Articles

Self-reactive T cells induce and perpetuate chronic relapsing arthritis

CD4⁺ T cells play a central role during the early stages of rheumatoid arthritis (RA), but to which extent they are required for the perpetuation of the disease is still not fully understood. The aim of the curre...

Authors: Jonatan Tuncel, Jens Holmberg, Sabrina Haag, Malin Hultqvist Hopkins, Lena Wester-Rosenlöf, Stefan Carlsen, Peter Olofsson and Rikard Holmdahl

Occurrence of anterior uveitis in patients with spondyloarthritis treated with tumor necrosis factor inhibitors: comparing the soluble receptor to monoclonal antibodies in a large observational cohort

The objective of this study was to compare in real life the occurrence of anterior uveitis in patients with spondyloarthritis (SpA), including psoriatic arthritis (PsA), treated with the soluble-receptor etane...

Authors: Gisèle Khoury, Jacques Morel, Bernard Combe and Cédric Lukas

Synergistic activation of NF-κB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory rheumatic disease. SLE susceptibility is affected by multiple genetic elements, environmental factors, and their interactions. We aimed in this ...

Authors: Taehyeung Kim, Sang-Cheol Bae and Changwon Kang

Obstructive sleep apnea and the risk of gout: a population-based case-control study

Patients with obstructive sleep apnea (OSA) might be at risk of gout because of pathophysiological mechanisms that can lead to hyperuricemia and eventually gout or because of shared risk factors between both d...

Authors: Caroline van Durme, Bart Spaetgens, Johanna Driessen, Johannes Nielen, Manuel Sastry, Annelies Boonen and Frank de Vries

Higher interferon score and normal complement levels may identify a distinct clinical subset in children with systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex multi-system disease, characterized by both autoimmune and autoinflammatory clinical and laboratory features. The role of type I interferon (IFN) in SLE has been...

Authors: Alessandra Tesser, Luciana Martins de Carvalho, Paula Sandrin-Garcia, Alessia Pin, Serena Pastore, Andrea Taddio, Luciana Rodrigues Roberti, Rosane Gomes de Paula Queiroz, Virginia Paes Leme Ferriani, Sergio Crovella and Alberto Tommasini

Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models

In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk est...

Authors: Grunde Wibetoe, Joseph Sexton, Eirik Ikdahl, Silvia Rollefstad, George D. Kitas, Piet van Riel, Sherine Gabriel, Tore K. Kvien, Karen Douglas, Aamer Sandoo, Elke E. Arts, Solveig Wållberg-Jonsson, Solbritt Rantapää Dahlqvist, George Karpouzas, Patrick H. Dessein, Linda Tsang…

Predictors of the use of analgesic drugs 1 year after joint replacement: a single-center analysis of 13,000 hip and knee replacements

Pain persists in a moderate number of patients following hip or knee replacement surgery. Persistent pain may subsequently lead to the prolonged consumption of analgesics after surgery and expose patients to t...

Authors: Tuomas Jaakko Rajamäki, Pia A. Puolakka, Aki Hietaharju, Teemu Moilanen and Esa Jämsen

A unique thymus-derived regulatory T cell subset associated with systemic lupus erythematosus

Foxp3 is a marker for regulatory T cells (Treg cells), but recent studies have shown the plasticity and heterogeneity of CD4⁺Foxp3⁺ T cells. This study aimed to examine the phenotype and function of circulating C...

Authors: Hironari Hanaoka, Tetsuya Nishimoto, Yuka Okazaki, Tsutomu Takeuchi and Masataka Kuwana

Data quality predicts care quality: findings from a national clinical audit

Missing clinical outcome data are a common occurrence in longitudinal studies. Data quality in clinical audit is a particular cause for concern. The relationship between departmental levels of missing clinical...

Authors: Mark Yates, Katie Bechman, Elaine M. Dennison, Alexander J. MacGregor, Jo Ledingham, Sam Norton and James B. Galloway

Gout is associated with an increased risk for incident heart failure among older adults: the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort study

Gout has been associated with a higher risk for coronary heart disease (CHD) and stroke in some prior studies. Few studies have assessed the association of gout with incident heart failure (HF).

Authors: Lisandro D. Colantonio, Kenneth G. Saag, Jasvinder A. Singh, Ligong Chen, Richard J. Reynolds, Angelo Gaffo, Timothy B. Plante, Jeffrey R. Curtis, S. Louis Bridges Jr., Emily B. Levitan, Ninad S. Chaudhary, George Howard, Monika M. Safford, Paul Muntner and Marguerite Ryan Irvin

Substitution of the quantitative serological component in the 2010 criteria for RA with qualitative presence of three autoantibodies yields similar performance: response to the article by Regueiro et al.

Authors: Bastiaan T. van Dijk, Leendert A. Trouw, Annette H. M. van der Helm-van Mil and Tom W. J. Huizinga

Repeated measurements of serum urate and mortality: a prospective cohort study of 152,358 individuals over 8 years of follow-up

Longitudinal evidence on change of serum urate level with mortality risk is limited as prior studies have a measurement of serum urate at a single time point. Further, the combined effect of serum urate and sy...

Authors: Shanshan Li, Liufu Cui, Jin Cheng, Rong Shu, Shuohua Chen, Uyen-Sa Nguyen, Devyani Misra, Shouling Wu and Xiang Gao

Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis

Dietary fatty acid (FA) content has been shown to influence the development of post-traumatic osteoarthritis (PTOA) in obesity. We used the fat-1 transgenic mouse to examine the hypothesis that endogenous reducti...

Authors: Kelly A. Kimmerling, Sara J. Oswald, Janet L. Huebner, Dianne Little, Virginia B. Kraus, Jing X. Kang, Chia-Lung Wu and Farshid Guilak

Disease features associated with a low disease impact in patients with psoriatic arthritis: results of a cross-sectional multicenter study

Patient-reported outcomes measures, such as those provided by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire, have been found to be a reliable indicator of change during treatment, predictive of ...

Authors: Ruben Queiro, Juan D. Cañete, María Montoro, Susana Gómez and Ana Cábez

Similarities in clinical course and outcome between juvenile idiopathic arthritis (JIA)-associated and ANA-positive idiopathic anterior uveitis: data from a population-based nationwide study in Germany

To analyze whether ANA-positive idiopathic anterior uveitis differs from JIA-associated uveitis concerning clinical course, response to treatment, and disease outcome.

Authors: Arnd Heiligenhaus, Jens Klotsche, Martina Niewerth, Gerd Horneff, Gerd Ganser, Johannes-Peter Haas and Kirsten Minden

Differential regulation and correlation between galectin-9 and anti-CCP antibody (ACPA) in rheumatoid arthritis patients

Galectin-9 (Gal-9) is involved in the regulatory process of immune responses or inflammation. The aim of the present study is to characterize circulating Gal-9 in patients with rheumatoid arthritis (RA) and it...

Authors: Yuya Fujita, Tomoyuki Asano, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Haruki Matsumoto, Makiko Yashiro Furuya, Eiji Suzuki, Hiroshi Watanabe, Atsushi Kawakami and Kiyoshi Migita

Retrospective analysis of infliximab and adalimumab treatment in a large cohort of juvenile dermatomyositis patients

Anti-TNF treatment may be useful for the treatment of patients with refractory juvenile dermatomyositis (JDM). The aim of this study was to describe the use of infliximab and adalimumab therapy in juvenile der...

Authors: Raquel Campanilho-Marques, Claire T. Deakin, Stefania Simou, Charalampia Papadopoulou, Lucy R. Wedderburn and Clarissa A. Pilkington

Cognitive dysfunction in autoimmune rheumatic diseases

For people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal cognitive functions are essential for per...

Authors: Csaba Oláh, Noa Schwartz, Christopher Denton, Zsófia Kardos, Chaim Putterman and Zoltán Szekanecz

Metformin rescues rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome

Rapamycin, an inhibitor of the serine/threonine protein kinase mTOR, is an immunosuppressant used to treat renal transplant recipients, but it can cause endothelial and mitochondrial dysfunction. Metformin is ...

Authors: Eun Kyung Kim, Hong Ki Min, Seon-Yeong Lee, Da-Som Kim, Jun-Geol Ryu, Hyun Sik Na, Kyoung Ah Jung, Jeong Won Choi, Sung-Hwan Park and Mi-La Cho

Alternatively activated macrophages are associated with the α2AP production that occurs with the development of dermal fibrosis

Fibrotic diseases are characterized by tissue overgrowth, hardening, and/or scarring because of the excessive production, deposition, and contraction of the extracellular matrix (ECM). However, the detailed me...

Authors: Yosuke Kanno, En Shu, Hirofumi Niwa, Hiroyuki Kanoh and Mariko Seishima

Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization

Spinal cord ischemia-reperfusion injury (SCIRI) often leads to neurological damage and mortality. In this regard, understanding the pathology of SCIRI and preventing its development are of great clinic value.

Authors: Ran Li, Kunchi Zhao, Qing Ruan, Chunyang Meng and Fei Yin

MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions

The association of HLA-B*27 with AS is amongst the strongest of any known association of a common variant with any human disease. Nonetheless, there is strong evidence indicating that other HLA-B alleles are invo...

Authors: Geng Wang, Tae-Hwan Kim, Zhixiu Li, Adrian Cortes, Kwangwoo Kim, So-Young Bang, Paul Leo, Matthew A. Brown and Huji Xu

Serum interleukin-16 significantly correlates with the Vasculitis Damage Index in antineutrophil cytoplasmic antibody-associated vasculitis

Interleukin (IL)-16 is a T cell chemoattractant produced by peripheral mononuclear cells. We investigated whether IL-16 plays a pro- or an anti-inflammatory role in antineutrophil cytoplasmic antibody-associat...

Authors: Taejun Yoon, Jung Yoon Pyo, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee

Associated factors of poor treatment outcomes in patients with giant cell arteritis: clinical implication of large vessel lesions

Relapses frequently occur in giant cell arteritis (GCA), and long-term glucocorticoid therapy is required. The identification of associated factors with poor treatment outcomes is important to decide the treat...

Authors: Takahiko Sugihara, Hitoshi Hasegawa, Haruhito A. Uchida, Hajime Yoshifuji, Yoshiko Watanabe, Eisuke Amiya, Yasuhiro Maejima, Masanori Konishi, Yohko Murakawa, Noriyoshi Ogawa, Shunsuke Furuta, Yasuhiro Katsumata, Yoshinori Komagata, Taio Naniwa, Takahiro Okazaki, Yoshiya Tanaka…

Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee

To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC).

Authors: Gabriella Giancane, Joost F. Swart, Elio Castagnola, Andreas H. Groll, Gerd Horneff, Hans-Iko Huppertz, Daniel J. Lovell, Tom Wolfs, Troels Herlin, Pavla Dolezalova, Helga Sanner, Gordana Susic, Flavio Sztajnbok, Despoina Maritsi, Tamas Constantin, Veronika Vargova…

Sarilumab and adalimumab differential effects on bone remodelling and cardiovascular risk biomarkers, and predictions of treatment outcomes

Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a key role in the pathogenesis of rheumatoid arthritis. Sarilumab is a human monoclonal antibody that binds membrane-bound and soluble IL-6 receptor-α ...

Authors: Cem Gabay, Gerd R. Burmester, Vibeke Strand, Jérôme Msihid, Moshe Zilberstein, Toshio Kimura, Hubert van Hoogstraten, Susan H. Boklage, Jonathan Sadeh, Neil M. H. Graham and Anita Boyapati

Expression of interferon-regulated genes in juvenile dermatomyositis versus Mendelian autoinflammatory interferonopathies

Juvenile dermatomyositis (JDM) is a systemic autoimmune disease with a prominent interferon (IFN) signature, but the pathogenesis of JDM and the etiology of its IFN signature remain unknown. The Mendelian auto...

Authors: Hanna Kim, Fatima Gunter-Rahman, John A. McGrath, Esther Lee, Adriana A. de Jesus, Ira N. Targoff, Yan Huang, Terrance P. O’Hanlon, Wanxia L. Tsai, Massimo Gadina, Frederick W. Miller, Raphaela Goldbach-Mansky and Lisa G. Rider

Pure platelet-rich plasma facilitates the repair of damaged cartilage and synovium in a rabbit hemorrhagic arthritis knee model

Hemorrhagic arthritis (HA) is a common disease of the musculoskeletal system caused by hemorrhage in the joints, leading to damages in the synovium and cartilage. Pure platelet-rich plasma (P-PRP) has been rec...

Authors: Yulun Xue, Xinlin Su, Miao Jiang, Ziqiang Yu, Huilin Yang, Ling Qin, Peter V. Giannoudis and Jiong Jiong Guo

The relation between physical joint examination and MRI-depicted inflammation of metatarsophalangeal joints in early arthritis

The relationship between physical joint examination (PE) and MRI-detected inflammation in early inflammatory arthritis has mostly been studied in the hands. Physical examination of MTP joints is considered dif...

Authors: Yousra J. Dakkak, Aleid C. Boer, Debbie M. Boeters, Ellis Niemantsverdriet, Monique Reijnierse and Annette H. M. van der Helm-van Mil

Inhibition of effector B cells by ibrutinib in systemic sclerosis

Systemic sclerosis (SSc) is a connective tissue disease with a significant morbidity and reduced survival of patients. Effective treatment and clinical control of the disease remain challenging. In particular,...

Authors: Jakob Einhaus, Ann-Christin Pecher, Elisa Asteriti, Hannes Schmid, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Reinhild Klein, Corina Schneidawind, Joerg Henes and Dominik Schneidawind

Iguratimod as an alternative induction therapy for refractory lupus nephritis: a preliminary investigational study

Iguratimod, a novel immunomodulatory agent for rheumatoid arthritis, has been shown to be effective against murine lupus. The aim of this study was to make a preliminary evaluation of the efficacy and safety o...

Authors: Yuening Kang, Qingran Yan, Qiong Fu, Ran Wang, Min Dai, Fang Du, Qing Dai, Ping Ye, Chunmei Wu, Liangjing Lu and Chunde Bao

Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) suppresses Staphylococcus aureus-induced CD80, CD86, and pro-inflammatory cytokine expression in human B cells

Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) competes with CD28 for binding CD80/CD86 on antigen-presenting cells (APCs) to limit T cell activation. B cells are believed to be important APCs in t...

Authors: Po-Chun Liu, Chih-Tai Ssu, Yen-Po Tsao, Teh-Ling Liou, Chang-Youh Tsai, Chung-Tei Chou, Ming-Han Chen and Chuen-Miin Leu

Reduction of circulating innate lymphoid cell progenitors results in impaired cytokine production by innate lymphoid cells in patients with lupus nephritis

Innate lymphoid cells (ILCs) play an essential role in maintaining homeostasis; however, they can also cause chronic inflammation and autoimmune disease. This study aimed to identify the role of ILCs in the pa...

Authors: Seungwon Ryu, Eun Young Lee, Dong Ki Kim, Yon Su Kim, Doo Hyun Chung, Ji Hyung Kim, Hajeong Lee and Hye Young Kim

Biological potential alterations of migratory chondrogenic progenitor cells during knee osteoarthritic progression

Although increasing studies have demonstrated that chondrogenic progenitor cells (CPCs) remain present in human osteoarthritic cartilage, the biological alterations of the CPCs from the less diseased lateral t...

Authors: Yu-Xing Wang, Zhi-Dong Zhao, Qian Wang, Zhong-Li Li, Ya Huang, Sen Zhao, Wei Hu, Jia-Wu Liang, Pei-Lin Li, Hua Wang, Ning Mao, Chu-Tse Wu and Heng Zhu

Resolvin D1 suppresses pannus formation via decreasing connective tissue growth factor caused by upregulation of miRNA-146a-5p in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint stiffness, finally leading to tissue destruction. Connective tissue growth factor (CTGF) is a critical factor i...

Authors: Weiwei Sun, Jinglan Ma, Han Zhao, Chipeng Xiao, Hao Zhong, Hanzhi Ling, Zhen Xie, Qingqing Tian, Huaijun Chen, Tingting Zhang, Mu Chen, Shengwei Jin and Jianguang Wang

Comparative clinical efficacy and safety of the proposed biosimilar ABP 710 with infliximab reference product in patients with rheumatoid arthritis

ABP 710 is being developed as a biosimilar to infliximab reference product (RP). Analytical similarity and pharmacokinetic equivalence between the two have been previously demonstrated. Here we report results ...

Authors: Mark C. Genovese, Juan Sanchez-Burson, MyungShin Oh, Eva Balazs, Jeffrey Neal, Andrea Everding, Tomas Hala, Rafal Wojciechowski, Gary Fanjiang and Stanley Cohen

ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis—a EUSTAR analysis

To investigate the effect of ACE inhibitors (ACEi) on the incidence of scleroderma renal crisis (SRC) when given prior to SRC in the prospectively collected cohort from the European Scleroderma Trial and Resea...

Authors: Lukas Bütikofer, Pierre A. Varisco, O. Distler, O. Kowal-Bielecka, Y. Allanore, G. Riemekasten, P. M. Villiger and S. Adler

Spondyloarthritis Research Consortium of Canada sacroiliac joint inflammation and structural scores: change score reliability and recalibration utility in children

The SPARCC sacroiliac joint inflammation (SIS) and structural (SSS) scores are reliable measures to quantify abnormalities in the pediatric sacroiliac joint. We aimed to evaluate the utility of online calibrat...

Authors: Pamela F. Weiss, Walter P. Maksymowych, Rui Xiao, David M. Biko, Michael L. Francavilla, Robert G. Lambert, Jacob L. Jaremko, Merav Heshin-Bekenstein, Timothy G. Brandon and Nancy A. Chauvin

Post-traumatic osteoarthritis following ACL injury

Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the inciden...

Authors: Li-Juan Wang, Ni Zeng, Zhi-Peng Yan, Jie-Ting Li and Guo-Xin Ni

Treatment modalities and drug survival in a systemic sclerosis real-life patient cohort

European data indicate that systemic sclerosis (SSc)-related death rates are increasing, thus raising concerns about SSc’s optimal management. Herein, we describe current treatment modalities and drug survival...

Authors: S. Panopoulos, Κ. Chatzidionysiou, M. G. Tektonidou, V. K. Bournia, A. A. Drosos, Stamatis-Nick C. Liossis, T. Dimitroulas, L. Sakkas, D. Boumpas, P. V. Voulgari, D. Daoussis, K. Thomas, G. Georgiopoulos, G. Vosvotekas, Α. Garyfallos, P. Sidiropoulos…

Response to: “Does ACPA-negative RA consist of subgroups related to sustained DMARD-free remission and serological markers at disease presentation” by Masi and Fleischmann

Authors: Debbie M. Boeters and Annette H. M. van der Helm–van Mil

A consensus-based framework for conducting and reporting osteoarthritis phenotype research

The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research...

Authors: W. E. van Spil, S. M. A. Bierma-Zeinstra, L. A. Deveza, N. K. Arden, A.-C. Bay-Jensen, V. Byers Kraus, L. Carlesso, R. Christensen, M. Van Der Esch, P. Kent, J. Knoop, C. Ladel, C. B. Little, R. F. Loeser, E. Losina, K. Mills…

A Canadian evaluation framework for quality improvement in childhood arthritis: key performance indicators of the process of care

The evaluation of quality of care in juvenile idiopathic arthritis (JIA) is critical for advancing patient outcomes but is not currently part of routine care across all centers in Canada. The study objective i...

Authors: Claire E. H. Barber, Marinka Twilt, Tram Pham, Gillian R. Currie, Susanne Benseler, Rae S. M. Yeung, Michelle Batthish, Nicholas Blanchette, Jaime Guzman, Bianca Lang, Claire LeBlanc, Deborah M. Levy, Christine O’Brien, Heinrike Schmeling, Gordon Soon, Lynn Spiegel…

Low frequency of flares during pregnancy and post-partum in stable lupus patients

Lupus patients are at risk for pregnancy loss, and it has been generally accepted that women with SLE should have low disease activity prior to conception. However, there are conflicting results regarding the ...

Authors: Julia Davis-Porada, Mimi Y. Kim, Marta M. Guerra, Carl A. Laskin, Michelle Petri, Michael D. Lockshin, Lisa R. Sammaritano, D. Ware Branch, Allen Sawitzke, Joan T. Merrill, Jill P. Buyon and Jane E. Salmon

Lipocalin 2 links inflammation and ankylosis in the clinical overlap of inflammatory bowel disease (IBD) and ankylosing spondylitis (AS)

Little is known about the mechanisms underlying the clinical overlap between gut inflammation and joint ankylosis, as exemplified by the concurrence of inflammatory bowel diseases (IBD) and ankylosing spondyli...

Authors: Aifeng Lin, Robert D. Inman, Catherine J. Streutker, Zhenbo Zhang, Kenneth P. H. Pritzker, Hing Wo Tsui and Florence W. L. Tsui

How much of skin improvement over time in systemic sclerosis is due to normal ageing? A prospective study with shear-wave elastography

Measurement of skin involvement is essential for the diagnosis and assessment of prognosis and disease progression in systemic sclerosis (SSc). The modified Rodnan skin score (mRSS) is the gold standard measur...

Authors: T. Santiago, M. Santiago, M. Coutinho, M. J. Salvador and J. A. P. Da Silva

The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H₂S) pathway against experimental osteoarthritis

Osteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood. The gasotransmitter hydrogen sulfide (H₂S...

Authors: Sonia Nasi, Driss Ehirchiou, Athanasia Chatzianastasiou, Noriyuki Nagahara, Andreas Papapetropoulos, Jessica Bertrand, Giuseppe Cirino, Alexander So and Nathalie Busso

High-throughput quantitative histology in systemic sclerosis skin disease using computer vision

Skin fibrosis is the clinical hallmark of systemic sclerosis (SSc), where collagen deposition and remodeling of the dermis occur over time. The most widely used outcome measure in SSc clinical trials is the mo...

Authors: Chase Correia, Seamus Mawe, Shane Lofgren, Roberta G. Marangoni, Jungwha Lee, Rana Saber, Kathleen Aren, Michelle Cheng, Shannon Teaw, Aileen Hoffmann, Isaac Goldberg, Shawn E. Cowper, Purvesh Khatri, Monique Hinchcliff and J. Matthew Mahoney

Identification of molecules associated with response to abatacept in patients with rheumatoid arthritis

Abatacept (ABA) is a biological disease-modifying antirheumatic drug (bDMARD) for rheumatoid arthritis (RA). The aim of this study was to identify molecules that are associated with therapeutic responses to AB...

Authors: Waka Yokoyama-Kokuryo, Hayato Yamazaki, Tsutomu Takeuchi, Koichi Amano, Jun Kikuchi, Tsuneo Kondo, Seiji Nakamura, Ryoko Sakai, Fumio Hirano, Toshihiro Nanki, Ryuji Koike and Masayoshi Harigai

Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout

The ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9, yet the effect size on gout is greater. We tested the h...

Authors: Rebekah Wrigley, Amanda J. Phipps-Green, Ruth K. Topless, Tanya J. Major, Murray Cadzow, Philip Riches, Anne-Kathrin Tausche, Matthijs Janssen, Leo A. B. Joosten, Tim L. Jansen, Alexander So, Jennie Harré Hindmarsh, Lisa K. Stamp, Nicola Dalbeth and Tony R. Merriman