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  1. Content type: Research article

    Spondyloarthritis (SpA) has a significant impact on patients’ quality of life due to functional impairments. Generic health instruments like the EuroQoL 5-dimension (EQ-5D) is important for the cost-utility an...

    Authors: Helen Hoi Lun Tsang, Jason Pui Yin Cheung, Carlos King Ho Wong, Prudence Wing Hang Cheung, Chak Sing Lau and Ho Yin Chung

    Citation: Arthritis Research & Therapy 2019 21:41

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  2. Content type: Research article

    Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE) and is characterized by glomerulosclerosis, interstitial fibrosis, and tubular atrophy, along with...

    Authors: Shijun He, Xing Liu, Zemin Lin, Yuting Liu, Lei Gu, Hu Zhou, Wei Tang and Jianping Zuo

    Citation: Arthritis Research & Therapy 2019 21:40

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  3. Content type: Research article

    Autophagy has emerged as a key mechanism in the survival and function of T and B lymphocytes, and its activation was involved in apoptosis resistance in rheumatoid arthritis (RA). To investigate whether the re...

    Authors: M. Vomero, V. Manganelli, C. Barbati, T. Colasanti, A. Capozzi, A. Finucci, F. R. Spinelli, F. Ceccarelli, C. Perricone, S. Truglia, S. Morrone, R. Maggio, R. Misasi, M. Bombardieri, M. Di Franco, F. Conti…

    Citation: Arthritis Research & Therapy 2019 21:39

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  4. Content type: Research article

    Ixekizumab improves signs/symptoms of psoriatic arthritis (PsA). We present an integrated analysis of baseline disease burden and post-baseline outcomes in ixekizumab-treated patients with enthesitis or dactyl...

    Authors: Dafna D. Gladman, Ana-Maria Orbai, Uta Klitz, James Cheng-Chung Wei, Gaia Gallo, Julie Birt, Suchitrita Rathmann, David Shrom and Helena Marzo-Ortega

    Citation: Arthritis Research & Therapy 2019 21:38

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  5. Content type: Editorial

    While many of intricacies of the mammalian circadian rhythm remain unknown, the role that this physiological clock plays in our everyday lives and within the global ecosystem is clearly evident. However, only ...

    Authors: Roman J. Krawetz

    Citation: Arthritis Research & Therapy 2019 21:37

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    The Research article to this article has been published in Arthritis Research & Therapy 2019 21:5

  6. Content type: Research article

    A consensus on digital ulcer (DU) definition in systemic sclerosis (SSc) has been recently reached (Suliman et al., J Scleroderma Relat Disord 2:115-20, 2017), while for their evaluation, classification and ca...

    Authors: J. Blagojevic, S. Bellando-Randone, G. Abignano, J. Avouac, L. Cometi, L. Czirják, C. P. Denton, O. Distler, M. Frerix, S. Guiducci, D. Huscher, V. K. Jaeger, V. Lóránd, B. Maurer, S. Nihtyanova, G. Riemekasten…

    Citation: Arthritis Research & Therapy 2019 21:35

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  7. Content type: Research article

    Endothelial activation and damage is commonly observed in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and is related to development of atherosclerosis and cardiovascular dise...

    Authors: Laura Atehortúa, Mauricio Rojas, Gloria Vásquez, Carlos H. Muñoz-Vahos, Adriana Vanegas-García, Rafael Andrés Posada-Duque and Diana Castaño

    Citation: Arthritis Research & Therapy 2019 21:34

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  8. Content type: Research article

    Individuals with rheumatoid arthritis (RA) are at risk of developing cardiovascular disease (CVD), but patient perceptions of CVD are not routinely assessed. We performed a systematic literature review to eval...

    Authors: Olivia R. Ghosh-Swaby and Bindee Kuriya

    Citation: Arthritis Research & Therapy 2019 21:33

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  9. Content type: Protocol

    Spondyloarthritis comprises a group of inflammatory diseases, characterised by inflammation within axial joints and/or peripheral arthritis, enthesitis and dactylitis. An increasing number of biologic treatmen...

    Authors: Ernest Choy, Xenofon Baraliakos, Frank Behrens, Salvatore D’Angelo, Kurt de Vlam, Bruce W. Kirkham, Mikkel Østergaard, Georg A. Schett, Michael Rissler, Kamel Chaouche-Teyara and Chiara Perella

    Citation: Arthritis Research & Therapy 2019 21:32

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  10. Content type: Research article

    Childhood Takayasu’s arteritis (c-TA) is scarcely reported but is characterized by devastating morbidity and mortality. This study aims to investigate the clinical course of c-TA and prognostic factors associa...

    Authors: Luyun Fan, Huimin Zhang, Jun Cai, Lirui Yang, Bin Liu, Dongmei Wei, Jiachen Yu, Jiali Fan, Lei Song, Wenjun Ma, Xianliang Zhou, Haiying Wu and Ying Lou

    Citation: Arthritis Research & Therapy 2019 21:31

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    The Correction to this article has been published in Arthritis Research & Therapy 2019 21:55

  11. Content type: Research article

    The effectiveness of autologous haematopoietic stem cell transplantation (auto-HSCT) in treating severe systemic sclerosis (SSc) is established; however, the necessity of purified CD34+ cell grafts and the app...

    Authors: Masahiro Ayano, Hiroshi Tsukamoto, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Toshihiro Miyamoto, Takahiko Horiuchi, Hiroaki Niiro, Koji Nagafuji, Mine Harada and Koichi Akashi

    Citation: Arthritis Research & Therapy 2019 21:30

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  12. Content type: Research article

    Cytosolic phospholipase A2 group IVA (cPLA2α)-deficient mice are resistant to collagen-induced arthritis, suggesting that cPLA2α is an important therapeutic target. Here, the anti-inflammatory effects of the A...

    Authors: A. J. Feuerherm, E. A. Dennis and B. Johansen

    Citation: Arthritis Research & Therapy 2019 21:29

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  13. Content type: Research article

    Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies like rheumatoid factor (RF), anti-cyclic citrullinated peptide-2 (anti-CCP2), and anti-carbamylated protein (anti-CarP) antibodies. ...

    Authors: Emma C. de Moel, Veerle F. A. M. Derksen, Leendert A. Trouw, Holger Bang, Gerard Collée, Leroy R. Lard, Sofia Ramiro, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes and Diane van der Woude

    Citation: Arthritis Research & Therapy 2019 21:28

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  14. Content type: Research article

    A high prevalence of periodontitis has been reported in rheumatoid arthritis (RA) patients, although the strength of this association, its temporal link and the possible relationship between the severity of pe...

    Authors: Beatriz Rodríguez-Lozano, Jerián González-Febles, Jorge Luis Garnier-Rodríguez, Shashi Dadlani, Sagrario Bustabad-Reyes, Mariano Sanz, Fernando Sánchez-Alonso, Carlos Sánchez-Piedra, Enrique González-Dávila and Federico Díaz-González

    Citation: Arthritis Research & Therapy 2019 21:27

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  15. Content type: Research article

    Chronic, low-grade inflammation of the synovium (synovitis) is a hallmark of osteoarthritis (OA), thus understanding of OA immunobiology, mediated by immune effectors, is of importance. Specifically, monocytes...

    Authors: Alejandro Gómez-Aristizábal, Rajiv Gandhi, Nizar N. Mahomed, K. Wayne Marshall and Sowmya Viswanathan

    Citation: Arthritis Research & Therapy 2019 21:26

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  16. Content type: Research article

    In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (H...

    Authors: Kim Wervers, Jolanda J. Luime, Ilja Tchetverikov, Andreas H. Gerards, Marc R. Kok, Cathelijne W. Y. Appels, Wiebo L. van der Graaff, Johannes H. L. M. van Groenendael, Lindy-Anne Korswagen, Josien J. Veris-van Dieren, Johanna M. W. Hazes and Marijn Vis

    Citation: Arthritis Research & Therapy 2019 21:25

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  17. Content type: Research article

    To assess the value of contrast-enhanced ultrasonography (CEUS) for monitoring disease activity of Takayasu arteritis (TA).

    Authors: Ling-Ying Ma, Chao-Lun Li, Li-Li Ma, Xiao-Meng Cui, Xiao-Min Dai, Ying Sun, Hui-Yong Chen, Bei-Jian Huang and Lin-Di Jiang

    Citation: Arthritis Research & Therapy 2019 21:24

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  18. Content type: Research article

    This study aimed to assess the minimal clinically important differences (MCIDs) for the modified Rodnan skin score (mRSS) using combined data from the Scleroderma Lung Studies (I and II).

    Authors: Dinesh Khanna, Philip J. Clements, Elizabeth R. Volkmann, Holly Wilhalme, Chi-hong Tseng, Daniel E. Furst, Michael D. Roth, Oliver Distler and Donald P. Tashkin

    Citation: Arthritis Research & Therapy 2019 21:23

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  19. Content type: Research article

    To investigate the association between 12 single nucleotide polymorphisms (SNPs) located on ERAP1 and IL23R with the presence of inflammation on the sacroiliac joint (SIJ) or spinal magnetic resonance imagery (MR...

    Authors: Adeline Ruyssen-Witrand, Cécile Luxembourger, Alain Cantagrel, Delphine Nigon, Pascal Claudepierre, Yannick Degboe and Arnaud Constantin

    Citation: Arthritis Research & Therapy 2019 21:22

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  20. Content type: Research article

    The aim of the study was to evaluate a simplified version of the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) for five joints of the hand (RAMRIS-5) in patients with early rheumatoid arthriti...

    Authors: Miriam Frenken, Christoph Schleich, Ralph Brinks, Daniel Benjamin Abrar, Christine Goertz, Matthias Schneider, Benedikt Ostendorf and Philipp Sewerin

    Citation: Arthritis Research & Therapy 2019 21:21

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  21. Content type: Correction

    Following publication of the original article [1], the authors reported an error in the affiliation of Ari Polachek.

    Authors: Ari Polachek, Richard Cook, Vinod Chandran, Dafna D. Gladman and Lihi Eder

    Citation: Arthritis Research & Therapy 2019 21:20

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    The original article was published in Arthritis Research & Therapy 2017 19:189

  22. Content type: Research article

    The aim of this study was to investigate whether vitamin D plays a protective role in podocyte injury induced by autoantibodies purified from the serum of patients with lupus nephritis (LN) via reducing aberra...

    Authors: Qi Yu, Yingjin Qiao, Dongwei Liu, Fengxun Liu, Congcong Gao, Jiayu Duan, Lulu Liang, Xueqi Di, Yi Yuan, Yukui Gao, Siwan Cui, Yilu Qin, Tianfang Li, Zhaohui Zheng and Zhangsuo Liu

    Citation: Arthritis Research & Therapy 2019 21:19

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  23. Content type: Research article

    Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-...

    Authors: Sabine Trellu, Alice Courties, Stéphane Jaisson, Laëtitia Gorisse, Philippe Gillery, Saadia Kerdine-Römer, Carlos Vaamonde-Garcia, Xavier Houard, François-Paul Ekhirch, Alain Sautet, Bertrand Friguet, Claire Jacques, Francis Berenbaum and Jérémie Sellam

    Citation: Arthritis Research & Therapy 2019 21:18

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  24. Content type: Research article

    Obesity is over-represented in patients with psoriatic arthritis (PsA) and associated with higher disease activity, poorer effect of treatment and increased cardiovascular morbidity. Studies on the effects of ...

    Authors: Eva Klingberg, Annelie Bilberg, Sofia Björkman, Martin Hedberg, Lennart Jacobsson, Helena Forsblad-d’Elia, Hans Carlsten, Björn Eliasson and Ingrid Larsson

    Citation: Arthritis Research & Therapy 2019 21:17

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  25. Content type: Research article

    Development of autoimmune diseases is the result of a complex interplay between hereditary and environmental factors, with multiple genes contributing to the pathogenesis in human disease and in experimental m...

    Authors: Samra Sardar, Alish Kerr, Daniëlle Vaartjes, Emilie Riis Moltved, Edita Karosiene, Ramneek Gupta and Åsa Andersson

    Citation: Arthritis Research & Therapy 2019 21:16

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  26. Content type: Review

    Cardiovascular (CV) disease and osteoporosis (OP) have become increasing challenges in the aging population and even more in patients with inflammatory rheumatic diseases, such as rheumatoid arthritis, spondyl...

    Authors: Zoltán Szekanecz, Hennie G. Raterman, Zsófia Pethő and Willem F. Lems

    Citation: Arthritis Research & Therapy 2019 21:15

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  27. Content type: Research article

    Ultrasonography (US) can directly demonstrate joint inflammation, including grayscale (GS) signs of synovial hypertrophy and power Doppler (PD) techniques to demonstrate increased blood flow and vascularizatio...

    Authors: Yasushi Kondo, Katsuya Suzuki, Yumiko Inoue, Koumei Sakata, Chihiro Takahashi, Masaru Takeshita, Yoshiaki Kassai, Takahiro Miyazaki, Rimpei Morita, Yasuo Niki, Yuko Kaneko, Hidekata Yasuoka, Kunihiro Yamaoka, Akihiko Yoshimura and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2019 21:14

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  28. Content type: Research article

    Sex-specific differences in the effect of genetic variants on serum urate levels have been described. The aim of this study was to systematically examine whether serum urate-associated genetic variants differ ...

    Authors: Ravi K. Narang, Ruth Topless, Murray Cadzow, Greg Gamble, Lisa K. Stamp, Tony R. Merriman and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2019 21:13

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  29. Content type: Research

    The objective was to determine if dose reduction is non-inferior to full-dose TNFi to maintain low disease activity (LDA) in patients already in remission with TNFi, in axial spondyloarthritis.

    Authors: Jordi Gratacós, Caridad Pontes, Xavier Juanola, Jesús Sanz, Ferran Torres, Cristina Avendaño, Antoni Vallano, Gonzalo Calvo, Eugenio de Miguel and Raimon Sanmartí

    Citation: Arthritis Research & Therapy 2019 21:11

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  30. Content type: Research article

    Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is an innate-immune receptor found in blood. Its presence reflects innate immune cell activation. We sought to investigate plasma sTREM-1 leve...

    Authors: Yonatan Edel, Vitaly Kliminski, Elisheva Pokroy-Shapira, Shirly Oren, Ariela Dortort Lazar, Yael Pri-Paz Basson, Mohammad Egbaria and Yair Molad

    Citation: Arthritis Research & Therapy 2019 21:10

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  31. Content type: Research article

    Adult-onset Still’s disease (AOSD) is a systemic inflammatory disease characterized by neutrophilia and NLRP3 inflammasome and macrophage activation. We investigated the role of neutrophil extracellular traps ...

    Authors: Qiongyi Hu, Hui Shi, Ting Zeng, Honglei Liu, Yutong Su, Xiaobing Cheng, Junna Ye, Yufeng Yin, Mengru Liu, Hui Zheng, Xinyao Wu, Huihui Chi, Zhuochao Zhou, Jinchao Jia, Yue Sun, Jialin Teng…

    Citation: Arthritis Research & Therapy 2019 21:9

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  32. Content type: Research article

    In gout, long-term urate-lowering therapy (ULT) promotes dissolution of tissue urate crystal deposits. However, no studies using combined xanthine oxidase inhibition and uricosuric ULT have focused on clinical...

    Authors: Nicola Dalbeth, Graeme Jones, Robert Terkeltaub, Dinesh Khanna, Maple Fung, Scott Baumgartner and Fernando Perez-Ruiz

    Citation: Arthritis Research & Therapy 2019 21:8

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  33. Content type: Research article

    A randomized controlled trial (RCT) was performed to confirm preliminary uncontrolled data indicating that regional adipose tissue (AT) grafting (G) is effective in inducing ischemic digital ulcer (IDU) healin...

    Authors: Nicoletta Del Papa, Gabriele Di Luca, Romina Andracco, Eleonora Zaccara, Wanda Maglione, Francesca Pignataro, Antonina Minniti and Claudio Vitali

    Citation: Arthritis Research & Therapy 2019 21:7

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  34. Content type: Research article

    Fibroblast-like synoviocytes (FLS) and CCR7 effector memory T (TEM) cells are two of the major cell types implicated in the progression of rheumatoid arthritis (RA). In particular, FLS become highly invasive, wh...

    Authors: Mark R. Tanner, Michael W. Pennington, Satendra S. Chauhan, Teresina Laragione, Pércio S. Gulko and Christine Beeton

    Citation: Arthritis Research & Therapy 2019 21:6

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  35. Content type: Research article

    The circadian clock plays a crucial role in regulating physiology and is important for maintaining immune homeostasis and responses to inflammatory stimuli. Inflammatory arthritis often shows diurnal variation...

    Authors: Laura E. Hand, Suzanna H. Dickson, Anthony J. Freemont, David W. Ray and Julie E. Gibbs

    Citation: Arthritis Research & Therapy 2019 21:5

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    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:37

  36. Content type: Research

    We aimed to evaluate the prevalence of hip and knee osteoarthritis (HOA and KOA) according to American College of Rheumatology (ACR) criteria among participants with suspected early symptomatic osteoarthritis ...

    Authors: Jurgen Damen, Rogier M. van Rijn, Pieter J. Emans, Willem K. H. A. Hilberdink, Janet Wesseling, Edwin H. G. Oei and Sita M. A. Bierma-Zeinstra

    Citation: Arthritis Research & Therapy 2019 21:4

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  37. Content type: Research article

    Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise bacterial metabolites presented by MHC class I-related protein 1 (MR1). Bacterial dysbiosis has been implicated in auto-inflam...

    Authors: Hester Koppejan, Diahann T. S. L. Jansen, Marjolijn Hameetman, Ranjeny Thomas, Rene E. M. Toes and Floris A. van Gaalen

    Citation: Arthritis Research & Therapy 2019 21:3

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  38. Content type: Research article

    Infliximab, an anti-tumor necrosis factor-alpha antibody, has been reported to have excellent efficacy for refractory uveoretinitis in Behçet’s disease (RUBD), and was approved for this indication in Japan. Ho...

    Authors: Shigeaki Ohno, Itsuro Umebayashi, Miyuki Matsukawa, Takashi Goto and Toshiro Yano

    Citation: Arthritis Research & Therapy 2019 21:2

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  39. Content type: Correction

    Following publication of the original article [1], the authors reported an error in Figs. 2C and 5C.

    Authors: Daniel J. Leong, Marwa Choudhury, Regina Hanstein, David M. Hirsh, Sun Jin Kim, Robert J. Majeska, Mitchell B. Schaffler, John A. Hardin, David C. Spray, Mary B. Goldring, Neil J. Cobelli and Hui B. Sun

    Citation: Arthritis Research & Therapy 2019 21:1

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    The original article was published in Arthritis Research & Therapy 2014 16:508

  40. Content type: Research article

    Pegloticase is a recombinant mammalian uricase conjugated to polyethylene glycol approved in the United States for treatment of chronic refractory gout. It can profoundly decrease serum urate to < 1 mg/dl. In ...

    Authors: Brian F. Mandell, Anthony E. Yeo and Peter E. Lipsky

    Citation: Arthritis Research & Therapy 2018 20:286

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  41. Content type: Research article

    The availability of methotrexate and the introduction of multiple biological agents have revolutionized the treatment of juvenile idiopathic arthritis (JIA). Several international and national drug registries ...

    Authors: Joost Swart, Gabriella Giancane, Gerd Horneff, Bo Magnusson, Michael Hofer, Еkaterina Alexeeva, Violeta Panaviene, Brigitte Bader-Meunier, Jordi Anton, Susan Nielsen, Fabrizio De Benedetti, Sylvia Kamphuis, Valda Staņēviča, Maria Tracahana, Laura Marinela Ailioaie, Elena Tsitsami…

    Citation: Arthritis Research & Therapy 2018 20:285

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  42. Content type: Research

    Ankylosing spondylitis (AS) begins early in life and often leads to reduced physical function, but less is known about the impacts it has on health-related quality of life (HRQoL). The aims of this study were ...

    Authors: Lucy Law, Jeanette Beckman Rehnman, Anna Deminger, Eva Klingberg, Lennart T. H. Jacobsson and Helena Forsblad-d’Elia

    Citation: Arthritis Research & Therapy 2018 20:284

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  43. Content type: Research article

    Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise trai...

    Authors: Brian J. Andonian, David B. Bartlett, Janet L. Huebner, Leslie Willis, Andrew Hoselton, Virginia B. Kraus, William E. Kraus and Kim M. Huffman

    Citation: Arthritis Research & Therapy 2018 20:283

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  44. Content type: Correction

    Following publication of the original article [1], the authors reported an error in the spelling of the ninth author’s name.

    Authors: Aurélie Najm, Benoît Le Goff, Carl Orr, Rogier Thurlings, Juan D. Cañete, Frances Humby, Stefano Alivernini, Antonio Manzo, Søren Andreas Just, Vasco C. Romão, Veit Krenn, Ulf Müller-Ladner, Olga Addimanda, Sander W. Tas, Maria Stoenoiu, Laurent Meric de Bellefon…

    Citation: Arthritis Research & Therapy 2018 20:282

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    The original article was published in Arthritis Research & Therapy 2018 20:265

  45. Content type: Research article

    To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis (SSc).

    Authors: Alfredo Guillén-Del-Castillo, Carmen Pilar Simeón-Aznar, Eduardo L. Callejas-Moraga, Carles Tolosa-Vilella, Serafín Alonso-Vila, Vicente Fonollosa-Pla and Albert Selva-O’Callaghan

    Citation: Arthritis Research & Therapy 2018 20:281

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  46. Content type: Research article

    The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort.

    Authors: Javier Narváez, Helena Borrell, Fernando Sánchez-Alonso, Iñigo Rúa-Figueroa, Francisco Javier López-Longo, María Galindo-Izquierdo, Jaime Calvo-Alén, Antonio Fernández-Nebro, Alejandro Olivé, José Luis Andreu, Víctor Martínez-Taboada, Joan Miquel Nolla and José María Pego-Reigosa

    Citation: Arthritis Research & Therapy 2018 20:280

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  47. Content type: Research article

    The value of joint ultrasonography (US) in the prediction of clinical arthritis in individuals at risk of developing rheumatoid arthritis (RA) is still a point of debate, due to varying scanning protocols and ...

    Authors: Marian H. van Beers-Tas, Annelies B. Blanken, Mark M. J. Nielen, Franktien Turkstra, Conny J. van der Laken, Marlies Meursinge Reynders and Dirkjan van Schaardenburg

    Citation: Arthritis Research & Therapy 2018 20:279

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  48. Content type: Research article

    CD4+ T cells are of great importance in the pathogenesis of systemic lupus erythematosus (SLE), as an imbalance between CD4+ regulatory T cells (Tregs) and CD4+ responder T cells (Tresps) causes flares of active ...

    Authors: Matthias Schaier, Claudius Gottschalk, Lorenz Uhlmann, Claudius Speer, Florian Kälble, Volker Eckstein, Carsten Müller-Tidow, Stefan Meuer, Karsten Mahnke, Hanns-Martin Lorenz, Martin Zeier and Andrea Steinborn

    Citation: Arthritis Research & Therapy 2018 20:278

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