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Most Accessed Articles: Arthritis Research & Therapyhttp://arthritis-research.biomedcentral.comMost Accessed Articles: Arthritis Research & TherapyUse of NSAIDs in treating patients with arthritis with rheumatic diseases, including rheumatoid arthritis and osteoarthritis, almost universally describe pain and stiffness as important contributors to reduced health-related quality of life. Of the t...Wed, 24 Jul 2013 00:00:00 GMT J Crofford2013-07-24T00:00:00ZCollagen-induced arthritis in common marmosets: a new nonhuman primate model for chronic arthritis is an ever-increasing need for animal models to evaluate efficacy and safety of new therapeutics in the field of rheumatoid arthritis (RA). Particularly for the early preclinical evaluation of human-spec...Tue, 26 Oct 2010 00:00:00 GMT PM Vierboom, Elia Breedveld, Ivanela Kondova and Bert A 't Hart2010-10-26T00:00:00ZRemission in psoriatic arthritis: is it possible and how can it be predicted? remission is now possible in psoriatic arthritis (PsA) we wished to examine remission rates in PsA patients following anti tumour necrosis factor alpha (TNFα) therapy and to examine possible predictors o...Tue, 18 May 2010 00:00:00 GMT P Saber, CT Ng, Guillaume Renard, Bernadette M Lynch, Eliza Pontifex, Ceara AE Walsh, Alexia Grier, Marian Molloy, Barry Bresnihan, Oliver FitzGerald, Ursula Fearon and Douglas J Veale2010-05-18T00:00:00ZMicrobes, the gut and ankylosing spondylitis is increasingly clear that the interaction between host and microbiome profoundly affects health. There are 10 times more bacteria in and on our bodies than the total of our own cells, and the human intesti...Thu, 06 Jun 2013 00:00:00 GMT Costello, Dirk Elewaut, Tony J Kenna and Matthew A Brown2013-06-06T00:00:00ZCartilage oligomeric matrix protein specific antibodies are pathogenic oligomeric matrix protein (COMP) is a major non-collagenous component of cartilage. Earlier, we developed a new mouse model for rheumatoid arthritis using COMP. This study was undertaken to investiga...Mon, 20 Aug 2012 00:00:00 GMT Geng, Kutty Selva Nandakumar, Anna Pramhed, Anders Aspberg, Ragnar Mattsson and Rikard Holmdahl2012-08-20T00:00:00Z

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Aims and scope

Arthritis Research & Therapy is an international, peer-reviewed online journal, publishing original research, reviews, commentaries and reports. The major focus of the journal is on cellular and molecular mechanisms of arthritis, musculoskeletal conditions and systemic autoimmune rheumatic diseases and translation of this knowledge into advances in clinical care. Original basic, translational laboratory and clinical research is considered for publication along with results of early and late phase therapeutic trials.

Review series: New technologies

Written by renowned experts in the field, this collection of open access Review articles explores the use of RNA sequencing, cytometry, metabolomics and next-generation DNA sequencing in rheumatic disease.

Featured review: Progress in defining clinically meaningful changes for clinical trials in nonrenal manifestations of SLE disease activity

“Since 2002, one new agent has been approved by the US Food and Drug Administration for systemic lupus erythematosus (SLE). Experiences from the field conducting trials of all the agents tested during this period have provided valuable practical insights. These insights harnessed with basic methodological work on the minimal clinically important difference (MCID) should improve the efficiency and the clinical relevance of future trials.”

This review, by Choi et al., provides an update on methods to determine a clinically meaningful difference when conducting trials of new agents for SLE.