Articles

“Non-criteria” antiphospholipid antibodies add value to antiphospholipid syndrome diagnoses in a large Chinese cohort

Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies in addition to IgG/IgM anti-cardiolipin antibodies (aCL)...

Authors: Tingting Liu, Jieyu Gu, Liyan Wan, Qiongyi Hu, Jialin Teng, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Yue Sun, Jinfeng Zhou, Gary L. Norman, Xuefeng Wang, Chengde Yang and Hui Shi

Acute kidney injury after primary total hip arthroplasty: a risk multiplier for complication, mortality, and healthcare utilization

To assess whether acute kidney injury (AKI) is associated with more complications and higher healthcare utilization in people undergoing primary total hip arthroplasty (THA).

Authors: Jasvinder A. Singh and John D. Cleveland

Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis

Systemic sclerosis (SSc) is a severe and highly heterogeneous disease. The modified Rodnan skin score (mRSS) is a widely used tool for the assessment of the extent and degree of skin thickness. This study aime...

Authors: Emmanuel Ledoult, David Launay, Hélène Béhal, Luc Mouthon, Grégory Pugnet, Jean-Christophe Lega, Christian Agard, Yannick Allanore, Patrick Jego, Anne-Laure Fauchais, Jean-Robert Harlé, Sabine Berthier, Achille Aouba, Arsène Mekinian, Elisabeth Diot, Marie-Elise Truchetet…

The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment

Synovitis is implicated in the severity and progression of pain and structural pathology of osteoarthritis (OA). Increases in inflammatory or immune cell subpopulations including macrophages and lymphocytes ha...

Authors: Cindy C. Shu, Sanaa Zaki, Varshini Ravi, Antonella Schiavinato, Margaret M. Smith and Christopher B. Little

Adverse events during oral colchicine use: a systematic review and meta-analysis of randomised controlled trials

Colchicine is a widely used drug to treat inflammatory diseases. Due to its long historical use in medicine, controlled clinical trials have been small and there remains some caution with the use of this drug ...

Authors: Sarah Stewart, Kevin Chih Kai Yang, Kate Atkins, Nicola Dalbeth and Philip C. Robinson

Association between periodontitis and anti-citrullinated protein antibodies in rheumatoid arthritis patients: a cross-sectional study

The aim of this study was to evaluate the association between periodontal parameters related with the periodontal disease severity and the presence and levels of anti-citrullinated protein antibodies (ACPAs) i...

Authors: Jerián González-Febles, Beatriz Rodríguez-Lozano, Carlos Sánchez-Piedra, Jorge Garnier-Rodríguez, Sagrario Bustabad, Martina Hernández-González, Enrique González-Dávila, Mariano Sanz and Federico Díaz-González

A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations

C-reactive protein (CRP) is often normal in patients with psoriatic disease. Herein, we aimed to define markers of systemic inflammation in patients with monomorphic and polymorphic psoriatic skin, entheseal, ...

Authors: Maria V. Sokolova, David Simon, Kemal Nas, Mario M. Zaiss, Yubin Luo, Yi Zhao, Jürgen Rech and Georg Schett

Innate lymphoid cells in inflammatory arthritis

Aberrant activation and dysregulation of immune system is a common feature of many forms of inflammatory arthritis. Since their identification as a distinctive population of leukocytes, innate lymphoid cells (...

Authors: Weiting Fang, Yuanyuan Zhang and Zhu Chen

Tumour necrosis factor alpha promotes secretion of 14-3-3η by inducing necroptosis in macrophages

14-3-3η is an intracellular protein also detected in the serum and synovial fluid of patients with rheumatoid arthritis (RA). It is closely related to disease activity and anti-cyclic citrullinated peptide ant...

Authors: Gulzhan Trimova, Kaoru Yamagata, Shigeru Iwata, Shintaro Hirata, Tong Zhang, Fumi Uemura, Minoru Satoh, Norma Biln, Shingo Nakayamada, Walter P. Maksymowych and Yoshiya Tanaka

Responses to “Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study”: authors’ reply

Authors: Yves Henrotin, Anne-Françoise Donneau, Kurt de Vlam, Ruth Wittoek and Frank Luyten

Response to “Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study”

Authors: Jean-Pierre Pelletier and Jean-Pierre Raynauld

Reply to: “Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study”

Authors: Nicola Veronese

Aryl hydrocarbon receptor signals attenuate lung fibrosis in the bleomycin-induced mouse model for pulmonary fibrosis through increase of regulatory T cells

Interstitial lung disease (ILD) is a serious complication of connective tissue diseases (CTDs). Although immune dysregulation triggered by genetic and environmental factors is thought to provoke inflammation a...

Authors: Hiroshi Takei, Hidekata Yasuoka, Keiko Yoshimoto and Tsutomu Takeuchi

Serial magnetic resonance imaging and ultrasound examinations demonstrate differential inflammatory lesion patterns in soft tissue and bone upon patient-reported flares in rheumatoid arthritis

Magnetic resonance imaging (MRI) and ultrasonography (US) are more sensitive than clinical evaluation in assessing inflammation in rheumatoid arthritis (RA). Data is scarce regarding potential link between pat...

Authors: Dorota Kuettel, Daniel Glinatsi, Mikkel Østergaard, Lene Terslev, Jette Primdahl, Sören Möller, Andreas Pedersen, Randi Petersen, Ulrich Weber and Kim Hørslev-Petersen

Assessing structural damage progression in psoriatic arthritis and its role as an outcome in research

Psoriatic arthritis (PsA) is an immune-mediated, clinically heterogeneous disease characterized by arthritis, enthesitis, dactylitis, spondylitis, and psoriasis of the skin and nails. Persistent articular infl...

Authors: Désirée van der Heijde, Dafna D. Gladman, Arthur Kavanaugh and Philip J. Mease

Does ACPA-negative RA consist of subgroups related to sustained DMARD-free remission and serological markers at disease presentation? Comment on article by Boeters DM et al.

Authors: Alfonse T. Masi and Roy Fleischmann

Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug

Proper blocking of toll-like receptor (TLR) activation during disease progression has been reported to have inhibitory effect on the pathogenesis of rheumatoid arthritis (RA). We tested whether the TLR4 inhibi...

Authors: Snigdha Samarpita, Joo Young Kim, Mahaboob Khan Rasool and Kyoung Soo Kim

Abatacept in rheumatoid arthritis: survival on drug, clinical outcomes, and their predictors—data from a large national quality register

There are limited data regarding efficacy of abatacept treatment for rheumatoid arthritis (RA) outside clinical trials. Quality registers have been useful for observational studies on tumor necrosis factor inh...

Authors: Giovanni Cagnotto, Minna Willim, Jan-Åke Nilsson, Michele Compagno, Lennart T. H. Jacobsson, Saedis Saevarsdottir and Carl Turesson

Safety results of ixekizumab with 1822.2 patient-years of exposure: an integrated analysis of 3 clinical trials in adult patients with psoriatic arthritis

The long-term safety was assessed in patients with psoriatic arthritis who were treated with ixekizumab in three clinical trials (SPIRIT-P1/-P2/-P3).

Authors: Bernard Combe, Proton Rahman, Hideto Kameda, Juan D. Cañete, Gaia Gallo, Noah Agada, Wen Xu and Mark C. Genovese

Reduced progression of bone erosion in cytomegalovirus seropositive rheumatoid arthritis patients

Human cytomegalovirus (HCMV) seropositivity has been associated with higher inflammation during rheumatoid arthritis (RA). However, no data are available on the impact of HCMV seropositivity on bone erosion pr...

Authors: B. Rauwel, Y. Degboé, D. Nigon, J.-F. Boyer, F. Abravanel, J. Izopet, B. Combe, A. Ruyssen-Witrand, A. Constantin, A. Cantagrel and J.-L. Davignon

Comorbid conditions and the transition among states of hip osteoarthritis and symptoms in a community-based study: a multi-state time-to-event model approach

We examined the association of three common chronic conditions (obesity, diabetes mellitus [DM], and cardiovascular disease [CVD]) with transitions among states of hip osteoarthritis (HOA).

Authors: Carolina Alvarez, Rebecca J. Cleveland, Todd A. Schwartz, Jordan B. Renner, Louise B. Murphy, Joanne M. Jordan, Leigh F. Callahan, Yvonne M. Golightly and Amanda E. Nelson

Improvement of symptoms in clinically suspect arthralgia and resolution of subclinical joint inflammation: a longitudinal study in patients that did not progress to clinical arthritis

Arthralgia and MRI-detected subclinical inflammation can precede the development of clinically evident rheumatoid arthritis (RA). However, part of the patients presenting with clinically suspect arthralgia (CS...

Authors: Robin M. ten Brinck, Debbie M. Boeters, Hanna W. van Steenbergen and Annette H. M. van der Helm-van Mil

Validation of prediction models of severe disease course and non-achievement of remission in juvenile idiopathic arthritis part 2: results of the Nordic model in the Canadian cohort

Validated clinical prediction models to identify children with poor prognosis at the time of juvenile idiopathic arthritis (JIA) diagnosis would be very helpful for tailoring treatments, and avoiding under- or...

Authors: Andrew Henrey, Veronika Rypdal, Martin Rypdal, Thomas Loughin, Ellen Nordal and Jaime Guzman

Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis

Endocannabinoids are showing great promise as effective mediators for controlling joint inflammation and pain. One strategy that could be harnessed to promote endogenous cannabinoid function is to inhibit the ...

Authors: Holly T. Philpott and Jason J. McDougall

Comparison of performance of specific (SLEQOL) and generic (SF36) health-related quality of life questionnaires and their associations with disease status of systemic lupus erythematosus: a longitudinal study

The utility of generic health-related quality of life (HRQoL) questionnaires in patients with systemic lupus erythematosus (SLE) is uncertain. We compared the performance of generic (SF36) and specific (SLEQOL...

Authors: Worawit Louthrenoo, Nuntana Kasitanon, Eric Morand and Rangi Kandane-Rathnayake

Identifying clinical subgroups in IgG4-related disease patients using cluster analysis and IgG4-RD composite score

To explore the clinical patterns of patients with IgG4-related disease (IgG4-RD) based on laboratory tests and the number of organs involved.

Authors: Jieqiong Li, Yu Peng, Yuelun Zhang, Panpan Zhang, Zheng Liu, Hui Lu, Linyi Peng, Liang Zhu, Huadan Xue, Yan Zhao, Xiaofeng Zeng, Yunyun Fei and Wen Zhang

Correction to: Management of adult-onset Still’s disease with interleukin-1 inhibitors: evidence- and consensus-based statements by a panel of Italian experts

Following publication of the original article [1], it was brought to our attention that the AOSD Consensus Group was incorrectly tagged and therefore not searchable. The publishers apologize for this error.

Authors: Serena Colafrancesco, Maria Manara, Alessandra Bortoluzzi, Teodora Serban, Gerolamo Bianchi, Luca Cantarini, Francesco Ciccia, Lorenzo Dagna, Marcello Govoni, Carlomaurizio Montecucco, Roberta Priori, Angelo Ravelli, Paolo Sfriso and Luigi Sinigaglia

Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients

To describe successful therapeutic strategies in statin-induced anti-HMGCR myopathy.

Authors: Alain Meyer, Yves Troyanov, Julie Drouin, Geneviève Oligny-Longpré, Océane Landon-Cardinal, Sabrina Hoa, Baptiste Hervier, Josiane Bourré-Tessier, Anne-Marie Mansour, Sara Hussein, Vincent Morin, Eric Rich, Jean-Richard Goulet, Sandra Chartrand, Marie Hudson, Jessica Nehme…

Barriers to treatment optimization and achievement of patients’ goals: perspectives from people living with rheumatoid arthritis enrolled in the ArthritisPower registry

Few studies have investigated patients’ own treatment goals in rheumatoid arthritis (RA). The objective of this real-world, cross-sectional study of US patients with RA was to identify factors that patients be...

Authors: Kelly Gavigan, W. Benjamin Nowell, Mylene S. Serna, Jeffrey L. Stark, Mohamed Yassine and Jeffrey R. Curtis

Psychometric validation of the Hand Disability in Systemic Sclerosis-Digital Ulcers (HDISS-DU®) patient-reported outcome instrument

We aimed to develop a patient-reported outcome measure, in accordance with the US Food and Drug Administration guidance, to capture the impact of systemic sclerosis-related digital ulcers (SSc-DUs) on hand fun...

Authors: Luc Mouthon, Serge Poiraudeau, Margaret Vernon, Kelly Papadakis, Loïc Perchenet and Dinesh Khanna

Association of circulating microRNAs with prevalent and incident knee osteoarthritis in women: the OFELY study

In the context of the scarcity of biomarkers for knee osteoarthritis (OA), we examined the associations of prevalent and incident OA with the expression levels of serum miRNAs in subjects with and without OA.

Authors: Jean-Charles Rousseau, Marjorie Millet, Martine Croset, Elisabeth Sornay-Rendu, Olivier Borel and Roland Chapurlat

The importance of ultrasound in identifying and differentiating patients with early inflammatory arthritis: a narrative review

Early differentiation between different types of inflammatory arthritis and subsequent initiation of modern treatments can improve patient outcomes by reducing disease activity and preventing joint damage. Rou...

Authors: Gurjit S. Kaeley, Catherine Bakewell and Atul Deodhar

Rule-based and machine learning algorithms identify patients with systemic sclerosis accurately in the electronic health record

Systemic sclerosis (SSc) is a rare disease with studies limited by small sample sizes. Electronic health records (EHRs) represent a powerful tool to study patients with rare diseases such as SSc, but validated...

Authors: Lia Jamian, Lee Wheless, Leslie J. Crofford and April Barnado

Significant association between clinical characteristics and changes in peripheral immuno-phenotype in large vessel vasculitis

Large vessel vasculitis (LVV) is a type of vasculitis characterized by granulomatous inflammation of medium- and large-sized arteries. Clinical assessment of acute phase reactants has been conventionally used ...

Authors: Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto, Noriyasu Seki, Hideto Tsujimoto, Kenji Chiba and Tsutomu Takeuchi

Unique primed status of microglia under the systemic autoimmune condition of lupus-prone mice

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of various autoantibodies. This disease causes disabling neuropsychiatric symptoms even in the absence of apparent in...

Authors: Atsushi Nomura, Daisuke Noto, Goh Murayama, Asako Chiba and Sachiko Miyake

Predicting gastrointestinal and renal involvement in adult IgA vasculitis

Immunoglobulin A vasculitis (IgAV) is still poorly defined in the adult population. We aimed to determine the predictors of gastrointestinal (GI) or renal involvement in adult IgAV.

Authors: Alojzija Hočevar, Matija Tomšič, Vesna Jurčić, Katja Perdan Pirkmajer and Žiga Rotar

High risk of gastrointestinal hemorrhage in patients with systemic sclerosis

Systemic sclerosis (SSc), a life-threatening autoimmune disease characterized by vasculopathy. Numerous SSc patients demonstrate gastrointestinal (GI) involvement but the delicate GI bleeding risk remains spar...

Authors: Yi-Ting Lin, Yun-Shiuan Chuang, Jiunn-Wei Wang and Ping-Hsun Wu

Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis

Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in the elderly. Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLR...

Authors: Zhuming Chen, Huan Zhong, Jinsong Wei, Sien Lin, Zhixian Zong, Fan Gong, Xinqia Huang, Jinhui Sun, Peng Li, Hao Lin, Bo Wei and Jiaqi Chu

Digital ulcers in systemic sclerosis: their epidemiology, clinical characteristics, and associated clinical and economic burden

To determine the frequency and clinical characteristics of systemic sclerosis-related digital ulcers, and associated direct health care costs, quality of life, and survival.

Authors: Kathleen Morrisroe, Wendy Stevens, Joanne Sahhar, Gene-Siew Ngian, Nava Ferdowsi, Catherine L. Hill, Janet Roddy, Jennifer Walker, Susanna Proudman and Mandana Nikpour

Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis

Although disease in a majority of rheumatoid arthritis (RA) patients is often initially limited to one or a few joints, currently approved medications including anti-tumor necrosis factor-α antibody (α-TNF) ar...

Authors: Kiyomitsu Katsumata, Jun Ishihara, Kazuto Fukunaga, Ako Ishihara, Eiji Yuba, Erica Budina and Jeffrey A. Hubbell

Enhanced angiogenic function in response to fibroblasts from psoriatic arthritis synovium compared to rheumatoid arthritis

Angiogenesis is an early event in the pathogenesis of both psoriatic arthritis (PsA) and rheumatoid arthritis (RA); however, there are striking differences in blood vessel morphology and activation between the...

Authors: S. Fromm, C. C. Cunningham, M. R. Dunne, D. J. Veale, U. Fearon and S. M. Wade

Native myeloperoxidase is required to make the experimental vasculitis model

Authors: Mayu Nonokawa, Ku Suzuki, Hideyuki Hayashi, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Satoshi Tanaka, Utano Tomaru and Akihiro Ishizu

High-throughput sequencing of CD4⁺ T cell repertoire reveals disease-specific signatures in IgG4-related disease

CD4⁺ T cells play critical roles in the pathogenesis of IgG4-related disease (IgG4-RD). The aim of this study was to investigate the TCR repertoire of peripheral blood CD4⁺ T cells in IgG4-RD.

Authors: Liwen Wang, Panpan Zhang, Jieqiong Li, Hui Lu, Linyi Peng, Jing Ling, Xuan Zhang, Xiaofeng Zeng, Yan Zhao and Wen Zhang

Integrated systems analysis of salivary gland transcriptomics reveals key molecular networks in Sjögren’s syndrome

Treatment of patients with Sjögren’s syndrome (SjS) is a clinical challenge with high unmet needs. Gene expression profiling and integrative network-based approaches to complex disease can offer an insight on ...

Authors: Hong Ki Min, Su-Jin Moon, Kyung-Su Park and Ki-Jo Kim

The immune system in sporadic inclusion body myositis patients is not compromised by blood-flow restricted exercise training

Sporadic inclusion body myositis (sIBM) is clinically characterised by progressive proximal and distal muscle weakness and impaired physical function while skeletal muscle tissue displays abnormal cellular inf...

Authors: Kasper Yde Jensen, Mikkel Jacobsen, Henrik Daa Schrøder, Per Aagaard, Jakob Lindberg Nielsen, Anders Nørkær Jørgensen, Eleanor Boyle, Rune Dueholm Bech, Sofie Rosmark, Louise Pyndt Diederichsen and Ulrik Frandsen

Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice

To examine the ability of takinib, a selective transforming growth factor beta-activated kinase 1 (TAK1) inhibitor, to reduce the severity of murine type II collagen-induced arthritis (CIA), and to affect func...

Authors: Scott A. Scarneo, Liesl S. Eibschutz, Phillip J. Bendele, Kelly W. Yang, Juliane Totzke, Philip Hughes, David A. Fox and Timothy A. J. Haystead

Prevalence and incidence of non-gout crystal arthropathy in southern Sweden

To estimate the prevalence and incidence of non-gout crystal arthropathy in relation to socioeconomic factors in southern Sweden.

Authors: Mohaned Hameed, Aleksandra Turkiewicz, Martin Englund, Lennart Jacobsson and Meliha C. Kapetanovic

DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models

Systemic sclerosis is a multisystem inflammatory and vascular lesion leading to extensive tissue fibrosis. A reversible S-adenosyl-l-homocysteine hydrolase (SAHH) inhibitor, DZ2002, modulates the pathologic pr...

Authors: Zongwang Zhang, Yanwei Wu, Bing Wu, Qing Qi, Heng Li, Huimin Lu, Chen Fan, Chunlan Feng, Jianping Zuo, Lili Niu and Wei Tang

The burden of metabolic syndrome on osteoarthritic joints

The prevalence of osteoarthritis (OA) increases with obesity, with up to two thirds of the elderly obese population affected by OA of the knee. The metabolic syndrome (MetS), frequently associated with central...

Authors: Bruce M. Dickson, Anke J. Roelofs, Justin J. Rochford, Heather M. Wilson and Cosimo De Bari

Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis

Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well ...

Authors: Mikael Brink, Anders Lundquist, Andrey Alexeyenko, Kristina Lejon and Solbritt Rantapää-Dahlqvist