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Page 5 of 125

  1. Content type: Research article

    This double-blind, active-controlled, randomized, multinational study evaluated the efficacy, safety, pharmacokinetics (PK), and immunogenicity of PF-06438179/GP1111 (IxifiTM/Zessly®), an infliximab biosimilar...

    Authors: Stanley B. Cohen, Rieke Alten, Hideto Kameda, Tomas Hala, Sebastiao C. Radominski, Muhammad I. Rehman, Ramesh Palaparthy, Karl Schumacher, Susanne Schmitt, Steven Y. Hua, Claudia Ianos and K. Lea Sewell

    Citation: Arthritis Research & Therapy 2018 20:155

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  2. Content type: Research article

    Although the effects of interleukin-17A (IL-17A) inhibition on the signs and symptoms of psoriatic arthritis (PsA) are well defined, little is known about its impact of local inflammatory and structural change...

    Authors: Eleni Kampylafka, Isabelle d’Oliveira, Christina Linz, Veronika Lerchen, Fabian Stemmler, David Simon, Matthias Englbrecht, Michael Sticherling, Jürgen Rech, Arnd Kleyer, Georg Schett and Axel J. Hueber

    Citation: Arthritis Research & Therapy 2018 20:153

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  3. Content type: Research article

    The molecular heterogeneity of autoimmune and inflammatory diseases has been one of the main obstacles to the development of safe and specific therapeutic options. Here, we evaluated the diagnostic and clinica...

    Authors: João J. Oliveira, Sarah Karrar, Daniel B. Rainbow, Christopher L. Pinder, Pamela Clarke, Arcadio Rubio García, Osama Al-Assar, Keith Burling, Sian Morris, Richard Stratton, Tim J. Vyse, Linda S. Wicker, John A. Todd and Ricardo C. Ferreira

    Citation: Arthritis Research & Therapy 2018 20:152

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  4. Content type: Research article

    Following the onset of rheumatoid arthritis (RA), patients experience a functional decline caused by various joint symptoms which affects their activities of daily living and can lead to reduced work productiv...

    Authors: Yoshiya Tanaka, Hideto Kameda, Kazuyoshi Saito, Yuko Kaneko, Eiichi Tanaka, Shinsuke Yasuda, Naoto Tamura, Keishi Fujio, Takao Fujii, Toshihisa Kojima, Tatsuhiko Anzai, Chikuma Hamada, Yoshihisa Fujino, Shinya Matsuda and Hitoshi Kohsaka

    Citation: Arthritis Research & Therapy 2018 20:151

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  5. Content type: Research article

    It is not known if sex-based disparities in immunological factors contribute to the disease process in rheumatoid arthritis (RA). Hence, we examined whether circulating T cell subset proportions and their asso...

    Authors: Jonathan Aldridge, Jayesh M. Pandya, Linda Meurs, Kerstin Andersson, Inger Nordström, Elke Theander, Anna-Carin Lundell and Anna Rudin

    Citation: Arthritis Research & Therapy 2018 20:150

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  6. Content type: Research article

    Dysbiosis occurs in spondyloarthritis (SpA) and inflammatory bowel disease (IBD), which is subdivided into Crohn’s disease (CD) and ulcerative colitis (UC). The immunologic consequences of alterations in micro...

    Authors: Emilie H. Regner, Neha Ohri, Andrew Stahly, Mark E. Gerich, Blair P. Fennimore, Diana Ir, Widian K. Jubair, Carsten Görg, Janet Siebert, Charles E. Robertson, Liron Caplan, Daniel N. Frank and Kristine A. Kuhn

    Citation: Arthritis Research & Therapy 2018 20:149

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  7. Content type: Research article

    Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we investigated the effects of the HDACi givinostat (ITF2357) o...

    Authors: Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steinkühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten and Timothy R. D. J. Radstake

    Citation: Arthritis Research & Therapy 2018 20:148

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  8. Content type: Research article

    Methotrexate (MTX) remains the disease-modifying anti-rheumatic drug of first choice in rheumatoid arthritis (RA) but response varies. Predicting non-response to MTX could enable earlier access to alternative ...

    Authors: Jamie C. Sergeant, Kimme L. Hyrich, James Anderson, Kamilla Kopec-Harding, Holly F. Hope, Deborah P. M. Symmons, Anne Barton and Suzanne M. M. Verstappen

    Citation: Arthritis Research & Therapy 2018 20:147

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  9. Content type: Research article

    Anti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated ...

    Authors: Maria Karolina Jonsson, Aase Haj Hensvold, Monika Hansson, Anna-Birgitte Aga, Joseph Sexton, Linda Mathsson-Alm, Martin Cornillet, Guy Serre, Siri Lillegraven, Bjørg-Tilde Svanes Fevang, Anca Irinel Catrina and Espen Andre Haavardsholm

    Citation: Arthritis Research & Therapy 2018 20:146

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  10. Content type: Research article

    A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis. Peroxisome proliferator ...

    Authors: Benjamin Korman, Roberta Goncalves Marangoni, Gabriel Lord, Jerrold Olefsky, Warren Tourtellotte and John Varga

    Citation: Arthritis Research & Therapy 2018 20:145

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  11. Content type: Research article

    The findings of a previous study by Jin et al. have shown that microRNA (miR)-155 was upregulated in patients with acute gouty arthritis and enhanced the proinflammatory cytokines. There is no direct evidence ...

    Authors: Qibin Yang, Quanbo Zhang, Yufeng Qing, Li Zhou, Qingsheng Mi and Jingguo Zhou

    Citation: Arthritis Research & Therapy 2018 20:144

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    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:177

  12. Content type: Research article

    Gout has an increasing global prevalence. Underutilization of urate-lowering therapy (ULT) is thought to be common, via both suboptimal dosing and poor medication adherence. The aims of this study were to dete...

    Authors: Huai Leng Pisaniello, Susan Lester, David Gonzalez-Chica, Nigel Stocks, Marie Longo, Greg R. Sharplin, Eleonora Dal Grande, Tiffany K. Gill, Samuel L. Whittle and Catherine L. Hill

    Citation: Arthritis Research & Therapy 2018 20:143

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  13. Content type: Research article

    Takayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the...

    Authors: Oh Chan Kwon, Sang-Won Lee, Yong-Beom Park, Ji Seon Oh, Sang Hoon Lee, Seokchan Hong, Chang-Keun Lee, Bin Yoo and Yong-Gil Kim

    Citation: Arthritis Research & Therapy 2018 20:142

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  14. Content type: Research article

    We aimed to evaluate the diagnostic utility of pelvic radiographs versus magnetic resonance imaging (MRI) of the sacroiliac joints in children with suspected sacroiliitis.

    Authors: Pamela F. Weiss, Rui Xiao, Timothy G. Brandon, David M. Biko, Walter P. Maksymowych, Robert G. Lambert, Jacob L. Jaremko and Nancy A. Chauvin

    Citation: Arthritis Research & Therapy 2018 20:141

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  15. Content type: Review

    Depression is common among patients with axial spondyloarthritis (axSpA), but reports of its prevalence are highly variable. We performed a systematic review to (i) describe the prevalence of depression in axS...

    Authors: Sizheng Zhao, Daniel Thong, Natasha Miller, Stephen J. Duffield, David M. Hughes, Laura Chadwick and Nicola J. Goodson

    Citation: Arthritis Research & Therapy 2018 20:140

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  16. Content type: Research article

    Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership...

    Authors: Laura T. Donlin, Deepak A. Rao, Kevin Wei, Kamil Slowikowski, Mandy J. McGeachy, Jason D. Turner, Nida Meednu, Fumitaka Mizoguchi, Maria Gutierrez-Arcelus, David J. Lieb, Joshua Keegan, Kaylin Muskat, Joshua Hillman, Cristina Rozo, Edd Ricker, Thomas M. Eisenhaure…

    Citation: Arthritis Research & Therapy 2018 20:139

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  17. Content type: Research article

    Monocyte-derived dendritic cells (moDCs) play important roles in the pathogenesis of systemic lupus erythematosus (SLE). Aberrant expression of long noncoding RNAs (lncRNAs) could affect the function of moDCs....

    Authors: Yilun Wang, Shuang Chen, Sunyi Chen, Juan Du, Jinran Lin, Haihong Qin, Jie Wang, Jun Liang and Jinhua Xu

    Citation: Arthritis Research & Therapy 2018 20:138

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  18. Content type: Research article

    Accumulating evidence implicates mitochondrial DNA (mtDNA) alleles, which are independent of the nuclear genome, in disease, especially in human metabolic diseases. However, this area of investigation has lagg...

    Authors: Chia-Chun Tseng, Chung-Jen Chen, Jeng-Hsien Yen, Hsi-Yuan Huang, Jan-Gowth Chang, Shun-Jen Chang and Wei-Ting Liao

    Citation: Arthritis Research & Therapy 2018 20:137

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  19. Content type: Research article

    Gout treatment remains suboptimal. Identifying populations at risk of developing gout may provide opportunities for prevention. Our aim was to assess the risk of incident gout associated with obesity, hyperten...

    Authors: Peter L. Evans, James A. Prior, John Belcher, Christian D. Mallen, Charles A. Hay and Edward Roddy

    Citation: Arthritis Research & Therapy 2018 20:136

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  20. Content type: Research article

    Increased coffee intake is associated with reduced serum urate concentrations and lower risk of gout. Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2 genes have been associated with both reduced coffee in...

    Authors: Joseph Hutton, Tahzeeb Fatima, Tanya J. Major, Ruth Topless, Lisa K. Stamp, Tony R. Merriman and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2018 20:135

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  21. Content type: Research article

    Dermatomyositis and polymyositis are the best known idiopathic inflammatory myopathies (IIMs). Classic histopathologic findings include the infiltration of inflammatory cells into muscle tissues. Neutrophil se...

    Authors: Siming Gao, Xiaoxia Zuo, Di Liu, Yizhi Xiao, Honglin Zhu, Huali Zhang and Hui Luo

    Citation: Arthritis Research & Therapy 2018 20:134

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  22. Content type: Research article

    Hydroxychloroquine (HCQ) retinopathy may be more common than previously recognized; recent ophthalmology guidelines have revised recommendations from ideal body weight (IBW)-based dosing to actual body weight ...

    Authors: April M. Jorge, Ronald B. Melles, Yuqing Zhang, Na Lu, Sharan K. Rai, Lucy H. Young, Karen H. Costenbader, Rosalind Ramsey-Goldman, S. Sam Lim, John M. Esdaile, Ann E. Clarke, M. B. Urowitz, Anca Askanase, Cynthia Aranow, Michelle Petri and Hyon Choi

    Citation: Arthritis Research & Therapy 2018 20:133

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  23. Content type: Research article

    Chemerin is a chemoattractant involved in immunity that also functions as an adipokine. Chemerin is secreted as an inactive precursor (chem163S), and its activation requires proteolytic cleavages at its C-term...

    Authors: Lei Zhao, Yasuto Yamaguchi, Xiaomei Ge, William H. Robinson, John Morser and Lawrence L. K. Leung

    Citation: Arthritis Research & Therapy 2018 20:132

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  24. Content type: Research article

    Changes of serum concentrations of glycated, oxidized, and nitrated amino acids and hydroxyproline and anticyclic citrullinated peptide antibody status combined by machine learning techniques in algorithms hav...

    Authors: Catherine Legrand, Usman Ahmed, Attia Anwar, Kashif Rajpoot, Sabah Pasha, Cécile Lambert, Rose K. Davidson, Ian M. Clark, Paul J. Thornalley, Yves Henrotin and Naila Rabbani

    Citation: Arthritis Research & Therapy 2018 20:131

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  25. Content type: Research article

    Previous studies have revealed that hepatitis B virus (HBV) infection may be related to rheumatoid arthritis (RA), but there are no studies on the presence of HBV antigens or nucleic acid in synovium from pati...

    Authors: Yu-Lan Chen, Jun Jing, Ying-Qian Mo, Jian-Da Ma, Li-Juan Yang, Le-Feng Chen, Xiang Zhang, Tao Yan, Dong-Hui Zheng, Frank Pessler and Lie Dai

    Citation: Arthritis Research & Therapy 2018 20:130

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  26. Content type: Research article

    The phase III MONARCH randomized controlled trial (NCT02332590) demonstrated that in patients with rheumatoid arthritis (RA), sarilumab (anti-interleukin-6 receptor monoclonal antibody) monotherapy is superior...

    Authors: Vibeke Strand, Laure Gossec, Clare W. J. Proudfoot, Chieh-I Chen, Matthew Reaney, Sophie Guillonneau, Toshio Kimura, Janet van Adelsberg, Yong Lin, Erin K. Mangan, Hubert van Hoogstraten and Gerd R. Burmester

    Citation: Arthritis Research & Therapy 2018 20:129

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  27. Content type: Research article

    In this study, we evaluated whether platelet-rich plasma (PRP) is superior to hyaluronic acid (HA) in the treatment of knee osteoarthritis.

    Authors: Yalong Di, Changxu Han, Liang Zhao and Yizhong Ren

    Citation: Arthritis Research & Therapy 2018 20:128

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  28. Content type: Research article

    Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and inc...

    Authors: David B. Bartlett, Leslie H. Willis, Cris A. Slentz, Andrew Hoselton, Leslie Kelly, Janet L. Huebner, Virginia B. Kraus, Jennifer Moss, Michael J. Muehlbauer, Guillaume Spielmann, William E. Kraus, Janet M. Lord and Kim M. Huffman

    Citation: Arthritis Research & Therapy 2018 20:127

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  29. Content type: Research article

    The application of more sensitive imaging techniques, such as ultrasonography (US), changed the concept of non-erosive arthritis in systemic lupus erythematosus (SLE), underlining the need for biomarkers to id...

    Authors: Fulvia Ceccarelli, Carlo Perricone, Tania Colasanti, Laura Massaro, Enrica Cipriano, Monica Pendolino, Francesco Natalucci, Riccardo Mancini, Francesca Romana Spinelli, Guido Valesini, Fabrizio Conti and Cristiano Alessandri

    Citation: Arthritis Research & Therapy 2018 20:126

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  30. Content type: Correction

    Unfortunately, after publication of this article [1], it was noticed that the panel for Fig. 4b was inadvertently obscured during the production process. The full, correct Fig. 4 can be seen below and the orig...

    Authors: Jie Qian, Lingxiao Xu, Xiaoxuan Sun, Yani Wang, Wenhua Xuan, Qian Zhang, Pengfei Zhao, Qin Wu, Rui Liu, Nan Che, Fang Wang, Wenfeng Tan and Miaojia Zhang

    Citation: Arthritis Research & Therapy 2018 20:125

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    The original article was published in Arthritis Research & Therapy 2018 20:26

  31. Content type: Research article

    Low C-C chemokine receptor 1 (CCR1) and interleukin (IL)-10 expression is associated with risk of Behçet’s disease (BD). The objective of the present study was to clarify the pathological roles of CCR1 and IL10 l...

    Authors: Hiroto Nakano, Yohei Kirino, Mitsuhiro Takeno, Kana Higashitani, Hideto Nagai, Ryusuke Yoshimi, Yukie Yamaguchi, Ikuma Kato, Ichiro Aoki and Hideaki Nakajima

    Citation: Arthritis Research & Therapy 2018 20:124

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  32. Content type: Research article

    Rheumatoid arthritis (RA) patients are at high risk of developing cardiovascular disease (CVD). In RA, chronic inflammation may lead to endothelial dysfunction, an early indicator of CVD, owing to diminished n...

    Authors: Unnikrishnan M. Chandrasekharan, Zeneng Wang, Yuping Wu, W. H. Wilson Tang, Stanley L. Hazen, Sihe Wang and M. Elaine Husni

    Citation: Arthritis Research & Therapy 2018 20:123

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  33. Content type: Letter

    Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis (ROC), registered 22 October 2009, NCT01000441

    Authors: Elodie Rivière, Jérémie Sellam, Juliette Pascaud, Philippe Ravaud, Jacques-Eric Gottenberg and Xavier Mariette

    Citation: Arthritis Research & Therapy 2018 20:122

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  34. Content type: Review

    Approaches for the prevention and treatment of hip osteoarthritis (OA) remain limited. There are recent data suggesting that low birth weight (LBW) and preterm birth may be risk factors for hip osteoarthritis....

    Authors: Sultana Monira Hussain, Ilana N. Ackerman, Yuanyuan Wang, Ella Zomer and Flavia M. Cicuttini

    Citation: Arthritis Research & Therapy 2018 20:121

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  35. Content type: Research article

    The pathogenesis of sacroiliitis is unclear; therefore, we aimed to systematically study the immunopathology of sacroiliitis in patients with axial spondyloarthritis (axSpA), and explore the relationship betwe...

    Authors: Dan min Wang, Ling Lin, Jian hua Peng, Yao Gong, Zhi duo Hou, Su biao Chen and Zheng yu Xiao

    Citation: Arthritis Research & Therapy 2018 20:120

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  36. Content type: Research article

    Epidemiologic studies have highlighted the association of environmental factors with the development and progression of autoimmune and chronic inflammatory diseases. Among the environmental factors, smoking ha...

    Authors: Jhimmy Talbot, Raphael S. Peres, Larissa G. Pinto, Rene D. R. Oliveira, Kalil A. Lima, Paula B. Donate, Jaqueline R. Silva, Bernard Ryffel, Thiago M. Cunha, José C. Alves-Filho, Foo Y. Liew, Paulo Louzada-Junior and Fernando de Queiroz Cunha

    Citation: Arthritis Research & Therapy 2018 20:119

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  37. Content type: Research article

    Systemic lupus erythematosus (SLE) is a chronic and incurable autoimmune disease involving the dysfunction of lymphocytes. Circular RNAs (circRNAs) are noncoding RNAs (ncRNAs) with a covalently closed loop str...

    Authors: Xin Wang, Chengzhong Zhang, Zhouwei Wu, Yue Chen and Weimin Shi

    Citation: Arthritis Research & Therapy 2018 20:118

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  38. Content type: Research article

    The prevalence of dermatomyositis (DM) versus DM and polymyositis (PM) combined has been shown to be negatively associated with latitude. This observation has been attributed to increasing exposure to ultravio...

    Authors: Joanna E. Parkes, Simon Rothwell, Alexander Oldroyd, Hector Chinoy and Janine A. Lamb

    Citation: Arthritis Research & Therapy 2018 20:117

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  39. Content type: Research article

    There is growing evidence that mast cells (MCs) play a role in knee osteoarthritis (OA). H1-antihistamines block H1-receptors of histamine, which is an important mediator of MCs. There is a lack of data on whethe...

    Authors: Ivan Shirinsky and Valery Shirinsky

    Citation: Arthritis Research & Therapy 2018 20:116

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  40. Content type: Research article

    IL-17A has recently emerged as a potential target that regulates the extensive inflammation and abnormal bone formation observed in ankylosing spondylitis (AS). Blocking IL-17A is expected to inhibit bony anky...

    Authors: Sungsin Jo, Sung Eun Wang, Young Lim Lee, Suman Kang, Bitnara Lee, Jinil Han, Il-Hoon Sung, Ye-Soo Park, Sang-Cheol Bae and Tae-Hwan Kim

    Citation: Arthritis Research & Therapy 2018 20:115

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  41. Content type: Research article

    B cells exert their pathogenic action in rheumatoid arthritis (RA) locally in the synovium. This study was undertaken to elucidate the chemokines responsible for the recruitment of B cells in the inflamed syno...

    Authors: Estefanía Armas-González, María Jesús Domínguez-Luis, Ana Díaz-Martín, Mayte Arce-Franco, Javier Castro-Hernández, Gabriela Danelon, Vanesa Hernández-Hernández, Sagrario Bustabad-Reyes, Alberto Cantabrana, Mariagrazia Uguccioni and Federico Díaz-González

    Citation: Arthritis Research & Therapy 2018 20:114

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  42. Content type: Research article

    Pain is one of the most important domains affecting health-related quality of life (HRQoL) in patients with psoriatic arthritis (PsA). Secukinumab has demonstrated rapid and sustained improvements in signs and...

    Authors: Iain B. McInnes, Philip J. Mease, Georg Schett, Bruce Kirkham, Vibeke Strand, Nicole Williams, Todd Fox, Luminita Pricop, Steffen M. Jugl and Kunal K. Gandhi

    Citation: Arthritis Research & Therapy 2018 20:113

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  43. Content type: Research article

    Aerobic exercise in general and high-intensity interval training (HIIT) specifically is known to improve vascular function in a range of clinical conditions. HIIT in particular has demonstrated improvements in...

    Authors: A. Mitropoulos, A. Gumber, H. Crank, M. Akil and M. Klonizakis

    Citation: Arthritis Research & Therapy 2018 20:112

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  44. Content type: Research article

    Gout is a metabolic disease and is the most common form of inflammatory arthritis affecting men. However, the pathogenesis of gout is still uncertain, and novel biomarkers are needed for early prediction and d...

    Authors: Yannan Zhang, Huanzhen Zhang, Dong Chang, Fuchuan Guo, Hongzhi Pan and Yuexin Yang

    Citation: Arthritis Research & Therapy 2018 20:111

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  45. Content type: Research article

    Prior qualitative research on gout has focused primarily on barriers to disease management. Our objective was to use patients’ perspectives to construct an explanatory framework to understand how patients beco...

    Authors: Alyssa Howren, Susan M. Cox, Kam Shojania, Sharan K. Rai, Hyon K. Choi and Mary A. De Vera

    Citation: Arthritis Research & Therapy 2018 20:110

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  46. Content type: Research article

    The aim of this study is to examine the occurrence of comorbidities at the time of first diagnosis of gout compared with matched population controls, overall and by sex, as well as to examine the crude and age...

    Authors: Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Svärd, Lennart T. H. Jacobsson and Mats Dehlin

    Citation: Arthritis Research & Therapy 2018 20:108

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    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:206

  47. Content type: Research article

    The relationship between inflammation and blood pressure (BP) has been studied mainly in the general population. In this study, we examined the association between inflammation and BP across a broader range of...

    Authors: Zhi Yu, Seoyoung C. Kim, Kathleen Vanni, Jie Huang, Rishi Desai, Shawn N. Murphy, Daniel H. Solomon and Katherine P. Liao

    Citation: Arthritis Research & Therapy 2018 20:107

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  48. Content type: Research article

    The perceived bother of skin and joint-related manifestations of psoriatic disease may differ among patients, rheumatologists, and dermatologists. This study identified and compared the patient and dermatologi...

    Authors: M. Elaine Husni, Anthony Fernandez, Brett Hauber, Rakesh Singh, Joshua Posner, Jessie Sutphin and Arijit Ganguli

    Citation: Arthritis Research & Therapy 2018 20:102

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