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  1. Content type: Research article

    Sex-specific differences in the effect of genetic variants on serum urate levels have been described. The aim of this study was to systematically examine whether serum urate-associated genetic variants differ ...

    Authors: Ravi K. Narang, Ruth Topless, Murray Cadzow, Greg Gamble, Lisa K. Stamp, Tony R. Merriman and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2019 21:13

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  2. Content type: Research

    The objective was to determine if dose reduction is non-inferior to full-dose TNFi to maintain low disease activity (LDA) in patients already in remission with TNFi, in axial spondyloarthritis.

    Authors: Jordi Gratacós, Caridad Pontes, Xavier Juanola, Jesús Sanz, Ferran Torres, Cristina Avendaño, Antoni Vallano, Gonzalo Calvo, Eugenio de Miguel and Raimon Sanmartí

    Citation: Arthritis Research & Therapy 2019 21:11

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  3. Content type: Research article

    Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is an innate-immune receptor found in blood. Its presence reflects innate immune cell activation. We sought to investigate plasma sTREM-1 leve...

    Authors: Yonatan Edel, Vitaly Kliminski, Elisheva Pokroy-Shapira, Shirly Oren, Ariela Dortort Lazar, Yael Pri-Paz Basson, Mohammad Egbaria and Yair Molad

    Citation: Arthritis Research & Therapy 2019 21:10

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  4. Content type: Research article

    Adult-onset Still’s disease (AOSD) is a systemic inflammatory disease characterized by neutrophilia and NLRP3 inflammasome and macrophage activation. We investigated the role of neutrophil extracellular traps ...

    Authors: Qiongyi Hu, Hui Shi, Ting Zeng, Honglei Liu, Yutong Su, Xiaobing Cheng, Junna Ye, Yufeng Yin, Mengru Liu, Hui Zheng, Xinyao Wu, Huihui Chi, Zhuochao Zhou, Jinchao Jia, Yue Sun, Jialin Teng…

    Citation: Arthritis Research & Therapy 2019 21:9

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  5. Content type: Research article

    In gout, long-term urate-lowering therapy (ULT) promotes dissolution of tissue urate crystal deposits. However, no studies using combined xanthine oxidase inhibition and uricosuric ULT have focused on clinical...

    Authors: Nicola Dalbeth, Graeme Jones, Robert Terkeltaub, Dinesh Khanna, Maple Fung, Scott Baumgartner and Fernando Perez-Ruiz

    Citation: Arthritis Research & Therapy 2019 21:8

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  6. Content type: Research article

    A randomized controlled trial (RCT) was performed to confirm preliminary uncontrolled data indicating that regional adipose tissue (AT) grafting (G) is effective in inducing ischemic digital ulcer (IDU) healin...

    Authors: Nicoletta Del Papa, Gabriele Di Luca, Romina Andracco, Eleonora Zaccara, Wanda Maglione, Francesca Pignataro, Antonina Minniti and Claudio Vitali

    Citation: Arthritis Research & Therapy 2019 21:7

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  7. Content type: Research article

    Fibroblast-like synoviocytes (FLS) and CCR7 effector memory T (TEM) cells are two of the major cell types implicated in the progression of rheumatoid arthritis (RA). In particular, FLS become highly invasive, wh...

    Authors: Mark R. Tanner, Michael W. Pennington, Satendra S. Chauhan, Teresina Laragione, Pércio S. Gulko and Christine Beeton

    Citation: Arthritis Research & Therapy 2019 21:6

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  8. Content type: Research article

    The circadian clock plays a crucial role in regulating physiology and is important for maintaining immune homeostasis and responses to inflammatory stimuli. Inflammatory arthritis often shows diurnal variation...

    Authors: Laura E. Hand, Suzanna H. Dickson, Anthony J. Freemont, David W. Ray and Julie E. Gibbs

    Citation: Arthritis Research & Therapy 2019 21:5

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    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:37

  9. Content type: Research

    We aimed to evaluate the prevalence of hip and knee osteoarthritis (HOA and KOA) according to American College of Rheumatology (ACR) criteria among participants with suspected early symptomatic osteoarthritis ...

    Authors: Jurgen Damen, Rogier M. van Rijn, Pieter J. Emans, Willem K. H. A. Hilberdink, Janet Wesseling, Edwin H. G. Oei and Sita M. A. Bierma-Zeinstra

    Citation: Arthritis Research & Therapy 2019 21:4

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  10. Content type: Research article

    Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise bacterial metabolites presented by MHC class I-related protein 1 (MR1). Bacterial dysbiosis has been implicated in auto-inflam...

    Authors: Hester Koppejan, Diahann T. S. L. Jansen, Marjolijn Hameetman, Ranjeny Thomas, Rene E. M. Toes and Floris A. van Gaalen

    Citation: Arthritis Research & Therapy 2019 21:3

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  11. Content type: Research article

    Infliximab, an anti-tumor necrosis factor-alpha antibody, has been reported to have excellent efficacy for refractory uveoretinitis in Behçet’s disease (RUBD), and was approved for this indication in Japan. Ho...

    Authors: Shigeaki Ohno, Itsuro Umebayashi, Miyuki Matsukawa, Takashi Goto and Toshiro Yano

    Citation: Arthritis Research & Therapy 2019 21:2

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  12. Content type: Correction

    Following publication of the original article [1], the authors reported an error in Figs. 2C and 5C.

    Authors: Daniel J. Leong, Marwa Choudhury, Regina Hanstein, David M. Hirsh, Sun Jin Kim, Robert J. Majeska, Mitchell B. Schaffler, John A. Hardin, David C. Spray, Mary B. Goldring, Neil J. Cobelli and Hui B. Sun

    Citation: Arthritis Research & Therapy 2019 21:1

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    The original article was published in Arthritis Research & Therapy 2014 16:508

  13. Content type: Research article

    Pegloticase is a recombinant mammalian uricase conjugated to polyethylene glycol approved in the United States for treatment of chronic refractory gout. It can profoundly decrease serum urate to < 1 mg/dl. In ...

    Authors: Brian F. Mandell, Anthony E. Yeo and Peter E. Lipsky

    Citation: Arthritis Research & Therapy 2018 20:286

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  14. Content type: Research article

    The availability of methotrexate and the introduction of multiple biological agents have revolutionized the treatment of juvenile idiopathic arthritis (JIA). Several international and national drug registries ...

    Authors: Joost Swart, Gabriella Giancane, Gerd Horneff, Bo Magnusson, Michael Hofer, Еkaterina Alexeeva, Violeta Panaviene, Brigitte Bader-Meunier, Jordi Anton, Susan Nielsen, Fabrizio De Benedetti, Sylvia Kamphuis, Valda Staņēviča, Maria Tracahana, Laura Marinela Ailioaie, Elena Tsitsami…

    Citation: Arthritis Research & Therapy 2018 20:285

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  15. Content type: Research

    Ankylosing spondylitis (AS) begins early in life and often leads to reduced physical function, but less is known about the impacts it has on health-related quality of life (HRQoL). The aims of this study were ...

    Authors: Lucy Law, Jeanette Beckman Rehnman, Anna Deminger, Eva Klingberg, Lennart T. H. Jacobsson and Helena Forsblad-d’Elia

    Citation: Arthritis Research & Therapy 2018 20:284

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  16. Content type: Research article

    Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise trai...

    Authors: Brian J. Andonian, David B. Bartlett, Janet L. Huebner, Leslie Willis, Andrew Hoselton, Virginia B. Kraus, William E. Kraus and Kim M. Huffman

    Citation: Arthritis Research & Therapy 2018 20:283

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  17. Content type: Correction

    Following publication of the original article [1], the authors reported an error in the spelling of the ninth author’s name.

    Authors: Aurélie Najm, Benoît Le Goff, Carl Orr, Rogier Thurlings, Juan D. Cañete, Frances Humby, Stefano Alivernini, Antonio Manzo, Søren Andreas Just, Vasco C. Romão, Veit Krenn, Ulf Müller-Ladner, Olga Addimanda, Sander W. Tas, Maria Stoenoiu, Laurent Meric de Bellefon…

    Citation: Arthritis Research & Therapy 2018 20:282

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    The original article was published in Arthritis Research & Therapy 2018 20:265

  18. Content type: Research article

    To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis (SSc).

    Authors: Alfredo Guillén-Del-Castillo, Carmen Pilar Simeón-Aznar, Eduardo L. Callejas-Moraga, Carles Tolosa-Vilella, Serafín Alonso-Vila, Vicente Fonollosa-Pla and Albert Selva-O’Callaghan

    Citation: Arthritis Research & Therapy 2018 20:281

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  19. Content type: Research article

    The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort.

    Authors: Javier Narváez, Helena Borrell, Fernando Sánchez-Alonso, Iñigo Rúa-Figueroa, Francisco Javier López-Longo, María Galindo-Izquierdo, Jaime Calvo-Alén, Antonio Fernández-Nebro, Alejandro Olivé, José Luis Andreu, Víctor Martínez-Taboada, Joan Miquel Nolla and José María Pego-Reigosa

    Citation: Arthritis Research & Therapy 2018 20:280

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  20. Content type: Research article

    The value of joint ultrasonography (US) in the prediction of clinical arthritis in individuals at risk of developing rheumatoid arthritis (RA) is still a point of debate, due to varying scanning protocols and ...

    Authors: Marian H. van Beers-Tas, Annelies B. Blanken, Mark M. J. Nielen, Franktien Turkstra, Conny J. van der Laken, Marlies Meursinge Reynders and Dirkjan van Schaardenburg

    Citation: Arthritis Research & Therapy 2018 20:279

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  21. Content type: Research article

    CD4+ T cells are of great importance in the pathogenesis of systemic lupus erythematosus (SLE), as an imbalance between CD4+ regulatory T cells (Tregs) and CD4+ responder T cells (Tresps) causes flares of active ...

    Authors: Matthias Schaier, Claudius Gottschalk, Lorenz Uhlmann, Claudius Speer, Florian Kälble, Volker Eckstein, Carsten Müller-Tidow, Stefan Meuer, Karsten Mahnke, Hanns-Martin Lorenz, Martin Zeier and Andrea Steinborn

    Citation: Arthritis Research & Therapy 2018 20:278

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  22. Content type: Research article

    The aim of this study was to identify fibrosis-related serological surrogate outcome measures in patients with immunoglobulin G4-related disease (IgG4-RD).

    Authors: Shin-ya Kawashiri, Tomoki Origuchi, Masataka Umeda, Ayako Nishino, Toshimasa Shimizu, Shoichi Fukui, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Takahiro Maeda, Mitsuhiro Kawano, Motohisa Yamamoto, Yasumori Izumi and Atsushi Kawakami

    Citation: Arthritis Research & Therapy 2018 20:277

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  23. Content type: Research article

    The objective was to evaluate the 25(OH) vitamin D (25(OH)D) status of patients with juvenile idiopathic arthritis (JIA) and determine whether the 25(OH)D level is associated with disease activity and the cour...

    Authors: Claudia Sengler, Julian Zink, Jens Klotsche, Martina Niewerth, Ina Liedmann, Gerd Horneff, Christoph Kessel, Gerd Ganser, Angelika Thon, Johannes-Peter Haas, Anton Hospach, Frank Weller-Heinemann, Arnd Heiligenhaus, Dirk Foell, Angela Zink and Kirsten Minden

    Citation: Arthritis Research & Therapy 2018 20:276

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  24. Content type: Research article

    Calprotectin is a biomarker of disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and predicts relapse in juvenile idiopathic arthritis. Higher drug trough serum levels are associated ...

    Authors: José Inciarte-Mundo, Julio Ramirez, Maria Victoria Hernández, Virginia Ruiz-Esquide, Andrea Cuervo, Sonia Raquel Cabrera-Villalba, Mariona Pascal, Jordi Yagüe, Juan D. Cañete and Raimon Sanmarti

    Citation: Arthritis Research & Therapy 2018 20:275

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  25. Content type: Research article

    Rheumatoid arthritis (RA) is associated with a high prevalence of atherosclerosis. Recently increased levels of microparticles (MPs) have been reported in patients with RA. MPs could represent a link between a...

    Authors: Cristiana Barbati, Marta Vomero, Tania Colasanti, Marco Diociaiuti, Fulvia Ceccarelli, Sara Ferrigno, Annacarla Finucci, Francesca Miranda, Lucia Novelli, Carlo Perricone, Francesca Romana Spinelli, Simona Truglia, Fabrizio Conti, Guido Valesini and Cristiano Alessandri

    Citation: Arthritis Research & Therapy 2018 20:273

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  26. Content type: Research

    Secukinumab has demonstrated sustained improvement in the signs and symptoms of psoriatic arthritis (PsA) over 2 years in the FUTURE 2 study (NCT01752634). This post hoc analysis assessed the ability of secuki...

    Authors: L. C. Coates, D. D. Gladman, P. Nash, O. FitzGerald, A. Kavanaugh, T. K. Kvien, L. Gossec, V. Strand, L. Rasouliyan, L. Pricop, K. Ding, S. M. Jugl and C. Gaillez

    Citation: Arthritis Research & Therapy 2018 20:272

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  27. Content type: Research article

    Although accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis repo...

    Authors: Lebin Song, Yi Wang, Jiayi Zhang, Ninghong Song, Xiaoyun Xu and Yan Lu

    Citation: Arthritis Research & Therapy 2018 20:270

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  28. Content type: Research article

    Increasing evidence indicates a pathogenic role of deregulated autophagy in rheumatoid arthritis (RA). We examined the relationship between autophagy and inflammatory parameters in patients with RA receiving b...

    Authors: Yi-Ming Chen, Chun-Yu Chang, Hsin-Hua Chen, Chia-Wei Hsieh, Kuo-Tung Tang, Meng-Chun Yang, Joung-Liang Lan and Der-Yuan Chen

    Citation: Arthritis Research & Therapy 2018 20:268

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  29. Content type: Research

    Comorbidities are common in chronic systemic connective tissue diseases and are associated with adverse outcomes, increased morbidity and mortality. Although the prevalence of comorbidities has been well-studi...

    Authors: Stylianos Panopoulos, Maria Tektonidou, Alexandros A. Drosos, Stamatis-Nick Liossis, Theodoros Dimitroulas, Alexandros Garyfallos, Lazaros Sakkas, Dimitrios Boumpas, Paraskevi V. Voulgari, Dimitrios Daoussis, Konstantinos Thomas, Georgios Georgiopoulos, Georgios Vosvotekas, Dimitrios Vassilopoulos and Petros P. Sfikakis

    Citation: Arthritis Research & Therapy 2018 20:267

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  30. Content type: Research article

    Common carotid artery intima-media thickness (CIMT), as measured by ultrasound, has utility in stratification of the accelerated cardiovascular risk seen in rheumatoid arthritis (RA); however, the technique ha...

    Authors: Lesley-Anne Bissell, Bara Erhayiem, Graham Fent, Elizabeth M. A. Hensor, Agata Burska, Helena Donica, Sven Plein, Maya H. Buch, John P. Greenwood and Jacqueline Andrews

    Citation: Arthritis Research & Therapy 2018 20:266

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  31. Content type: Research article

    The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG...

    Authors: Aurélie Najm, Benoît Le Goff, Carl Orr, Rogier Thurlings, Juan D. Cañete, Frances Humby, Stefano Alivernini, Antonio Manzo, Søren Andreas Just, Vasco C. Romão, Veit Krenn, Ulf Müller-Ladner, Olga Addimanda, Sander W. Tas, Maria Stoenoiu, Laurent Meric de Bellefon…

    Citation: Arthritis Research & Therapy 2018 20:265

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    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:282

    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:90

  32. Content type: Research article

    Diagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years before clinical manifestations. However, ANAs ar...

    Authors: Yuriy Baglaenko, Nan-Hua Chang, Sindhu R. Johnson, Waleed Hafiz, Kieran Manion, Dario Ferri, Babak Noamani, Dennisse Bonilla, Sina Rusta-Sellehy, Larissa Lisnevskaia, Earl Silverman, Arthur Bookman, Carolina Landolt-Marticorena and Joan Wither

    Citation: Arthritis Research & Therapy 2018 20:264

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  33. Content type: Research article

    The cholinergic anti-inflammatory pathway (CAP) has a strong anti-inflammatory effect on collagen-induced arthritis (CIA), a classic animal model of rheumatoid arthritis (RA). However, the underlying immune re...

    Authors: Di Liu, Tong Li, Hui Luo, Xiaoxia Zuo, Sijia Liu and Shiyao Wu

    Citation: Arthritis Research & Therapy 2018 20:263

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  34. Content type: Research article

    We aimed to evaluate the 1-year and 2-year outcome of a health-enhancing physical activity (HEPA) support program on global pain, pressure pain sensitivity, and exercise-induced segmental and plurisegmental hy...

    Authors: Monika Löfgren, Christina H. Opava, Ingrid Demmelmaier, Cecilia Fridén, Ingrid E. Lundberg, Birgitta Nordgren and Eva Kosek

    Citation: Arthritis Research & Therapy 2018 20:262

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  35. Content type: Research article

    Fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA) are autonomously activated to maintain inflammation and joint destruction in co-transplantation models. To elucidate inducing me...

    Authors: Oliver Frey, Marion Hückel, Mieczyslaw Gajda, Peter K. Petrow and Rolf Bräuer

    Citation: Arthritis Research & Therapy 2018 20:261

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  36. Content type: Research article

    Subclinical joint inflammation in patients with arthralgia is predictive for progression to rheumatoid arthritis (RA). However, the time course of progression for bone marrow edema (osteitis), synovitis, and/o...

    Authors: R. M. ten Brinck, H. W. van Steenbergen and A. H. M. van der Helm–van Mil

    Citation: Arthritis Research & Therapy 2018 20:260

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  37. Content type: Research article

    Interleukin (IL)-23 can facilitate the differentiation of IL-17-producing helper T cells (Th17). The IL-23/IL-17 axis is known to play a key role in the immunopathogenesis of ankylosing spondylitis (AS). We hy...

    Authors: Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang and Ming-Chi Lu

    Citation: Arthritis Research & Therapy 2018 20:259

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  38. Content type: Research article

    Comorbidities are known to exist in many rheumatological conditions. Polymyalgia rheumatica (PMR) is a common inflammatory rheumatological condition affecting older people which, prior to effective treatment, ...

    Authors: Richard Partington, Toby Helliwell, Sara Muller, Alyshah Abdul Sultan and Christian Mallen

    Citation: Arthritis Research & Therapy 2018 20:258

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  39. Content type: Research article

    We showed previously that Japanese individuals with familial Mediterranean fever (FMF) have a more atypical phenotype compared to endemic areas. The clinical differences between young-onset FMF (YOFMF), adult-...

    Authors: Yushiro Endo, Tomohiro Koga, Midori Ishida, Yuya Fujita, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Remi Sumiyoshi, Takashi Igawa, Masataka Umeda, Shoichi Fukui, Ayako Nishino, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai…

    Citation: Arthritis Research & Therapy 2018 20:257

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  40. Content type: Research article

    A multi-biomarker disease activity (MBDA) score has been validated as an objective measure of disease activity in rheumatoid arthritis (RA) and shown to track response to treatment with several disease-modifyi...

    Authors: Nadia M. T. Roodenrijs, Maria J. H. de Hair, Gill Wheater, Mohsen Elshahaly, Janneke Tekstra, Y. K. Onno Teng, Floris P. J. G. Lafeber, Ching Chang Hwang, Xinyu Liu, Eric H. Sasso and Jacob M. van Laar

    Citation: Arthritis Research & Therapy 2018 20:256

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  41. Content type: Research article

    Allopurinol dosing has frequently been limited based on creatinine clearance (CrCL), resulting in failure to achieve target serum urate (SU). The aim of this analysis was to determine how many milligrams of al...

    Authors: Lisa K. Stamp, Peter T. Chapman, Murray L. Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2018 20:255

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  42. Content type: Research article

    Neutrophil extracellular trap (NET) formation has been described to be closely involved in the pathogenesis of systemic lupus erythematosus (SLE). In this study, we aimed to investigate the effect of polydatin...

    Authors: Pan Liao, Yi He, Fangyuan Yang, Guihu Luo, Jian Zhuang, Zeqing Zhai, Lili Zhuang, Zhuomiao Lin, Jiehuang Zheng and Erwei Sun

    Citation: Arthritis Research & Therapy 2018 20:254

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  43. Content type: Research article

    Evidence for non-pharmacological interventions in hand osteoarthritis is promising but still scarce. Combined interventions are most likely to best cover the clinical needs of patients with hand osteoarthritis...

    Authors: Michaela A. Stoffer-Marx, Meike Klinger, Simone Luschin, Silvia Meriaux-Kratochvila, Monika Zettel-Tomenendal, Valerie Nell-Duxneuner, Jochen Zwerina, Ingvild Kjeken, Marion Hackl, Sylvia Öhlinger, Anthony Woolf, Kurt Redlich, Josef S. Smolen and Tanja A. Stamm

    Citation: Arthritis Research & Therapy 2018 20:253

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  44. Content type: Research article

    Varicella zoster virus (VZV)-specific cellular immunity is essential for viral control, and the incidence of VZV reactivation is increased in patients with rheumatic diseases. Because knowledge of the influenc...

    Authors: David Schub, Gunter Assmann, Urban Sester, Martina Sester and Tina Schmidt

    Citation: Arthritis Research & Therapy 2018 20:252

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  45. Content type: Research article

    There is evidence that knee pain not only is a consequence of structural deterioration in osteoarthritis (OA) but also contributes to structural progression. Clarifying this is important because targeting the ...

    Authors: Yuanyuan Wang, Andrew J. Teichtahl, François Abram, Sultana Monira Hussain, Jean-Pierre Pelletier, Flavia M. Cicuttini and Johanne Martel-Pelletier

    Citation: Arthritis Research & Therapy 2018 20:250

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  46. Content type: Research article

    Although one of the three obstetric manifestations of antiphospholipid syndrome (APS) is intrauterine fetal death (IUFD), little is known about it in this context. We report the first large series of patients ...

    Authors: Mériem Belhocine, Laetitia Coutte, Nicolas Martin Silva, Nathalie Morel, Gaëlle Guettrot-Imbert, Romain Paule, Claire Le Jeunne, Micaela Fredi, Michel Dreyfus, Jean-Charles Piette, Odile Souchaud-Debouverie, Catherine Deneux-Tharaux, Vassilis Tsatsaris, Emmanuelle Pannier, Véronique Le Guern and Nathalie Costedoat-Chalumeau

    Citation: Arthritis Research & Therapy 2018 20:249

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