Articles

Similar alteration for mental and physical aspects in health-related quality of life over 5 to 8 years in 1347 patients with early arthritis and early inflammatory back pain

Health-related quality of life (HRQoL) is a priority for patients. The objectives were to describe the changes in HRQoL over 5–8 years in patients with early arthritis (EA) or early inflammatory back pain (IBP...

Authors: Déborah Puyraimond-Zemmour, Benjamin Granger, Anna Molto, Cécile Gaujoux-Viala, Francis Guillemin, Adeline Ruyssen-Witrand, Maxime Dougados, Bruno Fautrel and Laure Gossec

Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren’s syndrome differ in molecular signatures and treatment perspectives

Previous studies and own clinical observations of patients with systemic lupus erythematosus (SLE) suggest that SLE harbors distinct immunophenotypes. This heterogeneity might result in differences in response...

Authors: Helena Idborg, Arash Zandian, Ann-Sofi Sandberg, Bo Nilsson, Kerstin Elvin, Lennart Truedsson, Azita Sohrabian, Johan Rönnelid, John Mo, Giorgia Grosso, Marika Kvarnström, Iva Gunnarsson, Janne Lehtiö, Peter Nilsson, Elisabet Svenungsson and Per-Johan Jakobsson

Health-related quality of life in systemic sclerosis compared with other rheumatic diseases: a cross-sectional study

Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis of the skin and the involvement of multiple internal organs. Previous studies reported poorer health-related quality of life (HRQ...

Authors: Eun Hye Park, Vibeke Strand, Yoon Jeong Oh, Yeong Wook Song and Eun Bong Lee

Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients—immune-related candidate proteins affected by TNF blocking treatment

Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blo...

Authors: Johanna Estelius, Johan Lengqvist, Elena Ossipova, Helena Idborg, Erwan Le Maître, Magnus L. A. Andersson, Lou Brundin, Mohsen Khademi, Elisabet Svenungsson, Per-Johan Jakobsson and Jon Lampa

Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia

Ultrasound (US) and magnetic resonance imaging (MRI) are recommended in the diagnostic process of rheumatoid arthritis. Research on its comparability in early disease phases is scarce. Therefore, we compared s...

Authors: Sarah Ohrndorf, Aleid C. Boer, Debbie M. Boeters, Robin M. ten Brinck, Gerd-R. Burmester, Marion C. Kortekaas and Annette H. M. van der Helm-van Mil

Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease

Biomarkers have been actively investigated to supplement functional and imaging modalities to predict the severity, therapeutic responsiveness, and progression of connective tissue disease-associated interstit...

Authors: Jeong Seok Lee, Eun Young Lee, You-Jung Ha, Eun Ha Kang, Yun Jong Lee and Yeong Wook Song

Significance of anti-neutrophil cytoplasmic antibodies in systemic sclerosis

Up to 12% of patients with systemic sclerosis (SSc) have anti-neutrophil cytoplasmic antibodies (ANCA). However, the majority of these patients do not manifest ANCA-associated vasculitis (AAV) and the signific...

Authors: Jayne Moxey, Molla Huq, Susanna Proudman, Joanne Sahhar, Gene-Siew Ngian, Jenny Walker, Gemma Strickland, Michelle Wilson, Laura Ross, Gabor Major, Janet Roddy, Wendy Stevens and Mandana Nikpour

What is the additional value of MRI of the foot to the hand in undifferentiated arthritis to predict rheumatoid arthritis development?

MRI-detected subclinical joint inflammation in the hand joints of patients with undifferentiated arthritis (UA) predicts progression to rheumatoid arthritis (RA). It is unknown if adding MRI of the foot increa...

Authors: Y. J. Dakkak, D. M. Boeters, A. C. Boer, M. Reijnierse and A. H. M. van der Helm-van Mil

Correction to: Clinical course and prognostic factors of childhood Takayasu’s arteritis: over 15-year comprehensive analysis of 101 patients

Following publication of the original article [1], the authors reported an error.

Authors: Luyun Fan, Huimin Zhang, Jun Cai, Lirui Yang, Bin Liu, Dongmei Wei, Jiachen Yu, Jiali Fan, Lei Song, Wenjun Ma, Xianliang Zhou, Haiying Wu and Ying Lou

Efficacy of canakinumab as first-line biologic agent in adult-onset Still’s disease

Authors: Giulio Cavalli, Alessandro Tomelleri, Giacomo De Luca, Corrado Campochiaro, Charles A. Dinarello, Elena Baldissera and Lorenzo Dagna

Adult-onset Still’s disease biological treatment strategy may depend on the phenotypic dichotomy

Adult-onset Still’s disease (AOSD) phenotype appears to be dichotomized in systemic or chronic articular forms. As biologicals and particularly interleukin (IL)-1 and IL-6 blockers play a more and more promine...

Authors: François Vercruysse, Thomas Barnetche, Estibaliz Lazaro, Emilie Shipley, François Lifermann, Alexandre Balageas, Xavier Delbrel, Bruno Fautrel, Christophe Richez, Thierry Schaeverbeke and Marie-Elise Truchetet

Exocrine pancreatic function is preserved in systemic sclerosis

Systemic sclerosis (SSc) has been suggested to cause exocrine pancreatic dysfunction. However, a case-control-based autopsy study failed to associate systemic sclerosis with any pancreatic histopathology. The ...

Authors: Gracijela Bozovic, Rille Pullerits, Arne Ståhl, Kristina Ydström, Daniel Wenger, Jan Marsal, Pontus Thulin and Kristofer Andréasson

Deregulation of microRNA expression in monocytes and CD4⁺ T lymphocytes from patients with axial spondyloarthritis

MicroRNAs (MiRs) play an important role in the pathogenesis of chronic inflammatory diseases. This study is the first to investigate miR expression profiles in purified CD4⁺ T lymphocytes and CD14⁺ monocytes from...

Authors: Olivier Fogel, Andreas Bugge Tinggaard, Maud Fagny, Nelly Sigrist, Elodie Roche, Laurence Leclere, Jean-François Deleuze, Frederic Batteux, Maxime Dougados, Corinne Miceli-Richard and Jörg Tost

Romidepsin suppresses monosodium urate crystal-induced cytokine production through upregulation of suppressor of cytokine signaling 1 expression

Acute gouty arthritis currently is the most common form of inflammatory arthritis in developed countries. Treatment is still suboptimal. Dosage of urate-lowering therapy is often too low to reach target urate ...

Authors: M. C. P. Cleophas, T. O. Crişan, V. Klück, N. Hoogerbrugge, R. T. Netea-Maier, C. A. Dinarello, M. G. Netea and L. A. B. Joosten

Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin

Infectious agents have long been postulated to be disease triggers for systemic sclerosis (SSc), but a definitive link has not been found. Metagenomic analyses of high-throughput data allows for the unbiased i...

Authors: Michael E. Johnson, Jennifer M. Franks, Guoshuai Cai, Bhaven K. Mehta, Tammara A. Wood, Kimberly Archambault, Patricia A. Pioli, Robert W. Simms, Nicole Orzechowski, Sarah Arron and Michael L. Whitfield

New-onset non-infectious pulmonary manifestations among patients with systemic lupus erythematosus in Sweden

The objective was to estimate the incidence of lung disease among patients with systemic lupus erythematosus (SLE).

Authors: Lindsy J. Forbess, Marios Rossides, Michael H. Weisman and Julia F. Simard

Rheumatoid arthritis reprograms circadian output pathways

We applied systems biology approaches to investigate circadian rhythmicity in rheumatoid arthritis (RA).

Authors: Toryn M. Poolman, Julie Gibbs, Amy L. Walker, Suzanna Dickson, Laura Farrell, James Hensman, Alexandra C. Kendall, Robert Maidstone, Stacey Warwood, Andrew Loudon, Magnus Rattray, Ian N. Bruce, Anna Nicolaou and David W. Ray

Tolerogenic XCR1⁺ dendritic cell population is dysregulated in HLA-B27 transgenic rat model of spondyloarthritis

Spondyloarthritis (SpA) is a chronic inflammatory disease affecting primarily axial and peripheral joints and sometimes also extra-articular organs, such as the gut. Rats transgenic for HLA-B27 and human β2-mi...

Authors: Kétia Ermoza, Simon Glatigny, Nadège Jah, Vânia Camilo, Hendrick Mambu Mambueni, Luiza M. Araujo, Gilles Chiocchia and Maxime Breban

Anti-citrullinated protein antibodies are associated with osteopenia but not with pain at diagnosis of rheumatoid arthritis: data from the BARFOT cohort

Anti-citrullinated protein antibodies (ACPA) have been suggested to have a potential role in both bone loss and pain in rheumatoid arthritis (RA), based on studies in vitro and in animal models. Here we addres...

Authors: Ingiäld Hafström, Sofia Ajeganova, Kristina Forslind and Björn Svensson

Differences and similarities between IgG4-related disease with and without dacryoadenitis and sialoadenitis: clinical manifestations and treatment efficacy

This study aimed to compare the differences and similarities in the clinical manifestations and treatment efficacy of IgG4-related disease (IgG4-RD) in patients with and without dacryoadenitis and sialoadeniti...

Authors: Mu Wang, Panpan Zhang, Wei Lin, Yunyun Fei, Hua Chen, Jing Li, Li Zhang, Wenjie Zheng, Yongze Li, Xiaofeng Zeng, Jiaxin Zhou, Yamin Lai, Xiaowei Liu, Huadan Xue, Yueying Cui, Lian Zhou…

IgG4:IgG RNA ratio differentiates active disease from remission in granulomatosis with polyangiitis: a new disease activity marker? A cross-sectional and longitudinal study

An important limitation in granulomatosis with polyangiitis (GPA) is the lack of disease activity markers. Immunoglobulin G4-positive (IgG4⁺) B cells and plasma cells are implicated in the pathogenesis of GPA. We...

Authors: A. Al-Soudi, M. E. Doorenspleet, R. E. Esveldt, L. T. Burgemeister, A. E. Hak, B. J. H. van den Born, S. W. Tas, R. F. van Vollenhoven, P. L. Klarenbeek and N. de Vries

Upregulation of miR-107 expression following hyperbaric oxygen treatment suppresses HMGB1/RAGE signaling in degenerated human nucleus pulposus cells

The expression of both high-mobility group box 1 (HMGB1) and receptor for advanced glycation end-products (RAGE) is upregulated in degenerated discs. HMGB1 is known to function as a coupling factor between hyp...

Authors: Chi-Chien Niu, Song-Shu Lin, Li-Jen Yuan, Meng-Ling Lu, Steve W. N. Ueng, Chuen-Yung Yang, Tsung-Ting Tsai and Po-Liang Lai

Psychometric validation of the EuroQoL 5-dimension (EQ-5D) questionnaire in patients with spondyloarthritis

Spondyloarthritis (SpA) has a significant impact on patients’ quality of life due to functional impairments. Generic health instruments like the EuroQoL 5-dimension (EQ-5D) is important for the cost-utility an...

Authors: Helen Hoi Lun Tsang, Jason Pui Yin Cheung, Carlos King Ho Wong, Prudence Wing Hang Cheung, Chak Sing Lau and Ho Yin Chung

Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage

Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE) and is characterized by glomerulosclerosis, interstitial fibrosis, and tubular atrophy, along with...

Authors: Shijun He, Xing Liu, Zemin Lin, Yuting Liu, Lei Gu, Hu Zhou, Wei Tang and Jianping Zuo

Reduction of autophagy and increase in apoptosis correlates with a favorable clinical outcome in patients with rheumatoid arthritis treated with anti-TNF drugs

Autophagy has emerged as a key mechanism in the survival and function of T and B lymphocytes, and its activation was involved in apoptosis resistance in rheumatoid arthritis (RA). To investigate whether the re...

Authors: M. Vomero, V. Manganelli, C. Barbati, T. Colasanti, A. Capozzi, A. Finucci, F. R. Spinelli, F. Ceccarelli, C. Perricone, S. Truglia, S. Morrone, R. Maggio, R. Misasi, M. Bombardieri, M. Di Franco, F. Conti…

Ixekizumab and complete resolution of enthesitis and dactylitis: integrated analysis of two phase 3 randomized trials in psoriatic arthritis

Ixekizumab improves signs/symptoms of psoriatic arthritis (PsA). We present an integrated analysis of baseline disease burden and post-baseline outcomes in ixekizumab-treated patients with enthesitis or dactyl...

Authors: Dafna D. Gladman, Ana-Maria Orbai, Uta Klitz, James Cheng-Chung Wei, Gaia Gallo, Julie Birt, Suchitrita Rathmann, David Shrom and Helena Marzo-Ortega

Resetting the clock on arthritis

While many of intricacies of the mammalian circadian rhythm remain unknown, the role that this physiological clock plays in our everyday lives and within the global ecosystem is clearly evident. However, only ...

Authors: Roman J. Krawetz

Self-reported sleep quality and sleep disorders in people with physician-diagnosed gout: an Internet cross-sectional survey

Limited information exists regarding sleep disorders in gout. Our objective was to assess the burden of sleep disorders in people with gout.

Authors: Jasvinder A. Singh

Classification, categorization and essential items for digital ulcer evaluation in systemic sclerosis: a DeSScipher/European Scleroderma Trials and Research group (EUSTAR) survey

A consensus on digital ulcer (DU) definition in systemic sclerosis (SSc) has been recently reached (Suliman et al., J Scleroderma Relat Disord 2:115-20, 2017), while for their evaluation, classification and ca...

Authors: J. Blagojevic, S. Bellando-Randone, G. Abignano, J. Avouac, L. Cometi, L. Czirják, C. P. Denton, O. Distler, M. Frerix, S. Guiducci, D. Huscher, V. K. Jaeger, V. Lóránd, B. Maurer, S. Nihtyanova, G. Riemekasten…

Endothelial activation and injury by microparticles in patients with systemic lupus erythematosus and rheumatoid arthritis

Endothelial activation and damage is commonly observed in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and is related to development of atherosclerosis and cardiovascular dise...

Authors: Laura Atehortúa, Mauricio Rojas, Gloria Vásquez, Carlos H. Muñoz-Vahos, Adriana Vanegas-García, Rafael Andrés Posada-Duque and Diana Castaño

Awareness and perceived risk of cardiovascular disease among individuals living with rheumatoid arthritis is low: results of a systematic literature review

Individuals with rheumatoid arthritis (RA) are at risk of developing cardiovascular disease (CVD), but patient perceptions of CVD are not routinely assessed. We performed a systematic literature review to eval...

Authors: Olivia R. Ghosh-Swaby and Bindee Kuriya

The need for comparative data in spondyloarthritis

Spondyloarthritis comprises a group of inflammatory diseases, characterised by inflammation within axial joints and/or peripheral arthritis, enthesitis and dactylitis. An increasing number of biologic treatmen...

Authors: Ernest Choy, Xenofon Baraliakos, Frank Behrens, Salvatore D’Angelo, Kurt de Vlam, Bruce W. Kirkham, Mikkel Østergaard, Georg A. Schett, Michael Rissler, Kamel Chaouche-Teyara and Chiara Perella

Clinical course and prognostic factors of childhood Takayasu’s arteritis: over 15-year comprehensive analysis of 101 patients

Childhood Takayasu’s arteritis (c-TA) is scarcely reported but is characterized by devastating morbidity and mortality. This study aims to investigate the clinical course of c-TA and prognostic factors associa...

Authors: Luyun Fan, Huimin Zhang, Jun Cai, Lirui Yang, Bin Liu, Dongmei Wei, Jiachen Yu, Jiali Fan, Lei Song, Wenjun Ma, Xianliang Zhou, Haiying Wu and Ying Lou

CD34-selected versus unmanipulated autologous haematopoietic stem cell transplantation in the treatment of severe systemic sclerosis: a post hoc analysis of a phase I/II clinical trial conducted in Japan

The effectiveness of autologous haematopoietic stem cell transplantation (auto-HSCT) in treating severe systemic sclerosis (SSc) is established; however, the necessity of purified CD34+ cell grafts and the app...

Authors: Masahiro Ayano, Hiroshi Tsukamoto, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Toshihiro Miyamoto, Takahiko Horiuchi, Hiroaki Niiro, Koji Nagafuji, Mine Harada and Koichi Akashi

Cytosolic group IVA phospholipase A2 inhibitors, AVX001 and AVX002, ameliorate collagen-induced arthritis

Cytosolic phospholipase A2 group IVA (cPLA2α)-deficient mice are resistant to collagen-induced arthritis, suggesting that cPLA2α is an important therapeutic target. Here, the anti-inflammatory effects of the A...

Authors: A. J. Feuerherm, E. A. Dennis and B. Johansen

In rheumatoid arthritis, changes in autoantibody levels reflect intensity of immunosuppression, not subsequent treatment response

Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies like rheumatoid factor (RF), anti-cyclic citrullinated peptide-2 (anti-CCP2), and anti-carbamylated protein (anti-CarP) antibodies. ...

Authors: Emma C. de Moel, Veerle F. A. M. Derksen, Leendert A. Trouw, Holger Bang, Gerard Collée, Leroy R. Lard, Sofia Ramiro, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes and Diane van der Woude

Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: a case–control study

A high prevalence of periodontitis has been reported in rheumatoid arthritis (RA) patients, although the strength of this association, its temporal link and the possible relationship between the severity of pe...

Authors: Beatriz Rodríguez-Lozano, Jerián González-Febles, Jorge Luis Garnier-Rodríguez, Shashi Dadlani, Sagrario Bustabad-Reyes, Mariano Sanz, Fernando Sánchez-Alonso, Carlos Sánchez-Piedra, Enrique González-Dávila and Federico Díaz-González

Synovial fluid monocyte/macrophage subsets and their correlation to patient-reported outcomes in osteoarthritic patients: a cohort study

Chronic, low-grade inflammation of the synovium (synovitis) is a hallmark of osteoarthritis (OA), thus understanding of OA immunobiology, mediated by immune effectors, is of importance. Specifically, monocytes...

Authors: Alejandro Gómez-Aristizábal, Rajiv Gandhi, Nizar N. Mahomed, K. Wayne Marshall and Sowmya Viswanathan

Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis

In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (H...

Authors: Kim Wervers, Jolanda J. Luime, Ilja Tchetverikov, Andreas H. Gerards, Marc R. Kok, Cathelijne W. Y. Appels, Wiebo L. van der Graaff, Johannes H. L. M. van Groenendael, Lindy-Anne Korswagen, Josien J. Veris-van Dieren, Johanna M. W. Hazes and Marijn Vis

Value of contrast-enhanced ultrasonography of the carotid artery for evaluating disease activity in Takayasu arteritis

To assess the value of contrast-enhanced ultrasonography (CEUS) for monitoring disease activity of Takayasu arteritis (TA).

Authors: Ling-Ying Ma, Chao-Lun Li, Li-Li Ma, Xiao-Meng Cui, Xiao-Min Dai, Ying Sun, Hui-Yong Chen, Bei-Jian Huang and Lin-Di Jiang

Minimal Clinically Important Differences for the Modified Rodnan Skin Score: Results from the Scleroderma Lung Studies (SLS-I and SLS-II)

This study aimed to assess the minimal clinically important differences (MCIDs) for the modified Rodnan skin score (mRSS) using combined data from the Scleroderma Lung Studies (I and II).

Authors: Dinesh Khanna, Philip J. Clements, Elizabeth R. Volkmann, Holly Wilhalme, Chi-hong Tseng, Daniel E. Furst, Michael D. Roth, Oliver Distler and Donald P. Tashkin

Association between IL23R and ERAP1 polymorphisms and sacroiliac or spinal MRI inflammation in spondyloarthritis: DESIR cohort data

To investigate the association between 12 single nucleotide polymorphisms (SNPs) located on ERAP1 and IL23R with the presence of inflammation on the sacroiliac joint (SIJ) or spinal magnetic resonance imagery (MR...

Authors: Adeline Ruyssen-Witrand, Cécile Luxembourger, Alain Cantagrel, Delphine Nigon, Pascal Claudepierre, Yannick Degboe and Arnaud Constantin

The value of the simplified RAMRIS-5 in early RA patients under methotrexate therapy using high-field MRI

The aim of the study was to evaluate a simplified version of the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) for five joints of the hand (RAMRIS-5) in patients with early rheumatoid arthriti...

Authors: Miriam Frenken, Christoph Schleich, Ralph Brinks, Daniel Benjamin Abrar, Christine Goertz, Matthias Schneider, Benedikt Ostendorf and Philipp Sewerin

Correction to: The association between sonographic enthesitis and radiographic damage in psoriatic arthritis

Following publication of the original article [1], the authors reported an error in the affiliation of Ari Polachek.

Authors: Ari Polachek, Richard Cook, Vinod Chandran, Dafna D. Gladman and Lihi Eder

Vitamin D protects podocytes from autoantibodies induced injury in lupus nephritis by reducing aberrant autophagy

The aim of this study was to investigate whether vitamin D plays a protective role in podocyte injury induced by autoantibodies purified from the serum of patients with lupus nephritis (LN) via reducing aberra...

Authors: Qi Yu, Yingjin Qiao, Dongwei Liu, Fengxun Liu, Congcong Gao, Jiayu Duan, Lulu Liang, Xueqi Di, Yi Yuan, Yukui Gao, Siwan Cui, Yilu Qin, Tianfang Li, Zhaohui Zheng and Zhangsuo Liu

Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis

Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-...

Authors: Sabine Trellu, Alice Courties, Stéphane Jaisson, Laëtitia Gorisse, Philippe Gillery, Saadia Kerdine-Römer, Carlos Vaamonde-Garcia, Xavier Houard, François-Paul Ekhirch, Alain Sautet, Bertrand Friguet, Claire Jacques, Francis Berenbaum and Jérémie Sellam

Weight loss improves disease activity in patients with psoriatic arthritis and obesity: an interventional study

Obesity is over-represented in patients with psoriatic arthritis (PsA) and associated with higher disease activity, poorer effect of treatment and increased cardiovascular morbidity. Studies on the effects of ...

Authors: Eva Klingberg, Annelie Bilberg, Sofia Björkman, Martin Hedberg, Lennart Jacobsson, Helena Forsblad-d’Elia, Hans Carlsten, Björn Eliasson and Ingrid Larsson

The oncoprotein TBX3 is controlling severity in experimental arthritis

Development of autoimmune diseases is the result of a complex interplay between hereditary and environmental factors, with multiple genes contributing to the pathogenesis in human disease and in experimental m...

Authors: Samra Sardar, Alish Kerr, Daniëlle Vaartjes, Emilie Riis Moltved, Edita Karosiene, Ramneek Gupta and Åsa Andersson

Common mechanisms and holistic care in atherosclerosis and osteoporosis

Cardiovascular (CV) disease and osteoporosis (OP) have become increasing challenges in the aging population and even more in patients with inflammatory rheumatic diseases, such as rheumatoid arthritis, spondyl...

Authors: Zoltán Szekanecz, Hennie G. Raterman, Zsófia Pethő and Willem F. Lems

Significant association between joint ultrasonographic parameters and synovial inflammatory factors in rheumatoid arthritis

Ultrasonography (US) can directly demonstrate joint inflammation, including grayscale (GS) signs of synovial hypertrophy and power Doppler (PD) techniques to demonstrate increased blood flow and vascularizatio...

Authors: Yasushi Kondo, Katsuya Suzuki, Yumiko Inoue, Koumei Sakata, Chihiro Takahashi, Masaru Takeshita, Yoshiaki Kassai, Takahiro Miyazaki, Rimpei Morita, Yasuo Niki, Yuko Kaneko, Hidekata Yasuoka, Kunihiro Yamaoka, Akihiko Yoshimura and Tsutomu Takeuchi