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  1. In previous clinical trials, patients with active rheumatoid arthritis (RA) treated with upadacitinib (UPA) have improved patient-reported outcomes (PROs). This post hoc analysis of SELECT-CHOICE, a phase 3 cl...

    Authors: Martin Bergman, Namita Tundia, Naomi Martin, Jessica L. Suboticki, Jayeshkumar Patel, Debbie Goldschmidt, Yan Song and Grace C. Wright
    Citation: Arthritis Research & Therapy 2022 24:155
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:248

  2. Axial spondyloarthritis (axSpA) is a common chronic inflammatory disease, associated with extracellular matrix (ECM) remodeling of the cartilage, bone, and connective tissues. The primary symptom of axSpA is b...

    Authors: Helena Port, Signe Holm Nielsen, Sofie Falkenløve Madsen, Anne-Christine Bay-Jensen, Morten Karsdal, Sengül Seven, Inge Juul Sørensen, Lone Morsel-Carlsen, Mikkel Østergaard and Susanne Juhl Pedersen
    Citation: Arthritis Research & Therapy 2022 24:152
    Content type: Research Published on:

  3. To estimate associations between fine particulate matter (PM2.5) and ozone and the onset of systemic autoimmune rheumatic diseases (SARDs).

    Authors: Naizhuo Zhao, Audrey Smargiassi, Sonia Jean, Philippe Gamache, Elhadji-Anassour Laouan-Sidi, Hong Chen, Mark S. Goldberg and Sasha Bernatsky
    Citation: Arthritis Research & Therapy 2022 24:151
    Content type: Research article Published on:

  4. Healthcare quality for systemic lupus erythematosus (SLE) is a modifiable target for improving patient outcomes. We aimed to assess the quality of care processes in different clinic settings, comparing a subsp...

    Authors: Sidha Sreedharan, Ning Li, Geoff Littlejohn, Russell Buchanan, Mandana Nikpour, Eric Morand, Alberta Hoi and Vera Golder
    Citation: Arthritis Research & Therapy 2022 24:150
    Content type: Research article Published on:

  5. Long-term patterns of serum uric acid (SUA) and their association with the risk of myocardial infarction (MI) and mortality are poorly characterized as prior studies measured SUA at a single time point. This s...

    Authors: Xue Tian, Yingting Zuo, Shuohua Chen, Shouling Wu, Anxin Wang and Yanxia Luo
    Citation: Arthritis Research & Therapy 2022 24:149
    Content type: Research article Published on:

  6. Calpains are a family of calcium-dependent thiol proteases that participate in a wide variety of biological activities. In our recent study, calpain is increased in the sera of scleroderma or systemic sclerosi...

    Authors: Li Zhang, Dong Zheng, Yuemei Yan, Yong Yu, Ruizhen Chen, Zheng Li, Peter A. Greer, Tianqing Peng and Qiang Wang
    Citation: Arthritis Research & Therapy 2022 24:148
    Content type: Research article Published on:

  7. The aetiology of ANCA-associated vasculitis (AAV) and triggers of relapse are poorly understood. Vitamin D (vitD) is an important immunomodulator, potentially responsible for the observed latitudinal differenc...

    Authors: Jennifer Scott, Enock Havyarimana, Albert Navarro-Gallinad, Arthur White, Jason Wyse, Jos van Geffen, Michiel van Weele, Antonia Buettner, Tamara Wanigasekera, Cathal Walsh, Louis Aslett, John D. Kelleher, Julie Power, James Ng, Declan O’Sullivan, Lucy Hederman…
    Citation: Arthritis Research & Therapy 2022 24:147
    Content type: Research article Published on:

  8. Echocardiography (2DE) is integral for screening and longitudinal evaluation of pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). In the present study, we sought to establish the reliability, ...

    Authors: Monica Mukherjee, Valentina Mercurio, Aparna Balasubramanian, Ami A. Shah, Steven Hsu, Catherine E. Simpson, Rachel Damico, Todd M. Kolb, Paul M. Hassoun and Stephen C. Mathai
    Citation: Arthritis Research & Therapy 2022 24:146
    Content type: Research Published on:

  9. Osteoarthritis (OA) is one of the costliest and most disabling forms of arthritis, and it poses a major public health burden; however, its detailed etiology, pathophysiology, and metabolism remain unclear. The...

    Authors: Eiji Sasaki, Hiroyuki Yamamoto, Toru Asari, Rira Matsuta, Seiya Ota, Yuka Kimura, Shizuka Sasaki, Kyota Ishibashi, Yuji Yamamoto, Kenjiro Kami, Masataka Ando, Eiichi Tsuda and Yasuyuki Ishibashi
    Citation: Arthritis Research & Therapy 2022 24:145
    Content type: Research article Published on:

  10. While low-dose oral glucocorticoids (GCs) are recommended in the management of early arthritis, their impact on mortality is unclear. The aim of this study is to evaluate the effect of GCs on mortality in pati...

    Authors: Garifallia Sakellariou, Carlo Alberto Scirè, Federica Rumi, Greta Carrara, Anna Zanetti, Carlo Cerra, Simona Migliazza, Serena Bugatti and Carlomaurizio Montecucco
    Citation: Arthritis Research & Therapy 2022 24:144
    Content type: Research article Published on:

  11. Prognostic biomarkers of treatment response to distinct biologic disease-modifying anti-rheumatic drugs (b-DMARDs) are still lacking within the management of rheumatoid arthritis (RA).

    Authors: Elisa Gremese, Barbara Tolusso, Luca Petricca, Clara Di Mario, Maria Rita Gigante, Gianfranco Ferraccioli and Stefano Alivernini
    Citation: Arthritis Research & Therapy 2022 24:143
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:177

  12. Systemic lupus erythematosus (SLE) can cause placental dysfunctions, which may result in pregnancy complications. Long noncoding RNAs (lncRNAs) are actively involved in the regulation of immune responses durin...

    Authors: Hui-hui Li, Lin-tao Sai, Yuan Liu, Colman I. Freel, Kai Wang, Chi Zhou, Jing Zheng, Qiang Shu and Ying-jie Zhao
    Citation: Arthritis Research & Therapy 2022 24:142
    Content type: Research article Published on:

  14. Antiphospholipid syndrome (APS) is an autoimmune disease characterized by persistent antiphospholipid antibodies (aPLs) positivity with a wide manifestation spectrum. A risk stratification is needed for manage...

    Authors: Wanting Qi, Jiuliang Zhao, Can Huang, Nan Jiang, Jing Li, Chanyuan Wu, Shangzhu Zhang, Chaojun Hu, Dong Xu, Qian Wang, Mengtao Li, Xinping Tian, Yan Zhao and Xiaofeng Zeng
    Citation: Arthritis Research & Therapy 2022 24:140
    Content type: Research Published on:

  15. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a large production of autoantibodies and deficient clearance of cellular waste. The disease typically oscillates between episodes of...

    Authors: Jesper Karlsson, Jonas Wetterö, Maria Weiner, Johan Rönnelid, Rafael Fernandez-Botran and Christopher Sjöwall
    Citation: Arthritis Research & Therapy 2022 24:139
    Content type: Research article Published on:

  16. Rheumatic heart disease (RHD) is a critical public health issue worldwide, and its epidemiological patterns have changed over the decades. This article aimed to estimate the global trends of RHD, and attributa...

    Authors: Zejin Ou, Danfeng Yu, Yuanhao Liang, Jinhua Wu, Huan He, Yongzhi Li, Wenqiao He, Yuhan Gao, Fei Wu and Qing Chen
    Citation: Arthritis Research & Therapy 2022 24:138
    Content type: Research article Published on:

  17. Post-traumatic osteoarthritis (PTOA) does not currently have clinical prognostic biomarkers or disease-modifying drugs, though promising candidates such as dexamethasone (Dex) exist. Many challenges in studyin...

    Authors: Rebecca Mae Black, Lisa L. Flaman, Karin Lindblom, Susan Chubinskaya, Alan J. Grodzinsky and Patrik Önnerfjord
    Citation: Arthritis Research & Therapy 2022 24:137
    Content type: Research Published on:

  18. To evaluate the efficacy and safety of HLX01, a rituximab biosimilar, as combination therapy with methotrexate in Chinese patients with active rheumatoid arthritis who had inadequate responses to methotrexate.

    Authors: Xiaofeng Zeng, Ju Liu, Xiumei Liu, Lijun Wu, Yi Liu, Xiangping Liao, Huaxiang Liu, Jiankang Hu, Xin Lu, Linjie Chen, Jian Xu, Zhenyu Jiang, Fu-ai Lu, Huaxiang Wu, Ying Li, Qingyu Wang…
    Citation: Arthritis Research & Therapy 2022 24:136
    Content type: Research article Published on:

  19. Infection is one of the primary concerns during treatment for rheumatoid arthritis (RA) in elderly patients. However, infection risk of patients with RA receiving targeted therapy (TT) including biological dis...

    Authors: Ryoko Sakai, Eiichi Tanaka, Masako Majima and Masayoshi Harigai
    Citation: Arthritis Research & Therapy 2022 24:135
    Content type: Research article Published on:

  20. Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). However, the precise mechanisms by which MTX stalls RA progression and alleviates the ensuing disease effects remain unknown...

    Authors: Jumpei Shoda, Shigeru Tanaka, Keishi Etori, Koto Hattori, Tadamichi Kasuya, Kei Ikeda, Yuko Maezawa, Akira Suto, Kotaro Suzuki, Junichi Nakamura, Yoshiro Maezawa, Minoru Takemoto, Christer Betsholtz, Koutaro Yokote, Seiji Ohtori and Hiroshi Nakajima
    Citation: Arthritis Research & Therapy 2022 24:134
    Content type: Research Published on:

  21. Subcutaneous tocilizumab (TCZ SC) is approved globally for giant cell arteritis (GCA). This phase Ib study investigated the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of intravenous (...

    Authors: Christophe Schmitt, Laura Brockwell, Mylène Giraudon, Mauro Zucchetto, Lisa Christ, Bettina Bannert, Thomas Daikeler and Peter M. Villiger
    Citation: Arthritis Research & Therapy 2022 24:133
    Content type: Research Published on:

  22. Rituximab is used for the treatment of active rheumatoid arthritis. In the present study, we examined the long-term flare risk and safety of reduced doses of rituximab.

    Authors: Antonios Bertsias, Nestor Avgoustidis, Ioannis Papalopoulos, Argyro Repa, Nikolaos Kougkas, Eleni Kalogiannaki, Georgios Bertsias, Irini Flouri and Prodromos Sidiropoulos
    Citation: Arthritis Research & Therapy 2022 24:132
    Content type: Research article Published on:

  23. To analyse the subsequent clinical course of patients with rheumatoid arthritis (RA) who either continued or discontinued biologic agents after hospitalization for infections.

    Authors: Yusuke Kashiwado, Chikako Kiyohara, Yasutaka Kimoto, Shuji Nagano, Takuya Sawabe, Kensuke Oryoji, Shinichi Mizuki, Hiroaki Nishizaka, Seiji Yoshizawa, Shigeru Yoshizawa, Tomomi Tsuru, Yasushi Inoue, Naoyasu Ueda, Shun-ichiro Ota, Yasuo Suenaga, Tomoya Miyamura…
    Citation: Arthritis Research & Therapy 2022 24:131
    Content type: Research article Published on:

  24. We report results from a phase II randomised placebo-controlled trial assessing zibotentan, a highly selective endothelin receptor antagonist (ERA), in chronic kidney disease (CKD) secondary to systemic sclero...

    Authors: Edward P. Stern, Lauren V. Host, Ivy Wanjiku, K. Jane Escott, Peter S. Gilmour, Rachel Ochiel, Robert Unwin, Aine Burns, Voon H. Ong, Helen Cadiou, Aidan G. O’Keeffe and Christopher P. Denton
    Citation: Arthritis Research & Therapy 2022 24:130
    Content type: Comment Published on:

  25. Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure between OA and KBD patients.

    Authors: Yujie Ning, Minhan Hu, Yi Gong, Ruitian Huang, Ke Xu, Sijie Chen, Feiyu Zhang, Yanli Liu, Feihong Chen, Yanhai Chang, Guanghui Zhao, Cheng Li, Rong Zhou, Mikko J. Lammi, Xiong Guo and Xi Wang
    Citation: Arthritis Research & Therapy 2022 24:129
    Content type: Research article Published on:

  26. Knee joint injuries, common in athletes, have a high risk of developing post-traumatic osteoarthritis (PTOA). Ligaments, matrix-rich connective tissues, play important mechanical functions stabilising the knee...

    Authors: Lorenzo Ramos-Mucci, Ahmed Elsheikh, Craig Keenan, Ashkan Eliasy, Kristiaan D’Aout, George Bou-Gharios, Eithne Comerford and Blandine Poulet
    Citation: Arthritis Research & Therapy 2022 24:128
    Content type: Research Published on:

  27. Although the survival rates of patients with relapsing polychondritis (RP) have increased remarkably, the high recurrence rate remains a significant concern for physicians and patients. This retrospective stud...

    Authors: Tsuneyasu Yoshida, Hajime Yoshifuji, Mirei Shirakashi, Akiyoshi Nakakura, Kosaku Murakami, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Koichiro Ohmura and Akio Morinobu
    Citation: Arthritis Research & Therapy 2022 24:127
    Content type: Research article Published on:

  28. Insulin resistance and beta-cell dysfunction are manifestations of rheumatoid arthritis (RA). Apolipoprotein C-III (ApoC3) has been associated with such insulin resistance and beta-cell dysfunction in the gene...

    Authors: Candelaria Martín-González, Tomás Martín-Folgueras, Juan Carlos Quevedo-Abeledo, Antonia de Vera-González, Alejandra González-Delgado, Laura de Armas-Rillo, Miguel Á. González-Gay and Iván Ferraz-Amaro
    Citation: Arthritis Research & Therapy 2022 24:126
    Content type: Research article Published on:

  29. Rheumatoid arthritis (RA) requires early diagnosis and tight surveillance of disease activity. Remote self-collection of blood for the analysis of inflammation markers and autoantibodies could improve the moni...

    Authors: Johannes Knitza, Koray Tascilar, Nicolas Vuillerme, Ekaterina Eimer, Paul Matusewicz, Giulia Corte, Louis Schuster, Timothée Aubourg, Gerlinde Bendzuck, Marianne Korinth, Corinna Elling-Audersch, Arnd Kleyer, Sebastian Boeltz, Axel J. Hueber, Gerhard Krönke, Georg Schett…
    Citation: Arthritis Research & Therapy 2022 24:125
    Content type: Research article Published on:

  30. Foot involvement is a significant concern in psoriatic arthritis (PsA) as it can lead to severe levels of foot pain and disability and reduced mobility and quality of life. Previous studies have shown moderate...

    Authors: Roua Walha, Pierre Dagenais, Nathaly Gaudreault, Gabriel Beaudoin-Côté and Patrick Boissy
    Citation: Arthritis Research & Therapy 2022 24:124
    Content type: Research article Published on:

  31. Authors: Johannes Knitza and Axel J. Hueber
    Citation: Arthritis Research & Therapy 2022 24:123
    Content type: Comment Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:82

    The original article was published in Arthritis Research & Therapy 2021 23:233

  32. With great interest, we have read the recent article “The risk of malignancy in patients with IgG4-related disease: a systematic review and meta-analysis” by Yu et al. While we have a great appreciation for th...

    Authors: Hann-Ziong Yueh, James Cheng-Chung Wei and Liyun Zhang
    Citation: Arthritis Research & Therapy 2022 24:122
    Content type: Correspondence Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:14

  33. Primary Sjogren’s syndrome (pSS) is a heterogeneous chronic autoimmune disorder characterized by lymphocyte infiltration of the exocrine glands and the involvement and dysfunction of multiple organs and tissue...

    Authors: Lei Shi, Jia Wang, Hong-Xia Guo, Xiao-Lei Han, Yu-Ping Tang and Guang-Ying Liu
    Citation: Arthritis Research & Therapy 2022 24:121
    Content type: Research article Published on:

  34. Osteoarthritis (OA) is a slowly developing and debilitating disease, and there are no validated specific biomarkers for its early detection. To improve therapeutic approaches, identification of specific molecu...

    Authors: Ginette Tardif, Frédéric Paré, Clarisse Gotti, Florence Roux-Dalvai, Arnaud Droit, Guangju Zhai, Guang Sun, Hassan Fahmi, Jean-Pierre Pelletier and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2022 24:120
    Content type: Research article Published on:

  35. Mechanical stress plays a crucial role in the pathogenesis of intervertebral disc degeneration (IVDD). The mechanosensitive Piezo1 ion channel can sense the changes in mechanical stress and convert the mechani...

    Authors: Sheng Shi, Xing-Jian Kang, Zhi Zhou, Zhi-Min He, Shuang Zheng and Shi-Sheng He
    Citation: Arthritis Research & Therapy 2022 24:119
    Content type: Research article Published on:

  37. Fluorescence optical imaging (FOI) enables visualisation of inflammation in both hands in rheumatoid arthritis (RA).

    Authors: S. Hertrampf, J. Klotsche, Q. Schefer, A. M. Glimm, G. R. Burmester, P. Hoff, G. Schmittat, T. Häupl, S. Hermann, M. Backhaus and Sarah Ohrndorf
    Citation: Arthritis Research & Therapy 2022 24:117
    Content type: Research Published on:

  38. The aim of this national population-based, retrospective database study is to compare the comorbidity profiles of systemic lupus erythematosus (SLE) patients and general population controls matched for age, ge...

    Authors: Fruzsina Kósa, Péter Kunovszki, Judit Gimesi-Országh, Melinda Kedves, Melinda Szabó, Chetan S. Karyekar and György Nagy
    Citation: Arthritis Research & Therapy 2022 24:116
    Content type: Research article Published on:

  39. This study aimed to search for blood biomarkers among the profiles of patients with RA-ILD by using machine learning classifiers and probe correlations between the markers and the characteristics of RA-ILD.

    Authors: Yan Qin, Yanlin Wang, Fanxing Meng, Min Feng, Xiangcong Zhao, Chong Gao and Jing Luo
    Citation: Arthritis Research & Therapy 2022 24:115
    Content type: Research Published on:

  40. Authors: Lingyi Li, Shelby Marozoff, Na Lu, Hui Xie, Jacek A. Kopec, Jolanda Cibere, John M. Esdaile and J. Antonio Avina-Zubieta
    Citation: Arthritis Research & Therapy 2022 24:114
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:85

  41. The nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome has been reported to be involved in the pathological process of osteoarthritis (OA) inflammation. ...

    Authors: Ganggang Kong, Jinyang Wang, Rong Li, Zhiping Huang and Le Wang
    Citation: Arthritis Research & Therapy 2022 24:113
    Content type: Research article Published on:

  42. Patients with systemic lupus erythematosus (SLE) have substantial unmet medical need. Baricitinib is a Janus kinase (JAK)1 and 2 inhibitor that was shown to have therapeutic benefit in patients with SLE in a p...

    Authors: Thomas Dörner, Ronald F. van Vollenhoven, Andrea Doria, Bochao Jia, Jorge A. Ross Terres, Maria E. Silk, Stephanie de Bono, Peter Fischer and Daniel J. Wallace
    Citation: Arthritis Research & Therapy 2022 24:112
    Content type: Research Published on:

  43. To investigate the imaging characteristics and clinically assess heel enthesitis in spondyloarthritis (SpA) by applying in a post hoc analysis the Heel Enthesitis Magnetic Resonance Imaging Scoring system (HEM...

    Authors: X. Baraliakos, P. Sewerin, E. de Miguel, E. Pournara, C. Kleinmond, A. Shekhawat, C. Jentzsch, A. Wiedon and F. Behrens
    Citation: Arthritis Research & Therapy 2022 24:111
    Content type: Research Published on:

  45. B cells have been highlighted in the pathogenesis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the identification of activated B cells in granulomatous lesions and the efficacy ...

    Authors: Chen Wang, Zhi-Ying Li, Yan Gong, Ran You, Ming-Hui, Zhao and Min Chen
    Citation: Arthritis Research & Therapy 2022 24:109
    Content type: Research Published on:

  46. Systemic sclerosis (SSc) is a disease of connective tissue with high rate of morbidity and mortality highlighted by extreme fibrosis affecting various organs such as the dermis, lungs, and heart. Until now, t...

    Authors: Mohsen Rokni, Mina Sadeghi Shaker, Hoda Kavosi, Shahrzad Shokoofi, Mahdi Mahmoudi and Elham Farhadi
    Citation: Arthritis Research & Therapy 2022 24:108
    Content type: Review Published on:

  47. Interstitial lung disease (ILD) is a severe pulmonary complication in inflammatory rheumatic diseases (IRD) and associated with significantly increased morbidity and mortality. That is why ILD screening at a v...

    Authors: Tobias Hoffmann, Peter Oelzner, Marcus Franz, Ulf Teichgräber, Diane Renz, Martin Förster, Joachim Böttcher, Claus Kroegel, P. Christian Schulze, Gunter Wolf and Alexander Pfeil
    Citation: Arthritis Research & Therapy 2022 24:107
    Content type: Research Published on:

  48. In IgG4-related disease, the relationship between pathological findings and relapse has not been well established. This study aimed to identify the clinical and pathological predictors of disease relapse in Ig...

    Authors: Ji Zongfei, Chen Lingli, Sun Ying, Ma Lingying, Zhang Lijuan, Liu Dongmei, Dai Xiaomin, Hou Yingyong, Chen Huiyong, Ma Lili and Jiang Lindi
    Citation: Arthritis Research & Therapy 2022 24:106
    Content type: Research article Published on:

  49. Osteoarthritis (OA) is one of the most common musculoskeletal degenerative diseases and contributes to heavy socioeconomic burden. Current pharmacological and conventional non-pharmacological therapies aim at ...

    Authors: Penghui Zhang, Kaihu Li, Amir Kamali, Reihane Ziadlou, Paras Ahmad, Xinluan Wang, R. Geoff Richards, Mauro Alini, Valentina Basoli, Zhen Li and Sibylle Grad
    Citation: Arthritis Research & Therapy 2022 24:105
    Content type: Review Published on:

  50. Systemic lupus erythematosus (SLE) has been associated with atherosclerotic cardiovascular disease (CV) and an altered lipid profile. High levels of apolipoprotein C-III (ApoC3) are associated with elevated tr...

    Authors: Candelaria Martín-González, Carmen Ferrer-Moure, Juan Carlos Quevedo-Abeledo, Antonia de Vera-González, Alejandra González-Delgado, Julio Sánchez-Martín, Miguel Á. González-Gay and Iván Ferraz-Amaro
    Citation: Arthritis Research & Therapy 2022 24:104
    Content type: Research article Published on:
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