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  1. Research article

    Preliminary safety and efficacy profile of prucalopride in the treatment of systemic sclerosis (SSc)-related intestinal involvement: results from the open label cross-over PROGASS study

    Prokinetics are used to treat enteric dismotility symptoms in systemic sclerosis (SSc) patients, but they often lack adequate efficacy. The most effective prokinetics belonging to the serotonin (5-HT4) receptor a...

    Barbara Vigone, Monica Caronni, Adriana Severino, Chiara Bellocchi, Anna Rita Baldassarri, Mirella Fraquelli, Gaia Montanelli, Alessandro Santaniello and Lorenzo Beretta

    Arthritis Research & Therapy 2017 19:145

    Published on: 20 June 2017

  2. Research article

    Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis

    Despite the important role that microRNAs (miRNAs) play in immunity and inflammation, their involvement in systemic sclerosis (SSc) remains poorly characterized. miRNA-155 (miR-155) plays a role in pulmonary f...

    Carol M. Artlett, Sihem Sassi-Gaha, Jennifer L. Hope, Carol A. Feghali-Bostwick and Peter D. Katsikis

    Arthritis Research & Therapy 2017 19:144

    Published on: 17 June 2017

  3. Research article

    Work outcome in yet undiagnosed patients with non-radiographic axial spondyloarthritis and ankylosing spondylitis; results of a cross-sectional study among patients with chronic low back pain

    To understand the impact of yet undiagnosed non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) on work outcomes in a cohort of patients with long-lasting chronic low back pain ...

    Lonneke van Hoeven, Annelies E. R. C. H. Boonen, Johanna M. W. Hazes and Angelique E. A. M. Weel

    Arthritis Research & Therapy 2017 19:143

    Published on: 17 June 2017

  4. Research article

    Differing specificities and isotypes of anti-citrullinated peptide/protein antibodies in palindromic rheumatism and rheumatoid arthritis

    To analyze differences in the recognition of anti-citrullinated peptide/protein antibody (ACPA) citrullinated epitopes and isotypes in patients with palindromic rheumatism (PR) and rheumatoid arthritis (RA).

    Sonia Cabrera-Villalba, María José Gomara, Juan D. Cañete, Julio Ramírez, Georgina Salvador, Virginia Ruiz-Esquide, Maria Victoria Hernández, José Inciarte-Mundo, Isabel Haro and Raimon Sanmartí

    Arthritis Research & Therapy 2017 19:141

    Published on: 15 June 2017

  5. Research article

    Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells

    The peripheral blood (PB) monocyte pool contains osteoclast progenitors (OCPs), which contribute to osteoresorption in inflammatory arthritides and are influenced by the cytokine and chemokine milieu. We aimed...

    Alan Sucur, Zrinka Jajic, Marinko Artukovic, Marina Ikic Matijasevic, Branimir Anic, Darja Flegar, Antonio Markotic, Tomislav Kelava, Sanja Ivcevic, Natasa Kovacic, Vedran Katavic and Danka Grcevic

    Arthritis Research & Therapy 2017 19:142

    Published on: 15 June 2017

  6. Research article

    IFN-λ1 with Th17 axis cytokines and IFN-α define different subsets in systemic lupus erythematosus (SLE)

    Interferon (IFN)-α is thought to have a pivotal role in systemic lupus erythematosus (SLE), and type III IFNs (IFN-λ) were recently also associated with SLE. In this study, we measured levels of IFN-α, IFN-λ1,...

    Vilija Oke, Susanna Brauner, Anders Larsson, Johanna Gustafsson, Agneta Zickert, Iva Gunnarsson and Elisabet Svenungsson

    Arthritis Research & Therapy 2017 19:139

    Published on: 15 June 2017

  7. Research article

    Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus

    Systemic lupus erythematosus (SLE) is a genetically complex rheumatic disease characterized by heterogeneous clinical manifestations of unknown etiology. Recent studies have suggested the existence of a geneti...

    Adrià Aterido, Antonio Julià, Patricia Carreira, Ricardo Blanco, José Javier López-Longo, José Javier Pérez Venegas, Àlex Olivé, José Luís Andreu, Maria Ángeles Aguirre-Zamorano, Paloma Vela, Joan M. Nolla, José Luís Marenco-de la Fuente, Antonio Zea, José María Pego, Mercedes Freire, Elvira Díez…

    Arthritis Research & Therapy 2017 19:138

    Published on: 15 June 2017

  8. Research article

    Serum levels of leptin and high molecular weight adiponectin are inversely associated with radiographic spinal progression in patients with ankylosing spondylitis: results from the ENRADAS trial

    Previous research indicates a role of adipokines in inflammation and osteogenesis. Hence adipokines might also have a pathophysiological role in inflammation and new bone formation in patients with ankylosing ...

    Agnes Hartl, Joachim Sieper, Uta Syrbe, Joachim Listing, Kay-Geert Hermann, Martin Rudwaleit and Denis Poddubnyy

    Arthritis Research & Therapy 2017 19:140

    Published on: 15 June 2017

  9. Research article

    Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells

    Leucine-rich alpha 2 glycoprotein (LRG) has been identified as a serum protein elevated in patients with active rheumatoid arthritis (RA). Although the function of LRG is ill-defined, LRG binds with transformi...

    Hayato Urushima, Minoru Fujimoto, Takashi Mishima, Tomoharu Ohkawara, Hiromi Honda, Hyun Lee, Hirohisa Kawahata, Satoshi Serada and Tetsuji Naka

    Arthritis Research & Therapy 2017 19:137

    Published on: 14 June 2017

  10. Research article

    Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients

    Persistent expansion of circulating CD4+ effector memory T cells (TEM) in patients with granulomatosis with polyangiitis (GPA) suggests their fundamental role in disease pathogenesis. Recent studies have shown th...

    Lucas L. Lintermans, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa and Wayel H. Abdulahad

    Arthritis Research & Therapy 2017 19:136

    Published on: 14 June 2017

  11. Research article

    High sensitivity and negative predictive value of the DETECT algorithm for an early diagnosis of pulmonary arterial hypertension in systemic sclerosis: application in a single center

    Pulmonary arterial hypertension (PAH) is one of the most relevant causes of death in systemic sclerosis. The aims of this study were to analyse the recently published DETECT algorithm comparing it with Europea...

    Alfredo Guillén-Del Castillo, Eduardo L. Callejas-Moraga, Gabriela García, José F. Rodríguez-Palomares, Antonio Román, Cristina Berastegui, Manuel López-Meseguer, Enric Domingo, Vicente Fonollosa-Plá and Carmen Pilar Simeón-Aznar

    Arthritis Research & Therapy 2017 19:135

    Published on: 14 June 2017

  12. Research article

    Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis

    Systemic sclerosis (SSc) is characterized by fibrosis of the skin and internal organs. Although the involvement of connective tissue growth factor (CTGF/CCN2) has been well-documented in SSc fibrosis, the ther...

    Katsunari Makino, Tomoko Makino, Lukasz Stawski, Kenneth E. Lipson, Andrew Leask and Maria Trojanowska

    Arthritis Research & Therapy 2017 19:134

    Published on: 13 June 2017

  13. Research article

    High-sensitivity cardiac troponin T is a biomarker for atherosclerosis in systemic lupus erythematous patients: a cross-sectional controlled study

    Cardiovascular disease (CVD) is the main cause of death in systemic lupus erythematous (SLE) patients. The Framingham score underestimates the risk for CVD in this population. Our study aimed to determine whet...

    Gillian Divard, Rachid Abbas, Camille Chenevier-Gobeaux, Noémie Chanson, Brigitte Escoubet, Marie-Paule Chauveheid, Antoine Dossier, Thomas Papo, Monique Dehoux and Karim Sacre

    Arthritis Research & Therapy 2017 19:132

    Published on: 13 June 2017

  14. Research article

    Drug safety analyses in a rheumatoid arthritis registry: application of different approaches regarding timing of exposure and confounder measurement

    Patient registry data serves an increasing role in drug safety and comparative effectiveness research, but registry databases often do not contain confounder information measured at the same time that treatmen...

    Daniel H. Solomon, Nancy A. Shadick, Michael E. Weinblatt, Agnes Zak, Michelle Frits and Jessica M. Franklin

    Arthritis Research & Therapy 2017 19:130

    Published on: 13 June 2017

  15. Research article

    The cumulative number of micro-haemorrhages and micro-thromboses in nailfold videocapillaroscopy is a good indicator of disease activity in systemic sclerosis: a validation study of the NEMO score

    Some abnormalities in nailfold videocapillaroscopy (NVC), such as the presence of micro-haemorrhages (MHEs), micro-thromboses (MTs), giant capillaries (GCs) and reduction in the number of capillaries (nCs), su...

    Romina Andracco, Rosaria Irace, Eleonora Zaccara, Serena Vettori, Wanda Maglione, Antonella Riccardi, Francesca Pignataro, Roberta Ferrara, Domenico Sambataro, Gianluca Sambataro, Claudio Vitali, Gabriele Valentini and Nicoletta Del Papa

    Arthritis Research & Therapy 2017 19:133

    Published on: 13 June 2017

  16. Research article

    The effects of resistance training on muscle strength, joint pain, and hand function in individuals with hand osteoarthritis: a systematic review and meta-analysis

    Hand osteoarthritis is a common condition characterised by joint pain and muscle weakness. These factors are thought to contribute to ongoing disability. Some evidence exists that resistance training decreases...

    Nicoló Edoardo Magni, Peter John McNair and David Andrew Rice

    Arthritis Research & Therapy 2017 19:131

    Published on: 13 June 2017

  17. Research article

    Negative anti-neutrophil cytoplasm antibody at switch to maintenance therapy is associated with a reduced risk of relapse

    Relapse of disease is frequent in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). It is unclear whether persistent ANCA when starting maintenance therapy increases the risk of relapse. W...

    Matthew David Morgan, Matthew Szeto, Michael Walsh, David Jayne, Kerstin Westman, Niels Rasmussen, Thomas F. Hiemstra, Oliver Flossmann, Annelies Berden, Peter Höglund and Lorraine Harper

    Arthritis Research & Therapy 2017 19:129

    Published on: 7 June 2017

  18. Research article

    Gout and subsequent erectile dysfunction: a population-based cohort study from England

    An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level ...

    Alyshah Abdul Sultan, Christian Mallen, Richard Hayward, Sara Muller, Rebecca Whittle, Matthew Hotston and Edward Roddy

    Arthritis Research & Therapy 2017 19:123

    Published on: 6 June 2017

  19. Research article

    MRI evidence of structural changes in the sacroiliac joints of patients with non-radiographic axial spondyloarthritis even in the absence of MRI inflammation

    Studies have shown that structural lesions may be present in patients with non-radiographic axial spondyloarthritis (nr-axSpA). However, the relevance of structural lesions in these patients is unclear, partic...

    Walter P. Maksymowych, Stephanie Wichuk, Maxime Dougados, Heather Jones, Annette Szumski, Jack F. Bukowski, Lisa Marshall and Robert G. Lambert

    Arthritis Research & Therapy 2017 19:126

    Published on: 6 June 2017

  20. Research article

    Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders—findings of a multicenter population-based study

    We determined the prevalence of anti-nuclear autoantibodies (ANAs) in the German adult population and examined the association between ANAs and cardiovascular and metabolic disorders.

    Manas K. Akmatov, Nadja Röber, Wolfgang Ahrens, Dieter Flesch-Janys, Julia Fricke, Halina Greiser, Kathrin Günther, Rudolf Kaaks, Yvonne Kemmling, Bastian Krone, Jakob Linseisen, Christa Meisinger, Susanne Moebus, Nadia Obi, Carlos A. Guzman, Karsten Conrad…

    Arthritis Research & Therapy 2017 19:127

    Published on: 6 June 2017

  21. Research article

    Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study

    Increasing evidences indicate that an unbalance between tryptases and their endogenous inhibitors, leading to an increased proteolytic activity, is implicated in the pathophysiology of rheumatoid arthritis. Th...

    Alexandre Denadai-Souza, Camilla Moreira Ribeiro, Corinne Rolland, Anne Thouard, Céline Deraison, Cristoforo Scavone, Daniel Gonzalez-Dunia, Nathalie Vergnolle and Maria Christina Werneck Avellar

    Arthritis Research & Therapy 2017 19:124

    Published on: 6 June 2017

  22. Research article

    High mobility group box-1 contributes to anti-myeloperoxidase antibody-induced glomerular endothelial cell injury through a moesin-dependent route

    Our previous study found that circulating and urinary levels of high mobility group box-1 (HMGB1) were closely associated with disease activity in patients with antineutrophil cytoplasmic antibody (ANCA)-assoc...

    Hui Deng, Chen Wang, Dong-Yuan Chang, Nan Hu, Min Chen and Ming-Hui Zhao

    Arthritis Research & Therapy 2017 19:125

    Published on: 6 June 2017

  23. Research article

    Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome

    This study reports the clinical and pathological features of 12 cases of primary Sjogren syndrome (pSS) with renal involvement presenting with proximal tubular dysfunction in a single center, and investigates ...

    Jing Wang, Yubing Wen, Mengyu Zhou, Xiaoxiao Shi, Lanping Jiang, Mingxi Li, Yang Yu, Xuemei Li, Xuewang Li, Wen Zhang, Andrew L. Lundquist and Limeng Chen

    Arthritis Research & Therapy 2017 19:120

    Published on: 2 June 2017

  24. Research article

    Survival and quality of life in incident systemic sclerosis-related pulmonary arterial hypertension

    Pulmonary arterial hypertension (PAH) is a leading cause of mortality in systemic sclerosis (SSc). We sought to determine survival, predictors of mortality, and health-related quality of life (HRQoL) related t...

    Kathleen Morrisroe, Wendy Stevens, Molla Huq, David Prior, Jo Sahhar, Gene-Siew Ngian, David Celermajer, Jane Zochling, Susanna Proudman and Mandana Nikpour

    Arthritis Research & Therapy 2017 19:122

    Published on: 2 June 2017

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