

    Authors: Eun Hye Park, Vibeke Strand, Yoon Jeong Oh, Yeong Wook Song and Eun Bong Lee

    Citation: Arthritis Research & Therapy 2019 21:61

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  30. Content type: Research article

    Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blo...

    Authors: Johanna Estelius, Johan Lengqvist, Elena Ossipova, Helena Idborg, Erwan Le Maître, Magnus L. A. Andersson, Lou Brundin, Mohsen Khademi, Elisabet Svenungsson, Per-Johan Jakobsson and Jon Lampa

    Citation: Arthritis Research & Therapy 2019 21:60

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  31. Content type: Research article

    Ultrasound (US) and magnetic resonance imaging (MRI) are recommended in the diagnostic process of rheumatoid arthritis. Research on its comparability in early disease phases is scarce. Therefore, we compared s...

    Authors: Sarah Ohrndorf, Aleid C. Boer, Debbie M. Boeters, Robin M. ten Brinck, Gerd-R. Burmester, Marion C. Kortekaas and Annette H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2019 21:59

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  32. Content type: Research article

    Biomarkers have been actively investigated to supplement functional and imaging modalities to predict the severity, therapeutic responsiveness, and progression of connective tissue disease-associated interstit...

    Authors: Jeong Seok Lee, Eun Young Lee, You-Jung Ha, Eun Ha Kang, Yun Jong Lee and Yeong Wook Song

    Citation: Arthritis Research & Therapy 2019 21:58

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  33. Content type: Research article

    Up to 12% of patients with systemic sclerosis (SSc) have anti-neutrophil cytoplasmic antibodies (ANCA). However, the majority of these patients do not manifest ANCA-associated vasculitis (AAV) and the signific...

    Authors: Jayne Moxey, Molla Huq, Susanna Proudman, Joanne Sahhar, Gene-Siew Ngian, Jenny Walker, Gemma Strickland, Michelle Wilson, Laura Ross, Gabor Major, Janet Roddy, Wendy Stevens and Mandana Nikpour

    Citation: Arthritis Research & Therapy 2019 21:57

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  34. Content type: Research article

    MRI-detected subclinical joint inflammation in the hand joints of patients with undifferentiated arthritis (UA) predicts progression to rheumatoid arthritis (RA). It is unknown if adding MRI of the foot increa...

    Authors: Y. J. Dakkak, D. M. Boeters, A. C. Boer, M. Reijnierse and A. H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2019 21:56

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  35. Content type: Correction

    Following publication of the original article [1], the authors reported an error.

    Authors: Luyun Fan, Huimin Zhang, Jun Cai, Lirui Yang, Bin Liu, Dongmei Wei, Jiachen Yu, Jiali Fan, Lei Song, Wenjun Ma, Xianliang Zhou, Haiying Wu and Ying Lou

    Citation: Arthritis Research & Therapy 2019 21:55

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    The original article was published in Arthritis Research & Therapy 2019 21:31

  36. Content type: Research article

    Adult-onset Still’s disease (AOSD) phenotype appears to be dichotomized in systemic or chronic articular forms. As biologicals and particularly interleukin (IL)-1 and IL-6 blockers play a more and more promine...

    Authors: François Vercruysse, Thomas Barnetche, Estibaliz Lazaro, Emilie Shipley, François Lifermann, Alexandre Balageas, Xavier Delbrel, Bruno Fautrel, Christophe Richez, Thierry Schaeverbeke and Marie-Elise Truchetet

    Citation: Arthritis Research & Therapy 2019 21:53

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  37. Content type: Research article

    Systemic sclerosis (SSc) has been suggested to cause exocrine pancreatic dysfunction. However, a case-control-based autopsy study failed to associate systemic sclerosis with any pancreatic histopathology. The ...

    Authors: Gracijela Bozovic, Rille Pullerits, Arne Ståhl, Kristina Ydström, Daniel Wenger, Jan Marsal, Pontus Thulin and Kristofer Andréasson

    Citation: Arthritis Research & Therapy 2019 21:52

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  38. Content type: Research article

    MicroRNAs (MiRs) play an important role in the pathogenesis of chronic inflammatory diseases. This study is the first to investigate miR expression profiles in purified CD4+ T lymphocytes and CD14+ monocytes from...

    Authors: Olivier Fogel, Andreas Bugge Tinggaard, Maud Fagny, Nelly Sigrist, Elodie Roche, Laurence Leclere, Jean-François Deleuze, Frederic Batteux, Maxime Dougados, Corinne Miceli-Richard and Jörg Tost

    Citation: Arthritis Research & Therapy 2019 21:51

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  39. Content type: Research article

    Acute gouty arthritis currently is the most common form of inflammatory arthritis in developed countries. Treatment is still suboptimal. Dosage of urate-lowering therapy is often too low to reach target urate ...

    Authors: M. C. P. Cleophas, T. O. Crişan, V. Klück, N. Hoogerbrugge, R. T. Netea-Maier, C. A. Dinarello, M. G. Netea and L. A. B. Joosten

    Citation: Arthritis Research & Therapy 2019 21:50

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  40. Content type: Research article

    Infectious agents have long been postulated to be disease triggers for systemic sclerosis (SSc), but a definitive link has not been found. Metagenomic analyses of high-throughput data allows for the unbiased i...

    Authors: Michael E. Johnson, Jennifer M. Franks, Guoshuai Cai, Bhaven K. Mehta, Tammara A. Wood, Kimberly Archambault, Patricia A. Pioli, Robert W. Simms, Nicole Orzechowski, Sarah Arron and Michael L. Whitfield

    Citation: Arthritis Research & Therapy 2019 21:49

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    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:81

  41. Content type: Research article

    We applied systems biology approaches to investigate circadian rhythmicity in rheumatoid arthritis (RA).

    Authors: Toryn M. Poolman, Julie Gibbs, Amy L. Walker, Suzanna Dickson, Laura Farrell, James Hensman, Alexandra C. Kendall, Robert Maidstone, Stacey Warwood, Andrew Loudon, Magnus Rattray, Ian N. Bruce, Anna Nicolaou and David W. Ray

    Citation: Arthritis Research & Therapy 2019 21:47

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  42. Content type: Research article

    Spondyloarthritis (SpA) is a chronic inflammatory disease affecting primarily axial and peripheral joints and sometimes also extra-articular organs, such as the gut. Rats transgenic for HLA-B27 and human β2-mi...

    Authors: Kétia Ermoza, Simon Glatigny, Nadège Jah, Vânia Camilo, Hendrick Mambu Mambueni, Luiza M. Araujo, Gilles Chiocchia and Maxime Breban

    Citation: Arthritis Research & Therapy 2019 21:46

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  43. Content type: Research

    Anti-citrullinated protein antibodies (ACPA) have been suggested to have a potential role in both bone loss and pain in rheumatoid arthritis (RA), based on studies in vitro and in animal models. Here we addres...

    Authors: Ingiäld Hafström, Sofia Ajeganova, Kristina Forslind and Björn Svensson

    Citation: Arthritis Research & Therapy 2019 21:45

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  44. Content type: Research article

    This study aimed to compare the differences and similarities in the clinical manifestations and treatment efficacy of IgG4-related disease (IgG4-RD) in patients with and without dacryoadenitis and sialoadeniti...

    Authors: Mu Wang, Panpan Zhang, Wei Lin, Yunyun Fei, Hua Chen, Jing Li, Li Zhang, Wenjie Zheng, Yongze Li, Xiaofeng Zeng, Jiaxin Zhou, Yamin Lai, Xiaowei Liu, Huadan Xue, Yueying Cui, Lian Zhou…

    Citation: Arthritis Research & Therapy 2019 21:44

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  45. Content type: Research article

    An important limitation in granulomatosis with polyangiitis (GPA) is the lack of disease activity markers. Immunoglobulin G4-positive (IgG4+) B cells and plasma cells are implicated in the pathogenesis of GPA. We...

    Authors: A. Al-Soudi, M. E. Doorenspleet, R. E. Esveldt, L. T. Burgemeister, A. E. Hak, B. J. H. van den Born, S. W. Tas, R. F. van Vollenhoven, P. L. Klarenbeek and N. de Vries

    Citation: Arthritis Research & Therapy 2019 21:43

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  46. Content type: Research article

    The expression of both high-mobility group box 1 (HMGB1) and receptor for advanced glycation end-products (RAGE) is upregulated in degenerated discs. HMGB1 is known to function as a coupling factor between hyp...

    Authors: Chi-Chien Niu, Song-Shu Lin, Li-Jen Yuan, Meng-Ling Lu, Steve W. N. Ueng, Chuen-Yung Yang, Tsung-Ting Tsai and Po-Liang Lai

    Citation: Arthritis Research & Therapy 2019 21:42

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