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  1. Osteoarthritis is complex in genetics, pathogenesis, monitoring and treatment. Current treatment of osteoarthritis does not influence progression. Much could be gained by more effective 'low-tech-low-cost' tre...

    Authors: L Stefan Lohmander

    Citation: Arthritis Research & Therapy 2000 2:95

    Content type: Commentary

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  2. Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy...

    Authors: Raphaela Goldbach-Mansky, Jennifer M Lee, Joseph M Hoxworth, David Smith II, Paul Duray, H Ralph Schumacher Jr, Cheryl H Yarboro, John Klippel, David Kleiner and Hani S El-Gabalawy

    Citation: Arthritis Research & Therapy 2000 2:145

    Content type: Research article

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  3. Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The me...

    Authors: Paul J Utz,, Timothy J Gensler and Paul Anderson

    Citation: Arthritis Research & Therapy 2000 2:101

    Content type: Review

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  4. A chance observation has led to the development of a new murine model for inflammatory arthritis. Arthritis is induced, and transferred, by T-cell-dependent antibodies to glucose-6-phosphate isomerase. This en...

    Authors: Hugh McDevitt

    Citation: Arthritis Research & Therapy 2000 2:85

    Content type: Commentary

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  5. CD8+ T cells dominate the lymphocyte population insynovial fluid in chronic inflammatory arthritis. It is known that theseCD8+ T cells are often clonally or oligoclonally expanded, but theirspecificity and their ...

    Authors: Linda C Tan, Alastair G Mowat, Chrysoula Fazou, Tim Rostron, Helen Roskell, P Rod Dunbar, Claire Tournay, François Romagné, Marie-Alix Peyrat, Elisabeth Houssaint, Marc Bonneville, Alan B Rickinson, Andrew J McMichael and Margaret FC Callan

    Citation: Arthritis Research & Therapy 2000 2:154

    Content type: Research article

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  6. Cytokines play a critical role in the normal development and function of the immune system. On the other hand, many rheumatologic diseases are characterized by poorly controlled responses to or dysregulated pr...

    Authors: Robert A Ortmann, Tammy Cheng, Roberta Visconti, David M Frucht and John J O'Shea

    Citation: Arthritis Research & Therapy 1999 2:16

    Content type: Review

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  7. IFN-γ was measured in supernatants after in vitro stimulation of peripheral blood mononuclear cells with collagen type II (CII), purified protein derivative or influenza virus. IFN-γ production in response to CII...

    Authors: Louise Berg, Johan Rönnelid, Carani B Sanjeevi, Jon Lampa and Lars Klareskog

    Citation: Arthritis Research & Therapy 1999 2(Suppl 1):75

    Content type: Research article

    Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  8. In the present study, we searched for mutant PTEN transcripts in aggressive rheumatoid arthritis synovial fibroblasts (RA-SF) and studied the expression of PTEN in RA. By automated sequencing, no evidence for the...

    Authors: Thomas Pap, Juliane K Franz, Klaus M Hummel, Elvira Jeisy, Renate Gay and Steffen Gay

    Citation: Arthritis Research & Therapy 1999 2:59

    Content type: Research article

    Published on:

  9. The present study was designed to analyze the level of B-cell clonal diversity in patients with rheumatoid arthritis by using HCDR3 (third complementarity determining region of the rearranged heavy chain varia...

    Authors: Kenji Itoh, Varsha Patki, Richard A Furie, Elliot K Chartash, Rita I Jain, Lewis Lane, Stanley E Asnis and Nicholas Chiorazzi

    Citation: Arthritis Research & Therapy 1999 2(Suppl 1):50

    Content type: Research article

    Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  10. Case reports suggest that solvents are associated with various connective tissue diseases (systemic sclerosis, scleroderma, undifferentiated connective tissue disease, systemic lupus erythematosis, and rheumat...

    Authors: David H Garabrant and Constantine Dumas

    Citation: Arthritis Research & Therapy 1999 2:5

    Content type: Review

    Published on:

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