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  1. Osteoarthritis (OA) is a common chronic condition but its association with other chronic conditions and mortality is largely unknown. This study aimed to use latent class analysis (LCA) of 30 comorbidities in ...

    Authors: Dawit T. Zemedikun, Helena Lee, Krishnarajah Nirantharakumar, Karim Raza, Joht Singh Chandan, Janet M. Lord and Thomas A. Jackson
    Citation: Arthritis Research & Therapy 2022 24:231
    Content type: Research Published on:

  2. Rheumatoid arthritis (RA) is characterized by the presence of disease-specific autoreactive B cell responses, in particular those generating anti-citrullinated protein antibodies (ACPA). For many years, Epstei...

    Authors: Sanne Kroos, Arieke S. B. Kampstra, René E. M. Toes, Linda M. Slot and Hans U. Scherer
    Citation: Arthritis Research & Therapy 2022 24:230
    Content type: Correspondence Published on:

  3. Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status. We performed a genome-wide association study (GWAS) and polyge...

    Authors: Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang and Shun-Jen Chang
    Citation: Arthritis Research & Therapy 2022 24:229
    Content type: Research Published on:

  4. Adipose-derived mesenchymal stem cells (ASCs) have gained attention as a new treatment for systemic sclerosis (SSc). Low-molecular-weight heparin (LMWH) enhances cell function and stimulates the production of ...

    Authors: Takayasu Suzuka, Takuya Kotani, Takashi Saito, Shogo Matsuda, Takako Sato and Tohru Takeuchi
    Citation: Arthritis Research & Therapy 2022 24:228
    Content type: Research Published on:

  5. X-ray images are commonly used to assess the bone destruction of rheumatoid arthritis. The purpose of this study is to propose an automatic-bone-destruction-evaluation system fully utilizing deep neural networ...

    Authors: Kazuki Miyama, Ryoma Bise, Satoshi Ikemura, Kazuhiro Kai, Masaya Kanahori, Shinkichi Arisumi, Taisuke Uchida, Yasuharu Nakashima and Seiichi Uchida
    Citation: Arthritis Research & Therapy 2022 24:227
    Content type: Research Published on:

  6. To detect dorsally located osteophytes (OP) on lateral x-ray views and to correlate their presence with the extent of structural joint damage, determined by histologic grading (cartilage damage and synovial in...

    Authors: Ilse-Gerlinde Sunk, Love Amoyo-Minar, Birgit Niederreiter, Afschin Soleiman, Franz Kainberger, Josef S. Smolen, Daniel Aletaha and Klaus Bobacz
    Citation: Arthritis Research & Therapy 2022 24:226
    Content type: Research Published on:

  7. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis; however, the mechanisms by which they contribute to disease progression are not well described. Previous studies demonstrated that rh...

    Authors: Megan M. Simonds, Kathleen E. Sullivan and AnneMarie C. Brescia
    Citation: Arthritis Research & Therapy 2022 24:225
    Content type: Research Published on:

  8. Authors: Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Tetsuya Saito, Fumitaka Mizoguchi and Shinsuke Yasuda
    Citation: Arthritis Research & Therapy 2022 24:224
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:45

  9. Subchondral bone plays an important role in the pathogenesis of radiographic osteoarthritis (OA). However, the bony changes that occur in hand OA (HOA) are much less understood. This study aimed to describe th...

    Authors: Canchen Ma, Dawn Aitken, Feitong Wu, Kathryn Squibb, Flavia Cicuttini and Graeme Jones
    Citation: Arthritis Research & Therapy 2022 24:223
    Content type: Research Published on:

  10. Rheumatoid arthritis (RA) patients present with abnormal methylation patterns in their fibroblast-like synoviocytes (FLS). Given that DNA demethylation is critical for producing DNA methylation patterns, we hy...

    Authors: Akio Kawabe, Kaoru Yamagata, Shigeaki Kato, Kazuhisa Nakano, Kei Sakata, Yu-ichi Tsukada, Koichiro Ohmura, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:222
    Content type: Research Published on:

  11. Osteoarthritis (OA) is a degenerative disease associated with cartilage degradation, osteophyte formation, and fibrillation. Autologous Protein Solution (APS), a type of autologous anti-inflammatory orthobiolo...

    Authors: Alexis N. Peña, Sven D. Sommerfeld, Amy E. Anderson, Jin Han, David R. Maestas Jr, Joscelyn C. Mejias, Jennifer Woodell-May, William King, Sudipto Ganguly and Jennifer H. Elisseeff
    Citation: Arthritis Research & Therapy 2022 24:221
    Content type: Research Published on:

  12. The IL-23/IL-17 axis is involved in inflammatory diseases including arthritis and psoriasis. However, the response to IL-23 or IL-17 inhibitors is different depending on the disease. The aim was to compare the...

    Authors: Mélissa Noack and Pierre Miossec
    Citation: Arthritis Research & Therapy 2022 24:220
    Content type: Research Published on:

  13. Cardiac involvement in patients with idiopathic inflammatory myopathies (IIM) is associated with increased morbidity and mortality risk; however, little is known about the progression of cardiac dysfunction an...

    Authors: Andrea Péter, Ágnes Balogh, Zoltán Csanádi, Katalin Dankó and Zoltan Griger
    Citation: Arthritis Research & Therapy 2022 24:219
    Content type: Research Published on:

  14. Pain is the main concern of patients with rheumatoid arthritis (RA) while reducing disease activity dominates specialist management. Disease activity assessments like the disease activity score for 28 joints w...

    Authors: Fowzia Ibrahim, Margaret Ma, David L. Scott and Ian C. Scott
    Citation: Arthritis Research & Therapy 2022 24:218
    Content type: Research Published on:

  15. To investigate whether the associations between cartilage defects and cartilage volumes with changes in knee symptoms were mediated by osteophytes.

    Authors: Tianxiang Fan, Shibo Chen, Muhui Zeng, Jia Li, Xiaoshuai Wang, Guangfeng Ruan, Peihua Cao, Yan Zhang, Tianyu Chen, Qianhua Ou, Qianyi Wang, Anita E. Wluka, Flavia Cicuttini, Changhai Ding and Zhaohua Zhu
    Citation: Arthritis Research & Therapy 2022 24:217
    Content type: Research Published on:

  16. Osteoarthritis (OA) is a chronic degenerative joint disease. Extracellular matrix (ECM) degradation is essential for OA progression. Previous studies have shown that circular RNAs (circRNAs) are involved in th...

    Authors: Wenzhong Que, Huili Liu and Qinqin Yang
    Citation: Arthritis Research & Therapy 2022 24:216
    Content type: Research article Published on:

  17. Fibroblasts are important structural cells in synovium and play key roles in maintaining the synovial homeostasis. By single-cell RNA sequencing (scRNA-seq), subpopulation of synovium-resident cells has been r...

    Authors: Nachun Chen, Baoying Fan, Zhiyong He, Xinping Yu and Jinjun Wang
    Citation: Arthritis Research & Therapy 2022 24:215
    Content type: Research Published on:

  18. To identify regulatory ncRNA molecules that can cause differential expression of CDH2 in intervertebral disc degeneration (IDD) and explore whether there are other ways to affect the progression of IDD.

    Authors: Zhenyu Wang, Yuguang Zhao, Yi Liu, Zhigang Qu, Xinming Zhuang, Qingxu Song, Haoyu Li and Jiali Leng
    Citation: Arthritis Research & Therapy 2022 24:214
    Content type: Research Published on:

  19. Patients with immune thrombocytopenia (ITP) have a risk of developing systemic lupus erythematosus (SLE). We sought to examine the clinical characteristics of patients with primary ITP who later developed SLE ...

    Authors: Soo Min Ahn, Eun-Ji Choi, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo and Seokchan Hong
    Citation: Arthritis Research & Therapy 2022 24:213
    Content type: Research Published on:

  20. Tophi are lesions commonly present at sites of bone erosion in gout-affected joints. The tophus comprises a core of monosodium urate (MSU) crystals surrounded by soft tissue that contains macrophages and other...

    Authors: Dorit Naot, Bregina Pool, Ashika Chhana, Ryan Gao, Jacob T. Munro, Jillian Cornish and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2022 24:212
    Content type: Research Published on:

  21. Systemic lupus erythematosus (SLE) is a disease that can lead to damage of multiple organs and, along with certain treatments, increase the risk of developing cancer, cardiovascular disease, diabetes, osteopor...

    Authors: Baptiste Chevet, Gabriel Figueroa-Parra, Jeffrey X. Yang, Mehmet Hocaoglu, Shirley-Ann Osei-Onomah, Cassondra A. Hulshizer, Tina M. Gunderson, Divi Cornec, Kamil E. Barbour, Kurt J. Greenlund, Cynthia S. Crowson and Alí Duarte-García
    Citation: Arthritis Research & Therapy 2022 24:211
    Content type: Research Published on:

  22. Activation of melanocortin 1 receptor (MC1R) is known to exert broad anti-inflammatory and anti-fibrotic effects. The purpose of this study is to investigate the potential of dersimelagon, a novel oral MC1R ag...

    Authors: Masahiro Kondo, Tsuyoshi Suzuki, Yuko Kawano, Shinji Kojima, Masahiko Miyashiro, Atsuhiro Matsumoto, Gabriela Kania, Przemysław Błyszczuk, Rebecca L. Ross, Panji Mulipa, Francesco Del Galdo, Yun Zhang and Jörg H. W. Distler
    Citation: Arthritis Research & Therapy 2022 24:210
    Content type: Research Published on:

  23. Recently, a novel humanized mouse model for systemic sclerosis (SSc) was established by transferring peripheral blood mononuclear cells (PBMC) from patients with SSc to Rag2−/−Il2rg−/− immunodeficient mice. Here,...

    Authors: Yaqing Shu, Xiaoyang Yue, Jacqueline Wax, Brigitte Kasper, Junping Yin, Xiaoqing Wang, Liang Zhang, Marjan Ahmadi, Harald Heidecke, Antje Müller, Peter Lamprecht, Xinhua Yu, Gabriela Riemekasten and Frank Petersen
    Citation: Arthritis Research & Therapy 2022 24:209
    Content type: Research Published on:

  24. Publications suggest immunomodulation co-therapy improves responder rates in uncontrolled/refractory gout patients undergoing pegloticase treatment. The MIRROR open-label trial showed a 6-month pegloticase + m...

    Authors: John K. Botson, John R. P. Tesser, Ralph Bennett, Howard M. Kenney, Paul M. Peloso, Katie Obermeyer, Yang Song, Brian LaMoreaux, Lin Zhao, Yan Xin, Jason Chamberlain, Srini Ramanathan, Michael E. Weinblatt and Jeff Peterson
    Citation: Arthritis Research & Therapy 2022 24:208
    Content type: Research Published on:

  25. Anemia is common in patients with rheumatoid arthritis (RA). Higher hemoglobin (Hb) levels may be associated with better clinical outcomes and patient-reported outcomes (PROs). To assess this hypothesis, we co...

    Authors: Andrea Rubbert-Roth, Daniel E. Furst, Stefano Fiore, Amy Praestgaard, Vivian Bykerk, Clifton O. Bingham, Christina Charles-Schoeman and Gerd Burmester
    Citation: Arthritis Research & Therapy 2022 24:207
    Content type: Research Published on:

    The Research to this article has been published in Arthritis Research & Therapy 2022 24:276

  26. Rheumatoid arthritis (RA) is a chronic autoimmune disease for which prediction of long-term prognosis from disease’s outset is not clinically feasible. The importance of immunoglobulin G (IgG) and its Fc N-glycos...

    Authors: Thomas Sénard, Irini Flouri, Frano Vučković, Garyfalia Papadaki, Panagiota Goutakoli, Aggelos Banos, Maja Pučić-Baković, Marija Pezer, George Bertsias, Gordan Lauc and Prodromos Sidiropoulos
    Citation: Arthritis Research & Therapy 2022 24:206
    Content type: Research Published on:

  27. Lumbar disc herniation (LDH) can be spontaneously absorbed without surgical treatment. However, the pathogenesis and physiological indications for predicting protrusion reabsorption are still unclear, which pr...

    Authors: Pengfei Yu, Feng Mao, Jingyun Chen, Xiaoying Ma, Yuxiang Dai, Guanhong Liu, Feng Dai and Jingtao Liu
    Citation: Arthritis Research & Therapy 2022 24:205
    Content type: Review Published on:

  28. This study investigated the characteristics of hypertrophic pachymeningitis (HP) in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), using information from a multicenter study in Japan.

    Authors: Yasuhiro Shimojima, Dai Kishida, Takanori Ichikawa, Takashi Kida, Nobuyuki Yajima, Satoshi Omura, Daiki Nakagomi, Yoshiyuki Abe, Masatoshi Kadoya, Naoho Takizawa, Atsushi Nomura, Yuji Kukida, Naoya Kondo, Yasuhiko Yamano, Takuya Yanagida, Koji Endo…
    Citation: Arthritis Research & Therapy 2022 24:204
    Content type: Research Published on:

  29. To investigate the association between psychosocial vulnerability, defined as either low social support or low decision latitude at work, and disease remission at 3, 12, and 60 months in patients with rheumato...

    Authors: Louise Hedenstierna, Anna Karin Hedström, Lars Klareskog, Daniela Di Giuseppe, Lars Alfredsson, Johan Askling, Sofia Ernestam, Saedis Saevarsdottir and Lotta Ljung
    Citation: Arthritis Research & Therapy 2022 24:203
    Content type: Research Published on:

  30. To compare cardiovascular disease (CVD) rates in rheumatoid arthritis (RA) beneficiaries of the Social Security Disability Insurance (SSDI) with commercially insured RA patients.

    Authors: Iris Navarro-Millán, Fenglong Xie, Cynthia S. Crowson, Monika M. Safford, Mangala Rajan, Sebastian E. Sattui and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2022 24:202
    Content type: Research article Published on:

  31. Granulomatosis with polyangiitis (GPA) is small vessel vasculitis with heterogeneous clinical presentation. In the present population-based cohort study, we classified patients with GPA based on clinical featu...

    Authors: Rasiah Thayakaran, Ruchika Goel, Nicola J. Adderley, Joht Singh Chandan, Dawit Zemedikun, Krishnarajah Nirantharakumar and Lorraine Harper
    Citation: Arthritis Research & Therapy 2022 24:201
    Content type: Research Published on:

  32. Assessing serological inflammation is difficult in tocilizumab (TCZ)-treated rheumatoid arthritis (RA) patients, as standard inflammation parameters, like erythrocyte sedimentation rate (ESR) and C-reactive pr...

    Authors: Michael Gernert, Marc Schmalzing, Hans-Peter Tony, Patrick-Pascal Strunz, Eva Christina Schwaneck and Matthias Fröhlich
    Citation: Arthritis Research & Therapy 2022 24:200
    Content type: Research Published on:

  33. Mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) is activated downstream of p38 MAPK and regulates stability of mRNAs encoding inflammatory cytokines. CC-99677 is a novel, irreversible,...

    Authors: Rajula Gaur, Kofi A. Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Dorota Cedzik, Jamie Connarn, Michael Thomas, Gerald Horan, Peter Schafer, Stuart Mair, Maria Palmisano and Francisco Ramírez-Valle
    Citation: Arthritis Research & Therapy 2022 24:199
    Content type: Research Published on:

  34. Traumatic knee injuries in humans trigger an immediate increase in synovial fluid levels of inflammatory cytokines that accompany impact damage to joint tissues. We developed a human in vitro cartilage-bone-sy...

    Authors: Garima Dwivedi, Lisa Flaman, Begum Alaybeyoglu, André Struglics, Eliot H. Frank, Susan Chubinskya, Stephen B. Trippel, Vicki Rosen, Murat Cirit and Alan J. Grodzinsky
    Citation: Arthritis Research & Therapy 2022 24:198
    Content type: Research Published on:

  35. Uncoupled extracellular matrix (ECM) causes cartilage degeneration and osteoarthritis (OA) by suppressing the synthesis and activating the degradation of ECM components. Gingko biloba is a natural Chinese herb wi...

    Authors: Zhijian Zhao, Yang Liu, Yingjie Lu, Mingzhuang Hou, Xu Shen, Huilin Yang, Qin Shi, Yijian Zhang, Fan He and Xuesong Zhu
    Citation: Arthritis Research & Therapy 2022 24:197
    Content type: Research Published on:

  36. Systemic sclerosis (SSc) is an autoimmune rheumatic disease with high mortality, which is featured by inflammation, vascular damage, and aggressive fibrosis. To date, the pathogenesis of SSc remains unclear an...

    Authors: Cong Lin, Zhixing Jiang, Ling Cao, Hejian Zou and Xiaoxia Zhu
    Citation: Arthritis Research & Therapy 2022 24:196
    Content type: Review Published on:

  37. Accumulating evidence supports the role of monocytes and neutrophils in radiographic axSpA (r-axSpA). Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a growth factor for both leukocyte lineages an...

    Authors: Charalampos Papagoras, Styliani Tsiami, Akrivi Chrysanthopoulou, Ioannis Mitroulis and Xenofon Baraliakos
    Citation: Arthritis Research & Therapy 2022 24:195
    Content type: Research Published on:

  38. Abatacept is a recombinant fusion protein composed of the extracellular domain of cytotoxic T-lymphocyte antigen 4 and the Fc portion of immunoglobulin (Ig) G. The mechanism of action of abatacept in rheumatoi...

    Authors: Ryosuke Fukue, Yuka Okazaki, Takahisa Gono and Masataka Kuwana
    Citation: Arthritis Research & Therapy 2022 24:194
    Content type: Research Published on:

  39. Medication adherence is suboptimal in rheumatoid arthritis (RA) patients and impacts outcomes. DMARD-free remission (DFR) is a sustainable and achievable outcome in a minority of RA patients. Different factors...

    Authors: Irazú Contreras-Yáñez, Guillermo Arturo Guaracha-Basáñez, Maximiliano Cuevas-Montoya, José de Jesús Hernández-Bautista and Virginia Pascual-Ramos
    Citation: Arthritis Research & Therapy 2022 24:193
    Content type: Research Published on:

  40. Venous thromboembolism (VTE) is a common complication in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) and confers significant morbidity and mortality. Both acute and pa...

    Authors: C. King, R. Patel, C. Mendoza, J. K. Walker, E. Y. Wu, P. Moss, M. D. Morgan, D. O’Dell Bunch, L. Harper and D. Chanouzas
    Citation: Arthritis Research & Therapy 2022 24:192
    Content type: Research Published on:

  41. Tumor necrosis factor (TNF) inhibitors use in patients with rheumatoid arthritis (RA) has raised safety concerns about cancer risk, but study results remain controversial. This largest nationwide study to date...

    Authors: Boyoon Choi, Hyun Jin Park, Yun-Kyoung Song, Yoon-Jeong Oh, In-Wha Kim and Jung Mi Oh
    Citation: Arthritis Research & Therapy 2022 24:191
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:238

  42. We conducted a single-center cohort study of rheumatoid arthritis (RA) patients from 2011 to 2020 to understand their real world treatment and outcomes, especially changes in physical function and quality of l...

    Authors: Wataru Fukuda, Masatoshi Kadoya, Atsushi Omoto, Takuya Yanagida, Yu Isoda, Atsuhiko Sunaga, Hiroaki Kusuoka, Kentaro Ueno, Satoshi Morita, Masataka Kohno and Yutaka Kawahito
    Citation: Arthritis Research & Therapy 2022 24:190
    Content type: Research Published on:

  43. Osteoarthritis is highly heritable and genome-wide studies have identified single nucleotide polymorphisms (SNPs) associated with the disease. One such locus is marked by SNP rs11732213 (T > C). Genotype at rs...

    Authors: Abby Brumwell, Guillaume Aubourg, Juhel Hussain, Eleanor Parker, David J. Deehan, Sarah J. Rice and John Loughlin
    Citation: Arthritis Research & Therapy 2022 24:189
    Content type: Research Published on:

  44. The upregulation of interferon (IFN)-stimulated genes induced by type I IFNs (namely type I IFN signature) in rheumatoid arthritis (RA) patients had implications in early diagnosis and prediction of therapy re...

    Authors: Yu Du, Ran Cui, Na Tian, Miao Chen, Xian-Long Zhang and Sheng-Ming Dai
    Citation: Arthritis Research & Therapy 2022 24:188
    Content type: Research Published on:

  45. To assess the efficacy and safety of infliximab versus placebo in the treatment of patients with juvenile-onset spondyloarthritis (JoSpA).

    Authors: Rubén Burgos-Vargas, Adalberto Loyola-Sanchez, Sofia Ramiro, Arturo Reding-Bernal, Everardo Alvarez-Hernandez, Desirée van der Heijde and Janitzia Vázquez-Mellado
    Citation: Arthritis Research & Therapy 2022 24:187
    Content type: Research Published on:

  46. Behçet’s syndrome (BS) is an immune-mediated disease characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin symptoms. HLA-B51, as well as other genetic polymorphisms, has been reported to be...

    Authors: Mai Okubo, Shuji Sumitomo, Yumi Tsuchida, Yasuo Nagafuchi, Yusuke Takeshima, Haruyuki Yanaoka, Harumi Shirai, Satomi Kobayashi, Yusuke Sugimori, Junko Maeda, Hiroaki Hatano, Yukiko Iwasaki, Hirofumi Shoda, Tomohisa Okamura, Kazuhiko Yamamoto, Mineto Ota…
    Citation: Arthritis Research & Therapy 2022 24:186
    Content type: Research Published on:

  47. To assess whether persistence to treatment with methotrexate (MTX) in early rheumatoid arthritis (RA) is shared among first-degree relatives with RA and to estimate any underlying heritability.

    Authors: Anton Öberg Sysojev, Thomas Frisell, Bénédicte Delcoigne, Saedis Saevarsdottir, Johan Askling and Helga Westerlind
    Citation: Arthritis Research & Therapy 2022 24:185
    Content type: Research Published on:

  48. Diastolic dysfunction (DD) is more prevalent in patients with rheumatoid arthritis (RA) compared to the general population. However, its evolution over time and its significant clinical predictors remain uncha...

    Authors: Elizabeth Park, Kazato Ito, Rabia Iqbal, Isabelle Amigues, Sabahat Bokhari, Jennifer Van Eyk, Christopher Depender, Jon T. Giles and Joan Bathon
    Citation: Arthritis Research & Therapy 2022 24:184
    Content type: Research Published on:

  49. There is no international consensus on an optimal ultrasound score for monitoring of rheumatoid arthritis (RA) on patient-level yet. Our aim was to reassess the US7 score for the identification of the most fre...

    Authors: A. F. Podewski, A. M. Glimm, I. Fischer, G. A. W. Bruyn, P. Hanova, H. B. Hammer, A. B. Aga, E. A. Haavardsholm, S. Ramiro, G. R. Burmester, M. Backhaus and S. Ohrndorf
    Citation: Arthritis Research & Therapy 2022 24:183
    Content type: Research Published on:
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