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This article is part of a Supplement: Volume 6 Supplement 1
This article is part of a Supplement: Volume 6 Supplement 1
This article is part of a Supplement: Volume 6 Supplement 1
This article is part of a Supplement: Volume 6 Supplement 1
This article is part of a Supplement: Volume 6 Supplement 1
This article is part of a Supplement: Volume 6 Supplement 1
This article is part of a Supplement: Volume 6 Supplement 1
Observational databanks have inherent strengths and shortcomings. As in randomized controlled trials, poor design of these databanks can either exaggerate or reduce estimates of drug effectiveness and can limi...
Abnormalities in lymphocyte signaling cascades are thought to play an important role in the development of autoimmune disease. However, the large amount of cellular material needed for standard biochemical ass...
The interest in naturally arising regulatory T (TR) cells as a paradigm for maintaining immunological self-tolerance has undergone an explosive re-emergence in recent years. This renaissance was triggered by seve...
Some research evidence supports early aggressive treatment of rheumatoid arthritis (RA) using combination therapy with two or more disease modifying anti-rheumatic drugs (DMARDs) plus steroids, or even DMARDs ...
Autoimmune diseases are often characterized as clinical syndromes caused by the inappropriate activation of T or B cells resulting in systemic or organ-specific damage. However, studies support a role for the ...
Whatever the initiating factor of osteoarthritis (OA), the process ultimately unmasks the immunogenic determinants of chondrocytes, proteoglycans and collagens, which then triggers autoimmune reactions. Althou...
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by the differentiation of short- and long-lived immunoglobulin secreting plasma cells that secrete pathogenic autoa...
This article is part of a Supplement: Volume 5 Supplement 4
The chimeric anti-CD20 monoclonal antibody rituximab has been used extensively in the treatment of B cell malignancies, and more recently it has emerged as a potential treatment for rheumatoid arthritis (RA), ...
This article is part of a Supplement: Volume 5 Supplement 4
B lymphocytes play several critical roles in the pathogenesis of rheumatoid arthritis. They are the source of the rheumatoid factors and anticitrullinated protein antibodies, which contribute to immune complex...
This article is part of a Supplement: Volume 5 Supplement 4
Antibodies directed to citrullinated proteins (anti-cyclic citrullinated peptide) are highly specific for rheumatoid arthritis (RA). Recent data suggest that the antibodies may be involved in the disease proce...
The 4th annual European League Against Rheumatism congress, held in Lisbon, 18–21 June 2003, had a record turnout of more than 8600 delegates and the abstract submissions increased to 2600. A heat wave and a s...
It is widely accepted that cell-mediated immune functions decline with age, rendering an individual more susceptible to infection and possibly cancer, as well as to age-associated autoimmune diseases. The exac...
Recent advances in the study of global patterns of gene expression with the use of microarray technology, coupled with data analysis using sophisticated statistical algorithms, have provided new insights into ...
Synovial tissue is readily accessible by closed needle or arthroscopic biopsy. These techniques provide adequate tissue for most diagnostic requirements. Examination of synovial tissue can assist in the diagno...
The CD20 cell marker appears early in the process of B cell development. In this review we focus on the results of attempts to utilize B cell depletion based on the use of a chimeric monoclonal antibody (MAb) ...
This article is part of a Supplement: Volume 5 Supplement 4
The role of B cells in rheumatoid arthritis (RA) has been debated for decades. However, recent clinical trial data indicating that depletion of B cells in RA patients is of therapeutic benefit has validated th...
This article is part of a Supplement: Volume 5 Supplement 4
Few diseases exemplify the integration of research from bench to bedside as well as neonatal lupus, often referred to as a model of passively acquired autoimmunity. In essence, this disease encompasses two pat...
Inflammation and inflammatory responses are modulated by a bidirectional communication between the neuroendocrine and immune system. Many lines of research have established the numerous routes by which the imm...
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
This article is part of a Supplement: Volume 5 Supplement 3
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