Kidney disease in lupus is not always 'lupus nephritis'

In lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current classification of the International Society of Nephrology/Renal Pathology Society. The signs of renal dysfunction may be caused by lupusunrelated renal injury such as drug toxicity or infection or by lupus-associated mechanisms that are not part of the classification, such as minimal change nephrotic syndrome or thrombotic microangiopathy. The latter seems to complicate lupus nephritis more frequently than previously thought. An unbiased assessment of kidney disease in lupus requires a kidney (re-)biopsy to define the appropriate management.

In the previous issue of Arthritis Research & Th erapy, Song and colleagues [1] discussed specifi c kidney abnormalities in patients with lupus erythematosus (LE). LE can manifest as cutaneous LE or as a systemic disorder (systemic lupus erythematosus, or SLE) [2]. In patients with LE, renal abnormalities, such as elevated serum creatinine levels or urinary abnormalities, require further diagnostic work-up because they may indicate renal involvement in SLE or an unrelated form of renal disease [3]. Furthermore, renal symptoms may indicate fl ares of disease activity in patients with established lupus nephritis but may also refl ect renal injury due to concomitant toxicity or infectious disease. How should lupus nephritis be defi ned? Th e current classifi cation of the International Society of Nephrology/Renal Pathology Society (ISN/RPS) is based on the phenotype of immune complex glomerulonephritis that depends on the predominant site of immune complex deposition within the glomerulus and on diff erent stages of acute (and poten tially reversible) injury and chronic (and potentially irreversible) scarring [4]. Th e article on ISN/RPS classification of lupus nephritis [4] emphasizes the importance of including all other forms of kidney injury, separate from immune complex-mediated glomerulonephritis, in the diagnostic evaluation of the renal biopsy in SLE, including thrombotic microangiopathy (TMA). Th e article advocates that 'the extent, severity, and type of tubulointerstitial injury (tubular atrophy, interstitial fi brosis, and chronic lesions) and vascular disease (vascular deposits, thrombi, vasculitis, sclerosis) should also be documented and graded (mild, moderate, severe) in the diagnostic line' [4].
Song and colleagues [1] presented a detailed histopatho logical analysis of a series of 148 patients with biopsy-proven lupus nephritis, focusing on the prevalence of TMA. Th e authors defi ned TMA by light microscopy as interlobular artery, arteriole, and glomerular capillary lesions, including endothelial swelling, lumen narrowing or obliteration, and thrombi formation. Electron microscopic TMA criteria are swelling of glomerular endothelial cells, detachment from glomerular basement membrane, and widening of the subendothelial space. Fibrin staining identifi es acute microthrombi, where as mucoid changes and onionskin lesions of arterioles were considered chronic. Th e authors found such TMA lesions in 36 out of the 148 patients with lupus nephritis [1]. In some of these cases, TMA was a manifestation of associated systemic autoimmune states such as the anti-phospholipid antibody syndrome, scleroderma, or thrombotic thrombocytopenic purpura, which have specifi c diagnostic criteria and are not included as a specifi c category in the current ISN/RPS classifi cation of lupus nephritis [4].
In the majority of cases, TMA was associated with immune complex-mediated forms of lupus nephritis. According to the authors, such cases can be missed easily unless fi brin immunostaining is performed. TMA results from severe injury to the vascular endothelium, which Song and colleagues [1] found to be associated with poorer renal outcomes as compared with patients with non-TMA lupus nephritis. As such, reporting TMA in the renal biopsy and defi ning the ISN/RPS class are important, even though the management implications

Abstract
In lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defi ned by the current classifi cation of the International Society of Nephrology/Renal Pathology Society. The signs of renal dysfunction may be caused by lupusunrelated renal injury such as drug toxicity or infection or by lupus-associated mechanisms that are not part of the classifi cation, such as minimal change nephrotic syndrome or thrombotic microangiopathy. The latter seems to complicate lupus nephritis more frequently than previously thought. An unbiased assessment of kidney disease in lupus requires a kidney (re-)biopsy to defi ne the appropriate management.
remain unclear unless a causative disorder such as the anti-phospholipid antibody syndrome (anticoagulation), overlap syndrome with scleroderma (angiotensin inhibition), or thrombotic thrombocytopenic purpura (plasma exchange) can be identifi ed.
Th e report by Song and colleagues reminds us that, in LE, elevated serum creatinine levels or urinary abnormalities (or both) may not always represent immune complex glomerulonephritis (that is, 'lupus nephritis'). In addition, patients with SLE can develop other kidney disorders that may be related or unrelated to SLE and SLE management (Table 1) [3].