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  1. Juvenile idiopathic arthritis (JIA) comprises a heterogeneous group of conditions that can cause marked disability and diminished quality of life. Data on predictors of clinical response are insufficient to gu...

    Authors: Hermine I Brunner, Grant S Schulert, Alyssa Sproles, Sherry Thornton, Gabriel Vega Cornejo, Jordi Antón, Ruben Cuttica, Michael Henrickson, Ivan Foeldvari, Daniel J Kingsbury, Margarita Askelson, Jinqi Liu, Sumanta Mukherjee, Robert L Wong, Daniel J Lovell, Alberto Martini…
    Citation: Arthritis Research & Therapy 2024 26:125
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2024 26:154

  2. Treatments for rheumatoid arthritis (RA) are associated with complex changes in lipids and lipoproteins that may impact cardiovascular (CV) risk. The objective of this study was to examine lipid and lipoprotei...

    Authors: Katherine P. Liao, Pamela Rist, Jon Giles, Leah Santacroce, Margery A. Connelly, Robert J. Glynn, Paul Ridker, Ahmed Tawakol, Joan Bathon and Daniel H. Solomon
    Citation: Arthritis Research & Therapy 2024 26:123
    Content type: Research Published on:

  3. To assess the real-world, long-term effectiveness of rituximab (RTX) as a rescue therapy in patients with antisynthetase syndrome and progressive interstitial lung disease (ASS-ILD).

    Authors: Javier Narváez, Elena Cañadillas, Iván Castellví, Juan José Alegre, Vanesa Vicens-Zygmunt, Guadalupe Bermudo, Paola Vidal-Montal, María Molina Molina and Joan Miquel Nolla
    Citation: Arthritis Research & Therapy 2024 26:122
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2024 26:128

  4. Janus kinase (JAK) inhibitors, such as baricitinib, are widely used to treat rheumatoid arthritis (RA). Clinical studies show that baricitinib is more effective at reducing pain than other similar drugs. Here,...

    Authors: Kenta Makabe, Hiroyuki Okada, Naohiro Tachibana, Hisatoshi Ishikura, Norihito Ito, Masaru Tanaka, Ryota Chijimatsu, Asuka Terashima, Fumiko Yano, Meiko Asaka, Dai Yanagihara, Shuji Taketomi, Takumi Matsumoto, Sakae Tanaka, Yasunori Omata and Taku Saito
    Citation: Arthritis Research & Therapy 2024 26:121
    Content type: Research Published on:

  5. Kinases are intracellular signalling mediators and key to sustaining the inflammatory process in rheumatoid arthritis (RA). Oral inhibitors of Janus Kinase family (JAKs) are widely used in RA, while inhibitors...

    Authors: Cankut Çubuk, Rachel Lau, Pedro Cutillas, Vinothini Rajeeve, Christopher R. John, Anna E. A. Surace, Rebecca Hands, Liliane Fossati-Jimack, Myles J. Lewis and Costantino Pitzalis
    Citation: Arthritis Research & Therapy 2024 26:120
    Content type: Research Published on:

  6. In gout, monosodium urate crystals are taken up by macrophages, triggering the activation of the NLRP3 inflammasome and the maturation of IL-1β. This study aimed to investigate the role of integrin CD11b in in...

    Authors: Driss Ehirchiou, Ilaria Bernabei, Vishnuprabu Durairaj Pandian, Sonia Nasi, Veronique Chobaz, Mariela Castelblanco, Alexander So, Fabio Martinon, Xiaoyun Li, Hans Acha-Orbea, Thomas Hugle, Li Zhang and Nathalie Busso
    Citation: Arthritis Research & Therapy 2024 26:119
    Content type: Research Published on:

  7. Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is a major contributing factor to OA, and as one ages, various joint tiss...

    Authors: Sher Bahadur Poudel, Ryan R. Ruff, Gozde Yildirim, Richard A. Miller, David E. Harrison, Randy Strong, Thorsten Kirsch and Shoshana Yakar
    Citation: Arthritis Research & Therapy 2024 26:118
    Content type: Research Published on:

  8. The objective of this study was to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF‑06835375, a potent selective afucosyl immunoglobulin G1 antibody targeting C-X-C chemokine rec...

    Authors: Stanley Cohen, Jean S. Beebe, Vishala Chindalore, Shunjie Guan, Mina Hassan-Zahraee, Madhurima Saxena, Li Xi, Craig Hyde, Sarita Koride, Robert Levin, Shannon Lubaczewski, Mikhail Salganik, Abigail Sloan, Erin Stevens, Elena Peeva, Michael S. Vincent…
    Citation: Arthritis Research & Therapy 2024 26:117
    Content type: Research Published on:

  9. A substantial proportion of patients with giant cell arteritis (GCA) relapse despite standard therapy with glucocorticoids, methotrexate and tocilizumab. The Janus kinase/signal transducer and activator of tra...

    Authors: Javier Loricera, Toluwalase Tofade, Diana Prieto-Peña, Susana Romero-Yuste, Eugenio de Miguel, Anne Riveros-Frutos, Iván Ferraz-Amaro, Eztizen Labrador, Olga Maiz, Elena Becerra, Javier Narváez, Eva Galíndez-Agirregoikoa, Ismael González-Fernández, Ana Urruticoechea-Arana, Ángel Ramos-Calvo, Fernando López-Gutiérrez…
    Citation: Arthritis Research & Therapy 2024 26:116
    Content type: Research Published on:

  10. Immune checkpoints have emerged as promising therapeutic targets for autoimmune diseases. However, the specific roles of immune checkpoints in the pathophysiology of ankylosing spondylitis (AS) remain unclear.

    Authors: Feihong Huang, Zhiping Su, Yibin Huang, Yuxiang Huang, Chengyu Zhou, Sitan Feng, Xiong Qin, Xi Xie, Chong Liu and Chaojie Yu
    Citation: Arthritis Research & Therapy 2024 26:115
    Content type: Research Published on:

  11. Gout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of this study was to investigate the mechanisms of gene expression regulation in gout disea...

    Authors: Yubiao Yang, Ping Hu, Qinnan Zhang, Boyuan Ma, Jinyu Chen, Bitao Wang, Jun Ma, Derong Liu, Jian Hao and Xianhu Zhou
    Citation: Arthritis Research & Therapy 2024 26:114
    Content type: Research Published on:

  12. It has been reported that in western countries malignancy risk was higher in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) compared with that in the general population. I...

    Authors: Xiang-Yu Han, Zhi-Ying Li, Ming-Hui Zhao, Mark A. Little and Min Chen
    Citation: Arthritis Research & Therapy 2024 26:113
    Content type: Research Published on:

  13. The progression of knee osteoarthritis (OA) can be defined as either radiographic progression or pain progression. This study aimed to construct models to predict radiographic progression and pain progression ...

    Authors: Xiaoyu Li, Chunpu Li and Peng Zhang
    Citation: Arthritis Research & Therapy 2024 26:112
    Content type: Research Published on:

  14. Due to the unclear pathogenesis of osteoarthritis (OA), effective treatment for this ailment is presently unavailable. Accumulating evidence points to chondrocyte senescence as a key driver in OA development. ...

    Authors: Yucheng Lin, Lu Zhang, Mingliang Ji, Sinuo Shen, Yuzhi Chen, Shichao Wu, Xiaotao Wu, Nancy Q. Liu and Jun Lu
    Citation: Arthritis Research & Therapy 2024 26:111
    Content type: Research Published on:

  15. Diffusion kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) provide more comprehensive and informative perspective on microstructural alterations of cerebral white matter (W...

    Authors: Wenjun Hu, Ziru Qiu, Qin Huang, Yuhao Lin, Jiaying Mo, Linhui Wang, Jingyi Wang, Kan Deng, Yanqiu Feng, Xinyuan Zhang and Xiangliang Tan
    Citation: Arthritis Research & Therapy 2024 26:110
    Content type: Research Published on:

  16. The 2022 European Society of Cardiology/European Respiratory Society (ESC/ERS) guideline has recently revised the hemodynamic definition of pulmonary arterial hypertension. However, there is currently limited ...

    Authors: Yutong Li, Junyan Qian, Xingbei Dong, Jiuliang Zhao, Qian Wang, Yanhong Wang, Xiaofeng Zeng, Zhuang Tian and Mengtao Li
    Citation: Arthritis Research & Therapy 2024 26:109
    Content type: Research Published on:

  17. Psoriatic arthritis (PsA) is a chronic, potentially debilitating inflammatory arthritis often associated with psoriasis. Understanding the epidemiology of PsA across diverse populations can provide valuable in...

    Authors: Amir Haddad, Perach Chen Elkayam, Nili Stein, Ilan Feldhamer, Arnon Dov Cohen, Walid Saliba and Devy Zisman
    Citation: Arthritis Research & Therapy 2024 26:108
    Content type: Research Published on:

  18. Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. PsA disease involves flares, which are associated with increased joint inflammation and tissue remodeling. There is a need for ...

    Authors: Solveig Skovlund Groen, Signe Holm Nielsen, Anne Christine Bay-Jensen, Mozhgan Rasti, Darshini Ganatra, Katerina Oikonomopoulou and Vinod Chandran
    Citation: Arthritis Research & Therapy 2024 26:107
    Content type: Research Published on:

  19. Previously, fragments from Sirtuin 1 (SIRT1) were identified in preclinical and clinical samples to display an increase in serum levels for N-terminal (NT) SIRT1 vs. C-terminal (CT) SIRT1, indicative of early ...

    Authors: Miya Marco, Mylène Jansen, Goran van der Weiden, Eli Reich, Yonathan H. Maatuf, Simon C. Mastbergen and Mona Dvir-Ginzberg
    Citation: Arthritis Research & Therapy 2024 26:106
    Content type: Research Published on:

  20. Tofacitinib is an oral Janus kinase inhibitor for treatment of ankylosing spondylitis (AS). Time to improvement in core domains of AS was estimated in tofacitinib-treated patients with AS.

    Authors: Victoria Navarro-Compán, Atul Deodhar, Rachid Bahiri, Andrew G. Bushmakin, Joseph C. Cappelleri and Jihane Rammaoui
    Citation: Arthritis Research & Therapy 2024 26:105
    Content type: Research Published on:

  21. Epidemiological observational studies have elucidated a correlation between rheumatoid arthritis (RA) and bronchiectasis. However, the causal nature of this association remains ambiguous. To clarify this poten...

    Authors: Zehu Chen, Xuegang Li, Honglei Shi, Yiying Huang and Jing Liu
    Citation: Arthritis Research & Therapy 2024 26:104
    Content type: Research Published on:

  22. Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component in the inflamed synovium of patients with rheumatoid arthritis (RA). FLSs are emerging as promisin...

    Authors: Hongyan Qian, Chaoqiong Deng, Shiju Chen, Xinwei Zhang, Yan He, Jingying Lan, Aodi Wang, Guixiu Shi and Yuan Liu
    Citation: Arthritis Research & Therapy 2024 26:103
    Content type: Review Published on:

  23. To perform a detailed morphological analysis of the inorganic portion of two different clinical presentations of calcium-based deposits retrieved from subjects with SSc and identify a chemical dissolution of t...

    Authors: Phillip Lee, Lorraine Green, Bartosz Marzec, Fiona Meldrum, Francesco Del Galdo and Begonya Alcacer-Pitarch
    Citation: Arthritis Research & Therapy 2024 26:102
    Content type: Research Published on:

  25. Exploring the pathogenesis of osteoarthritis (OA) is important for its prevention, diagnosis, and treatment. Therefore, we aimed to construct novel signature genes (c-FRGs) combining cuproptosis-related genes ...

    Authors: Baoqiang He, Yehui Liao, Minghao Tian, Chao Tang, Qiang Tang, Fei Ma, Wenyang Zhou, Yebo Leng and Dejun Zhong
    Citation: Arthritis Research & Therapy 2024 26:100
    Content type: Research Published on:

  26. This study aims to elucidate the transcriptomic signatures and dysregulated pathways in patients with Systemic Lupus Erythematosus (SLE), with a particular focus on those persisting during disease remission.

    Authors: Frank Qingyun Wang, Li Shao, Xiao Dang, Yong-Fei Wang, Shuxiong Chen, Zhongyi Liu, Yujing Mao, Yuping Jiang, Fei Hou, Xianghua Guo, Jian Li, Lili Zhang, Yuting Sang, Xuan Zhao, Ruirui Ma, Kai Zhang…
    Citation: Arthritis Research & Therapy 2024 26:99
    Content type: Research Published on:

  27. Targeted small-molecule drugs in the treatment of systemic lupus erythematosus (SLE) have attracted increasing attention from clinical investigators. However, there is still a lack of evidence on the differenc...

    Authors: Shiheng Wang, Wanling Ning, Hanqing Tang, Chaochao Mu and Xiaosong Huang
    Citation: Arthritis Research & Therapy 2024 26:98
    Content type: Research Published on:

  28. The macrophage activation syndrome (MAS) secondary to systemic lupus erythematosus (SLE) is a severe and life-threatening complication. Early diagnosis of MAS is particularly challenging. In this study, machin...

    Authors: Wenxun Lin, Xi Xie, Zhijun Luo, Xiaoqi Chen, Heng Cao, Xun Fang, You Song, Xujing Yuan, Xiaojing Liu and Rong Du
    Citation: Arthritis Research & Therapy 2024 26:92
    Content type: Research Published on:

  29. Neutrophil extracellular trap formation and cell-free DNA (cfDNA) contribute to the inflammation in rheumatoid arthritis (RA), but it is unknown if mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) is more abund...

    Authors: Julia Lehmann, Stavros Giaglis, Diego Kyburz, Douglas Daoudlarian and Ulrich A. Walker
    Citation: Arthritis Research & Therapy 2024 26:97
    Content type: Research Published on:

  30. Gout is caused by monosodium urate (MSU) crystals deposition to trigger immune response. A recent study suggested that inhibition of Class I Histone deacetylases (HDACs) can significantly reduce MSU crystals-i...

    Authors: Qi-Bin Yang, Meng-Yun Zhang, Liu Yang, Jie Wang, Qing-Sheng Mi and Jing-Guo Zhou
    Citation: Arthritis Research & Therapy 2024 26:96
    Content type: Research Published on:

  31. Rheumatoid arthritis (RA) related interstitial lung disease (ILD) impacts on the treatment strategy and its prognosis in patients with RA. However, the relationship between RA disease activity and the severity...

    Authors: Yuhei Ito, Yasutaka Ichikawa, Shuichi Murashima, Hajime Sakuma and Ayako Nakajima
    Citation: Arthritis Research & Therapy 2024 26:95
    Content type: Research Published on:

  32. Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and inflammation, followed by excessive fibrosis of the skin and other internal organs, including the lungs. CX3CL1 (fractalki...

    Authors: Takumi Hasegawa, Akira Utsunomiya, Takenao Chino, Hiroshi Kasamatsu, Tomomi Shimizu, Takashi Matsushita, Takashi Obara, Naoto Ishii, Hideaki Ogasawara, Wataru Ikeda, Toshio Imai, Noritaka Oyama and Minoru Hasegawa
    Citation: Arthritis Research & Therapy 2024 26:94
    Content type: Research Published on:

  33. Anti-SS-A/Ro antibody (anti-SSA), the diagnostic marker of Sjögren’s syndrome (SS), is often detected in systemic sclerosis (SSc). Some patients are diagnosed with SSc/SS overlap syndromes, while there are ant...

    Authors: Tomoya Watanabe, Yasushi Ototake, Asami Akita, Mao Suzuki, Miwa Kanaoka, Jun Tamura, Yusuke Saigusa and Yukie Yamaguchi
    Citation: Arthritis Research & Therapy 2024 26:93
    Content type: Research Published on:

  34. To characterize aspects of triiodothyronine (T3) induced chondrocyte terminal maturation within the molecular osteoarthritis pathophysiology using the previously established T3 human ex vivo osteochondral explant...

    Authors: N. M. Korthagen, E. Houtman, I. Boone, R. Coutinho de Almeida, K. Sivasubramaniyan, R. Mahdad, R. G. H. H Nelissen, Y. F. M. Ramos, M. A Tessari and I. Meulenbelt
    Citation: Arthritis Research & Therapy 2024 26:91
    Content type: Research Published on:

  35. We aimed to investigate whether there are sex differences in disease activity measures among patients with axial spondyloarthritis (axSpA) and to determine any potential impact on the assessment of treatment r...

    Authors: Seulkee Lee, Seonyoung Kang, Hyungjin Kim, Jaejoon Lee, Min-Ji Kim and Hoon-Suk Cha
    Citation: Arthritis Research & Therapy 2024 26:90
    Content type: Research Published on:

  38. We aimed to reveal the effect of abatacept (ABT) on atherosclerosis in rheumatoid arthritis (RA) patients, 3-year efficacy for arthritis, and safety in a population of older vs. younger patients.

    Authors: Zento Yamada, Sei Muraoka, Mai Kawazoe, Wataru Hirose, Hajime Kono, Shinsuke Yasuda, Takahiko Sugihara and Toshihiro Nanki
    Citation: Arthritis Research & Therapy 2024 26:87
    Content type: Research Published on:

  39. Little is known about long-term clinical outcomes or urate-lowering (ULT) therapy use following pegloticase discontinuation. We examined ULT use, serum urate (SU), inflammatory biomarkers, and renal function f...

    Authors: Emily E. Holladay, Amy S. Mudano, Fenglong Xie, Jingyi Zhang, Ted R. Mikuls, Brian LaMoreaux, Lissa Padnick-Silver and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2024 26:86
    Content type: Research Published on:

  40. Immunoglobulin A vasculitis (IgAV) in adults has a variable disease course, with patients often developing gastrointestinal and renal involvement and thus contributing to higher mortality. Due to understudied ...

    Authors: Matija Bajželj, Matjaž Hladnik, Rok Blagus, Vesna Jurčić, Ana Markež, Tanya Deniz Toluay, Snežna Sodin-Šemrl, Alojzija Hočevar and Katja Lakota
    Citation: Arthritis Research & Therapy 2024 26:85
    Content type: Research Published on:

  41. We attempted to identify abnormal immune cell components and signaling pathways in lupus nephritis (LN) and to identify potential therapeutic targets.

    Authors: Shuping Wei, Haiyun Shen, Yidan Zhang, Chunrui Liu, Shoushan Li, Jing Yao, Zhibin Jin and Hongliang Yu
    Citation: Arthritis Research & Therapy 2024 26:84
    Content type: Research Published on:

  42. Hip and knee osteoarthritis (OA) are highly prevalent worldwide. The guidelines recommend physical activity and education as the core treatments for osteoarthritis. Digital health has the potential to engage p...

    Authors: F. Weber, C. Kloek, S. Stuhrmann, Y. Blum, C. Grüneberg and C. Veenhof
    Citation: Arthritis Research & Therapy 2024 26:83
    Content type: Research Published on:

  43. Previous studies have shown that growing up with rheumatic conditions can fuel dissatisfaction and psychological distress, which in turn affects disease self-management and treatment adherence. Primary objecti...

    Authors: Florian Milatz, Jens Klotsche, Martina Niewerth, Claudia Sengler, Daniel Windschall, Tilmann Kallinich, Frank Dressler, Ralf Trauzeddel, Reinhard W. Holl, Ivan Foeldvari, Normi Brück, Svenja Temming, Toni Hospach, Petra Warschburger, Rainer Berendes, Gabriele Erbis…
    Citation: Arthritis Research & Therapy 2024 26:82
    Content type: Research Published on:

  44. Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere and Maurizio Cutolo
    Citation: Arthritis Research & Therapy 2024 26:81
    Content type: Correction Published on:

    The original article was published in Arthritis Research & Therapy 2024 26:74

  45. Our study aimed to provide real-world evidence on the treatment patterns, effectiveness and safety of canakinumab in France in Familial Mediterranean Fever (FMF), Mevalonate Kinase Deficiency (MKD), and Tumor ...

    Authors: Isabelle Koné-Paut, Sophie Georgin-Lavialle, Alexandre Belot, Magali Jover, Mathilde Pouriel, Laure Lacoin, Pascal Pillet and Véronique Hentgen
    Citation: Arthritis Research & Therapy 2024 26:80
    Content type: Research Published on:

  46. Idiopathic inflammatory myopathies (IIM) represent a rare and heterogenous group diseases, and their treatment is not fully defined yet. According to previous small case series, the combination of mycophenolat...

    Authors: Corrado Campochiaro, Nicola Farina, Giacomo De Luca, Veronica Batani, Giorgia Trignani, Davide Vignale, Anna Palmisano, Marco Matucci-Cerinic and Lorenzo Dagna
    Citation: Arthritis Research & Therapy 2024 26:79
    Content type: Research Published on:

  47. Transitioning from a genetic association signal to an effector gene and a targetable molecular mechanism requires the application of functional fine-mapping tools such as reporter assays and genome editing. In...

    Authors: Jack B. Roberts, Olivia L.G. Boldvig, Guillaume Aubourg, S. Tanishq Kanchenapally, David J. Deehan, Sarah J. Rice and John Loughlin
    Citation: Arthritis Research & Therapy 2024 26:78
    Content type: Research Published on:

  48. Peptidoglycan (PG) is an arthritogenic bacterial cell wall component whose role in human osteoarthritis is poorly understood. The purpose of this study was to determine if PG is present in synovial tissue of o...

    Authors: Meaghan N Holub, Amanda Wahhab, Joseph R Rouse, Rebecca Danner, Lauren G Hackner, Christine B Duris, Mecaila E McClune, Jules M Dressler, Klemen Strle, Brandon L Jutras, Adam I Edelstein and Robert B Lochhead
    Citation: Arthritis Research & Therapy 2024 26:77
    Content type: Research Published on:

  49. Autoimmune responses have been suggested to involvement in patients with Behcet’s syndrome (BS). There has been growing attention towards the roles of cutaneous lymphocyte antigen (CLA)+ regular T cells (Tregs) i...

    Authors: Jiachen Li, Feng Sun, Danxue Zhu, Yuke Hou, Gong Cheng, Ping Wang, Xu Jin, Wenyan Zhou, Xiaolin Sun, Zhanguo Li and Tian Liu
    Citation: Arthritis Research & Therapy 2024 26:76
    Content type: Research Published on:

  50. Treatment with high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (aHSCT) is an intensive treatment option for patients with severe forms of systemic sclerosis (SSc). Even th...

    Authors: Ann-Christin Pecher, Reinhild Klein, Ina Koetter, Marieke Wagner, Wichard Vogel, Stefan Wirths, Claudia Lengerke and Joerg Christoph Henes
    Citation: Arthritis Research & Therapy 2024 26:75
    Content type: Research Published on:
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Arthritis Research & Therapy

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