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  1. To investigate the efficacy of secukinumab in patients with active non-radiographic axial spondyloarthritis (nr-axSpA) grouped by disease activity as assessed by C-reactive protein (CRP) levels and/or magnetic...

    Authors: Jürgen Braun, Ricardo Blanco, Helena Marzo-Ortega, Lianne S. Gensler, Filip van den Bosch, Stephen Hall, Hideto Kameda, Denis Poddubnyy, Marleen van de Sande, Anna S. Wiksten, Brian O. Porter, Abhijit Shete, Hanno B. Richards, Sibylle Haemmerle and Atul Deodhar
    Citation: Arthritis Research & Therapy 2021 23:231
  2. Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-tra...

    Authors: Sanne Reijm, Theresa Kissel, Gerrie Stoeken-Rijsbergen, Linda M. Slot, Corrie M. Wortel, Hugo J. van Dooren, Nivine E. W. Levarht, Arieke S. B. Kampstra, Veerle F. A. M. Derksen, Pleuni Ooijevaar-de Heer, Holger Bang, Jan W. Drijfhout, Leendert A. Trouw, Tom W. J. Huizinga, Theo Rispens, Hans U. Scherer…
    Citation: Arthritis Research & Therapy 2021 23:230
  3. Systemic lupus erythematosus (SLE) is a chronic inflammatory multi systematic disease of unknown aetiology. SLE has a wide range of symptoms. The most common symptoms are joint pain, skin rash and fever. Oral ...

    Authors: Mayssoun Kudsi, Louei Darjazini Nahas, Rama Alsawah, Ahmad Hamsho and Abdullah Omar
    Citation: Arthritis Research & Therapy 2021 23:229
  4. The aim of this study was to compare the clinical effectiveness of tofacitinib and abatacept and clarify the impact of the HLA-DRB1 shared epitope (SE) on responses to these treatments in patients with rheumat...

    Authors: Wataru Hirose, Masayoshi Harigai, Koichi Amano, Toshihiko Hidaka, Kenji Itoh, Kazutoshi Aoki, Masahiro Nakashima, Hayato Nagasawa, Yukiko Komano and Toshihiro Nanki
    Citation: Arthritis Research & Therapy 2021 23:228
  5. Cartilage degeneration is assessed using various methods. Although macroscopic evaluation can directly measure cartilage degeneration, it cannot accurately assess cartilage properties. Histological examination...

    Authors: Taku Ukai, Masato Sato, Shiho Wasai, Takumi Takahashi, Haruka Omura and Masahiko Watanabe
    Citation: Arthritis Research & Therapy 2021 23:227
  6. To compare C-reactive protein (CRP) and matrix metalloproteinase-generated neoepitope of CRP (CRPM) as biomarkers of inflammation and radiographic severity in patients with knee osteoarthritis.

    Authors: Louie C. Alexander Jr, Grant McHorse, Janet L. Huebner, Anne-Christine Bay-Jensen, Morten A. Karsdal and Virginia B. Kraus
    Citation: Arthritis Research & Therapy 2021 23:226
  7. Osteoarthritis (OA) is the most common form of arthritis with multiple risk factors implicated including female sex and obesity. Metabolic dysregulation associated with obesity leading to metabolic syndrome is...

    Authors: Stefan Kluzek, Katrine Hass Rubin, Maria Sanchez-Santos, Mary S. O’Hanlon, Marianne Andersen, Dorte Glintborg and Bo Abrahamsen
    Citation: Arthritis Research & Therapy 2021 23:225
  8. Behçet’s disease (BD), a chronic systemic vasculitis, has distinct geographical and ethnic variation. Data regarding the epidemiology of patients with BD in the U.S. are limited; therefore, we sought to descri...

    Authors: Nevin Hammam, Jing Li, Michael Evans, Julia L. Kay, Zara Izadi, Christine Anastasiou, Milena A. Gianfrancesco, Jinoos Yazdany and Gabriela Schmajuk
    Citation: Arthritis Research & Therapy 2021 23:224
  9. Screening abnormal pathways and complement components in the kidneys of patients with lupus nephritis (LN) and NZB/W mice may help to identify complement-related therapeutic targets for LN.

    Authors: Tao Liu, Mingyue Yang, Ying Xia, Chuan Jiang, Chenxu Li, Zhenyu Jiang and Xiaosong Wang
    Citation: Arthritis Research & Therapy 2021 23:223
  10. The incidence of rheumatoid arthritis is correlated with age. In this study, we analyzed the association of the incidence and severity of glucose-6-phosphate isomerase (G6PI)-induced arthritis with age in two ...

    Authors: Nico Andreas, Sylvia Müller, Nicole Templin, Paul M. Jordan, Harald Schuhwerk, Michael Müller, Jana Gerstmeier, Laura Miek, Saskia Andreas, Oliver Werz and Thomas Kamradt
    Citation: Arthritis Research & Therapy 2021 23:222
  11. Peficitinib (ASP015K), a novel oral Janus kinase inhibitor, has demonstrated efficacy and safety in the treatment of patients with rheumatoid arthritis (RA). This study evaluated the effect of peficitinib on p...

    Authors: Yoshiya Tanaka, Tsutomu Takeuchi, Hiroyuki Izutsu, Yuichiro Kaneko, Daisuke Kato, Musashi Fukuda, Mitsuhiro Rokuda and Neil M. Schultz
    Citation: Arthritis Research & Therapy 2021 23:221
  12. This post hoc analysis assessed clinical and functional responses to tofacitinib monotherapy, tofacitinib + methotrexate (MTX), and adalimumab + MTX, in patients with rheumatoid arthritis enrolled in the ORAL ...

    Authors: Tsutomu Takeuchi, Roy Fleischmann, Noriko Iikuni, Harry Shi, Koshika Soma, Jerome Paulissen, Tomohiro Hirose and Josef S. Smolen
    Citation: Arthritis Research & Therapy 2021 23:220
  13. Little evidence is available about the impact of diet on disease activity of axial spondyloarthritis (axSpA). This study evaluated the impact of a 6-month nutritional advice based on the Mediterranean diet on ...

    Authors: Francesca Ometto, Augusta Ortolan, Davide Farber, Mariagrazia Lorenzin, Giulia Dellamaria, Giacomo Cozzi, Marta Favero, Romina Valentini, Andrea Doria and Roberta Ramonda
    Citation: Arthritis Research & Therapy 2021 23:219

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:282

  14. TNF-α-stimulated gene 6 (TSG-6) protein, a TNF-α-responsive hyaladherin, possesses enzymatic activity that can catalyze covalent crosslinks of the polysaccharide hyaluronic acid (HA) to another protein to form...

    Authors: Diana C. Fasanello, Jin Su, Siyu Deng, Rose Yin, Marshall J. Colville, Joshua M. Berenson, Carolyn M. Kelly, Heather Freer, Alicia Rollins, Bettina Wagner, Felipe Rivas, Adam R. Hall, Elaheh Rahbar, Paul L. DeAngelis, Matthew J. Paszek and Heidi L. Reesink
    Citation: Arthritis Research & Therapy 2021 23:218
  15. Early diagnosis of knee osteoarthritis (OA) is important in managing this disease, but such an early diagnostic tool is still lacking in clinical practice. The purpose of this study was to develop diagnostic m...

    Authors: Qiuke Wang, Jos Runhaar, Margreet Kloppenburg, Maarten Boers, Johannes W. J. Bijlsma and Sita M. A. Bierma-Zeinstra
    Citation: Arthritis Research & Therapy 2021 23:217
  16. Excessive osteoclast activity, which is strongly stimulated by pro-inflammatory mediators, results in bone and cartilage degeneration as central features of many arthritides. Levels of the alarmin S100A8/A9 an...

    Authors: Irene Di Ceglie, Peter L. E. M. van Lent, Edwin J. W. Geven, Marije I. Koenders, Arjen B. Blom, Thomas Vogl, Johannes Roth and Martijn H. J. van den Bosch
    Citation: Arthritis Research & Therapy 2021 23:216
  17. Failing of intrinsic chondrocyte repair after mechanical stress is known as one of the most important initiators of osteoarthritis. Nonetheless, insight into these early mechano-pathophysiological processes in...

    Authors: Evelyn Houtman, Margo Tuerlings, Janne Riechelman, Eka H. E. D. Suchiman, Robert J. P. van der Wal, Rob G. H. H. Nelissen, Hailiang Mei, Yolande F. M. Ramos, Rodrigo Coutinho de Almeida and Ingrid Meulenbelt
    Citation: Arthritis Research & Therapy 2021 23:215
  18. Our previous studies reveal that CCL18-CCR8 chemokine axis is upregulated in patients of immunoglobulin G4-related disease (IgG4-RD), suggesting that the CCL18–CCR8 axis is implicated in the etiology of IgG4-R...

    Authors: Fumika Honda, Hiroto Tsuboi, Yuko Ono, Saori Abe, Hiroyuki Takahashi, Kiyoaki Ito, Kazunori Yamada, Mitsuhiro Kawano, Yuya Kondo, Kenichi Asano, Masato Tanaka, Marie Malissen, Bernard Malissen, Isao Matsumoto and Takayuki Sumida
    Citation: Arthritis Research & Therapy 2021 23:214
  19. During rheumatoid arthritis (RA), the angiogenic processes, occurring with pannus-formation, may be a therapeutic target. JAK/STAT-pathway may play a role and the aim of this work was to investigate the inhibi...

    Authors: Paola Di Benedetto, Piero Ruscitti, Onorina Berardicurti, Noemi Panzera, Nicolò Grazia, Mauro Di Vito Nolfi, Barbara Di Francesco, Luca Navarini, Antonio Maurizi, Nadia Rucci, Anna Maria Teti, Francesca Zazzeroni, Giuliana Guggino, Francesco Ciccia, Vincenza Dolo, Edoardo Alesse…
    Citation: Arthritis Research & Therapy 2021 23:213
  20. Screening and follow-up of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) is a challenge in clinical practice. In fact, the majority of RA-ILD patients are asymptomatic and optimal too...

    Authors: Yukai Wang, Shaoqi Chen, Shaoyu Zheng, Jianqun Lin, Shijian Hu, Jinghua Zhuang, Qisheng Lin, Xuezhen Xie, Kedi Zheng, Weijin Zhang, Guangzhou Du, Guohong Zhang, Anna-Maria Hoffmann-Vold, Marco Matucci-Cerinic and Daniel E. Furst
    Citation: Arthritis Research & Therapy 2021 23:212
  21. Anti-drug antibodies (ADAs) can impact on the efficacy and safety of biologicals, today used to treat several chronic inflammatory conditions. Specific patient groups may be more prone to develop ADAs. Rituxim...

    Authors: Francesca Faustini, Nicky Dunn, Nastya Kharlamova, Malin Ryner, Annette Bruchfeld, Vivianne Malmström, Anna Fogdell-Hahn and Iva Gunnarsson
    Citation: Arthritis Research & Therapy 2021 23:211
  22. First-degree relatives (FDRs) of people with rheumatoid arthritis (RA) have a fourfold increased risk of developing RA. The Symptoms in Persons At Risk of Rheumatoid Arthritis (SPARRA) questionnaire was develo...

    Authors: R. E. Costello, J. H. Humphreys, J. C. Sergeant, M. Haris, F. Stirling, K. Raza, D. van Schaardenburg and Ian N. Bruce
    Citation: Arthritis Research & Therapy 2021 23:210

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:263

  23. Tea is a popular beverage around the world and has properties that can affect the immune system. The association between tea consumption and the risk of rheumatoid arthritis (RA), a chronic autoimmune disease ...

    Authors: Helga Westerlind, Ida Palmqvist, Saedis Saevarsdottir, Lars Alfredsson, Lars Klareskog and Daniela Di Giuseppe
    Citation: Arthritis Research & Therapy 2021 23:209
  24. Trabecular bone texture analysis (TBTA) has been identified as an imaging biomarker that provides information on trabecular bone changes due to knee osteoarthritis (KOA). Consequently, it is important to condu...

    Authors: Ahmad Almhdie-Imjabbar, Pawel Podsiadlo, Richard Ljuhar, Rachid Jennane, Khac-Lan Nguyen, Hechmi Toumi, Simo Saarakkala and Eric Lespessailles
    Citation: Arthritis Research & Therapy 2021 23:208
  25. Clinical research projects often use traditional methods in which data collection and signing informed consent forms rely on patients’ visits to the research institutes. However, during challenging times when ...

    Authors: L. Boekel, F. Hooijberg, E. H. Vogelzang, P. L. Klarenbeek, W. H. Bos, S. W. Tas and G. J. Wolbink
    Citation: Arthritis Research & Therapy 2021 23:207
  26. Rheumatoid arthritis (RA) patients have an increased risk of cardiovascular disease (CVD). In the present study, we evaluated the inflammatory activity of the ascending aorta in RA patients who received biolog...

    Authors: D. A. M. Thuy Trang, Koichi Okamura, Takahito Suto, Hideo Sakane, Yukio Yonemoto, Takahito Nakajima, Yoshito Tsushima and Hirotaka Chikuda
    Citation: Arthritis Research & Therapy 2021 23:206
  27. Circulating fibrocytes are an important source of fibroblasts and myofibroblasts, which are involved in fibrotic processes, including systemic sclerosis (SSc).

    Authors: Maurizio Cutolo, Emanuele Gotelli, Paola Montagna, Samuele Tardito, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith and Stefano Soldano
    Citation: Arthritis Research & Therapy 2021 23:205
  28. To evaluate the changes in disease-related biomarkers and safety of paquinimod, an oral immunomodulatory compound, in patients with systemic sclerosis (SSc).

    Authors: Roger Hesselstrand, Jörg H. W. Distler, Gabriela Riemekasten, Dirk M. Wuttge, Marie Törngren, Helén C. Nyhlén, Fredrik Andersson, Helena Eriksson, Birgitta Sparre, Helén Tuvesson and Oliver Distler
    Citation: Arthritis Research & Therapy 2021 23:204
  29. Systemic lupus erythematosus (SLE) is a heterogeneous systemic autoimmune condition for which there are limited licensed therapies. Clinical trial design is challenging in SLE due at least in part to imperfect...

    Authors: John A. Reynolds, Jennifer Prattley, Nophar Geifman, Mark Lunt, Caroline Gordon and Ian N. Bruce
    Citation: Arthritis Research & Therapy 2021 23:203
  30. Hyperuricemia is a metabolic condition central to gout pathogenesis. Urate exposure primes human monocytes towards a higher capacity to produce and release IL-1β. In this study, we assessed the epigenetic proc...

    Authors: M. Badii, O. I. Gaal, M. C. Cleophas, V. Klück, R. Davar, E. Habibi, S. T. Keating, B. Novakovic, M. M. Helsen, N. Dalbeth, L. K. Stamp, D. Macartney-Coxson, A. J. Phipps-Green, H. G. Stunnenberg, C. A. Dinarello, T. R. Merriman…
    Citation: Arthritis Research & Therapy 2021 23:202
  31. The increased risk of cardiovascular events (CVE) in rheumatoid arthritis (RA) is not fully explained by traditional risk factors. Immuno-inflammatory mechanisms and autoantibodies could be involved in the pat...

    Authors: Sofia Ajeganova, Maria L. E. Andersson, Johan Frostegård and Ingiäld Hafström
    Citation: Arthritis Research & Therapy 2021 23:201
  32. Oxylipins are biological lipids that have been implicated in inflammation. We previously found that certain oxylipins correlated with clinical manifestations in psoriatic arthritis (PsA) patients. Here, we com...

    Authors: Roxana Coras, Arthur Kavanaugh, Angela Kluzniak, Dustina Holt, Amy Weilgosz, Armando Aaron, Oswald Quehenberger, Christopher Ritchlin and Monica Guma
    Citation: Arthritis Research & Therapy 2021 23:200
  33. Targeting TNFα is beneficial in many autoimmune and inflammatory diseases, including rheumatoid arthritis. However, the response to each of the existing TNFα inhibitors (TNFis) can be patient- and/or disease-d...

    Authors: Ching-Huang Ho, Andrea A. Silva, Beverly Tomita, Hui-Ying Weng and I-Cheng Ho
    Citation: Arthritis Research & Therapy 2021 23:199
  34. Interstitial lung disease (ILD) and its rapid progression (RP) are the main contributors to unfavourable outcomes of patients with idiopathic inflammatory myopathy (IIM). This study aimed to identify the clini...

    Authors: Junyu Liang, Heng Cao, Yinuo Liu, Bingjue Ye, Yiduo Sun, Yini Ke, Ye He, Bei Xu and Jin Lin
    Citation: Arthritis Research & Therapy 2021 23:198
  35. To compare the efficacy and safety of tofacitinib and baricitinib in patients with RA in a real-world setting.

    Authors: Naoki Iwamoto, Shuntaro Sato, Shota Kurushima, Toru Michitsuji, Shinya Nishihata, Momoko Okamoto, Yoshika Tsuji, Yushiro Endo, Toshimasa Shimizu, Remi Sumiyoshi, Takahisa Suzuki, Akitomo Okada, Tomohiro Koga, Shin-ya Kawashiri, Keita Fujikawa, Takashi Igawa…
    Citation: Arthritis Research & Therapy 2021 23:197
  36. Hypertension occurred in 30–80% of Takayasu arteritis (TAK) patients around the world and the occurrence of hypertension might worsen the disease prognosis. This study aimed to investigate the clinical charact...

    Authors: Sun Ying, Wu Sifan, Wang Yujiao, Chen Rongyi, Huang Qingrong, Ma Lili, Chen Huiyong and Jiang Lindi
    Citation: Arthritis Research & Therapy 2021 23:196
  37. Authors: Hiroto Minamino, Masao Katsushima, Yoshihito Fujita and Motomu Hashimoto
    Citation: Arthritis Research & Therapy 2021 23:195

    The Letter to this article has been published in Arthritis Research & Therapy 2021 23:183

    The Research article to this article has been published in Arthritis Research & Therapy 2021 23:96

  38. Effector memory T cells are pivotal effectors of adaptive immunity with enhanced migration characteristics and are involved in the pathogenesis of ANCA-associated vasculitis (AAV). The diversity of effector me...

    Authors: Zhonghua Liao, Jiale Tang, Liying Luo, Shuanglinzi Deng, Lisa Luo, Fangyuan Wang, Xiangning Yuan, Xinyue Hu, Juntao Feng and Xiaozhao Li
    Citation: Arthritis Research & Therapy 2021 23:194
  39. HLA-B27/human β2m transgenic rats (B27-rats) develop an inflammatory disorder resembling spondyloarthritis (SpA) with dysregulated IL-10/IL-17 production by regulatory T cells (Treg). Treg plays a major role i...

    Authors: L. M. Araujo, Q. Jouhault, I. Fert, I. Bouiller, G. Chiocchia and M. Breban
    Citation: Arthritis Research & Therapy 2021 23:193
  40. Anterior uveitis (AU) is the most frequent extra-articular feature of axial spondyloarthritis (axSpA). We aimed to assess and compare the incidence of AU in axSpA patients treated with anti-TNF or anti-IL17A.

    Authors: Damien Roche, Martin Badard, Laurent Boyer, Pierre Lafforgue and Thao Pham
    Citation: Arthritis Research & Therapy 2021 23:192
  41. We sought to examine the disease course of High Disease Activity Status (HDAS) patients and their different disease patterns in a real-world longitudinal cohort. Disease resolution till Lupus Low Disease Activ...

    Authors: Alberta Hoi, Rachel Koelmeyer, Julie Bonin, Ying Sun, Amy Kao, Oliver Gunther, Hieu T. Nim and Eric Morand
    Citation: Arthritis Research & Therapy 2021 23:191
  42. The interleukin-23p19-subunit inhibitor guselkumab effectively treats signs and symptoms of psoriatic arthritis (PsA). We evaluated the effect of guselkumab on fatigue.

    Authors: Proton Rahman, Philip J. Mease, Philip S. Helliwell, Atul Deodhar, Laure Gossec, Arthur Kavanaugh, Alexa P. Kollmeier, Elizabeth C. Hsia, Bei Zhou, Xiwu Lin, May Shawi, Chetan S. Karyekar and Chenglong Han
    Citation: Arthritis Research & Therapy 2021 23:190
  43. The type I interferon (IFN) gene signature is present in a subgroup of patients with early rheumatoid arthritis (RA). Protein levels of IFNα have not been measured in RA and it is unknown whether they associat...

    Authors: Marit Stockfelt, Anna-Carin Lundell, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Marte Schrumpf Heiberg, Espen A. Haavardsholm, Michael T. Nurmohamed, Jon Lampa, Dan Nordström, Kim Hørslev Petersen, Bjorn Gudbjornsson, Gerdur Gröndal, Jonathan Aldridge, Kerstin Andersson, Kaj Blennow…
    Citation: Arthritis Research & Therapy 2021 23:189
  44. The risk of severe COVID-19 and its determinants remain largely unknown in patients with autoimmune and inflammatory rheumatic diseases. The objective of this study was to assess the prevalence of COVID-19 inf...

    Authors: Renaud Felten, Marc Scherlinger, Aurélien Guffroy, Vincent Poindron, Alain Meyer, Margherita Giannini, Anne-Sophie Korganow, Christelle Sordet, Emmanuel Chatelus, Rose-Marie Javier, Aurore Meyer, Luc Pijnenburg, Jean-François Kleinmann, Jacques-Eric Gottenberg, Jean Sibilia, Thierry Martin…
    Citation: Arthritis Research & Therapy 2021 23:188
  45. Exercise training, including high-intensity interval training (HIIT), improves rheumatoid arthritis (RA) inflammatory disease activity via unclear mechanisms. Because exercise requires skeletal muscle, skeleta...

    Authors: Brian J. Andonian, Andrew Johannemann, Monica J. Hubal, David M. Pober, Alec Koss, William E. Kraus, David B. Bartlett and Kim M. Huffman
    Citation: Arthritis Research & Therapy 2021 23:187
  46. MicroRNAs (miRNAs) are short single-stranded RNAs that play a role in the post-transcriptional regulation of gene expression. Their deregulation can be associated with various diseases, such as cancer, neurode...

    Authors: Jana Bohatá, Veronika Horváthová, Markéta Pavlíková and Blanka Stibůrková
    Citation: Arthritis Research & Therapy 2021 23:186
  47. To investigate whether baseline monosodium urate (MSU) burden estimated by ultrasound (US) predicts the achievement of the 2016 remission criteria for gout after 12 months.

    Authors: Edoardo Cipolletta, Jacopo Di Battista, Marco Di Carlo, Andrea Di Matteo, Fausto Salaffi, Walter Grassi and Emilio Filippucci
    Citation: Arthritis Research & Therapy 2021 23:185
  48. The new concept of difficult-to-treat rheumatoid arthritis (D2T RA) refers to RA patients who remain symptomatic after several lines of treatment, resulting in a high patient and economic burden. During a hack...

    Authors: Marianne A. Messelink, Nadia M. T. Roodenrijs, Bram van Es, Cornelia A. R. Hulsbergen-Veelken, Sebastiaan Jong, L. Malin Overmars, Leon C. Reteig, Sander C. Tan, Tjebbe Tauber, Jacob M. van Laar, Paco M. J. Welsing and Saskia Haitjema
    Citation: Arthritis Research & Therapy 2021 23:184
  49. Authors: Reza Rastmanesh
    Citation: Arthritis Research & Therapy 2021 23:183

    The Letter to this article has been published in Arthritis Research & Therapy 2021 23:195

    The Research article to this article has been published in Arthritis Research & Therapy 2021 23:96

  50. Tapering or stopping biological disease-modifying anti-rheumatic drugs has been proposed for patients with rheumatoid arthritis (RA) in remission, but it frequently results in high rates of recurrence. This st...

    Authors: Sang Youn Jung, Jung Hee Koh, Ki-Jo Kim, Yong-Wook Park, Hyung-In Yang, Sung Jae Choi, Jisoo Lee, Chan-Bum Choi and Wan-Uk Kim
    Citation: Arthritis Research & Therapy 2021 23:182

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