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  1. Content type: Research article

    Previous studies have revealed that hepatitis B virus (HBV) infection may be associated with rheumatoid arthritis (RA), while there are no further clinical studies regarding the role of HBV infection in RA pro...

    Authors: Yu-Lan Chen, Jian-Zi Lin, Ying-Qian Mo, Jian-Da Ma, Qian-Hua Li, Xiao-Ying Wang, Ze-Hong Yang, Tao Yan, Dong-Hui Zheng and Lie Dai

    Citation: Arthritis Research & Therapy 2018 20:81

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  2. Content type: Research article

    The purpose of this study was to investigate the frequency and the distribution of inflammatory cell infiltrate in two sets of cutaneous biopsies derived from clinically affected and unaffected skin in patient...

    Authors: Silvia Bosello, Cristiana Angelucci, Gina Lama, Stefano Alivernini, Gabriella Proietti, Barbara Tolusso, Gigliola Sica, Elisa Gremese and Gianfranco Ferraccioli

    Citation: Arthritis Research & Therapy 2018 20:75

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  3. Content type: Research article

    Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and ...

    Authors: Portia P. E. Flowers, Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Howard J. Hillstrom, Adam P. Goode, Marian T. Hannan, Jordan B. Renner, Joanne M. Jordan and Yvonne M. Golightly

    Citation: Arthritis Research & Therapy 2018 20:76

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  4. Content type: Research article

    Knee pain is common with obesity and weight gain being important risk factors. Previous clinical trials have focused on overweight or obese adults with knee pain and osteoarthritis and demonstrated modest effe...

    Authors: Yuanyuan Wang, Catherine Lombard, Sultana Monira Hussain, Cheryce Harrison, Samantha Kozica, Sharmayne R. E. Brady, Helena Teede and Flavia M. Cicuttini

    Citation: Arthritis Research & Therapy 2018 20:74

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  5. Content type: Research article

    Premature atherosclerosis is one of the major complications of systemic lupus erythematosus (SLE). Recently, the biological linkage between atherosclerosis and osteoporosis has garnered much attention. The aim...

    Authors: Kazumasa Ohmura, Masaru Kato, Toshiyuki Watanabe, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Yoichi M. Ito, Norihiro Sato and Tatsuya Atsumi

    Citation: Arthritis Research & Therapy 2018 20:72

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  6. Content type: Research article

    The efficacy of corticosteroids in patients with psoriatic arthritis (PsA) and inflammatory back pain has not been studied to date. In this controlled trial, we aimed to investigate the comparative performance...

    Authors: Muhammad Haroon, Muddassar Ahmad, Muhammad Nouman Baig, Olivia Mason, John Rice and Oliver FitzGerald

    Citation: Arthritis Research & Therapy 2018 20:73

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  7. Content type: Correction

    After publication of the article [1], it has been brought to our attention that the labels in Fig. 2b have been switched and are as a result incorrect. The label for the red line should have the label “non-CAM...

    Authors: Hanbo Yang, Qinglin Peng, Liguo Yin, Shanshan Li, Jingli Shi, Yamei Zhang, Xin Lu, Xiaoming Shu, Sigong Zhang and Guochun Wang

    Citation: Arthritis Research & Therapy 2018 20:71

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    The original article was published in Arthritis Research & Therapy 2017 19:259

  8. Content type: Research article

    The aim of this study was to assess the outcomes of remission induction in patients with IgG4-related disease (IgG4-RD) in our cohort, and to investigate the characteristics, prognosis, and risk factors in the...

    Authors: Liwen Wang, Panpan Zhang, Mu Wang, Ruie Feng, Yamin Lai, Linyi Peng, Yunyun Fei, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang and Wen Zhang

    Citation: Arthritis Research & Therapy 2018 20:65

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  9. Content type: Research article

    Osteoclasts have been strongly implicated in osteoarthritic cartilage degradation, at least indirectly via bone resorption, and have been shown to degrade cartilage in vitro. The osteoclast resorption processe...

    Authors: Henrik Löfvall, Hannah Newbould, Morten A. Karsdal, Morten H. Dziegiel, Johan Richter, Kim Henriksen and Christian S. Thudium

    Citation: Arthritis Research & Therapy 2018 20:67

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  10. Content type: Research article

    African Americans with systemic lupus erythematosus (SLE) have increased renal disease compared to Caucasians, but differences in other comorbidities have not been well-described. We used an electronic health ...

    Authors: April Barnado, Robert J. Carroll, Carolyn Casey, Lee Wheless, Joshua C. Denny and Leslie J. Crofford

    Citation: Arthritis Research & Therapy 2018 20:69

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  11. Content type: Research article

    Tripterygium wilfordii Hook F (TwHF) alone or in combination with methotrexate (MTX) has been shown to be more effective than MTX monotherapy in controlling the manifestations in subjects with disease-modifying a...

    Authors: Yang-zhong Zhou, Li-dan Zhao, Hua Chen, Yan Zhang, Dan-feng Wang, Lin-fang Huang, Qian-wen Lv, Bin Liu, Zhenbin Li, Wei Wei, Hongbin Li, Xiangping Liao, Hui Liu, Xiumei Liu, Hongtao Jin, Junxiang Wang…

    Citation: Arthritis Research & Therapy 2018 20:70

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  12. Content type: Research article

    Innate immunity including macrophages (Mϕ) in lupus nephritis (LN) has been gaining attention, but roles of Mϕ in LN remain uncertain.

    Authors: Daiga Kishimoto, Yohei Kirino, Maasa Tamura, Mitsuhiro Takeno, Yosuke Kunishita, Kaoru Takase-Minegishi, Hiroto Nakano, Ikuma Kato, Kiyotaka Nagahama, Ryusuke Yoshimi, Kazuhiko Igarashi, Ichiro Aoki and Hideaki Nakajima

    Citation: Arthritis Research & Therapy 2018 20:64

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  13. Content type: Research article

    Anticitrullinated protein antibodies (ACPA) and citrullinated proteins play key roles in the pathogenesis of rheumatoid arthritis (RA). Many candidate citrullinated antigens have been identified in joints, but...

    Authors: Hoshimi Kawaguchi, Isao Matsumoto, Atsumu Osada, Izumi Kurata, Hiroshi Ebe, Yuki Tanaka, Asuka Inoue, Naoto Umeda, Yuya Kondo, Hiroto Tsuboi, Yasuhiro Shinkai, Yoshito Kumagai, Akihito Ishigami and Takayuki Sumida

    Citation: Arthritis Research & Therapy 2018 20:66

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  14. Content type: Letter

    Authors: Giovanni Orsolini, Ombretta Viapiana, Maurizio Rossini, Giovanni Adami, Cristian Caimmi, Angelo Fassio and Davide Gatti

    Citation: Arthritis Research & Therapy 2018 20:63

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    The original article was published in Arthritis Research & Therapy 2018 20:16

  15. Content type: Research article

    Although infrequent, some rheumatoid arthritis (RA) patients achieve disease-modifying antirheumatic drug (DMARD)-free sustained remission. The absence of RA-specific autoantibodies, such as anticitrullinated ...

    Authors: L. E. Burgers, D. M. Boeters, M. Reijnierse and A. H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2018 20:68

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  16. Content type: Research article

    Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of inflammatory diseases and in osteoarthritis (OA). We identified previously a new GM-CSF→Jmjd3→in...

    Authors: Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J. Fleetwood, Irmgard Förster, John A. Hamilton and Andrew D. Cook

    Citation: Arthritis Research & Therapy 2018 20:62

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  17. Content type: Research article

    Adalimumab was effective in treating patients with nonradiographic axial spondyloarthritis (nr-axSpA) in the 12-week ABILITY-1 trial. We present long-term efficacy and safety results of adalimumab from the ope...

    Authors: Désirée van der Heijde, Joachim Sieper, Walter P. Maksymowych, Robert G. Lambert, Su Chen, Maja Hojnik, Jaclyn K. Anderson and Aileen L. Pangan

    Citation: Arthritis Research & Therapy 2018 20:61

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  18. Content type: Research article

    The aim was to assess patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA) treated with filgotinib during two phase 2b, 24-week, randomized, placebo-controlled studies.

    Authors: Mark Genovese, Rene Westhovens, Luc Meuleners, Annegret Van der Aa, Pille Harrison, Chantal Tasset and Arthur Kavanaugh

    Citation: Arthritis Research & Therapy 2018 20:57

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  19. Content type: Research article

    Tofacitinib is the first oral Janus kinase inhibitor approved for the treatment of rheumatoid arthritis (RA). We compared the effectiveness and safety of tofacitinib, disease-modifying antirheumatic drugs (DMA...

    Authors: Marina Amaral de Ávila Machado, Cristiano Soares de Moura, Steve Ferreira Guerra, Jeffrey R. Curtis, Michal Abrahamowicz and Sasha Bernatsky

    Citation: Arthritis Research & Therapy 2018 20:60

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    The Letter to this article has been published in Arthritis Research & Therapy 2018 20:198

  20. Content type: Research article

    Defining environmental factors responsible for development of autoimmunity in rheumatoid arthritis (RA) is critical for understanding mechanisms of disease initiation and propagation. Notably, a history of cig...

    Authors: Laura C. Cappelli, Maximilian F. Konig, Allan C. Gelber, Clifton O. Bingham III and Erika Darrah

    Citation: Arthritis Research & Therapy 2018 20:59

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  21. Content type: Commentary

    Europe and North America have been leaders in rheumatology for many years. However, for more than a decade now the East Asian region has been catching up dramatically. Some aspects of rheumatology in East Asia...

    Authors: Kazuhiko Yamamoto, Yeong-Wook Song and Zhan-guo Li

    Citation: Arthritis Research & Therapy 2018 20:58

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  22. Content type: Research article

    Interleukin (IL)-37 has been known to play an immunosuppressive role in various inflammatory disorders, but whether it participates in the regulation of pathogenesis of adult-onset Still’s disease (AOSD) has n...

    Authors: Huihui Chi, Dongzhou Liu, Yue Sun, Qiongyi Hu, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Yufeng Yin, Mengru Liu, Xinyao Wu, Zhuochao Zhou, Jialin Teng, Chengde Yang and Yutong Su

    Citation: Arthritis Research & Therapy 2018 20:54

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  23. Content type: Research article

    Effects of methotrexate (MTX) on the proliferation of rheumatoid arthritis (RA) synovial fibroblasts are incompletely understood. We explored actions of MTX in view of circadian transcriptions of synovial fibr...

    Authors: Kohjin Suzuki, Kohsuke Yoshida, Takeshi Ueha, Kenta Kaneshiro, Ayako Nakai, Naonori Hashimoto, Koto Uchida, Teppei Hashimoto, Yoshiko Kawasaki, Nao Shibanuma, Natsuko Nakagawa, Yoshitada Sakai and Akira Hashiramoto

    Citation: Arthritis Research & Therapy 2018 20:55

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  24. Content type: Research article

    The chemokine receptors CXCR3 and CXCR4 are involved in the pathogenesis of fibrosis, a key feature of systemic sclerosis (SSc). It is hypothesized that immunoglobulin (Ig)G antibodies (abs) against these two ...

    Authors: Florian Weigold, Jeannine Günther, Moritz Pfeiffenberger, Otavio Cabral-Marques, Elise Siegert, Duska Dragun, Aurélie Philippe, Ann-Katrin Regensburger, Andreas Recke, Xinhua Yu, Frank Petersen, Rusan Catar, Robert Biesen, Falk Hiepe, Gerd R. Burmester, Harald Heidecke…

    Citation: Arthritis Research & Therapy 2018 20:52

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  25. Content type: Research article

    Diuretics have been associated with impaired response and refractoriness in gout, but whether this effect is still present with new urate-lowering drugs (ULD) and treat-to-target strategies is unknown. The aim...

    Authors: Laura Ranieri, Carolina Contero, Maria-Luisa Peral, Irene Calabuig, Pedro Zapater and Mariano Andres

    Citation: Arthritis Research & Therapy 2018 20:53

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    The Letter to this article has been published in Arthritis Research & Therapy 2018 20:241

  26. Content type: Research article

    Published methods for quantification of magnetic resonance imaging (MRI) evidence of inflammation in the sacroiliac joint lack validation in pediatric populations. We evaluated the reliability and construct va...

    Authors: Pamela F. Weiss, Walter P. Maksymowych, Robert G. Lambert, Jacob L. Jaremko, David M. Biko, Joel Paschke, Timothy G. Brandon, Rui Xiao and Nancy A. Chauvin

    Citation: Arthritis Research & Therapy 2018 20:56

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  27. Content type: Research article

    A key feature of joints in rheumatoid arthritis (RA) is the formation of hyperplastic destructive pannus tissue, which is orchestrated by activated fibroblast-like synoviocytes (FLS). We have demonstrated that...

    Authors: Beatrice Bergström, Hans Carlsten and Anna-Karin Hultgård Ekwall

    Citation: Arthritis Research & Therapy 2018 20:49

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  28. Content type: Research article

    Oral methotrexate (MTX) is the first-line therapy for patients with rheumatoid arthritis (RA). However, approximately one quarter of patients discontinue MTX within 12 months. MTX failure, defined as MTX cessa...

    Authors: James Bluett, Jamie C. Sergeant, Alex J. MacGregor, Jacqueline R. Chipping, Tarnya Marshall, Deborah P. M. Symmons and Suzanne M. M. Verstappen

    Citation: Arthritis Research & Therapy 2018 20:50

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  29. Content type: Research article

    The study aimed to assess 52-week efficacy and safety of secukinumab self-administration by autoinjector in patients with active psoriatic arthritis (PsA) in the FUTURE 3 study (

    Authors: Peter Nash, Philip J. Mease, Iain B. McInnes, Proton Rahman, Christopher T. Ritchlin, Ricardo Blanco, Eva Dokoupilova, Mats Andersson, Radhika Kajekar, Shephard Mpofu and Luminita Pricop

    Citation: Arthritis Research & Therapy 2018 20:47

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  30. Content type: Research article

    Transforming growth factor-β (TGF-β)/Smad signaling is well known to play a critical role in the pathogenesis of systemic sclerosis (SSc). We previously developed an artificial molecule, the histidine-pyridine...

    Authors: Vu Huy Luong, Takenao Chino, Noritaka Oyama, Takashi Matsushita, Yoko Sasaki, Dai Ogura, Shin-ichiro Niwa, Tanima Biswas, Akiyuki Hamasaki, Mikako Fujita, Yoshinari Okamoto, Masami Otsuka, Hironobu Ihn and Minoru Hasegawa

    Citation: Arthritis Research & Therapy 2018 20:46

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  31. Content type: Research article

    We aimed to explore pressure pain sensitivity and the function of segmental and plurisegmental exercise-induced hypoalgesia (EIH) in persons with rheumatoid arthritis (RA) compared with healthy control subject...

    Authors: Monika Löfgren, Christina H. Opava, Ingrid Demmelmaier, Cecilia Fridén, Ingrid E. Lundberg, Birgitta Nordgren and Eva Kosek

    Citation: Arthritis Research & Therapy 2018 20:48

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  32. Content type: Research article

    MicroRNAs (miRNAs) serve as important regulators of inflammatory and immune responses and are implicated in several immune disorders including gouty arthritis. The expression of miR-146a is upregulated in the ...

    Authors: Quan-Bo Zhang, Yu-Feng Qing, Cong-Cong Yin, Li Zhou, Xian-shuang Liu, Qing-Sheng Mi and Jing-Guo Zhou

    Citation: Arthritis Research & Therapy 2018 20:45

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  33. Content type: Research article

    Traditional Chinese medicine (TCM) formula Bi-Qi capsule (Bi-Qi) is a commonly prescribed drug to treat rheumatoid arthritis (RA). However, the mechanism of Bi-Qi-mediated amelioration of RA pathogenesis is st...

    Authors: Kai Wang, Dongmei Zhang, Yan Liu, Xuan Wang, Jiantong Zhao, Tingting Sun, Tingting Jin, Baoli Li and Janak L. Pathak

    Citation: Arthritis Research & Therapy 2018 20:43

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  34. Content type: Research article

    Galactosylation of immunoglobulin G (IgG) is reduced in rheumatoid arthritis (RA) and assumed to correlate with inflammation and altered humoral immunity. IgG hypogalactosylation also increases with age. To in...

    Authors: Christian Schwedler, Thomas Häupl, Ulrich Kalus, Véronique Blanchard, Gerd-Rüdiger Burmester, Denis Poddubnyy and Berthold Hoppe

    Citation: Arthritis Research & Therapy 2018 20:44

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  35. Content type: Research article

    Sirukumab, a high-affinity human monoclonal antibody that selectively binds to interleukin-6, has demonstrated efficacy in the treatment of rheumatoid arthritis (RA) in global phase 1 and phase 2 studies. The ...

    Authors: Tsutomu Takeuchi, Hisashi Yamanaka, Masayoshi Harigai, Ryo Tamamura, Yuichi Kato, Yoshifumi Ukyo, Toshikazu Nakano, Benjamin Hsu and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2018 20:42

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  36. Content type: Research article

    Kashin-Beck disease (KBD) is an endemic osteochondropathy of unknown etiology. Osteoarthritis (OA) is a form of degenerative joint disease sharing similar clinical manifestations and pathological changes to ar...

    Authors: Yan Wen, Ping Li, Jingcan Hao, Chen Duan, Jing Han, Awen He, Yanan Du, Li Liu, Xiao Liang, Feng Zhang and Xiong Guo

    Citation: Arthritis Research & Therapy 2018 20:41

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  37. Content type: Research article

    The weight of recommendation for intra-articular therapies such as hyaluronic acid injections varies from one set of guidelines to another, and they have not yet reached unanimity with respect to the usefulnes...

    Authors: Jean-Pierre Pelletier, Jean-Pierre Raynauld, François Abram, Marc Dorais, Philippe Delorme and Johanne Martel-Pelletier

    Citation: Arthritis Research & Therapy 2018 20:40

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  38. Content type: Research article

    Prostaglandin E2 (PGE2) acts via its EP4 receptor as a cytokine amplifier (e.g., interleukin [IL]-6) and induces the differentiation and expansion of inflammatory T-helper (Th) lymphocytes. These mechanisms play ...

    Authors: Gianfranco Caselli, Albino Bonazzi, Marco Lanza, Flora Ferrari, Daniele Maggioni, Cristian Ferioli, Roberto Giambelli, Eleonora Comi, Silvia Zerbi, Marco Perrella, Ornella Letari, Elena Di Luccio, Milena Colovic, Stefano Persiani, Tiziano Zanelli, Laura Mennuni…

    Citation: Arthritis Research & Therapy 2018 20:39

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  39. Content type: Research article

    Anti-CD74 IgG antibodies are reported to be elevated in patients with axial spondyloarthritis (axSpA). This study assessed the diagnostic value of anti-CD74 antibodies in patients with early axSpA.

    Authors: Janneke J. de Winter, Marleen G. van de Sande, Niklas Baerlecken, Inger Berg, Roberta Ramonda, Désirée van der Heijde, Floris A. van Gaalen, Torsten Witte and Dominique L. Baeten

    Citation: Arthritis Research & Therapy 2018 20:38

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  40. Content type: Research article

    Using self-report questionnaires of key fibromyalgia symptom domains (pain, fatigue, sleep disturbance, function, stiffness, dyscognition, depression, and anxiety), we previously identified four unique symptom...

    Authors: Tanya L. Hoskin, Mary O. Whipple, Sanjeev Nanda and Ann Vincent

    Citation: Arthritis Research & Therapy 2018 20:37

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  41. Content type: Research article

    Immunoglobulin M (IgM) autoreactivity to malondialdehyde (MDA) protein modifications is part of the natural antibody repertoire in health and may have beneficial functions. In contrast, IgG anti-MDA are increa...

    Authors: Uta Hardt, Anders Larsson, Iva Gunnarsson, Robert M. Clancy, Michelle Petri, Jill P. Buyon, Gregg J. Silverman, Elisabet Svenungsson and Caroline Grönwall

    Citation: Arthritis Research & Therapy 2018 20:36

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  42. Content type: Research article

    Systemic autoimmunity can be present years before clinical onset of rheumatoid arthritis (RA). Adaptive immunity is initiated in lymphoid tissue where lymph node stromal cells (LNSCs) regulate immune responses...

    Authors: Janine S. Hähnlein, Reza Nadafi, Tineke de Jong, Tamara H. Ramwadhdoebe, Johanna F. Semmelink, Karen I. Maijer, IJsbrand A. Zijlstra, Mario Maas, Danielle M. Gerlag, Teunis B. H. Geijtenbeek, Paul P. Tak, Reina E. Mebius and Lisa G. M. van Baarsen

    Citation: Arthritis Research & Therapy 2018 20:35

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  43. Content type: Research article

    The autoantibody profile of seropositive rheumatoid arthritis (RA) is very diverse and consists of various isotypes and antibodies to multiple post-translational modifications. It is yet unknown whether this v...

    Authors: Emma C. de Moel, Veerle F. A. M. Derksen, Gerrie Stoeken, Leendert A. Trouw, Holger Bang, Robbert J. Goekoop, Irene Speyer, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes and Diane van der Woude

    Citation: Arthritis Research & Therapy 2018 20:33

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  44. Content type: Research article

    Interleukin-1β (IL-1β) is a pivotal proinflammatory cytokine that is strongly associated with the inflammation of gout. However, the underlying mechanism through which the production of IL-1β is regulated has ...

    Authors: Teng Ma, Xiao Liu, Zhifu Cen, Chuan Xin, Mingfeng Guo, Chaoyu Zou, Wenpeng Song, Rou Xie, Kailun Wang, Hong Zhou, Jun Zhang, Zhen Wang, Ce Bian, Kaijun Cui, Jiong Li, Yu-Quan Wei…

    Citation: Arthritis Research & Therapy 2018 20:34

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  45. Content type: Correction

    Unfortunately, after publication of this article [1], it was noticed that Table 2 was not correctly formatted during the production process. The corrected Table 2 can be seen below and the original article has...

    Authors: Anh Hoang, Susan M. Goodman, Iris Y. Navarro-Millán, Lisa A. Mandl, Mark P. Figgie, Mathias P. Bostrom, Douglas E. Padgett, Peter K. Sculco, Alexander S. McLawhorn and Jasvinder A. Singh

    Citation: Arthritis Research & Therapy 2018 20:32

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    The original article was published in Arthritis Research & Therapy 2017 19:267

  46. Content type: Research article

    Sjögren’s syndrome (SS) is a primary autoimmune disease (pSS) or secondarily associated with other autoimmune diseases (sSS). The mechanisms underlying immune dysregulation in this syndrome remain unknown, and...

    Authors: Yu-Hui Li, Ya-Ping Gao, Jie Dong, Lian-Jie Shi, Xiao-Lin Sun, Ru Li, Xue-Wu Zhang, Yu Liu, Li Long, Jing He, Qun-Jie Zhong, Eric Morand, Guang Yang and Zhan-Guo Li

    Citation: Arthritis Research & Therapy 2018 20:30

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  47. Content type: Research article

    Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid. Roles have been proposed for galectins in the regula...

    Authors: Martin J. O’Brien, Qiang Shu, W.Alexander Stinson, Pei-Suen Tsou, Jeffrey H. Ruth, Takeo Isozaki, Phillip L. Campbell, Ray A. Ohara, Alisa E. Koch, David A. Fox and M. Asif Amin

    Citation: Arthritis Research & Therapy 2018 20:31

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