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  2. Neutrophil extracellular traps (NETs) are critically involved in microscopic polyangiitis (MPA) pathogenesis, and some patients with MPA possess anti-NET antibody (ANETA). Anti-myosin light chain 6 (MYL6) anti...

    Authors: Miku Yoshinari, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Yoshihiro Arimura, Koichi Amano, Yukio Yuzawa, Ken-Ei Sada, Tatsuya Atsumi, Hiroaki Dobashi, Hitoshi Hasegawa, Masayoshi Harigai, Seiichi Matsuo, Hirofumi Makino and Akihiro Ishizu
    Citation: Arthritis Research & Therapy 2022 24:274
    Content type: Research Published on:

  3. Bone marrow-derived mesenchymal stem cells (BMSCs) are general progenitor cells of osteoblasts and adipocytes and they are characterized as a fundamental mediator for bone formation. The current research studi...

    Authors: Lixia Fan, Kaiyun Yang, Ruixuan Yu, Houde Hui and Wenliang Wu
    Citation: Arthritis Research & Therapy 2022 24:273
    Content type: Research Published on:

  4. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13075-022-02973-w.

    Authors: Gianluca Bagnato, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Donatella Sangari, Maurizio Cinquegrani, William Neal Roberts, Marco Atteritano, Domenica Altavilla, Francesco Squadrito, Gianfilippo Bagnato and Antonino Saitta
    Citation: Arthritis Research & Therapy 2022 24:272
    Content type: Retraction Note Published on:

  5. To analyze therapy adherence, safety, and outcome in adult patients with juvenile idiopathic arthritis (JIA) treated with the etanercept biosimilar Benepali® (Biogen Inc, Cambridge, USA).

    Authors: Kristina Vollbach, Klaus Tenbrock, Nobert Wagner, Gerd Horneff, Ariane Klein, Ivan Foeldvari, Johannes-Peter Haas, Peer Aries, Georg Gauler, Frank Striesow, Paula Hoff, Christine Scholz, Stefanie Tatsis, Eva Seipelt, Jens Klotsche and Kirsten Minden
    Citation: Arthritis Research & Therapy 2022 24:271
    Content type: Research Published on:

  6. The associations of rheumatoid arthritis (RA) with risk of site-specific cancers beyond lymphohematopoietic cancer have been scarcely explored. We conducted a Mendelian randomization investigation of the assoc...

    Authors: Shuai Yuan, Jie Chen, Xixian Ruan, Mathew Vithayathil, Siddhartha Kar, Xue Li, Amy M. Mason, Stephen Burgess and Susanna C. Larsson
    Citation: Arthritis Research & Therapy 2022 24:270
    Content type: Research Published on:

  7. Although cross-sectional and cohort data suggest that higher serum blood glucose levels in patients with knee osteoarthritis (KOA) are associated with more severe knee symptoms, little is known about the longi...

    Authors: Daisuke Chiba, Tetsushi Ohyama, Eiji Sasaki, Makoto Daimon, Shigeyuki Nakaji and Yasuyuki Ishibashi
    Citation: Arthritis Research & Therapy 2022 24:269
    Content type: Research Published on:

  8. Rheumatoid arthritis is an autoimmune condition that predominantly affects the synovial joints, causing joint destruction, pain, and disability. Historically, the standard for measuring the long-term efficacy ...

    Authors: Alix Bird, Lauren Oakden-Rayner, Christopher McMaster, Luke A. Smith, Minyan Zeng, Mihir D. Wechalekar, Shonket Ray, Susanna Proudman and Lyle J. Palmer
    Citation: Arthritis Research & Therapy 2022 24:268
    Content type: Review Published on:

  9. Lupus nephritis (LN) is an inflammatory disease of the kidneys affecting patients with systemic lupus erythematosus. Current immunosuppressive and cytotoxic therapies are associated with serious side effects a...

    Authors: Justin Knapp, Marsela Braunstein, Spencer Iner Thomas Berg and Cody Shirriff
    Citation: Arthritis Research & Therapy 2022 24:267
    Content type: Research Published on:

  10. Takayasu arteritis (TAK) is characterized by pro-inflammatory M1 macrophage infiltration and increased interferon (IFN)-γ expression in vascular lesions. IFN-γ is a key cytokine involved in M1 polarization. Ma...

    Authors: Rongyi Chen, Jinghua Wang, Xiaojuan Dai, Sifan Wu, Qingrong Huang, Lindi Jiang and Xiufang Kong
    Citation: Arthritis Research & Therapy 2022 24:266
    Content type: Research Published on:

  11. Loss of bone is a common medical problem and, while it can be treated with available therapies, some of these therapies have critical side effects. We have previously demonstrated that CGS21680, a selective A2A a...

    Authors: Ane Larrañaga-Vera, Kiran S. Toti, James S. Flatow, Alexandra J. Haraczy, Eugene Warnick, Harsha Rao, Zhan-Guo Gao, Sarah M. Sussman, Aranzazu Mediero, Philipp Leucht, Kenneth A. Jacobson and Bruce N. Cronstein
    Citation: Arthritis Research & Therapy 2022 24:265
    Content type: Research Published on:

  12. This exploratory study compared the inhibition of bone erosion progression in rheumatoid arthritis (RA) patients treated with a conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) plus denos...

    Authors: Naoki Iwamoto, Ko Chiba, Shuntaro Sato, Kazuteru Shiraishi, Kounosuke Watanabe, Nozomi Oki, Akitomo Okada, Tomohiro Koga, Shin-ya Kawashiri, Mami Tamai, Naoki Hosogaya, Masako Furuyama, Makiko Kobayashi, Kengo Saito, Naoki Okubo, Masataka Uetani…
    Citation: Arthritis Research & Therapy 2022 24:264
    Content type: Research Published on:

  13. The autoimmune exocrinopathy, Sjögren’s syndrome (SjS), is associated with secretory defects in salivary glands. The cystic fibrosis transmembrane conductance regulator (CFTR) of the chloride channel is a mast...

    Authors: Qi Zhang, Xiuying Lv, Ying Wang, Bin Wang, Yan He, Chubing Chen, Guixiu Shi and Yan Li
    Citation: Arthritis Research & Therapy 2022 24:263
    Content type: Research Published on:

  14. Psoriatic Arthritis (PsA) is an immune-mediated disease with heterogenous symptoms indicating differences in the underlying immunopathogenesis. The primary objective of the study explored the dynamic mechanism...

    Authors: Marie Skougaard, Sisse B. Ditlev, Zara R. Stisen, Laura C. Coates, Karen Ellegaard and Lars Erik Kristensen
    Citation: Arthritis Research & Therapy 2022 24:262
    Content type: Research Published on:

  15. Numerous potential therapeutic alternatives for intervertebral disc degeneration (IDD) have been investigated, the most promising of which are based on biological variables such as microRNAs (miRNAs). Therefor...

    Authors: Zhonghui Chen, Jianghua Ming, Yajing Liu, Geliang Hu and Qi Liao
    Citation: Arthritis Research & Therapy 2022 24:261
    Content type: Research Published on:

  16. Intra-articular injection is indicated for mild or moderate osteoarthritis (OA). However, the superiority of cell-based injection and the role of diverse cell sources are still unclear. This study aimed to com...

    Authors: Yijian Zhang, Huilin Yang, Fan He and Xuesong Zhu
    Citation: Arthritis Research & Therapy 2022 24:260
    Content type: Review Published on:

  17. Non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) has been confirmed to have subtle changes in brain structure before the appearance of obvious neuropsychiatric symptoms. Previous literature mainly...

    Authors: Shu Li, Ru Bai, Yifan Yang, Ruotong Zhao, Bibhuti Upreti, Xiangyu Wang, Shuang Liu, Yuqi Cheng and Jian Xu
    Citation: Arthritis Research & Therapy 2022 24:259
    Content type: Research Published on:

  18. Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell therapy (HSCT) can be a rescue therapy for patients with rapidly progressive SSc.

    Authors: Norbert Blank, Marc Schmalzing, Pia Moinzadeh, Max Oberste, Elise Siegert, Ulf Müller-Ladner, Gabriela Riemekasten, Claudia Günther, Ina Kötter, Gabriele Zeidler, Christiane Pfeiffer, Aaron Juche, Ilona Jandova, Jan Ehrchen, Laura Susok, Tim Schmeiser…
    Citation: Arthritis Research & Therapy 2022 24:258
    Content type: Research Published on:

  19. To investigate the occurrence and frequency of anti-citrullinated protein antibodies (ACPA) to cyclic citrullinated type II collagen (COL2) epitope with a capacity to bind joint cartilage.

    Authors: Qixing Li, Yanpeng Li, Bibo Liang, Rui Xu, Bingze Xu, Erik Lönnblom, Hui Feng, Jing’an Bai, Roma Stawikowska, Changrong Ge, Aiping Lu, Gregg B. Fields, Lianbo Xiao and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2022 24:257
    Content type: Research Published on:

  20. Dysbiotic intestinal and oral microbiota have been implicated in the pathogenesis of rheumatoid arthritis (RA), but the mechanisms how microbiota could impact disease activity have remained elusive. The aim of...

    Authors: J. Parantainen, G. Barreto, R. Koivuniemi, H. Kautiainen, D. Nordström, E. Moilanen, M. Hämäläinen, M. Leirisalo-Repo, K. Nurmi and K. K. Eklund
    Citation: Arthritis Research & Therapy 2022 24:256
    Content type: Research Published on:

  21. The prevalence of rheumatoid arthritis (RA) in persons 60 years or older is estimated to be 2%. Late-onset rheumatoid arthritis (LORA) is traditionally defined as the onset of RA after the age of 60 years. Com...

    Authors: Xiuying Li, Angela Cesta, Mohammad Movahedi and Claire Bombardier
    Citation: Arthritis Research & Therapy 2022 24:255
    Content type: Research Published on:

  22. EC-18, a synthetic monoacetyldiaglyceride, exhibits protective effects against lung inflammation, allergic asthma, and abdominal sepsis. However, there have been no investigations to determine whether EC-18 ha...

    Authors: Jin-Sil Park, Seung Cheon Yang, Ha Yeon Jeong, Seon-Young Lee, Jun-Geol Ryu, Jeong Won Choi, Hye Yeon Kang, Sung-Min Kim, Sun-Hee Hwang, Mi-La Cho and Sung-Hwan Park
    Citation: Arthritis Research & Therapy 2022 24:254
    Content type: Research Published on:

  23. This study aimed to investigate the trajectory of damage accrual, associated factors, and impact on health-related quality of life (HR-QoL) in a multicenter cohort of patients with Behçet’s syndrome (BS) over ...

    Authors: Alberto Floris, Matteo Piga, Riccardo Laconi, Gerard Espinosa, Giuseppe Lopalco, Luisa Serpa Pinto, Nikolaos Kougkas, Jurgen Sota, Andrea Lo Monaco, Marcello Govoni, Luca Cantarini, George Bertsias, João Correia, Florenzo Iannone, Ricard Cervera, Carlos Vasconcelos…
    Citation: Arthritis Research & Therapy 2022 24:253
    Content type: Research Published on:

  24. Pain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common feature. However, sensitization can be originally related to the periphe...

    Authors: Jesus Pujol, Laura Blanco-Hinojo, Andrea Doreste, Fabiola Ojeda, Gerard Martínez-Vilavella, Víctor Pérez-Sola, Joan Deus and Jordi Monfort
    Citation: Arthritis Research & Therapy 2022 24:252
    Content type: Research Published on:

  25. To evaluate the levels of periostin in patients with systemic sclerosis (SSc) and their association with features of systemic sclerosis.

    Authors: Fatima El-Adili, Justin K. Lui, Mortada Najem, Giuseppina Farina, Maria Trojanowska, Flora Sam and Andreea M. Bujor
    Citation: Arthritis Research & Therapy 2022 24:251
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:11

  26. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s13075-022-02950-3.

    Authors: Yanhong Li, Jing Wang, Yanchao Ma, Wenjia Du, Haijun Feng, Kai Feng, Guangjie Li and Shuanke Wang
    Citation: Arthritis Research & Therapy 2022 24:250
    Content type: Retraction Note Published on:

  27. Macrophages are key innate immune cells implicated in the pathogenesis of Behçet’s disease (BD), and macrophage polarization plays a pivotal role in inflammatory response. This study aimed to investigate the r...

    Authors: Xiuhua Wu, Zhimian Wang, Jing Shi, Xin Yu, Chaoran Li, Jinjing Liu, Fengchun Zhang, Hua Chen and Wenjie Zheng
    Citation: Arthritis Research & Therapy 2022 24:249
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:275

  28. Authors: Martin Bergman, Namita Tundia, Naomi Martin, Jessica L. Suboticki, Jayeshkumar Patel, Debbie Goldschmidt, Yan Song and Grace C. Wright
    Citation: Arthritis Research & Therapy 2022 24:248
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:155

  29. The cytoskeletal protein, PSTPIP2, is associated with inflammation and is predominantly expressed in macrophages. Previous data have shown that PSTPIP2 inhibits articular bone damage in arthritic rats. The aim...

    Authors: Yao Yao, Xiaoyu Cai, Meng Zhang, Xiao Zhang, Fujia Ren, Yan Zheng, Weidong Fei, Mengdan Zhao and Caihong Zheng
    Citation: Arthritis Research & Therapy 2022 24:247
    Content type: Research Published on:

  30. Authors: Thales R. Hein, Leonardo Peterson, Barbara J. Bartikoski, Juliana Portes, Rafaela C. Espirito Santo and Ricardo M. Xavier
    Citation: Arthritis Research & Therapy 2022 24:246
    Content type: Letter Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:245

  31. We read with great interest the article by Hein et al., which described the meta-analysis study on the impact of disease-modifying anti-rheumatic drugs (DMARDs) therapy on skeletal muscle mass in rheumatoid ar...

    Authors: Hiroto Minamino, Mie Torii, Masao Katsushima, Yoshihito Fujita and Motomu Hashimoto
    Citation: Arthritis Research & Therapy 2022 24:245
    Content type: Comment Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:171

    The Letter to this article has been published in Arthritis Research & Therapy 2022 24:246

  32. Authors: Koichiro Komiya, Hiroyuki Enomoto, Isao Inoki, Satoko Okazaki, Yoshinari Fujita, Eiji Ikeda, Eiko Ohuchi, Hideo Matsumoto, Yoshiaki Toyama and Yasunori Okada
    Citation: Arthritis Research & Therapy 2022 24:244
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2005 7:R1158

  33. Observational studies have demonstrated associations between gout and hypertension, but whether they are causal remains unclear. Our work aims to assess the causal relationship between gout and hypertension.

    Authors: Benjamin Lai, Huang-Ping Yu, Yu-Jing Chang, Liang-Chin Wang, Che-Kai Chen, Weiya Zhang, Michael Doherty, Shang-Hung Chang, Jun-Te Hsu, Kuang-Hui Yu and Chang-Fu Kuo
    Citation: Arthritis Research & Therapy 2022 24:243
    Content type: Research Published on:

  34. Clustering is an important clinical feature of Behçet’s syndrome (BS) and may have pathogenetic and therapeutic implications. Recent and previous studies on BS phenotype differ substantially in terms of method...

    Authors: Ufuk İlgen
    Citation: Arthritis Research & Therapy 2022 24:242
    Content type: Commentary Published on:

  35. In patients with tracheobronchial involvement, the differential diagnosis between granulomatosis with polyangiitis (GPA) and relapsing polychondritis (RP) can be challenging. The aim of this study was to descr...

    Authors: Carole Jalaber, Xavier Puéchal, Ines Saab, Emma Canniff, Benjamin Terrier, Luc Mouthon, Eglantine Cabanne, Sandra Mghaieth, Marie-Pierre Revel and Guillaume Chassagnon
    Citation: Arthritis Research & Therapy 2022 24:241
    Content type: Research Published on:

  36. We compared the treatment effectiveness between guselkumab and adalimumab in patients with pustulotic arthro-osteitis (PAO). In addition, we performed peripheral blood immunophenotyping to elucidate the immuno...

    Authors: Masanobu Ueno, Ippei Miyagawa, Yusuke Miyazaki, Kentaro Hanami, Shunsuke Fukuyo, Satoshi Kubo, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:240
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:24

  37. Authors: Jingjing Zhu, Zheng Niu, Lars Alfredsson, Lars Klareskog, Leonid Padyukov and Xia Jiang
    Citation: Arthritis Research & Therapy 2022 24:239
    Content type: Letter Published on:

    The original article was published in Arthritis Research & Therapy 2022 24:237

  39. With great interest, we have read the recent article “Age at menarche, age at natural menopause, and risk of rheumatoid arthritis — a Mendelian randomization study” by Zhu et al. While we have a great apprecia...

    Authors: Zhenqian Wang and Jiawen Lu
    Citation: Arthritis Research & Therapy 2022 24:237
    Content type: Correspondence Published on:

    The original article was published in Arthritis Research & Therapy 2021 23:108

    The Letter to this article has been published in Arthritis Research & Therapy 2022 24:239

  40. Endothelial dysfunction contributes to increased cardiovascular (CV) disease in rheumatoid arthritis (RA). Angiogenic T cells (Tang) are a key regulator of vascular function via their interaction with endothel...

    Authors: Giacomo Cafaro, Eleonora Petito, Onelia Bistoni, Emanuela Falcinelli, Sabrina Cipriani, Maria Chiara Borghi, Angelo F. Bonifacio, Elisa Giglio, Alessia Alunno, Carlo Perricone, Roberto Gerli, Paolo Gresele and Elena Bartoloni
    Citation: Arthritis Research & Therapy 2022 24:236
    Content type: Research Published on:

  41. Animal models of spontaneous osteoarthritis (OA) are sparse and not well characterized. The purpose of the present study is to examine OA-related changes and mechanisms in senescence-accelerated mouse prone 8 ...

    Authors: Yohei Sanada, Yasunari Ikuta, Chenyang Ding, Masahiro Shinohara, Dilimulati Yimiti, Hiroyuki Ishitobi, Keita Nagira, Minjung Lee, Takayuki Akimoto, Sachi Shibata, Masakazu Ishikawa, Tomoyuki Nakasa, Kiminori Matsubara, Martin K. Lotz, Nobuo Adachi and Shigeru Miyaki
    Citation: Arthritis Research & Therapy 2022 24:235
    Content type: Research Published on:

  42. Abnormal proliferation of fibroblast-like synoviocytes (FLSs) in the synovial lining layer is the primary cause of synovial hyperplasia and joint destruction in rheumatoid arthritis (RA). Currently, the relati...

    Authors: Ying Lu, Chongbo Hao, Shanshan Yu, Zuan Ma, Xuelian Fu, Mingqing Qin, Menglei Ding, Zengguang Xu and Lieying Fan
    Citation: Arthritis Research & Therapy 2022 24:234
    Content type: Research Published on:

  43. The purpose of this study was to stratify patients with rheumatoid arthritis (RA) according to the trend of disease activity by trajectory-based clustering and to identify contributing factors for treatment re...

    Authors: Bon San Koo, Seongho Eun, Kichul Shin, Seokchan Hong, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo and Ji Seon Oh
    Citation: Arthritis Research & Therapy 2022 24:233
    Content type: Research Published on:

  44. To evaluate the impact of cardiovascular risk (CVR) on the diagnostic accuracy of the ultrasonographic (US) Halo Score in patients with suspected giant cell arteritis (GCA).

    Authors: Juan Molina-Collada, Katerine López Gloria, Isabel Castrejón, Juan Carlos Nieto-González, Julia Martínez-Barrio, Ana M. Anzola Alfaro, Javier Rivera and José María Álvaro-Gracia
    Citation: Arthritis Research & Therapy 2022 24:232
    Content type: Research Published on:

  45. Osteoarthritis (OA) is a common chronic condition but its association with other chronic conditions and mortality is largely unknown. This study aimed to use latent class analysis (LCA) of 30 comorbidities in ...

    Authors: Dawit T. Zemedikun, Helena Lee, Krishnarajah Nirantharakumar, Karim Raza, Joht Singh Chandan, Janet M. Lord and Thomas A. Jackson
    Citation: Arthritis Research & Therapy 2022 24:231
    Content type: Research Published on:

  46. Rheumatoid arthritis (RA) is characterized by the presence of disease-specific autoreactive B cell responses, in particular those generating anti-citrullinated protein antibodies (ACPA). For many years, Epstei...

    Authors: Sanne Kroos, Arieke S. B. Kampstra, René E. M. Toes, Linda M. Slot and Hans U. Scherer
    Citation: Arthritis Research & Therapy 2022 24:230
    Content type: Correspondence Published on:

  47. Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status. We performed a genome-wide association study (GWAS) and polyge...

    Authors: Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang and Shun-Jen Chang
    Citation: Arthritis Research & Therapy 2022 24:229
    Content type: Research Published on:

  48. Adipose-derived mesenchymal stem cells (ASCs) have gained attention as a new treatment for systemic sclerosis (SSc). Low-molecular-weight heparin (LMWH) enhances cell function and stimulates the production of ...

    Authors: Takayasu Suzuka, Takuya Kotani, Takashi Saito, Shogo Matsuda, Takako Sato and Tohru Takeuchi
    Citation: Arthritis Research & Therapy 2022 24:228
    Content type: Research Published on:

  49. X-ray images are commonly used to assess the bone destruction of rheumatoid arthritis. The purpose of this study is to propose an automatic-bone-destruction-evaluation system fully utilizing deep neural networ...

    Authors: Kazuki Miyama, Ryoma Bise, Satoshi Ikemura, Kazuhiro Kai, Masaya Kanahori, Shinkichi Arisumi, Taisuke Uchida, Yasuharu Nakashima and Seiichi Uchida
    Citation: Arthritis Research & Therapy 2022 24:227
    Content type: Research Published on:

  50. To detect dorsally located osteophytes (OP) on lateral x-ray views and to correlate their presence with the extent of structural joint damage, determined by histologic grading (cartilage damage and synovial in...

    Authors: Ilse-Gerlinde Sunk, Love Amoyo-Minar, Birgit Niederreiter, Afschin Soleiman, Franz Kainberger, Josef S. Smolen, Daniel Aletaha and Klaus Bobacz
    Citation: Arthritis Research & Therapy 2022 24:226
    Content type: Research Published on:
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