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  1. Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies in addition to IgG/IgM anti-cardiolipin antibodies (aCL)...

    Authors: Tingting Liu, Jieyu Gu, Liyan Wan, Qiongyi Hu, Jialin Teng, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Yue Sun, Jinfeng Zhou, Gary L. Norman, Xuefeng Wang, Chengde Yang and Hui Shi

    Citation: Arthritis Research & Therapy 2020 22:33

    Content type: Research article

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  2. Systemic sclerosis (SSc) is a severe and highly heterogeneous disease. The modified Rodnan skin score (mRSS) is a widely used tool for the assessment of the extent and degree of skin thickness. This study aime...

    Authors: Emmanuel Ledoult, David Launay, Hélène Béhal, Luc Mouthon, Grégory Pugnet, Jean-Christophe Lega, Christian Agard, Yannick Allanore, Patrick Jego, Anne-Laure Fauchais, Jean-Robert Harlé, Sabine Berthier, Achille Aouba, Arsène Mekinian, Elisabeth Diot, Marie-Elise Truchetet…

    Citation: Arthritis Research & Therapy 2020 22:30

    Content type: Research article

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  3. Synovitis is implicated in the severity and progression of pain and structural pathology of osteoarthritis (OA). Increases in inflammatory or immune cell subpopulations including macrophages and lymphocytes ha...

    Authors: Cindy C. Shu, Sanaa Zaki, Varshini Ravi, Antonella Schiavinato, Margaret M. Smith and Christopher B. Little

    Citation: Arthritis Research & Therapy 2020 22:29

    Content type: Research article

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  4. Colchicine is a widely used drug to treat inflammatory diseases. Due to its long historical use in medicine, controlled clinical trials have been small and there remains some caution with the use of this drug ...

    Authors: Sarah Stewart, Kevin Chih Kai Yang, Kate Atkins, Nicola Dalbeth and Philip C. Robinson

    Citation: Arthritis Research & Therapy 2020 22:28

    Content type: Research article

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  5. The aim of this study was to evaluate the association between periodontal parameters related with the periodontal disease severity and the presence and levels of anti-citrullinated protein antibodies (ACPAs) i...

    Authors: Jerián González-Febles, Beatriz Rodríguez-Lozano, Carlos Sánchez-Piedra, Jorge Garnier-Rodríguez, Sagrario Bustabad, Martina Hernández-González, Enrique González-Dávila, Mariano Sanz and Federico Díaz-González

    Citation: Arthritis Research & Therapy 2020 22:27

    Content type: Research article

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  6. C-reactive protein (CRP) is often normal in patients with psoriatic disease. Herein, we aimed to define markers of systemic inflammation in patients with monomorphic and polymorphic psoriatic skin, entheseal, ...

    Authors: Maria V. Sokolova, David Simon, Kemal Nas, Mario M. Zaiss, Yubin Luo, Yi Zhao, Jürgen Rech and Georg Schett

    Citation: Arthritis Research & Therapy 2020 22:26

    Content type: Research article

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  7. Aberrant activation and dysregulation of immune system is a common feature of many forms of inflammatory arthritis. Since their identification as a distinctive population of leukocytes, innate lymphoid cells (...

    Authors: Weiting Fang, Yuanyuan Zhang and Zhu Chen

    Citation: Arthritis Research & Therapy 2020 22:25

    Content type: Review

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  8. 14-3-3η is an intracellular protein also detected in the serum and synovial fluid of patients with rheumatoid arthritis (RA). It is closely related to disease activity and anti-cyclic citrullinated peptide ant...

    Authors: Gulzhan Trimova, Kaoru Yamagata, Shigeru Iwata, Shintaro Hirata, Tong Zhang, Fumi Uemura, Minoru Satoh, Norma Biln, Shingo Nakayamada, Walter P. Maksymowych and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2020 22:24

    Content type: Research article

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  9. Citation: Arthritis Research & Therapy 2020 22:22

    Content type: Letter

    Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:179

    The Letter to this article has been published in Arthritis Research & Therapy 2020 22:23

    The Letter to this article has been published in Arthritis Research & Therapy 2020 22:21

  10. Interstitial lung disease (ILD) is a serious complication of connective tissue diseases (CTDs). Although immune dysregulation triggered by genetic and environmental factors is thought to provoke inflammation a...

    Authors: Hiroshi Takei, Hidekata Yasuoka, Keiko Yoshimoto and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2020 22:20

    Content type: Research article

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  11. Magnetic resonance imaging (MRI) and ultrasonography (US) are more sensitive than clinical evaluation in assessing inflammation in rheumatoid arthritis (RA). Data is scarce regarding potential link between pat...

    Authors: Dorota Kuettel, Daniel Glinatsi, Mikkel Østergaard, Lene Terslev, Jette Primdahl, Sören Möller, Andreas Pedersen, Randi Petersen, Ulrich Weber and Kim Hørslev-Petersen

    Citation: Arthritis Research & Therapy 2020 22:19

    Content type: Research article

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  12. Psoriatic arthritis (PsA) is an immune-mediated, clinically heterogeneous disease characterized by arthritis, enthesitis, dactylitis, spondylitis, and psoriasis of the skin and nails. Persistent articular infl...

    Authors: Désirée van der Heijde, Dafna D. Gladman, Arthur Kavanaugh and Philip J. Mease

    Citation: Arthritis Research & Therapy 2020 22:18

    Content type: Review

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  13. Citation: Arthritis Research & Therapy 2020 22:17

    Content type: Letter

    Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:121

    The Letter to this article has been published in Arthritis Research & Therapy 2020 22:55

  14. Proper blocking of toll-like receptor (TLR) activation during disease progression has been reported to have inhibitory effect on the pathogenesis of rheumatoid arthritis (RA). We tested whether the TLR4 inhibi...

    Authors: Snigdha Samarpita, Joo Young Kim, Mahaboob Khan Rasool and Kyoung Soo Kim

    Citation: Arthritis Research & Therapy 2020 22:16

    Content type: Research article

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  15. There are limited data regarding efficacy of abatacept treatment for rheumatoid arthritis (RA) outside clinical trials. Quality registers have been useful for observational studies on tumor necrosis factor inh...

    Authors: Giovanni Cagnotto, Minna Willim, Jan-Åke Nilsson, Michele Compagno, Lennart T. H. Jacobsson, Saedis Saevarsdottir and Carl Turesson

    Citation: Arthritis Research & Therapy 2020 22:15

    Content type: Research article

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  16. The long-term safety was assessed in patients with psoriatic arthritis who were treated with ixekizumab in three clinical trials (SPIRIT-P1/-P2/-P3).

    Authors: Bernard Combe, Proton Rahman, Hideto Kameda, Juan D. Cañete, Gaia Gallo, Noah Agada, Wen Xu and Mark C. Genovese

    Citation: Arthritis Research & Therapy 2020 22:14

    Content type: Research article

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  17. Human cytomegalovirus (HCMV) seropositivity has been associated with higher inflammation during rheumatoid arthritis (RA). However, no data are available on the impact of HCMV seropositivity on bone erosion pr...

    Authors: B. Rauwel, Y. Degboé, D. Nigon, J.-F. Boyer, F. Abravanel, J. Izopet, B. Combe, A. Ruyssen-Witrand, A. Constantin, A. Cantagrel and J.-L. Davignon

    Citation: Arthritis Research & Therapy 2020 22:13

    Content type: Research article

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  18. We examined the association of three common chronic conditions (obesity, diabetes mellitus [DM], and cardiovascular disease [CVD]) with transitions among states of hip osteoarthritis (HOA).

    Authors: Carolina Alvarez, Rebecca J. Cleveland, Todd A. Schwartz, Jordan B. Renner, Louise B. Murphy, Joanne M. Jordan, Leigh F. Callahan, Yvonne M. Golightly and Amanda E. Nelson

    Citation: Arthritis Research & Therapy 2020 22:12

    Content type: Research article

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  19. Arthralgia and MRI-detected subclinical inflammation can precede the development of clinically evident rheumatoid arthritis (RA). However, part of the patients presenting with clinically suspect arthralgia (CS...

    Authors: Robin M. ten Brinck, Debbie M. Boeters, Hanna W. van Steenbergen and Annette H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2020 22:11

    Content type: Research article

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  20. Validated clinical prediction models to identify children with poor prognosis at the time of juvenile idiopathic arthritis (JIA) diagnosis would be very helpful for tailoring treatments, and avoiding under- or...

    Authors: Andrew Henrey, Veronika Rypdal, Martin Rypdal, Thomas Loughin, Ellen Nordal and Jaime Guzman

    Citation: Arthritis Research & Therapy 2020 22:10

    Content type: Research article

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  21. Endocannabinoids are showing great promise as effective mediators for controlling joint inflammation and pain. One strategy that could be harnessed to promote endogenous cannabinoid function is to inhibit the ...

    Authors: Holly T. Philpott and Jason J. McDougall

    Citation: Arthritis Research & Therapy 2020 22:9

    Content type: Research article

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  22. The utility of generic health-related quality of life (HRQoL) questionnaires in patients with systemic lupus erythematosus (SLE) is uncertain. We compared the performance of generic (SF36) and specific (SLEQOL...

    Authors: Worawit Louthrenoo, Nuntana Kasitanon, Eric Morand and Rangi Kandane-Rathnayake

    Citation: Arthritis Research & Therapy 2020 22:8

    Content type: Research article

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  23. To explore the clinical patterns of patients with IgG4-related disease (IgG4-RD) based on laboratory tests and the number of organs involved.

    Authors: Jieqiong Li, Yu Peng, Yuelun Zhang, Panpan Zhang, Zheng Liu, Hui Lu, Linyi Peng, Liang Zhu, Huadan Xue, Yan Zhao, Xiaofeng Zeng, Yunyun Fei and Wen Zhang

    Citation: Arthritis Research & Therapy 2020 22:7

    Content type: Research article

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  24. Following publication of the original article [1], it was brought to our attention that the AOSD Consensus Group was incorrectly tagged and therefore not searchable. The publishers apologize for this error.

    Authors: Serena Colafrancesco, Maria Manara, Alessandra Bortoluzzi, Teodora Serban, Gerolamo Bianchi, Luca Cantarini, Francesco Ciccia, Lorenzo Dagna, Marcello Govoni, Carlomaurizio Montecucco, Roberta Priori, Angelo Ravelli, Paolo Sfriso and Luigi Sinigaglia

    Citation: Arthritis Research & Therapy 2020 22:6

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2019 21:275

  25. To describe successful therapeutic strategies in statin-induced anti-HMGCR myopathy.

    Authors: Alain Meyer, Yves Troyanov, Julie Drouin, Geneviève Oligny-Longpré, Océane Landon-Cardinal, Sabrina Hoa, Baptiste Hervier, Josiane Bourré-Tessier, Anne-Marie Mansour, Sara Hussein, Vincent Morin, Eric Rich, Jean-Richard Goulet, Sandra Chartrand, Marie Hudson, Jessica Nehme…

    Citation: Arthritis Research & Therapy 2020 22:5

    Content type: Research article

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  26. Few studies have investigated patients’ own treatment goals in rheumatoid arthritis (RA). The objective of this real-world, cross-sectional study of US patients with RA was to identify factors that patients be...

    Authors: Kelly Gavigan, W. Benjamin Nowell, Mylene S. Serna, Jeffrey L. Stark, Mohamed Yassine and Jeffrey R. Curtis

    Citation: Arthritis Research & Therapy 2020 22:4

    Content type: Research article

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  27. We aimed to develop a patient-reported outcome measure, in accordance with the US Food and Drug Administration guidance, to capture the impact of systemic sclerosis-related digital ulcers (SSc-DUs) on hand fun...

    Authors: Luc Mouthon, Serge Poiraudeau, Margaret Vernon, Kelly Papadakis, Loïc Perchenet and Dinesh Khanna

    Citation: Arthritis Research & Therapy 2020 22:3

    Content type: Research article

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  28. In the context of the scarcity of biomarkers for knee osteoarthritis (OA), we examined the associations of prevalent and incident OA with the expression levels of serum miRNAs in subjects with and without OA.

    Authors: Jean-Charles Rousseau, Marjorie Millet, Martine Croset, Elisabeth Sornay-Rendu, Olivier Borel and Roland Chapurlat

    Citation: Arthritis Research & Therapy 2020 22:2

    Content type: Research article

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  29. Early differentiation between different types of inflammatory arthritis and subsequent initiation of modern treatments can improve patient outcomes by reducing disease activity and preventing joint damage. Rou...

    Authors: Gurjit S. Kaeley, Catherine Bakewell and Atul Deodhar

    Citation: Arthritis Research & Therapy 2020 22:1

    Content type: Review

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  30. Systemic sclerosis (SSc) is a rare disease with studies limited by small sample sizes. Electronic health records (EHRs) represent a powerful tool to study patients with rare diseases such as SSc, but validated...

    Authors: Lia Jamian, Lee Wheless, Leslie J. Crofford and April Barnado

    Citation: Arthritis Research & Therapy 2019 21:305

    Content type: Research article

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  31. Large vessel vasculitis (LVV) is a type of vasculitis characterized by granulomatous inflammation of medium- and large-sized arteries. Clinical assessment of acute phase reactants has been conventionally used ...

    Authors: Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto, Noriyasu Seki, Hideto Tsujimoto, Kenji Chiba and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2019 21:304

    Content type: Research article

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  32. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of various autoantibodies. This disease causes disabling neuropsychiatric symptoms even in the absence of apparent in...

    Authors: Atsushi Nomura, Daisuke Noto, Goh Murayama, Asako Chiba and Sachiko Miyake

    Citation: Arthritis Research & Therapy 2019 21:303

    Content type: Research article

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  33. Systemic sclerosis (SSc), a life-threatening autoimmune disease characterized by vasculopathy. Numerous SSc patients demonstrate gastrointestinal (GI) involvement but the delicate GI bleeding risk remains spar...

    Authors: Yi-Ting Lin, Yun-Shiuan Chuang, Jiunn-Wei Wang and Ping-Hsun Wu

    Citation: Arthritis Research & Therapy 2019 21:301

    Content type: Research article

    Published on:

  34. Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in the elderly. Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLR...

    Authors: Zhuming Chen, Huan Zhong, Jinsong Wei, Sien Lin, Zhixian Zong, Fan Gong, Xinqia Huang, Jinhui Sun, Peng Li, Hao Lin, Bo Wei and Jiaqi Chu

    Citation: Arthritis Research & Therapy 2019 21:300

    Content type: Research article

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  35. To determine the frequency and clinical characteristics of systemic sclerosis-related digital ulcers, and associated direct health care costs, quality of life, and survival.

    Authors: Kathleen Morrisroe, Wendy Stevens, Joanne Sahhar, Gene-Siew Ngian, Nava Ferdowsi, Catherine L. Hill, Janet Roddy, Jennifer Walker, Susanna Proudman and Mandana Nikpour

    Citation: Arthritis Research & Therapy 2019 21:299

    Content type: Research article

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  36. Although disease in a majority of rheumatoid arthritis (RA) patients is often initially limited to one or a few joints, currently approved medications including anti-tumor necrosis factor-α antibody (α-TNF) ar...

    Authors: Kiyomitsu Katsumata, Jun Ishihara, Kazuto Fukunaga, Ako Ishihara, Eiji Yuba, Erica Budina and Jeffrey A. Hubbell

    Citation: Arthritis Research & Therapy 2019 21:298

    Content type: Research article

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  37. Angiogenesis is an early event in the pathogenesis of both psoriatic arthritis (PsA) and rheumatoid arthritis (RA); however, there are striking differences in blood vessel morphology and activation between the...

    Authors: S. Fromm, C. C. Cunningham, M. R. Dunne, D. J. Veale, U. Fearon and S. M. Wade

    Citation: Arthritis Research & Therapy 2019 21:297

    Content type: Research article

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  38. CD4+ T cells play critical roles in the pathogenesis of IgG4-related disease (IgG4-RD). The aim of this study was to investigate the TCR repertoire of peripheral blood CD4+ T cells in IgG4-RD.

    Authors: Liwen Wang, Panpan Zhang, Jieqiong Li, Hui Lu, Linyi Peng, Jing Ling, Xuan Zhang, Xiaofeng Zeng, Yan Zhao and Wen Zhang

    Citation: Arthritis Research & Therapy 2019 21:295

    Content type: Research article

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  39. Treatment of patients with Sjögren’s syndrome (SjS) is a clinical challenge with high unmet needs. Gene expression profiling and integrative network-based approaches to complex disease can offer an insight on ...

    Authors: Hong Ki Min, Su-Jin Moon, Kyung-Su Park and Ki-Jo Kim

    Citation: Arthritis Research & Therapy 2019 21:294

    Content type: Research article

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  40. Sporadic inclusion body myositis (sIBM) is clinically characterised by progressive proximal and distal muscle weakness and impaired physical function while skeletal muscle tissue displays abnormal cellular inf...

    Authors: Kasper Yde Jensen, Mikkel Jacobsen, Henrik Daa Schrøder, Per Aagaard, Jakob Lindberg Nielsen, Anders Nørkær Jørgensen, Eleanor Boyle, Rune Dueholm Bech, Sofie Rosmark, Louise Pyndt Diederichsen and Ulrik Frandsen

    Citation: Arthritis Research & Therapy 2019 21:293

    Content type: Research article

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  41. To examine the ability of takinib, a selective transforming growth factor beta-activated kinase 1 (TAK1) inhibitor, to reduce the severity of murine type II collagen-induced arthritis (CIA), and to affect func...

    Authors: Scott A. Scarneo, Liesl S. Eibschutz, Phillip J. Bendele, Kelly W. Yang, Juliane Totzke, Philip Hughes, David A. Fox and Timothy A. J. Haystead

    Citation: Arthritis Research & Therapy 2019 21:292

    Content type: Research article

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  42. Systemic sclerosis is a multisystem inflammatory and vascular lesion leading to extensive tissue fibrosis. A reversible S-adenosyl-l-homocysteine hydrolase (SAHH) inhibitor, DZ2002, modulates the pathologic pr...

    Authors: Zongwang Zhang, Yanwei Wu, Bing Wu, Qing Qi, Heng Li, Huimin Lu, Chen Fan, Chunlan Feng, Jianping Zuo, Lili Niu and Wei Tang

    Citation: Arthritis Research & Therapy 2019 21:290

    Content type: Research article

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  43. The prevalence of osteoarthritis (OA) increases with obesity, with up to two thirds of the elderly obese population affected by OA of the knee. The metabolic syndrome (MetS), frequently associated with central...

    Authors: Bruce M. Dickson, Anke J. Roelofs, Justin J. Rochford, Heather M. Wilson and Cosimo De Bari

    Citation: Arthritis Research & Therapy 2019 21:289

    Content type: Review

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  44. Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well ...

    Authors: Mikael Brink, Anders Lundquist, Andrey Alexeyenko, Kristina Lejon and Solbritt Rantapää-Dahlqvist

    Citation: Arthritis Research & Therapy 2019 21:288

    Content type: Research article

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