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  1. N6-methyladenosine (m6A) methylation modification is involved in the regulation of various biological processes, including inflammation, antitumor, and antiviral immunity. However, the role of m6A modification...

    Authors: Yurong Huang, Qiuyun Xue, Jun Chang, Yuting Wang, Chenglong Cheng, Suowen Xu, Xiao Wang and Chenggui Miao
    Citation: Arthritis Research & Therapy 2023 25:189
    Content type: Review Published on:

  2. To examine and quantify liver and kidney lesions and their response to anti-tumor necrosis factor (TNF) therapy in a TNF-Tg mouse model of rheumatoid arthritis (RA).

    Authors: Xuefei Li, Yi Wang, Ziqiang Chen, Ming Ruan, Can Yang, Maolin Zhou, Ning Li, Lianping Xing, Hao Xu, Ling Yang, Qi Shi, Yongjun Wang, Jinman Chen and Qianqian Liang
    Citation: Arthritis Research & Therapy 2023 25:188
    Content type: Research Published on:

  4. Rheumatoid arthritis (RA) has a variable impact on different synovial joints, with inflammation being more commonly observed in some joints than others. Emerging evidence suggests that the anatomical variation...

    Authors: Adrian Ciurea, Oliver Distler, Kenneth Kwok, Hyejin Jo, Lisy Wang, Tim Killeen, Caroline Ospelt and Mojca Frank Bertoncelj
    Citation: Arthritis Research & Therapy 2023 25:185
    Content type: Research Published on:

  5. Studies evaluating the association of knee and hip osteoarthritis (OA) with falls and fractures have inconsistent findings. We aimed to investigate associations of symptomatic and radiographic knee and hip OA ...

    Authors: Youyou Zhang, Xiaoxi Li, Yining Wang, Liru Ge, Faming Pan, Tania Winzenberg and Guoqi Cai
    Citation: Arthritis Research & Therapy 2023 25:184
    Content type: Research Published on:

  6. To compare a treat-to-target (T2T) approach and routine care (RC) in adults with active to severely active rheumatoid arthritis (RA) initiating subcutaneous abatacept.

    Authors: Louis Bessette, Boulos Haraoui, Emmanouil Rampakakis, Joanna Dembowy, Marc-Olivier Trépanier and Janet Pope
    Citation: Arthritis Research & Therapy 2023 25:183
    Content type: Research Published on:

  7. Physical function is an important determinant of health-related quality of life in radiographic axial spondyloarthritis patients (r-axSpA). To improve the basis of effective healthcare efforts, we aimed to inv...

    Authors: Magnus Hallström, Eva Klingberg, Anna Deminger, Jeannette Beckman Rehnman, Mats Geijer and Helena Forsblad-d’Elia
    Citation: Arthritis Research & Therapy 2023 25:182
    Content type: Research Published on:

  8. This work aims to develop a deep learning model, assessing atlantoaxial subluxation (AAS) in rheumatoid arthritis (RA), which can often be ambiguous in clinical practice.

    Authors: Yasutaka Okita, Toru Hirano, Bowen Wang, Yuta Nakashima, Saki Minoda, Hajime Nagahara and Atsushi Kumanogoh
    Citation: Arthritis Research & Therapy 2023 25:181
    Content type: Research article Published on:

  9. Dimerization of the myeloid differentiation primary response 88 protein (MyD88) plays a pivotal role in the exacerbated response to innate immunity-dependent signaling in rheumatoid arthritis (RA). ST2825 is a...

    Authors: Sergio Ramirez-Perez, Rushi Vekariya, Surabhi Gautam, Itzel Viridiana Reyes-Perez, Hicham Drissi and Pallavi Bhattaram
    Citation: Arthritis Research & Therapy 2023 25:180
    Content type: Research Published on:

  10. Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, and environm...

    Authors: Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhongyue Liu, Xiaolei Ren and Zhihong Li
    Citation: Arthritis Research & Therapy 2023 25:179
    Content type: Research Published on:

  11. This study aimed to investigate the long-term effect of vitamin D supplementation compared to placebo over 5 years in participants with knee osteoarthritis (OA). We also aimed to describe the effect of maintai...

    Authors: Zhiqiang Wang, Zhaohua Zhu, Feng Pan, Shuang Zheng, Venkat Parameswaran, Leigh Blizzard, Changhai Ding and Benny Antony
    Citation: Arthritis Research & Therapy 2023 25:178
    Content type: Research Published on:

  12. Juvenile idiopathic arthritis (JIA) treatment is aimed at inducing remission to prevent joint destruction and disability. However, it is unclear what is the long-term impact on health-related outcomes of the t...

    Authors: Filipa Oliveira Ramos, Ana Maria Rodrigues, Ana Teresa Melo, Francisca Aguiar, Luísa Brites, Soraia Azevedo, Ana Catarina Duarte, José António Melo Gomes, Carolina Furtado, Ana Filipa Mourão, Graça Sequeira, Inês Cunha, Ricardo Figueira, Maria José Santos and João Eurico Fonseca
    Citation: Arthritis Research & Therapy 2023 25:177
    Content type: Research Published on:

  13. Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual inhibition of these pathways by phytobiologi...

    Authors: Shanzay Ahmed, Christopher B. Mahony, Alyssa Torres, Jessica Murillo-Saich, Samuel Kemble, Martha Cedeno, Peter John, Attya Bhatti, Adam P. Croft and Monica Guma
    Citation: Arthritis Research & Therapy 2023 25:176
    Content type: Research Published on:

  14. Pulmonary arterial hypertension (PAH) is a rare complication of primary Sjögren’s syndrome (pSS). Several genes have proven to be associated with pSS and PAH. However, there is no study specifically addressing...

    Authors: Mucong Li, Yue Shi, Jiuliang Zhao, Qian Wang, Mengtao Li and Xiuli Zhao
    Citation: Arthritis Research & Therapy 2023 25:175
    Content type: Research Published on:

  15. While the availability of biological or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) has improved outcomes for rheumatoid arthritis (RA) patients, there remains a subset of individual...

    Authors: Ju-Yang Jung, Eunyoung Lee, Ji-Won Kim, Chang-Hee Suh, Kichul Shin, Jinhyun Kim and Hyoun-Ah Kim
    Citation: Arthritis Research & Therapy 2023 25:174
    Content type: Research Published on:

  16. Osteoarthritis (OA) is driven by low-grade inflammation, and controlling local inflammation may offer symptomatic relief. Here, we developed an indoleamine 2,3-dioxygenase and galectin-3 fusion protein (IDO-Ga...

    Authors: Brittany D. Partain, Evelyn Bracho-Sanchez, Shaheen A. Farhadi, Elena G. Yarmola, Benjamin G. Keselowsky, Gregory A. Hudalla and Kyle D. Allen
    Citation: Arthritis Research & Therapy 2023 25:173
    Content type: Research Published on:

  17. Upadacitinib, a Janus kinase inhibitor, has demonstrated efficacy and an acceptable safety profile in patients with ankylosing spondylitis (AS) in the phase III SELECT-AXIS programs. We report the 1-year effic...

    Authors: Xenofon Baraliakos, Désirée van der Heijde, Joachim Sieper, Robert D. Inman, Hideto Kameda, Yihan Li, Xianwei Bu, Anna Shmagel, Peter Wung, In-Ho Song and Atul Deodhar
    Citation: Arthritis Research & Therapy 2023 25:172
    Content type: Research Published on:

  18. Several observational studies have explored the associations between Sjögren’s syndrome (SS) and certain cancers. Nevertheless, the causal relationships remain unclear. Mendelian randomization (MR) method was ...

    Authors: Yiwei Jia, Peizhuo Yao, Jia Li, Xinyu Wei, Xuanyu Liu, Huizi Wu, Weiwei Wang, Cong Feng, Chaofan Li, Yu Zhang, Yifan Cai, Shuqun Zhang and Xingcong Ma
    Citation: Arthritis Research & Therapy 2023 25:171
    Content type: Research Published on:

  19. Authors: Georg Schett, Warner Chen, Sheng Gao, Soumya D. Chakravarty, May Shawi, Frederic Lavie, Miriam Zimmermann, Mohamed Sharaf, Laura C. Coates and Stefan Siebert
    Citation: Arthritis Research & Therapy 2023 25:170
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2023 25:150

  20. Nail psoriasis is a common, physiologically, and psychologically disruptive, and yet often under-treated manifestation of psoriasis. The objectives of this analysis were to investigate the trajectory of nail p...

    Authors: William Tillett, Alexander Egeberg, Enikö Sonkoly, Patricia Gorecki, Anna Tjärnlund, Jozefien Buyze, Sven Wegner and Dennis McGonagle
    Citation: Arthritis Research & Therapy 2023 25:169
    Content type: Research Published on:

  21. Osteoarthritis (OA) is a degenerative joint disease associated with aging, which often leads to joint stiffness and disability. Exercise is one of the most important non-pharmacological treatments and is presc...

    Authors: Kosuke Norimatsu, Kazuki Nakanishi, Toshiro Ijuin, Shotaro Otsuka, Seiya Takada, Akira Tani, Ryoma Matsuzaki, Teruki Matsuoka and Harutoshi Sakakima
    Citation: Arthritis Research & Therapy 2023 25:168
    Content type: Research Published on:

  22. Uncontrolled T-cell activation plays a key role in systemic sclerosis (SSc). Arsenic trioxide (ATO) has immunological effects and has demonstrated potential in preclinical SSc models. In this study, we assesse...

    Authors: Anne Cauvet, Arthur Decellas, Christophe Guignabert, Dominique Rongvaux-Gaïda, Raphaël Thuillet, Mina Ottaviani, Ly Tu, François Rieger, Jérôme Avouac and Yannick Allanore
    Citation: Arthritis Research & Therapy 2023 25:167
    Content type: Research Published on:

  23. Real-world studies assessing the comparative effectiveness of biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) as first-line targeted therapy are scarce. We analyzed the real-w...

    Authors: Dimitrios A. Pappas, Jacqueline O’Brien, Lin Guo, Ying Shan, Joshua F. Baker, Gregory Kricorian, Scott Stryker and David H. Collier
    Citation: Arthritis Research & Therapy 2023 25:166
    Content type: Research Published on:

  24. Neuropsychiatric systemic lupus erythematosus (NPSLE), with various morbidities and multiple manifestations in the central nervous system, remains a limited standard for diagnosis. Our study was to discover no...

    Authors: Jiali Ni, Chen Chen, Shuangan Wang, Xuan Liu, Liping Tan, Li Lu, Yu Fan, Yayi Hou, Huan Dou and Jun Liang
    Citation: Arthritis Research & Therapy 2023 25:165
    Content type: Research Published on:

  25. Low urine pH, which may be mediated by metabolic syndrome (MetS), is common in gout. Tart cherries are shown to improve MetS symptoms and possess anti-inflammatory properties. However, the efficacy of tart che...

    Authors: Can Wang, Wenyan Sun, Nicola Dalbeth, Zhongjun Wang, Xuefeng Wang, Xiaopeng Ji, Xiaomei Xue, Lin Han, Lingling Cui, Xinde Li, Zhen Liu, Aichang Ji, Yuwei He, Mingshu Sun and Changgui Li
    Citation: Arthritis Research & Therapy 2023 25:164
    Content type: Research Published on:

  26. We investigated sensitivity of the 2020 Revised Comprehensive Diagnostic Criteria (RCD) and the 2019 ACR/EULAR classification criteria across the four identified IgG4-related disease (IgG4-RD) phenotypes: “Pan...

    Authors: Jens Vikse, Øyvind Midtvedt, Bjørg-Tilde Svanes Fevang, Torhild Garen, Øyvind Palm, Marianne Wallenius, Gunnstein Bakland, Katrine Brække Norheim, Øyvind Molberg and Anna-Maria Hoffmann-Vold
    Citation: Arthritis Research & Therapy 2023 25:163
    Content type: Research Published on:

  27. Interstitial lung disease (ILD) is the most common cause of death in patients with systemic sclerosis (SSc). Prognostic biomarkers are needed to identify SSc-ILD patients at risk for progressive pulmonary fibr...

    Authors: Viggo Hamberg, Azita Sohrabian, Elizabeth R. Volkmann, Marie Wildt, Anna Löfdahl, Dirk M. Wuttge, Roger Hesselstrand, Göran Dellgren, Gunilla Westergren-Thorsson, Johan Rönnelid and Kristofer Andréasson
    Citation: Arthritis Research & Therapy 2023 25:162
    Content type: Research Published on:

  28. Curcumin, a component of the South-Asian spice turmeric, elicits anti-inflammatory functions. We have previously demonstrated that a highly bioavailable formulation of cucurmin, Cureit/Acuminâ„¢ (CUR), can suppr...

    Authors: Mahadevappa Hemshekhar, Dylan Lloyd, Hani El-Gabalawy and Neeloffer Mookherjee
    Citation: Arthritis Research & Therapy 2023 25:161
    Content type: Correspondence Published on:

  29. Authors: Mumina Akthar, Nisha Nair, Lucy M. Carter, Edward M. Vital, Emily Sutton, Neil McHugh, Ian N. Bruce and John A. Reynolds
    Citation: Arthritis Research & Therapy 2023 25:160
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2023 25:111

  30. Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease of unknown etiology with erosive, symmetric polyarthritis as the main clinical manifestations. Its basic pathological changes are the format...

    Authors: Yubo Shao, Hong Zhang, Qi Shi, Yongjun Wang and Qianqian Liang
    Citation: Arthritis Research & Therapy 2023 25:159
    Content type: Review Published on:

  31. Rheumatoid arthritis (RA) is one of the most prevalent and debilitating joint diseases worldwide. RA is characterized by synovial inflammation (synovitis), which is linked to the development of joint destructi...

    Authors: Wessel F. Theeuwes, Irene Di Ceglie, Daphne N. Dorst, Arjen B. Blom, Desiree L. Bos, Thomas Vogl, Sander W. Tas, Pilar Jimenez-Royo, Mats Bergstrom, Matthew Cleveland, Peter M. van der Kraan, Peter Laverman, Marije I. Koenders, Peter L. van Lent and Martijn H. J. van den Bosch
    Citation: Arthritis Research & Therapy 2023 25:158
    Content type: Research Published on:

  32. To investigate if extracellular matrix (ECM) blood-based biomarkers reflect the pharmacodynamic effect and response to TNF-α inhibitor therapy (adalimumab, ADA), in patients with axial spondyloarthritis (axSpA).

    Authors: Helena Port, Signe Holm Nielsen, Peder Frederiksen, Sofie Falkenløve Madsen, Anne-Christine Bay-Jensen, Inge Juul Sørensen, Bente Jensen, Anne Gitte Loft, Ole Rintek Madsen, Mikkel Østergaard and Susanne Juhl Pedersen
    Citation: Arthritis Research & Therapy 2023 25:157
    Content type: Research Published on:

  33. Systemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs, such as the lungs. Activated differentiation of progenitor cells, which are mainly res...

    Authors: Hiroshi Kasamatsu, Takenao Chino, Takumi Hasegawa, Natsuko Utsunomiya, Akira Utsunomiya, Masami Yamada, Noritaka Oyama and Minoru Hasegawa
    Citation: Arthritis Research & Therapy 2023 25:156
    Content type: Research Published on:

  34. Pulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE). This study aims to explore the clinical characteristics and prognosis in SLE-PAH based on consensus cluster...

    Authors: Mengmeng Dai, Chunyi Zhang, Chaoying Li, Qianqian Wang, Congcong Gao, Runzhi Yue, Menghui Yao, Zhaohui Su and Zhaohui Zheng
    Citation: Arthritis Research & Therapy 2023 25:155
    Content type: Research Published on:

  35. Osteoarthritis (OA) is increasingly recognised as a whole joint disease, with an important role for synovium. However, the repertoire of immune cells and fibroblasts that constitute OA synovium remains underst...

    Authors: Jolet Y. Mimpen, Robert Hedley, Anna Ridley, Mathew J. Baldwin, Dylan Windell, Ananya Bhalla, Lorenzo Ramos-Mucci, Christopher D. Buckley, Mark C. Coles, Abtin Alvand, Andrew J. Price, Andrew J. Carr, Stephanie G. Dakin and Sarah J. B. Snelling
    Citation: Arthritis Research & Therapy 2023 25:154
    Content type: Research Published on:

  36. Tofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis (PsA). This post hoc analysis assessed tofacitinib efficacy on enthesitis by baseline location and severity, and impact on...

    Authors: Philip J. Mease, Ana-Maria Orbai, Oliver FitzGerald, Mohamed Bedaiwi, Dona L. Fleishaker, Rajiv Mundayat, Pamela Young and Philip S. Helliwell
    Citation: Arthritis Research & Therapy 2023 25:153
    Content type: Research Published on:

  37. Iguratimod (IGU) reduces hypergammaglobulinemia and disease activity in pSS (primary Sjögren’s syndrome) patients. However, the therapeutical mechanism of IGU for pSS remains largely unknown. This study aimed ...

    Authors: Taibiao Lyu, Hui Jiang, Liuting Zeng, Suying Liu, Chengmei He, Chaowen Luo, Lin Qiao, Yan Zhao and Hua Chen
    Citation: Arthritis Research & Therapy 2023 25:152
    Content type: Research Published on:

  38. The early growth response 1 (EGR1) is a central transcription factor involved in systemic sclerosis (SSc) pathogenesis. Iguratimod is a synthesized anti-rheumatic disease-modifying drug, which shows drastic in...

    Authors: Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen and Qingran Yan
    Citation: Arthritis Research & Therapy 2023 25:151
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2024 26:34

  39. Guselkumab is a selective interleukin (IL)-23 inhibitor targeting the IL-23p19 subunit. In the phase 3b COSMOS trial, guselkumab demonstrated efficacy in treating participants with active psoriatic arthritis (...

    Authors: Georg Schett, Warner Chen, Sheng Gao, Soumya D. Chakravarty, May Shawi, Frederic Lavie, Miriam Zimmermann, Mohamed Sharaf, Laura C. Coates and Stefan Siebert
    Citation: Arthritis Research & Therapy 2023 25:150
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:170

  40. While it is known that klotho has negative regulatory effects in a variety of diseases such as metabolic disorders and kidney disease, the specific role of klotho in rheumatoid arthritis (RA) and its effect on...

    Authors: Qin-cheng Che, Qian Jia, Xiao-yu Zhang, Shu-ning Sun, Xiao-jie Zhang and Qiang Shu
    Citation: Arthritis Research & Therapy 2023 25:149
    Content type: Research Published on:

  41. In addition to decreasing the level of cholesterol, proprotein convertase subtilis kexin 9 (PCSK9) inhibitor has pleiotropic effects, including immune regulation. However, the impact of PCSK9 on autoimmune dis...

    Authors: Weijia Xie, Jiaxin Li, Hao Du and Jian Xia
    Citation: Arthritis Research & Therapy 2023 25:148
    Content type: Research Published on:

  42. Assess the efficacy of single and multiple intra-articular injections of autologous adipose-derived stem cells (ASCs) and adipose-derived stromal vascular fraction (ADSVF) for the treatment of knee osteoarthri...

    Authors: Yang Yang, Zhibin Lan, Jiangbo Yan, Zhiqun Tang, Linghui Zhou, Dian Jin and Qunhua Jin
    Citation: Arthritis Research & Therapy 2023 25:147
    Content type: Review Published on:

  43. Tau protein serves a pro-inflammatory function in neuroinflammation. However, the role of tau in other inflammatory disorders such as rheumatoid arthritis (RA) is less explored. This study is to investigate th...

    Authors: Meng Chen, Wenyu Fu, Huiyun Xu and Chuan-ju Liu
    Citation: Arthritis Research & Therapy 2023 25:146
    Content type: Research Published on:

  44. Axial spondyloarthritis (axSpA) is known to be associated with several extra-skeletal manifestations (ESM), including the inflammatory skin disease psoriasis. It is important to recognize and diagnose psoriasi...

    Authors: Angelique Rondags, Laura van Marle, Barbara Horváth, Freke R. Wink, Suzanne Arends and Anneke Spoorenberg
    Citation: Arthritis Research & Therapy 2023 25:145
    Content type: Research Published on:

  45. Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease. Over-activation of fibroblast-like synoviocytes is responsible for the hyperplasia of synovium and destruction of cartilage and bone and ...

    Authors: Xingxing Mao, Weijie Wu, Yunyi Nan, Weiwei Sun and Youhua Wang
    Citation: Arthritis Research & Therapy 2023 25:144
    Content type: Research Published on:

  46. Periodontitis (PD) may affect temporomandibular joint disorders (TMD) and TMD may influence PD in previous observational studies. Nevertheless, these studies were prone to confounders and reverse causation, le...

    Authors: Shaotai Wang, Huan Jiang, Huichuan Qi, Danfeng Luo, Tianyuan Qiu and Min Hu
    Citation: Arthritis Research & Therapy 2023 25:143
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:208

  47. Radiographic axial spondyloarthritis (r-axSpA) is one of the most common chronic inflammatory rheumatic diseases, affecting about 0.2% of the Swedish population. Adequate nutritional intake is essential for ma...

    Authors: Erik Hulander, Tatiana Zverkova Sandström, Jeannette Beckman Rehnman, Lucy Law, Stefan Söderberg and Helena Forsblad-d’Elia
    Citation: Arthritis Research & Therapy 2023 25:142
    Content type: Research Published on:

  48. The HFA-PEFF score has been validated to hold great diagnostic and prognostic utility for heart failure with preserved ejection fraction (HFpEF). Idiopathic inflammatory myopathy (IIM) is recognized as one of ...

    Authors: Yunjing Shi, Hao Zhang, Zeping Qiu, Yanjia Chen, Xiuxiu Su, Huihui Chi, Tienan Feng, Yue Sun, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Qiongyi Hu, Zhuochao Zhou, Jianfen Meng, Jialin Teng…
    Citation: Arthritis Research & Therapy 2023 25:141
    Content type: Research Published on:

  49. Disruption of glucocorticoid (GC) signaling in osteoblasts results in a marked attenuation of acute antibody-induced arthritis. The role of endogenous GCs in chronic inflammatory arthritis is however not fully...

    Authors: Tazio Maleitzke, Edgar Wiebe, Dörte Huscher, Cornelia M. Spies, Jinwen Tu, Timo Gaber, Yu Zheng, Frank Buttgereit, Markus J. Seibel and Hong Zhou
    Citation: Arthritis Research & Therapy 2023 25:140
    Content type: Research Published on:

  50. To investigate the relationship between disease-related parameters and joint space width (JSW) on high-resolution peripheral quantitative computed tomography (HR-pQCT) in psoriatic arthritis (PsA) patients.

    Authors: Yingzhao Jin, Isaac T Cheng, Ho So, Dongze Wu, James F Griffith, Vivian W Hung, Ling Qin, Cheuk-Chun Szeto, Agnes WS Chan and Lai-Shan Tam
    Citation: Arthritis Research & Therapy 2023 25:138
    Content type: Research Published on:
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