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  1. Content type: Research article

    Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and inc...

    Authors: David B. Bartlett, Leslie H. Willis, Cris A. Slentz, Andrew Hoselton, Leslie Kelly, Janet L. Huebner, Virginia B. Kraus, Jennifer Moss, Michael J. Muehlbauer, Guillaume Spielmann, William E. Kraus, Janet M. Lord and Kim M. Huffman

    Citation: Arthritis Research & Therapy 2018 20:127

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  2. Content type: Research article

    The application of more sensitive imaging techniques, such as ultrasonography (US), changed the concept of non-erosive arthritis in systemic lupus erythematosus (SLE), underlining the need for biomarkers to id...

    Authors: Fulvia Ceccarelli, Carlo Perricone, Tania Colasanti, Laura Massaro, Enrica Cipriano, Monica Pendolino, Francesco Natalucci, Riccardo Mancini, Francesca Romana Spinelli, Guido Valesini, Fabrizio Conti and Cristiano Alessandri

    Citation: Arthritis Research & Therapy 2018 20:126

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  3. Content type: Correction

    Unfortunately, after publication of this article [1], it was noticed that the panel for Fig. 4b was inadvertently obscured during the production process. The full, correct Fig. 4 can be seen below and the orig...

    Authors: Jie Qian, Lingxiao Xu, Xiaoxuan Sun, Yani Wang, Wenhua Xuan, Qian Zhang, Pengfei Zhao, Qin Wu, Rui Liu, Nan Che, Fang Wang, Wenfeng Tan and Miaojia Zhang

    Citation: Arthritis Research & Therapy 2018 20:125

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    The original article was published in Arthritis Research & Therapy 2018 20:26

  4. Content type: Research article

    Low C-C chemokine receptor 1 (CCR1) and interleukin (IL)-10 expression is associated with risk of Behçet’s disease (BD). The objective of the present study was to clarify the pathological roles of CCR1 and IL10 l...

    Authors: Hiroto Nakano, Yohei Kirino, Mitsuhiro Takeno, Kana Higashitani, Hideto Nagai, Ryusuke Yoshimi, Yukie Yamaguchi, Ikuma Kato, Ichiro Aoki and Hideaki Nakajima

    Citation: Arthritis Research & Therapy 2018 20:124

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  5. Content type: Research article

    Epidemiologic studies have highlighted the association of environmental factors with the development and progression of autoimmune and chronic inflammatory diseases. Among the environmental factors, smoking ha...

    Authors: Jhimmy Talbot, Raphael S. Peres, Larissa G. Pinto, Rene D. R. Oliveira, Kalil A. Lima, Paula B. Donate, Jaqueline R. Silva, Bernard Ryffel, Thiago M. Cunha, José C. Alves-Filho, Foo Y. Liew, Paulo Louzada-Junior and Fernando de Queiroz Cunha

    Citation: Arthritis Research & Therapy 2018 20:119

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  6. Content type: Research article

    Systemic lupus erythematosus (SLE) is a chronic and incurable autoimmune disease involving the dysfunction of lymphocytes. Circular RNAs (circRNAs) are noncoding RNAs (ncRNAs) with a covalently closed loop str...

    Authors: Xin Wang, Chengzhong Zhang, Zhouwei Wu, Yue Chen and Weimin Shi

    Citation: Arthritis Research & Therapy 2018 20:118

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  7. Content type: Research article

    The pathogenesis of sacroiliitis is unclear; therefore, we aimed to systematically study the immunopathology of sacroiliitis in patients with axial spondyloarthritis (axSpA), and explore the relationship betwe...

    Authors: Dan min Wang, Ling Lin, Jian hua Peng, Yao Gong, Zhi duo Hou, Su biao Chen and Zheng yu Xiao

    Citation: Arthritis Research & Therapy 2018 20:120

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  8. Content type: Review

    Approaches for the prevention and treatment of hip osteoarthritis (OA) remain limited. There are recent data suggesting that low birth weight (LBW) and preterm birth may be risk factors for hip osteoarthritis....

    Authors: Sultana Monira Hussain, Ilana N. Ackerman, Yuanyuan Wang, Ella Zomer and Flavia M. Cicuttini

    Citation: Arthritis Research & Therapy 2018 20:121

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  9. Content type: Research article

    Rheumatoid arthritis (RA) patients are at high risk of developing cardiovascular disease (CVD). In RA, chronic inflammation may lead to endothelial dysfunction, an early indicator of CVD, owing to diminished n...

    Authors: Unnikrishnan M. Chandrasekharan, Zeneng Wang, Yuping Wu, W. H. Wilson Tang, Stanley L. Hazen, Sihe Wang and M. Elaine Husni

    Citation: Arthritis Research & Therapy 2018 20:123

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  10. Content type: Letter

    Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis (ROC), registered 22 October 2009, NCT01000441

    Authors: Elodie Rivière, Jérémie Sellam, Juliette Pascaud, Philippe Ravaud, Jacques-Eric Gottenberg and Xavier Mariette

    Citation: Arthritis Research & Therapy 2018 20:122

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  11. Content type: Research article

    The prevalence of dermatomyositis (DM) versus DM and polymyositis (PM) combined has been shown to be negatively associated with latitude. This observation has been attributed to increasing exposure to ultravio...

    Authors: Joanna E. Parkes, Simon Rothwell, Alexander Oldroyd, Hector Chinoy and Janine A. Lamb

    Citation: Arthritis Research & Therapy 2018 20:117

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  12. Content type: Research article

    IL-17A has recently emerged as a potential target that regulates the extensive inflammation and abnormal bone formation observed in ankylosing spondylitis (AS). Blocking IL-17A is expected to inhibit bony anky...

    Authors: Sungsin Jo, Sung Eun Wang, Young Lim Lee, Suman Kang, Bitnara Lee, Jinil Han, Il-Hoon Sung, Ye-Soo Park, Sang-Cheol Bae and Tae-Hwan Kim

    Citation: Arthritis Research & Therapy 2018 20:115

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  13. Content type: Research article

    B cells exert their pathogenic action in rheumatoid arthritis (RA) locally in the synovium. This study was undertaken to elucidate the chemokines responsible for the recruitment of B cells in the inflamed syno...

    Authors: Estefanía Armas-González, María Jesús Domínguez-Luis, Ana Díaz-Martín, Mayte Arce-Franco, Javier Castro-Hernández, Gabriela Danelon, Vanesa Hernández-Hernández, Sagrario Bustabad-Reyes, Alberto Cantabrana, Mariagrazia Uguccioni and Federico Díaz-González

    Citation: Arthritis Research & Therapy 2018 20:114

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  14. Content type: Research article

    Pain is one of the most important domains affecting health-related quality of life (HRQoL) in patients with psoriatic arthritis (PsA). Secukinumab has demonstrated rapid and sustained improvements in signs and...

    Authors: Iain B. McInnes, Philip J. Mease, Georg Schett, Bruce Kirkham, Vibeke Strand, Nicole Williams, Todd Fox, Luminita Pricop, Steffen M. Jugl and Kunal K. Gandhi

    Citation: Arthritis Research & Therapy 2018 20:113

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  15. Content type: Research article

    There is growing evidence that mast cells (MCs) play a role in knee osteoarthritis (OA). H1-antihistamines block H1-receptors of histamine, which is an important mediator of MCs. There is a lack of data on whethe...

    Authors: Ivan Shirinsky and Valery Shirinsky

    Citation: Arthritis Research & Therapy 2018 20:116

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  16. Content type: Research article

    Gout is a metabolic disease and is the most common form of inflammatory arthritis affecting men. However, the pathogenesis of gout is still uncertain, and novel biomarkers are needed for early prediction and d...

    Authors: Yannan Zhang, Huanzhen Zhang, Dong Chang, Fuchuan Guo, Hongzhi Pan and Yuexin Yang

    Citation: Arthritis Research & Therapy 2018 20:111

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  17. Content type: Research article

    Aerobic exercise in general and high-intensity interval training (HIIT) specifically is known to improve vascular function in a range of clinical conditions. HIIT in particular has demonstrated improvements in...

    Authors: A. Mitropoulos, A. Gumber, H. Crank, M. Akil and M. Klonizakis

    Citation: Arthritis Research & Therapy 2018 20:112

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  18. Content type: Research article

    Prior qualitative research on gout has focused primarily on barriers to disease management. Our objective was to use patients’ perspectives to construct an explanatory framework to understand how patients beco...

    Authors: Alyssa Howren, Susan M. Cox, Kam Shojania, Sharan K. Rai, Hyon K. Choi and Mary A. De Vera

    Citation: Arthritis Research & Therapy 2018 20:110

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  19. Content type: Research article

    The aim of this study is to examine the occurrence of comorbidities at the time of first diagnosis of gout compared with matched population controls, overall and by sex, as well as to examine the crude and age...

    Authors: Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Svärd, Lennart T. H. Jacobsson and Mats Dehlin

    Citation: Arthritis Research & Therapy 2018 20:108

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    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:206

  20. Content type: Research article

    The relationship between inflammation and blood pressure (BP) has been studied mainly in the general population. In this study, we examined the association between inflammation and BP across a broader range of...

    Authors: Zhi Yu, Seoyoung C. Kim, Kathleen Vanni, Jie Huang, Rishi Desai, Shawn N. Murphy, Daniel H. Solomon and Katherine P. Liao

    Citation: Arthritis Research & Therapy 2018 20:107

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  21. Content type: Research article

    The perceived bother of skin and joint-related manifestations of psoriatic disease may differ among patients, rheumatologists, and dermatologists. This study identified and compared the patient and dermatologi...

    Authors: M. Elaine Husni, Anthony Fernandez, Brett Hauber, Rakesh Singh, Joshua Posner, Jessie Sutphin and Arijit Ganguli

    Citation: Arthritis Research & Therapy 2018 20:102

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  22. Content type: Research article

    Febuxostat immediate release (IR), a xanthine oxidase inhibitor, is indicated for the management of hyperuricemia in patients with gout by lowering urate levels. An extended release (XR) formulation of febuxos...

    Authors: Lhanoo Gunawardhana, Michael A. Becker, Andrew Whelton, Barbara Hunt, Majin Castillo and Kenneth Saag

    Citation: Arthritis Research & Therapy 2018 20:99

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  23. Content type: Research article

    Meniscal calcification is considered to play a relevant role in the pathogenesis of osteoarthritis of the knee. Little is known about the biology of acetabular labral disease and its importance in hip patholog...

    Authors: Thelonius Hawellek, Jan Hubert, Sandra Hischke, Matthias Krause, Jessica Bertrand, Burkhard C. Schmidt, Andreas Kronz, Klaus Püschel, Wolfgang Rüther and Andreas Niemeier

    Citation: Arthritis Research & Therapy 2018 20:104

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  24. Content type: Research article

    Achieving the best possible health-related quality of life (HRQoL) for a patient is an important treatment goal in juvenile idiopathic arthritis (JIA). We investigated the 36-month trajectories of HRQoL in chi...

    Authors: Miriam Listing, Kirsten Mönkemöller, Ina Liedmann, Martina Niewerth, Claudia Sengler, Joachim Listing, Dirk Foell, Arnd Heiligenhaus, Ariane Klein, Gerd Horneff, Gerd Ganser, Johannes-Peter Haas, Jens Klotsche and Kirsten Minden

    Citation: Arthritis Research & Therapy 2018 20:106

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  25. Content type: Research article

    The term systemic juvenile idiopathic arthritis (sJIA) describes an autoinflammatory condition characterized by arthritis and severe systemic inflammation, which in later stages can transform into interleukin ...

    Authors: Boris Hügle, Anastasia Schippers, Nadine Fischer, Kim Ohl, Bernd Denecke, Fabio Ticconi, Bas Vastert, Ivan G. Costa, Johannes-Peter Haas and Klaus Tenbrock

    Citation: Arthritis Research & Therapy 2018 20:98

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  26. Content type: Research article

    Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with a complex genetic inheritance. Genome-wide association studies (GWAS) have significantly increased the number of significant loci...

    Authors: Antonio Julià, Francisco Javier López-Longo, José J. Pérez Venegas, Silvia Bonàs-Guarch, Àlex Olivé, José Luís Andreu, Mª. Ángeles Aguirre-Zamorano, Paloma Vela, Joan M. Nolla, José Luís Marenco de la Fuente, Antonio Zea, José María Pego-Reigosa, Mercedes Freire, Elvira Díez, Esther Rodríguez-Almaraz, Patricia Carreira…

    Citation: Arthritis Research & Therapy 2018 20:100

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  27. Content type: Research article

    Evidence is emerging that pain in rheumatoid arthritis (RA) exists without underlying inflammation. Our objective was to evaluate the prognostic value of pain classification at treatment initiation using the p...

    Authors: Signe Rifbjerg-Madsen, Anton Wulf Christensen, Mikael Boesen, Robin Christensen, Bente Danneskiold-Samsøe, Henning Bliddal, Lene Dreyer, Henning Locht and Kirstine Amris

    Citation: Arthritis Research & Therapy 2018 20:105

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  28. Content type: Research article

    Work disability remains a significant problem in ankylosing spondylitis (AS) and rheumatoid arthritis (RA), despite biological therapy. This study aimed to test the hypothesis that the prevalent symptom of fat...

    Authors: Katie L. Druce, Laraine Aikman, Maria Dilleen, Annie Burden, Piotr Szczypa and Neil Basu

    Citation: Arthritis Research & Therapy 2018 20:96

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  29. Content type: Research article

    In this study, we examined the effect of oxidative stress on cellular energy metabolism and pro-angiogenic/pro-inflammatory mechanisms of primary rheumatoid arthritis synovial fibroblast cells (RASFC) and huma...

    Authors: Emese Balogh, Douglas J. Veale, Trudy McGarry, Carl Orr, Zoltan Szekanecz, Chin-Teck Ng, Ursula Fearon and Monika Biniecka

    Citation: Arthritis Research & Therapy 2018 20:95

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  30. Content type: Research article

    Gout is associated with higher cardiovascular risk that increases with disease severity. The objective of this study was to explore the relationship between the extent of monosodium urate (MSU) crystal deposit...

    Authors: Tristan Pascart, Benoist Capon, Agathe Grandjean, Julie Legrand, Nasser Namane, Vincent Ducoulombier, Marguerite Motte, Marie Vandecandelaere, Hélène Luraschi, Catherine Godart, Eric Houvenagel, Laurène Norberciak and Jean-François Budzik

    Citation: Arthritis Research & Therapy 2018 20:97

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  31. Content type: Research article

    Systemic lupus erythematous (SLE) is a complex autoimmune disease with female predominance, particularly affecting those of childbearing age. We performed analysis of three genome-wide genotyping datasets of p...

    Authors: Huoru Zhang, Yan Zhang, Yong-Fei Wang, David Morris, Nattiya Hirankarn, Yujun Sheng, Jiangshan Shen, Hai-Feng Pan, Jing Yang, Sen Yang, Yong Cui, Dong-Qing Ye, Timothy J. Vyse, Xuejun Zhang, Yu Lung Lau and Wanling Yang

    Citation: Arthritis Research & Therapy 2018 20:92

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  32. Content type: Research article

    The aim was to develop prediction rules that may guide early treatment decisions based on baseline clinical predictors of long-term unfavorable outcome in juvenile idiopathic arthritis (JIA).

    Authors: Veronika Rypdal, Ellen Dalen Arnstad, Kristiina Aalto, Lillemor Berntson, Maria Ekelund, Anders Fasth, Mia Glerup, Troels Herlin, Susan Nielsen, Suvi Peltoniemi, Marek Zak, Marite Rygg, Martin Rypdal and Ellen Nordal

    Citation: Arthritis Research & Therapy 2018 20:91

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  33. Content type: Research article

    Within established rheumatoid arthritis (RA), stress can have pro-inflammatory effects by activating the immune system via the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. It is unknow...

    Authors: Aleid C. Boer, Robin M. ten Brinck, Andrea W. M. Evers and Annette H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2018 20:93

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  34. Content type: Research article

    Many gout comorbidities (e.g., hypertension) are correlated with serum urate. In this investigation, we identified risk factors (e.g., systolic blood pressure [SBP]), that (1) are associated with incident gout...

    Authors: Mengying Sun, Ana I. Vazquez, Richard J. Reynolds, Jasvinder A. Singh, Mathew Reeves, Tony R. Merriman, Angelo L. Gaffo and Gustavo de los Campos

    Citation: Arthritis Research & Therapy 2018 20:90

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  35. Content type: Research article

    Anti-citrullinated protein antibodies (ACPA) are associated with more severe joint erosions in rheumatoid arthritis (RA), but the underlying mechanism is unclear. Recent in vitro and murine studies indicate th...

    Authors: R. M. ten Brinck, R. E. M. Toes and A. H. M. van der Helm–van Mil

    Citation: Arthritis Research & Therapy 2018 20:89

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  36. Content type: Research article

    The presence of autoantibodies is considered an important characteristic of rheumatoid arthritis (RA); therefore, both anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF) are included in the...

    Authors: Debbie M. Boeters, Leendert A. Trouw, Annette H. M. van der Helm-van Mil and Hanna W. van Steenbergen

    Citation: Arthritis Research & Therapy 2018 20:94

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  37. Content type: Research article

    ADAMTS aggrecanases play a major role in cartilage degeneration during degenerative and inflammatory arthritis. The cartilage-specific secreted protein Upper zone of growth plate and cartilage matrix associate...

    Authors: Fritz Seuffert, Daniela Weidner, Wolfgang Baum, Georg Schett and Michael Stock

    Citation: Arthritis Research & Therapy 2018 20:88

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  38. Content type: Research article

    This study estimated the extent and predictors of primary nonadherence (i.e., prescriptions made by physicians but not initiated by patients) to methotrexate and to biologics or tofacitinib in rheumatoid arthr...

    Authors: Hong J. Kan, Kirill Dyagilev, Peter Schulam, Suchi Saria, Hadi Kharrazi, David Bodycombe, Charles T. Molta and Jeffrey R. Curtis

    Citation: Arthritis Research & Therapy 2018 20:79

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  39. Content type: Research article

    Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study was undertaken to evaluate the potential of targe...

    Authors: Suzanne Cole, Alice Walsh, Xuefeng Yin, Mihir D. Wechalekar, Malcolm D. Smith, Susanna M. Proudman, Douglas J. Veale, Ursula Fearon, Costantino Pitzalis, Frances Humby, Michele Bombardieri, Amy Axel, Homer Adams III, Christopher Chiu, Michael Sharp, John Alvarez…

    Citation: Arthritis Research & Therapy 2018 20:85

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  40. Content type: Research article

    Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likel...

    Authors: Charlotte H. Hulme, Emma L. Wilson, Heidi R. Fuller, Sally Roberts, James B. Richardson, Pete Gallacher, Mandy J. Peffers, Sally L. Shirran, Catherine H. Botting and Karina T. Wright

    Citation: Arthritis Research & Therapy 2018 20:87

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  41. Content type: Research article

    Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanism...

    Authors: Emil Rydell, Kristina Forslind, Jan-Åke Nilsson, Lennart T. H. Jacobsson and Carl Turesson

    Citation: Arthritis Research & Therapy 2018 20:82

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  42. Content type: Research article

    Osteoclast-mediated bone erosion is a central feature of rheumatoid arthritis (RA). Immune complexes, present in a large percentage of patients, bind to Fcγ receptors (FcγRs), thereby modulating the activity o...

    Authors: Irene Di Ceglie, Giuliana Ascone, Niels A. J. Cremers, Annet W. Sloetjes, Birgitte Walgreen, Thomas Vogl, Johannes Roth, J. Sjef Verbeek, Fons A. J. van de Loo, Marije I. Koenders, Peter M. van der Kraan, Arjen B. Blom, Martijn H. J. van den Bosch and Peter L. E. M. van Lent

    Citation: Arthritis Research & Therapy 2018 20:80

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  43. Content type: Research article

    Myofibroblasts contribute to fibrosis through the overproduction of extracellular matrix (ECM) proteins, primarily type I collagen (COL-1) and fibronectin (FN), a process which is mediated in systemic sclerosi...

    Authors: Maurizio Cutolo, Barbara Ruaro, Paola Montagna, Renata Brizzolara, Emanuela Stratta, Amelia Chiara Trombetta, Stefano Scabini, Pier Paolo Tavilla, Aurora Parodi, Claudio Corallo, Nicola Giordano, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith and Stefano Soldano

    Citation: Arthritis Research & Therapy 2018 20:77

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  44. Content type: Research article

    Rheumatoid arthritis (RA) preferentially affects women, with the peak incidence coinciding with estrogen decrease in menopause. Estrogen (E2) may therefore have intrinsic immune-regulatory properties that vani...

    Authors: Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, René Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga-Lill Mårtensson, Falk Nimmerjahn, Gerhard Krönke, Hans U. Scherer, Helena Forsblad-d’Elia and Georg Schett

    Citation: Arthritis Research & Therapy 2018 20:84

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  45. Content type: Research article

    Polymyositis (PM) and dermatomyositis (DM) are severe chronic autoimmune diseases, characterized by muscle fatigue and low muscle endurance. Conventional treatment includes high doses of glucocorticoids and im...

    Authors: Joan Raouf, Helena Idborg, Petter Englund, Helene Alexanderson, Maryam Dastmalchi, Per-Johan Jakobsson, Ingrid E. Lundberg and Marina Korotkova

    Citation: Arthritis Research & Therapy 2018 20:83

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  46. Content type: Research article

    The uric acid (UA) level in patients with gout is a key factor in disease management and is typically measured in the laboratory using plasma samples obtained after venous puncture. This study aimed to assess ...

    Authors: Stéphanie Fabre, Pierre Clerson, Jean-Marie Launay, Jean-François Gautier, Tiphaine Vidal-Trecan, Jean-Pierre Riveline, Adam Platt, Anna Abrahamsson, Jeffrey N. Miner, Glen Hughes, Pascal Richette and Thomas Bardin

    Citation: Arthritis Research & Therapy 2018 20:78

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