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  1. Interstitial lung disease (ILD) is the most common cause of death in patients with systemic sclerosis (SSc). Prognostic biomarkers are needed to identify SSc-ILD patients at risk for progressive pulmonary fibr...

    Authors: Viggo Hamberg, Azita Sohrabian, Elizabeth R. Volkmann, Marie Wildt, Anna Löfdahl, Dirk M. Wuttge, Roger Hesselstrand, Göran Dellgren, Gunilla Westergren-Thorsson, Johan Rönnelid and Kristofer Andréasson
    Citation: Arthritis Research & Therapy 2023 25:162
    Content type: Research Published on:

  2. Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease of unknown etiology with erosive, symmetric polyarthritis as the main clinical manifestations. Its basic pathological changes are the format...

    Authors: Yubo Shao, Hong Zhang, Qi Shi, Yongjun Wang and Qianqian Liang
    Citation: Arthritis Research & Therapy 2023 25:159
    Content type: Review Published on:

  3. Rheumatoid arthritis (RA) is one of the most prevalent and debilitating joint diseases worldwide. RA is characterized by synovial inflammation (synovitis), which is linked to the development of joint destructi...

    Authors: Wessel F. Theeuwes, Irene Di Ceglie, Daphne N. Dorst, Arjen B. Blom, Desiree L. Bos, Thomas Vogl, Sander W. Tas, Pilar Jimenez-Royo, Mats Bergstrom, Matthew Cleveland, Peter M. van der Kraan, Peter Laverman, Marije I. Koenders, Peter L. van Lent and Martijn H. J. van den Bosch
    Citation: Arthritis Research & Therapy 2023 25:158
    Content type: Research Published on:

  4. To investigate if extracellular matrix (ECM) blood-based biomarkers reflect the pharmacodynamic effect and response to TNF-α inhibitor therapy (adalimumab, ADA), in patients with axial spondyloarthritis (axSpA).

    Authors: Helena Port, Signe Holm Nielsen, Peder Frederiksen, Sofie Falkenløve Madsen, Anne-Christine Bay-Jensen, Inge Juul Sørensen, Bente Jensen, Anne Gitte Loft, Ole Rintek Madsen, Mikkel Østergaard and Susanne Juhl Pedersen
    Citation: Arthritis Research & Therapy 2023 25:157
    Content type: Research Published on:

  5. Systemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs, such as the lungs. Activated differentiation of progenitor cells, which are mainly res...

    Authors: Hiroshi Kasamatsu, Takenao Chino, Takumi Hasegawa, Natsuko Utsunomiya, Akira Utsunomiya, Masami Yamada, Noritaka Oyama and Minoru Hasegawa
    Citation: Arthritis Research & Therapy 2023 25:156
    Content type: Research Published on:

  6. Pulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE). This study aims to explore the clinical characteristics and prognosis in SLE-PAH based on consensus cluster...

    Authors: Mengmeng Dai, Chunyi Zhang, Chaoying Li, Qianqian Wang, Congcong Gao, Runzhi Yue, Menghui Yao, Zhaohui Su and Zhaohui Zheng
    Citation: Arthritis Research & Therapy 2023 25:155
    Content type: Research Published on:

  7. Osteoarthritis (OA) is increasingly recognised as a whole joint disease, with an important role for synovium. However, the repertoire of immune cells and fibroblasts that constitute OA synovium remains underst...

    Authors: Jolet Y. Mimpen, Robert Hedley, Anna Ridley, Mathew J. Baldwin, Dylan Windell, Ananya Bhalla, Lorenzo Ramos-Mucci, Christopher D. Buckley, Mark C. Coles, Abtin Alvand, Andrew J. Price, Andrew J. Carr, Stephanie G. Dakin and Sarah J. B. Snelling
    Citation: Arthritis Research & Therapy 2023 25:154
    Content type: Research Published on:

  8. Tofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis (PsA). This post hoc analysis assessed tofacitinib efficacy on enthesitis by baseline location and severity, and impact on...

    Authors: Philip J. Mease, Ana-Maria Orbai, Oliver FitzGerald, Mohamed Bedaiwi, Dona L. Fleishaker, Rajiv Mundayat, Pamela Young and Philip S. Helliwell
    Citation: Arthritis Research & Therapy 2023 25:153
    Content type: Research Published on:

  9. Iguratimod (IGU) reduces hypergammaglobulinemia and disease activity in pSS (primary Sjögren’s syndrome) patients. However, the therapeutical mechanism of IGU for pSS remains largely unknown. This study aimed ...

    Authors: Taibiao Lyu, Hui Jiang, Liuting Zeng, Suying Liu, Chengmei He, Chaowen Luo, Lin Qiao, Yan Zhao and Hua Chen
    Citation: Arthritis Research & Therapy 2023 25:152
    Content type: Research Published on:

  10. The early growth response 1 (EGR1) is a central transcription factor involved in systemic sclerosis (SSc) pathogenesis. Iguratimod is a synthesized anti-rheumatic disease-modifying drug, which shows drastic in...

    Authors: Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen and Qingran Yan
    Citation: Arthritis Research & Therapy 2023 25:151
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2024 26:34

  11. Guselkumab is a selective interleukin (IL)-23 inhibitor targeting the IL-23p19 subunit. In the phase 3b COSMOS trial, guselkumab demonstrated efficacy in treating participants with active psoriatic arthritis (...

    Authors: Georg Schett, Warner Chen, Sheng Gao, Soumya D. Chakravarty, May Shawi, Frederic Lavie, Miriam Zimmermann, Mohamed Sharaf, Laura C. Coates and Stefan Siebert
    Citation: Arthritis Research & Therapy 2023 25:150
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:170

  12. While it is known that klotho has negative regulatory effects in a variety of diseases such as metabolic disorders and kidney disease, the specific role of klotho in rheumatoid arthritis (RA) and its effect on...

    Authors: Qin-cheng Che, Qian Jia, Xiao-yu Zhang, Shu-ning Sun, Xiao-jie Zhang and Qiang Shu
    Citation: Arthritis Research & Therapy 2023 25:149
    Content type: Research Published on:

  13. In addition to decreasing the level of cholesterol, proprotein convertase subtilis kexin 9 (PCSK9) inhibitor has pleiotropic effects, including immune regulation. However, the impact of PCSK9 on autoimmune dis...

    Authors: Weijia Xie, Jiaxin Li, Hao Du and Jian Xia
    Citation: Arthritis Research & Therapy 2023 25:148
    Content type: Research Published on:

  14. Assess the efficacy of single and multiple intra-articular injections of autologous adipose-derived stem cells (ASCs) and adipose-derived stromal vascular fraction (ADSVF) for the treatment of knee osteoarthri...

    Authors: Yang Yang, Zhibin Lan, Jiangbo Yan, Zhiqun Tang, Linghui Zhou, Dian Jin and Qunhua Jin
    Citation: Arthritis Research & Therapy 2023 25:147
    Content type: Review Published on:

  15. Tau protein serves a pro-inflammatory function in neuroinflammation. However, the role of tau in other inflammatory disorders such as rheumatoid arthritis (RA) is less explored. This study is to investigate th...

    Authors: Meng Chen, Wenyu Fu, Huiyun Xu and Chuan-ju Liu
    Citation: Arthritis Research & Therapy 2023 25:146
    Content type: Research Published on:

  16. Axial spondyloarthritis (axSpA) is known to be associated with several extra-skeletal manifestations (ESM), including the inflammatory skin disease psoriasis. It is important to recognize and diagnose psoriasi...

    Authors: Angelique Rondags, Laura van Marle, Barbara Horváth, Freke R. Wink, Suzanne Arends and Anneke Spoorenberg
    Citation: Arthritis Research & Therapy 2023 25:145
    Content type: Research Published on:

  17. Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease. Over-activation of fibroblast-like synoviocytes is responsible for the hyperplasia of synovium and destruction of cartilage and bone and ...

    Authors: Xingxing Mao, Weijie Wu, Yunyi Nan, Weiwei Sun and Youhua Wang
    Citation: Arthritis Research & Therapy 2023 25:144
    Content type: Research Published on:

  18. Periodontitis (PD) may affect temporomandibular joint disorders (TMD) and TMD may influence PD in previous observational studies. Nevertheless, these studies were prone to confounders and reverse causation, le...

    Authors: Shaotai Wang, Huan Jiang, Huichuan Qi, Danfeng Luo, Tianyuan Qiu and Min Hu
    Citation: Arthritis Research & Therapy 2023 25:143
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:208

  19. Radiographic axial spondyloarthritis (r-axSpA) is one of the most common chronic inflammatory rheumatic diseases, affecting about 0.2% of the Swedish population. Adequate nutritional intake is essential for ma...

    Authors: Erik Hulander, Tatiana Zverkova Sandström, Jeannette Beckman Rehnman, Lucy Law, Stefan Söderberg and Helena Forsblad-d’Elia
    Citation: Arthritis Research & Therapy 2023 25:142
    Content type: Research Published on:

  20. The HFA-PEFF score has been validated to hold great diagnostic and prognostic utility for heart failure with preserved ejection fraction (HFpEF). Idiopathic inflammatory myopathy (IIM) is recognized as one of ...

    Authors: Yunjing Shi, Hao Zhang, Zeping Qiu, Yanjia Chen, Xiuxiu Su, Huihui Chi, Tienan Feng, Yue Sun, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Qiongyi Hu, Zhuochao Zhou, Jianfen Meng, Jialin Teng…
    Citation: Arthritis Research & Therapy 2023 25:141
    Content type: Research Published on:

  21. Disruption of glucocorticoid (GC) signaling in osteoblasts results in a marked attenuation of acute antibody-induced arthritis. The role of endogenous GCs in chronic inflammatory arthritis is however not fully...

    Authors: Tazio Maleitzke, Edgar Wiebe, Dörte Huscher, Cornelia M. Spies, Jinwen Tu, Timo Gaber, Yu Zheng, Frank Buttgereit, Markus J. Seibel and Hong Zhou
    Citation: Arthritis Research & Therapy 2023 25:140
    Content type: Research Published on:

  22. This study intends to analyze the hemodynamic parameters of the renal artery in patients with Takayasu’s arteritis (TAK) to explore the diagnostic efficacy of duplex ultrasonography in assessing the involved r...

    Authors: Yahong Wang, Ying Wang, Li Zhang, Zhitong Ge, Jing Li, Yunjiao Yang, Yu Chen, Xiao Yang, Jianchu Li and Xinping Tian
    Citation: Arthritis Research & Therapy 2023 25:139
    Content type: Research Published on:

  23. To investigate the relationship between disease-related parameters and joint space width (JSW) on high-resolution peripheral quantitative computed tomography (HR-pQCT) in psoriatic arthritis (PsA) patients.

    Authors: Yingzhao Jin, Isaac T Cheng, Ho So, Dongze Wu, James F Griffith, Vivian W Hung, Ling Qin, Cheuk-Chun Szeto, Agnes WS Chan and Lai-Shan Tam
    Citation: Arthritis Research & Therapy 2023 25:138
    Content type: Research Published on:

  24. The IL-6R antibody tocilizumab has been proven effective in treating Takayasu arteritis (TA). However, some patients show silent vascular stenosis progression (VSP) despite treatment with tocilizumab. The aim ...

    Authors: Chen Rongyi, Dai Xiaojuan, Wang Jinghua, Ma Lingying, Dai Xiaomin, Ma Lili, Chen Huiyong, Jiang Lindi and Sun Ying
    Citation: Arthritis Research & Therapy 2023 25:137
    Content type: Research Published on:

  25. In patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA), concomitant depression might have a negative impact on the course of disease and treatment outcomes. The aims of this analysis are...

    Authors: Andreas Reich, Anja Weiß, Lisa Lindner, Xenofon Baraliakos, Denis Poddubnyy, Silke Zinke, Carsten Stille, Anja Strangfeld and Anne C. Regierer
    Citation: Arthritis Research & Therapy 2023 25:136
    Content type: Research Published on:

  26. Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children, causing significant morbidity. Despite the dramatic improvement in treatment, many patients do not achieve complete...

    Authors: Merav Heshin-Bekenstein, Szilvia Baron, Grant Schulert, Anna Shusterman, Victoria Fidel, Yoav Ben-Shahar, Rachel Shukrun, Yoav Binenbaum and Ronit Elhasid
    Citation: Arthritis Research & Therapy 2023 25:135
    Content type: Research Published on:

  27. Authors: Maurizio Cutolo, Emanuele Gotelli, Paola Montagna, Samuele Tardito, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith and Stefano Soldano
    Citation: Arthritis Research & Therapy 2023 25:134
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2021 23:205

  28. Antibiotic prophylaxis is recommended during ANCA-associated vasculitis (AAV) induction. We aimed to describe the frequency, persistence, and factors associated with trimethoprim-sulfamethoxazole (TMP-SMX) use...

    Authors: Arielle Mendel, Hassan Behlouli, Cristiano Soares de Moura, Évelyne Vinet, Jeffrey R. Curtis and Sasha Bernatsky
    Citation: Arthritis Research & Therapy 2023 25:133
    Content type: Research Published on:

  30. Patients with psoriatic arthritis (PsA) are frequently obese. We have previously shown decreased disease activity in patients with PsA with a body mass index (BMI) ≥ 33 kg/m2 following weight loss treatment with ...

    Authors: A. J. Landgren, C. A. Jonsson, A. Bilberg, B. Eliasson, L. Torres, M. Dehlin, L. T. H. Jacobsson, I. Gjertsson, I. Larsson and E. Klingberg
    Citation: Arthritis Research & Therapy 2023 25:131
    Content type: Research Published on:

  31. Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease that leads to joint destruction and functional disability due to the targeting of self-antigens present in the synovium, cartilage, and bone...

    Authors: Jeonghyeon Moon, A. Ram Lee, Heejung Kim, JooYeon Jhun, Seon-Yeong Lee, Jeong Won Choi, Yunju Jeong, Myeong Soo Park, Geun Eog Ji, Mi-La Cho and Sung-Hwan Park
    Citation: Arthritis Research & Therapy 2023 25:130
    Content type: Research Published on:

  34. This study aimed to describe the clinical characteristics and analyze the poor prognostic factors in patients with anti-MDA5 dermatomyositis.

    Authors: Huyan Wang, Xin Chen, Yan Du, Lihua Wang, Qiyuan Wang, Huaxiang Wu, Lei Liu and Jing Xue
    Citation: Arthritis Research & Therapy 2023 25:127
    Content type: Research Published on:

  36. Anti-Jo-1 autoantibodies represent essential markers in the diagnosis of antisynthetase syndrome (ASS). In this retrospective study, we aimed to investigate whether their concentrations and fluctuations could ...

    Authors: Robin Arcani, Louise Rey, Alice Mazziotto, Daniel Bertin, Gilles Kaplanski, Pierre-André Jarrot, Pierre Lafforgue, Geoffroy Venton, Xavier Heim, Patrick Villani, Jean-Louis Mège, Alexandre Brodovitch and Nathalie Bardin
    Citation: Arthritis Research & Therapy 2023 25:125
    Content type: Research Published on:

  37. Rheumatoid arthritis (RA) patients have a 1.5- to twofold higher risk of developing heart failure (HF) and a twofold increased risk of HF-associated mortality compared to those without RA. HF is preceded subcl...

    Authors: Elizabeth Park, Kazato Ito, Christopher Depender, Jon T. Giles and Joan Bathon
    Citation: Arthritis Research & Therapy 2023 25:124
    Content type: Correspondence Published on:

  38. To investigate the presence of different isotypes of anti-carbamylated protein (CarP) antibodies in systemic sclerosis (SSc) patients and its association with skin involvement.

    Authors: Sophie I. E. Liem, E. M. Hoekstra, E. W. Nivine Levarht, Annemarie L. Dorjee, Hans U. Scherer, René E. M. Toes, Tom W. J. Huizinga, Jeska K. de Vries-Bouwstra and Cynthia M. Fehres
    Citation: Arthritis Research & Therapy 2023 25:123
    Content type: Research Published on:

  40. Previous studies have revealed that Sirt3 deficiency is associated with several inflammatory responses. The purpose of this study is to investigate the role and potential molecular mechanisms of Sirt3 in the i...

    Authors: Linxi Lv, Hui Jiang, Dianze Song, Xiaoqin Zhou, Feng Chen, Long Ren, Yongen Xie and Mei Zeng
    Citation: Arthritis Research & Therapy 2023 25:121
    Content type: Research Published on:

  41. Neck pain (NP) is a common symptom reported in the elderly. However, no study has examined the relationship between NP and osteoarthritis (OA) so far, and this study aimed to investigate the association of nec...

    Authors: Xi Chen, Lihua Gong, Cheng Li, Siyuan Wang and Yixin Zhou
    Citation: Arthritis Research & Therapy 2023 25:120
    Content type: Research Published on:

  42. A proof-of-concept study to evaluate the feasibility and safety of minimally invasive ultrasound (US)-guided synovial biopsy of the radiocarpal (RC) joint using the anatomical snuffbox as an access route.

    Authors: Ludovico De Stefano, Serena Bugatti, Veronica Piccin, Gioacchino D’Ambrosio, Terenzj Luvaro, Blerina Xoxi, Carlomaurizio Montecucco and Antonio Manzo
    Citation: Arthritis Research & Therapy 2023 25:119
    Content type: Research Published on:

  43. Many clinical trial results are available to inform best practices in the treatment of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD).

    Authors: Jean Paul Higuero Sevilla, Areeka Memon and Monique Hinchcliff
    Citation: Arthritis Research & Therapy 2023 25:118
    Content type: Review Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:132

  44. Intervertebral disc degeneration (IVDD) is closely associated with the structural damage in the annulus fibrosus (AF). Aberrant mechanical loading is an important inducement of annulus fibrosus cells (AFCs) ap...

    Authors: Chenhao Liu, Xiaoxin Gao, Jinhui Lou, Haiyin Li, Yuxuan Chen, Molong Chen, Yuyao Zhang, Zhilei Hu, Xian Chang, Menglin Luo, Yu Zhai and Changqing Li
    Citation: Arthritis Research & Therapy 2023 25:117
    Content type: Research Published on:

  45. Cerebrovascular ischemic events (CIE) are among the most severe complications of giant cell arteritis (GCA). Heterogeneity between different studies in the definition of GCA-related CIE leads to uncertainty re...

    Authors: Thomas Penet, Marc Lambert, Clio Baillet, Olivier Outteryck, Hilde Hénon, Sandrine Morell-Dubois, Eric Hachulla, David Launay and Mohammad Ryadh Pokeerbux
    Citation: Arthritis Research & Therapy 2023 25:116
    Content type: Research Published on:

  47. Comorbidities are common in patients with osteoarthritis (OA). This study aimed to determine the association of a wide range of previously diagnosed comorbidities in adults with newly diagnosed OA compared wit...

    Authors: Anne Kamps, Jos Runhaar, Maria A. J. de Ridder, Marcel de Wilde, Johan van der Lei, Weiya Zhang, Daniel Prieto-Alhambra, Martin Englund, Evelien I. T. de Schepper and Sita M. A. Bierma-Zeinstra
    Citation: Arthritis Research & Therapy 2023 25:114
    Content type: Research Published on:

  48. Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of innate and adaptive immune systems-associated inflammatory responses. Due to the local inflammation, the expression of v...

    Authors: Yuchen Zhang, Di Liu, Djandan Tadum Arthur Vithran, Bosomtwe Richmond Kwabena, Wenfeng Xiao and Yusheng Li
    Citation: Arthritis Research & Therapy 2023 25:113
    Content type: Review Published on:

  49. Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). However, the current management of LN remains unsatisfactory due to sneaky symptoms during early stages and l...

    Authors: Xueyao Wang, Shaojie Fu, Jinyu Yu, Fuzhe Ma, Lihong Zhang, Jiahui Wang, Luyu Wang, Yue Tan, Huanfa Yi, Hao Wu and Zhonggao Xu
    Citation: Arthritis Research & Therapy 2023 25:112
    Content type: Research Published on:

  50. Systemic lupus erythematosus (SLE) is a clinically and biologically heterogeneous autoimmune disease. We explored whether the deconvolution of whole blood transcriptomic data could identify differences in pred...

    Authors: Mumina Akthar, Nisha Nair, Lucy M. Carter, Edward M. Vital, Emily Sutton, Neil McHugh, Ian N. Bruce and John A. Reynolds
    Citation: Arthritis Research & Therapy 2023 25:111
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:160

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Arthritis Research & Therapy

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