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  1. Although adjacent segmental intervertebral disc degeneration (ASDD) is one of the most common complications after lumbar fusion, its exact mechanism remains unclear. As an antibody to RANKL, denosumab (Dmab) e...

    Authors: Qi Sun, Fa-Ming Tian, Fang Liu, Jia-Kang Fang, Yun-Peng Hu, Qiang-Qiang Lian, Zhuang Zhou and Liu Zhang

    Citation: Arthritis Research & Therapy 2021 23:152

    Content type: Research article

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  2. Multimorbidity raises the number of essential information needed for delivery of high-quality care in patients with chronic diseases like rheumatoid arthritis (RA). We evaluated an innovative ICT platform for ...

    Authors: Jutta G. Richter, Gamal Chehab, Catarina Schwartz, Elisabeth Ricken, Monika Tomczak, Hasan Acar, Henrike Gappa, Carlos A. Velasco, Peter Rosengren, Armanas Povilionis, Matthias Schneider and Jesper Thestrup

    Citation: Arthritis Research & Therapy 2021 23:151

    Content type: Research article

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  3. Immunoglobulin G4-related disease (IgG4-RD) is characterized by increased serum IgG4 concentration and infiltration of IgG4+ plasma cells in the affected organs. The present study aimed to characterize the serum ...

    Authors: Haruki Matsumoto, Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Yashiro-Furuya, Tomoyuki Asano, Shuzo Sato, Hiroshi Watanabe, Eiji Suzuki, Sosuke Tsuji, Shoichi Fukui, Masataka Umeda, Naoki Iwamoto, Atsushi Kawakami and Kiyoshi Migita

    Citation: Arthritis Research & Therapy 2021 23:148

    Content type: Research article

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  4. Axial spondyloarthritis (axSpA) has strong connections with intestinal inflammation as occurs in Crohn’s disease (CD). However, the immunologic mechanisms that distinguish axSpA, CD, and those with features of...

    Authors: Adam R. Lefferts, Emilie H. Regner, Andrew Stahly, Becky O’Rourke, Mark E. Gerich, Blair P. Fennimore, Frank I. Scott, Alison E. Freeman, Ken Jones and Kristine A. Kuhn

    Citation: Arthritis Research & Therapy 2021 23:147

    Content type: Research article

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  5. Opioids are frequently prescribed for pain control in knee osteoarthritis patients, despite recommendations by current guidelines. Previous studies have investigated the chondrotoxicity of different opioid sub...

    Authors: Jannis Bodden, Gabby B. Joseph, Silvia Schirò, John A. Lynch, Nancy E. Lane, Charles E. McCulloch, Michael C. Nevitt and Thomas M. Link

    Citation: Arthritis Research & Therapy 2021 23:146

    Content type: Research article

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  6. Intervertebral disc degeneration contributes to low back pain. The avascular intervertebral disc consists of a central hypoxic nucleus pulpous (NP) surrounded by the more oxygenated annulus fibrosus (AF). Lact...

    Authors: Dong Wang, Robert Hartman, Chao Han, Chao-ming Zhou, Brandon Couch, Matias Malkamaki, Vera Roginskaya, Bennett Van Houten, Steven J. Mullett, Stacy G. Wendell, Michael J. Jurczak, James Kang, Joon Lee, Gwendolyn Sowa and Nam Vo

    Citation: Arthritis Research & Therapy 2021 23:145

    Content type: Research article

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  7. Tofacitinib is a novel Janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. In clinical trials, the most common adverse events observed ...

    Authors: Heike C. Hawerkamp, Alina Domdey, Lisa Radau, Philipp Sewerin, Péter Oláh, Bernhard Homey and Stephan Meller

    Citation: Arthritis Research & Therapy 2021 23:144

    Content type: Research article

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  8. To assess the efficacy and tolerance of tocilizumab (TCZ) in giant cell arteritis (GCA) patients over 80.

    Authors: Hubert de Boysson, Maelle Le Besnerais, Félix Blaison, Aurélie Daumas, Pierre-André Jarrot, François Perrin, Nathalie Tieulié, Alexandre Maria, Pierre Duffau, Bruno Gombert, Maxime Samson, Olivier Espitia, Marc Lambert, Arsène Mékinian and Achille Aouba

    Citation: Arthritis Research & Therapy 2021 23:143

    Content type: Research article

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  9. To investigate the role and regulatory mechanisms of fargesin, one of the main components of Magnolia fargesii, in macrophage reprogramming and crosstalk across cartilage and synovium during osteoarthritis (OA) d...

    Authors: Jiansen Lu, Hongbo Zhang, Jianying Pan, Zhiqiang Hu, Liangliang Liu, Yanli Liu, Xiao Yu, Xiaochun Bai, Daozhang Cai and Haiyan Zhang

    Citation: Arthritis Research & Therapy 2021 23:142

    Content type: Research article

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  10. Informative serum biomarkers for monitoring inflammatory activity and treatment responses in axial spondyloarthritis (axSpA) are lacking. We assessed whether Lipocalin 2 (LCN2) and Oncostatin M (OSM), both hav...

    Authors: Florence W. L. Tsui, Aifeng Lin, Ismail Sari, Zhenbo Zhang, Hing Wo Tsui and Robert D. Inman

    Citation: Arthritis Research & Therapy 2021 23:141

    Content type: Research article

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  11. This study aimed to clarify predictors of preterm birth in pregnancy of women with systemic lupus erythematosus (SLE). We investigated the predictors of preterm birth before pregnancy from the perspective of t...

    Authors: Yuri Hiramatsu, Kentaro Isoda, Takuya Kotani, Eri Nakamura, Yumiko Wada, Youhei Fujiki, Shigeki Makino, Daisuke Fujita and Tohru Takeuchi

    Citation: Arthritis Research & Therapy 2021 23:140

    Content type: Research article

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  12. Several studies suggested that thrombotic and obstetric antiphospholipid syndromes could be independent identities, but few have systematically compared their clinical characteristics and prognosis.

    Authors: Hui Jiang, Chu-Han Wang, Nan Jiang, Jing Li, Chan-Yuan Wu, Qian Wang, Meng-Tao Li, Xin-Ping Tian, Jiu-Liang Zhao, Yan Zhao and Xiao-Feng Zeng

    Citation: Arthritis Research & Therapy 2021 23:138

    Content type: Research article

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  13. Aldehyde dehydrogenase 1 family member A1 (RALDH1)-producing dermal dendritic cells (DCs), a conventional DC subset regulating skin fibrosis, are decreased in the involved skin of patients with systemic sclero...

    Authors: Shunsuke Miura, Yusuke Watanabe, Ryosuke Saigusa, Takashi Yamashita, Kouki Nakamura, Megumi Hirabayashi, Takuya Miyagawa, Ayumi Yoshizaki, Maria Trojanowska, Shinichi Sato and Yoshihide Asano

    Citation: Arthritis Research & Therapy 2021 23:137

    Content type: Research article

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  14. Leukocyte activation by anti-neutrophil cytoplasmic antibody (ANCA) and the subsequent leukocyte–endothelium interaction play a key role in the development of endothelial damage in ANCA-associated vasculitis (...

    Authors: Kotaro Matsumoto, Takahiko Kurasawa, Keiko Yoshimoto, Katsuya Suzuki and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2021 23:136

    Content type: Research article

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  15. Earlier, we reported that the microRNA (miR)-155 expression in dendritic cells (DCs) from Behcet’s disease (BD) patients was decreased and affected cytokine production of DCs. In this study, we investigated th...

    Authors: Liang Liang, Qingyun Zhou and Lujia Feng

    Citation: Arthritis Research & Therapy 2021 23:135

    Content type: Research article

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  16. The criteria for antiphospholipid syndrome (APS) include severe preeclampsia and/or placental insufficiency leading to preterm delivery before 34 weeks of gestation, but this APS manifestation has been rarely ...

    Authors: Maddalena Larosa, Véronique Le Guern, Nathalie Morel, Mériem Belhocine, Amelia Ruffatti, Nicolas Martin Silva, Romain Paule, Luc Mouthon, Michel Dreyfus, Jean-Charles Piette, Odile Souchaud-Debouverie, Catherine Deneux-Tharaux, Gaelle Guettrot-Imbert, Vassilis Tsatsaris, Emmanuelle Pannier-Metzger, Anne Murarasu…

    Citation: Arthritis Research & Therapy 2021 23:134

    Content type: Research article

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  17. Systemic sclerosis (SSc) is a chronic autoimmune-mediated connective tissue disorder. Although the etiology of the disease remains undetermined, SSc is characterized by fibrosis and proliferative vascular lesi...

    Authors: Yuzuru Yamamoto, Takaichi Okano, Hirotaka Yamada, Kengo Akashi, Sho Sendo, Yo Ueda, Akio Morinobu and Jun Saegusa

    Citation: Arthritis Research & Therapy 2021 23:133

    Content type: Research article

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  18. The objective of the study was to explore the disease pathways activated in the inflammatory foci of skin lesions in cutaneous lupus erythematosus (CLE) and dermatomyositis (DM).

    Authors: Timothy B. Niewold, Alexander Meves, Julia S. Lehman, Karin Popovic-Silwerfeldt, Aliisa Häyry, Therese Söderlund-Matell, Cristine M. Charlesworth, Benjamin Madden, Ingrid E. Lundberg, Marie Wahren-Herlenius, Elisabet Svenungsson and Vilija Oke

    Citation: Arthritis Research & Therapy 2021 23:132

    Content type: Research article

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  19. Calcific tendonitis of the rotator cuff is due to carbonated apatite deposits in the shoulder tendons. During the evolution of the disease, an acute inflammatory episode may occur leading to the disappearance ...

    Authors: Julien Herman, Benoit Le Goff, Julien De Lima, Régis Brion, Catherine Chevalier, Frédéric Blanchard and Christelle Darrieutort-Laffite

    Citation: Arthritis Research & Therapy 2021 23:131

    Content type: Research article

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  20. Gout flare prophylaxis and therapy use in people with underlying chronic kidney disease (CKD) is challenging, given limited treatment options and risk of worsening renal function with inappropriate treatment d...

    Authors: Huai Leng Pisaniello, Mark C. Fisher, Hamish Farquhar, Ana Beatriz Vargas-Santos, Catherine L. Hill, Lisa K. Stamp and Angelo L. Gaffo

    Citation: Arthritis Research & Therapy 2021 23:130

    Content type: Review

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  21. Changes in gait speed are required in various situations and can be achieved by changing stride length, cadence, or both. Differences in strategies for increasing gait speed may have different effects on hip j...

    Authors: Hiroshige Tateuchi, Haruhiko Akiyama, Koji Goto, Kazutaka So, Yutaka Kuroda and Noriaki Ichihashi

    Citation: Arthritis Research & Therapy 2021 23:129

    Content type: Research article

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  22. Gout is an autoinflammatory disease driven by interleukin-1 (IL-1) induction in response to uric acid crystals. IL-1β production is dependent on inflammasome activation, which requires a priming signal, follow...

    Authors: Yuya Fujita, Toru Yago, Haruki Matsumoto, Tomoyuki Asano, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Makiko Yashiro-Furuya, Eiji Suzuki, Hiroshi Watanabe, Atsushi Kawakami and Kiyoshi Migita

    Citation: Arthritis Research & Therapy 2021 23:128

    Content type: Research article

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  23. Patients with rheumatoid arthritis (RA) are at increased risk of fractures. Although their decline in bone mineral density (BMD) is well-established, data regarding the alterations in bone microarchitecture ar...

    Authors: Shangyi Jin, Mengtao Li, Qian Wang, Xiaofeng Zeng, Weibo Xia, Wei Yu, Wenmin Guan and Evelyn Hsieh

    Citation: Arthritis Research & Therapy 2021 23:127

    Content type: Research article

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  24. Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) are manifestations of an autoinflammatory disorder with complex pathophysiology and significant morbidity, together also ter...

    Authors: Cristina Segú-Vergés, Mireia Coma, Christoph Kessel, Serge Smeets, Dirk Foell and Anna Aldea

    Citation: Arthritis Research & Therapy 2021 23:126

    Content type: Research article

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  25. The University of California Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract Instrument 2.0 (UCLA GIT 2.0) is validated to capture gastrointestinal (GI) tract morbidity in patients wit...

    Authors: Norina Zampatti, Alexandru Garaiman, Suzana Jordan, Rucsandra Dobrota, Mike Oliver Becker, Britta Maurer, Oliver Distler and Carina Mihai

    Citation: Arthritis Research & Therapy 2021 23:125

    Content type: Research article

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  26. In the pathogenesis of rheumatoid arthritis (RA), the role of mast cells has not been revealed clearly. We aimed to define the inflammatory and tissue-destructive roles of mast cells in rheumatoid arthritis (RA).

    Authors: Kyoung-Woon Kim, Bo-Mi Kim, Ji-Yeon Won, Hong-Ki Min, Kyung-Ann Lee, Sang-Heon Lee and Hae-Rim Kim

    Citation: Arthritis Research & Therapy 2021 23:124

    Content type: Research article

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  27. To conduct a systematic review and thematic synthesis of qualitative studies on the pregnancy and early parenting experiences of patients with inflammatory arthritis (IA).

    Authors: Nevena Rebić, Ria Garg, Ursula Ellis, Vanessa Kitchin, Sarah Munro, Glen Hazlewood, Neda Amiri, Nick Bansback and Mary A. De Vera

    Citation: Arthritis Research & Therapy 2021 23:123

    Content type: Review

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  28. The esophagus involvement in systemic sclerosis (SSc) is very common yet underestimated due to the lack of suitable screening tools. This study aims to explore the usefulness of ultrasound (US) in the assessme...

    Authors: Li Ma, Qingli Zhu, Yan Zhang, Jianchu Li, Yuxin Jiang, Dong Xu, Xiaofeng Zeng, Yong Hou and He Liu

    Citation: Arthritis Research & Therapy 2021 23:122

    Content type: Research article

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  29. Mobile medical applications (Apps) offer innovative solutions for patients’ self-monitoring and new patient management opportunities. Prior to routine clinical application feasibility and acceptance of disease...

    Authors: Jutta G. Richter, Christina Nannen, Gamal Chehab, Hasan Acar, Arnd Becker, Reinhart Willers, Dörte Huscher and Matthias Schneider

    Citation: Arthritis Research & Therapy 2021 23:121

    Content type: Research article

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  30. Premature atherosclerosis occurs in patients with SLE; however, the mechanisms remain unclear. Both mitochondrial machinery and proinflammatory cytokine interferon alpha (IFN-α) potentially contribute to ather...

    Authors: Jenn-Haung Lai, Li-Feng Hung, Chuan-Yueh Huang, De-Wei Wu, Chien-Hsiang Wu and Ling-Jun Ho

    Citation: Arthritis Research & Therapy 2021 23:120

    Content type: Research article

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  31. A subcutaneous (SC) formulation of infliximab biosimilar CT-P13 is approved in Europe for the treatment of adult patients with rheumatoid arthritis (RA). It may offer improved efficacy versus intravenous (IV) ...

    Authors: Bernard Combe, Yannick Allanore, Rieke Alten, Roberto Caporali, Patrick Durez, Florenzo Iannone, Michael T. Nurmohamed, Mondher Toumi, Sang Joon Lee, Taek Sang Kwon, Jiwon Noh, Gahee Park and Dae Hyun Yoo

    Citation: Arthritis Research & Therapy 2021 23:119

    Content type: Research article

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  32. To determine (i) correlates for etanercept (ETA) discontinuation after achieving an inactive disease and for the subsequent risk of flare and (ii) to analyze the effectiveness of ETA in the re-treatment after ...

    Authors: Jens Klotsche, Ariane Klein, Martina Niewerth, Paula Hoff, Daniel Windschall, Ivan Foeldvari, Johannes-Peter Haas, Gerd Horneff and Kirsten Minden

    Citation: Arthritis Research & Therapy 2021 23:118

    Content type: Research article

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  33. There is an increased level of senescent cells and toll-like teceptor-1, -2, -4, and -6 (TLR) expression in degenerating intervertebral discs (IVDs) from back pain patients. However, it is currently not known ...

    Authors: Matthew Mannarino, Hosni Cherif, Li Li, Kai Sheng, Oded Rabau, Peter Jarzem, Michael H. Weber, Jean A. Ouellet and Lisbet Haglund

    Citation: Arthritis Research & Therapy 2021 23:117

    Content type: Research article

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  34. This multi-center, retrospective study aimed to clarify retention rates and reasons for discontinuation of either tumor necrosis factor inhibitors (TNFi) or interleukin-6 inhibitors (IL-6i) in patients with el...

    Authors: Sadao Jinno, Akira Onishi, Maureen Dubreuil, Motomu Hashimoto, Wataru Yamamoto, Koichi Murata, Tohru Takeuchi, Takuya Kotani, Yuichi Maeda, Kosuke Ebina, Yonsu Son, Hideki Amuro, Ryota Hara, Masaki Katayama and Jun Saegusa

    Citation: Arthritis Research & Therapy 2021 23:116

    Content type: Research article

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  35. Gout stems from both modifiable and genetic sources. We evaluated the risk of gout among Taiwanese adults with aldehyde dehydrogenase-2 (ALDH2) rs671 single nucleotide polymorphism (SNP) according to body mass...

    Authors: Yu-Ruey Liu, Disline Manli Tantoh, Chuan-Chao Lin, Chih-Hsuan Hsiao and Yung-Po Liaw

    Citation: Arthritis Research & Therapy 2021 23:115

    Content type: Research article

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  36. Ribonucleases (RNases) play central roles in the post-transcriptional regulation of mRNA stability. Our preliminary results revealed that the endonuclease Regnase-1 is specifically upregulated in osteoarthriti...

    Authors: Jeong-In Yang and Jang-Soo Chun

    Citation: Arthritis Research & Therapy 2021 23:114

    Content type: Research article

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  37. Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be respo...

    Authors: Anne Gigout, Donata Harazin, Louise M. Topping, Didier Merciris, Sven Lindemann, Christian Brenneis and Ahuva Nissim

    Citation: Arthritis Research & Therapy 2021 23:113

    Content type: Research article

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  38. Timely diagnosis and treatment are essential in the effective management of inflammatory rheumatic diseases (IRDs). Symptom checkers (SCs) promise to accelerate diagnosis, reduce misdiagnoses, and guide patien...

    Authors: Johannes Knitza, Jacob Mohn, Christina Bergmann, Eleni Kampylafka, Melanie Hagen, Daniela Bohr, Harriet Morf, Elizabeth Araujo, Matthias Englbrecht, David Simon, Arnd Kleyer, Timo Meinderink, Wolfgang Vorbrüggen, Cay Benedikt von der Decken, Stefan Kleinert, Andreas Ramming…

    Citation: Arthritis Research & Therapy 2021 23:112

    Content type: Research article

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  39. Vaspin is a novel anti-inflammatory adipokine associated with cardiovascular (CV) disease and inflammation in chronic inflammatory conditions different from axial spondyloarthritis (axSpA). Given the high inci...

    Authors: Javier Rueda-Gotor, Raquel López-Mejías, Sara Remuzgo-Martínez, Verónica Pulito-Cueto, Alfonso Corrales, Leticia Lera-Gómez, Virginia Portilla, Íñigo González-Mazón, Ricardo Blanco, Rosa Expósito, Cristina Mata, Javier Llorca, Vanesa Hernández-Hernández, Carlos Rodríguez-Lozano, Nuria Barbarroja, Rafaela Ortega Castro…

    Citation: Arthritis Research & Therapy 2021 23:111

    Content type: Research article

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  40. Osteoarthritis (OA) has long been regarded as a disease of cartilage degeneration, whereas mounting evidence implies that low-grade inflammation contributes to OA. Among inflammatory cells involved, macrophage...

    Authors: Xiaobo Zhu, Chien-Wei Lee, Hongtao Xu, Yu-Fan Wang, Patrick S. H. Yung, Yangzi Jiang and Oscar K. Lee

    Citation: Arthritis Research & Therapy 2021 23:110

    Content type: Review

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  41. Neutrophils are the most prevalent immune cells in the synovial fluid in inflamed joints of children with oligoarticular juvenile idiopathic arthritis (JIA). Despite this, little is known about neutrophil func...

    Authors: Sabine Arve-Butler, Tobias Schmidt, Anki Mossberg, Elisabet Berthold, Birgitta Gullstrand, Anders A. Bengtsson, Fredrik Kahn and Robin Kahn

    Citation: Arthritis Research & Therapy 2021 23:109

    Content type: Research article

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  42. Hormonal reproductive factors have been suggested to play an important role in the etiology of rheumatoid arthritis (RA), an autoimmune inflammatory disorder affecting primarily women. We conducted a two-sampl...

    Authors: Jingjing Zhu, Zheng Niu, Lars Alfredsson, Lars Klareskog, Leonid Padyukov and Xia Jiang

    Citation: Arthritis Research & Therapy 2021 23:108

    Content type: Research article

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  43. To perform a meta-analysis comparing the structural progression and clinical symptom outcomes as well as adverse events experienced from intra-articular injections of sprifermin compared to a placebo treatment...

    Authors: Ni Zeng, Xin-Yuan Chen, Zhi-Peng Yan, Jie-Ting Li, Tao Liao and Guo-Xin Ni

    Citation: Arthritis Research & Therapy 2021 23:107

    Content type: Review

    Published on:

  44. Radiographs of the sacroiliac joints are commonly used for the diagnosis and classification of axial spondyloarthritis. The aim of this study was to develop and validate an artificial neural network for the de...

    Authors: Keno K. Bressem, Janis L. Vahldiek, Lisa Adams, Stefan Markus Niehues, Hildrun Haibel, Valeria Rios Rodriguez, Murat Torgutalp, Mikhail Protopopov, Fabian Proft, Judith Rademacher, Joachim Sieper, Martin Rudwaleit, Bernd Hamm, Marcus R. Makowski, Kay-Geert Hermann and Denis Poddubnyy

    Citation: Arthritis Research & Therapy 2021 23:106

    Content type: Research article

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  45. The dietary inflammatory index (DII®), a quantitative measure of the inflammatory potential of daily food and nutrient intake, and associations between a variety of health outcomes have been reported. However,...

    Authors: Yoshinari Matsumoto, Nitin Shivappa, Yuko Sugioka, Masahiro Tada, Tadashi Okano, Kenji Mamoto, Kentaro Inui, Daiki Habu, James R. Hebert and Tatsuya Koike

    Citation: Arthritis Research & Therapy 2021 23:105

    Content type: Research article

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  46. Elevated levels of periostin (Postn) in the cartilage and bone are associated with osteoarthritis (OA). However, it remains unknown whether Postn loss-of-function can delay or prevent the development of OA. In...

    Authors: Mukundan Attur, Xin Duan, Lei Cai, Tianzhen Han, Weili Zhang, Eric D. Tycksen, Jonathan Samuels, Robert H. Brophy, Steven B. Abramson and Muhammad Farooq Rai

    Citation: Arthritis Research & Therapy 2021 23:104

    Content type: Research article

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  47. Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic, immune-mediated, and fibro-inflammatory disease. Hypocomplementemia was found in part of IgG4-RD patients especially in the setting o...

    Authors: Linyi Peng, Hui Lu, Jiaxin Zhou, Panpan Zhang, Jieqiong Li, Zheng Liu, Di Wu, Shangzhu Zhang, Yunjiao Yang, Wei Bai, Li Wang, Yunyun Fei, Wen Zhang, Yan Zhao, Xiaofeng Zeng and Fengchun Zhang

    Citation: Arthritis Research & Therapy 2021 23:102

    Content type: Research article

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