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  1. Research article

    Sex differences in the association of skin advanced glycation endproducts with knee osteoarthritis progression

    The accumulation of advanced glycation endproducts in articular cartilage has been suggested as an etiologic factor in the development and progression of knee osteoarthritis (KOA).

    Charles B. Eaton, Maria Sayeed, Syeda Ameernaz, Mary B. Roberts, John D. Maynard, Jeffrey B. Driban and Timothy E. McAlindon

    Arthritis Research & Therapy 2017 19:36

    Published on: 17 February 2017

  2. Research article

    CD14brightCD16+ intermediate monocytes are induced by interleukin-10 and positively correlate with disease activity in rheumatoid arthritis

    Three different subsets of circulating human monocytes, CD14brightCD16- (classical), CD14brightCD16+ (intermediate), and CD14dimCD16+ (non-classical) have been recently identified. It has been reported that CD14b...

    Masako Tsukamoto, Noriyuki Seta, Keiko Yoshimoto, Katsuya Suzuki, Kunihiro Yamaoka and Tsutomu Takeuchi

    Arthritis Research & Therapy 2017 19:28

    Published on: 10 February 2017

  3. Research article

    Prevalence and associated factors of resting electrocardiogram abnormalities among systemic lupus erythematosus patients without cardiovascular disease

    Electrocardiogram (ECG) cardiovascular disease (CVD) abnormalities (ECG-CVD) are predictive of subsequent CVD events in the general population. Systemic lupus erythematosus (SLE) patients are vulnerable to CVD...

    Hanan Al Rayes, Paula J. Harvey, Dafna D. Gladman, Jiandong Su, Arthy Sabapathy, Murray B. Urowitz and Zahi Touma

    Arthritis Research & Therapy 2017 19:31

    Published on: 10 February 2017

  4. Commentary

    Latin-American challenges and opportunities in rheumatology

    The importance of diseases to mankind is very similar worldwide. However, social and environmental issues, not to mention political and individual aspects, affect the prevalence and management of diseases and ...

    Francisco Airton Castro Rocha

    Arthritis Research & Therapy 2017 19:29

    Published on: 10 February 2017

  5. Research article

    Development of three-dimensional prints of arthritic joints for supporting patients’ awareness to structural damage

    Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) result in severe joint destruction and functional disability if left untreated. We aim to develop tools that help patients with RA and PsA to understand ...

    Arnd Kleyer, Laura Beyer, Christoph Simon, Fabian Stemmler, Matthias Englbrecht, Christian Beyer, Jürgen Rech, Bernhard Manger, Gerhard Krönke, Georg Schett and Axel J. Hueber

    Arthritis Research & Therapy 2017 19:34

    Published on: 10 February 2017

  6. Research article

    Endothelial injury in rheumatoid arthritis: a crosstalk between dimethylarginines and systemic inflammation

    Symmetric (SDMA) and asymmetric (ADMA) dimethylarginines have emerged as novel biomarkers of cardiovascular disease (CVD) in several disease settings associated with atherosclerosis. Rheumatoid arthritis (RA) ...

    Theodoros Dimitroulas, James Hodson, Aamer Sandoo, Jacqueline Smith and George D. Kitas

    Arthritis Research & Therapy 2017 19:32

    Published on: 10 February 2017

  7. Research article

    Th17 and CD24hiCD27+ regulatory B lymphocytes are biomarkers of response to biologics in rheumatoid arthritis

    The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomark...

    Sarah Salomon, Caroline Guignant, Pierre Morel, Gauthier Flahaut, Clément Brault, Clément Gourguechon, Patrice Fardellone, Jean-Pierre Marolleau, Brigitte Gubler and Vincent Goëb

    Arthritis Research & Therapy 2017 19:33

    Published on: 10 February 2017

  8. Research article

    Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts

    It has been hypothesized that chronic inflammatory diseases such as rheumatoid arthritis (RA) may be caused by a failure of negative feedback mechanisms. This study sought to examine negative feedback mechanis...

    Thomas Crowley, John D. O’Neil, Holly Adams, Andrew M. Thomas, Andrew Filer, Christopher D. Buckley and Andrew R. Clark

    Arthritis Research & Therapy 2017 19:35

    Published on: 10 February 2017

  9. Research article

    Ultrasound-detected pathologies cluster into groups with different clinical outcomes: data from 3000 community referrals for shoulder pain

    Ultrasound is increasingly used to evaluate shoulder pain, but the benefits of this are unclear. In this study, we examined whether ultrasound-defined pathologies have implications for clinical outcomes.

    Gui Tran, Elizabeth M. A. Hensor, Aaron Ray, Sarah R. Kingsbury, Philip O’Connor and Philip G. Conaghan

    Arthritis Research & Therapy 2017 19:30

    Published on: 10 February 2017

  10. Research article

    Fat mass and fat distribution are associated with low back pain intensity and disability: results from a cohort study

    Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim ...

    Sultana Monira Hussain, Donna M. Urquhart, Yuanyuan Wang, Jonathan E. Shaw, Dianna J. Magliano, Anita E. Wluka and Flavia M. Cicuttini

    Arthritis Research & Therapy 2017 19:26

    Published on: 10 February 2017

  11. Research article

    Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells

    Systemic sclerosis (SSc) is characterized by endothelial cell (EC) apoptosis, impaired angiogenesis and peripheral microvasculopathy. Soluble α-Klotho (sKl) is a pleiotropic molecule with multiple effects on E...

    Celestina Mazzotta, Mirko Manetti, Irene Rosa, Eloisa Romano, Jelena Blagojevic, Silvia Bellando-Randone, Cosimo Bruni, Gemma Lepri, Serena Guiducci, Lidia Ibba-Manneschi and Marco Matucci-Cerinic

    Arthritis Research & Therapy 2017 19:27

    Published on: 10 February 2017

  12. Research article

    Circulating plasmablasts/plasma cells: a potential biomarker for IgG4-related disease

    Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a multisystem fibroinflammatory disease. We previously reported that a circulating cell population expressing CD19+CD24CD38hi was increased in patients with ...

    Wei Lin, Panpan Zhang, Hua Chen, Yu Chen, Hongxian Yang, Wenjie Zheng, Xuan Zhang, Fengxiao Zhang, Wen Zhang and Peter E. Lipsky

    Arthritis Research & Therapy 2017 19:25

    Published on: 10 February 2017

  13. Research article

    Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells

    Osteoarthritis (OA) is a chronic debilitating joint disorder of particularly high prevalence in the elderly population. Intra-articular basic calcium phosphate (BCP) crystals are present in the majority of OA ...

    Emma M. Corr, Clare C. Cunningham, Laura Helbert, Geraldine M. McCarthy and Aisling Dunne

    Arthritis Research & Therapy 2017 19:23

    Published on: 7 February 2017

  14. Research article

    α2AP regulates vascular alteration by inhibiting VEGF signaling in systemic sclerosis: the roles of α2AP in vascular dysfunction in systemic sclerosis

    Systemic sclerosis (SSc) is a connective tissues disease of unknown origin characterized by vascular damage and extensive fibrosis. Recently, we demonstrated that α2-antiplasmin (α2AP) is associated with the d...

    Yosuke Kanno, En Shu, Hiroyuki Kanoh, Ayaka Matsuda and Mariko Seishima

    Arthritis Research & Therapy 2017 19:22

    Published on: 3 February 2017

  15. Research article

    Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis

    Here we integrate verified signals from previous genetic association studies with gene expression and pathway analysis for discovery of new candidate genes and signaling networks, relevant for rheumatoid arthr...

    Klementy Shchetynsky, Lina-Marcella Diaz-Gallo, Lasse Folkersen, Aase Haj Hensvold, Anca Irinel Catrina, Louise Berg, Lars Klareskog and Leonid Padyukov

    Arthritis Research & Therapy 2017 19:19

    Published on: 2 February 2017

  16. Research article

    A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing spondylitis

    Patients with ankylosing spondylitis (AS) are at increased risk of developing inflammatory bowel disease (IBD). We aimed to determine the variation in fecal calprotectin in AS over 5 years in relation to disea...

    Eva Klingberg, Hans Strid, Arne Ståhl, Anna Deminger, Hans Carlsten, Lena Öhman and Helena Forsblad-d’Elia

    Arthritis Research & Therapy 2017 19:21

    Published on: 2 February 2017

  17. Research article

    Blood chemokine profile in untreated early rheumatoid arthritis: CXCL10 as a disease activity marker

    We have recently analyzed the profile of T-cell subtypes based on chemokine receptor expression in blood from untreated early rheumatoid arthritis (ueRA) patients compared to healthy controls (HC). Here, we co...

    Jayesh M. Pandya, Anna-Carin Lundell, Kerstin Andersson, Inger Nordström, Elke Theander and Anna Rudin

    Arthritis Research & Therapy 2017 19:20

    Published on: 2 February 2017

  18. Research article

    Persistent stromal fibroblast activation is present in chronic tendinopathy

    Growing evidence supports a key role for inflammation in the onset and progression of tendinopathy. However, the effect of the inflammatory infiltrate on tendon cells is poorly understood.

    Stephanie G. Dakin, Christopher D. Buckley, Mohammad Hussein Al-Mossawi, Robert Hedley, Fernando O. Martinez, Kim Wheway, Bridget Watkins and Andrew J. Carr

    Arthritis Research & Therapy 2017 19:16

    Published on: 25 January 2017

  19. Research article

    Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis

    There is a long-lasting need for non-invasive, more accurate diagnostic techniques when evaluating primary Sjögren’s syndrome (pSS) patients. Incorporation of additional diagnostics involving screening for dis...

    Lara A. Aqrawi, Hilde Kanli Galtung, Beate Vestad, Reidun Øvstebø, Bernd Thiede, Shermin Rusthen, Alix Young, Eduarda M. Guerreiro, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm and Janicke Liaaen Jensen

    Arthritis Research & Therapy 2017 19:14

    Published on: 25 January 2017

  20. Research article

    Comparative analyses of muscle MRI and muscular function in anti-synthetase syndrome patients and matched controls: a cross-sectional study

    Magnetic resonance imaging (MRI) of thigh muscles is increasingly used to assess disease activity and damage extent in chronic myositis, but the validity of the findings is not clear. Here, the primary aim was...

    Helena Andersson, Eva Kirkhus, Torhild Garen, Ragnhild Walle-Hansen, Else Merckoll and Øyvind Molberg

    Arthritis Research & Therapy 2017 19:17

    Published on: 25 January 2017

  21. Research article

    The 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial

    Pneumococcal pneumonia is the most frequent form of pneumonia. We herein assessed the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in the prevention of pneumonia overall in rheum...

    Yasumori Izumi, Manabu Akazawa, Yukihiro Akeda, Shigeto Tohma, Fuminori Hirano, Haruko Ideguchi, Ryutaro Matsumura, Tomoya Miyamura, Shunsuke Mori, Takahiro Fukui, Nozomi Iwanaga, Yuka Jiuchi, Hideko Kozuru, Hiroshi Tsutani, Kouichirou Saisyo, Takao Sugiyama…

    Arthritis Research & Therapy 2017 19:15

    Published on: 25 January 2017

  22. Erratum

    Erratum to: Serum IL-33, a new marker predicting response to rituximab in rheumatoid arthritis

    Jérémie Sellam, Elodie Rivière, Alice Courties, Paul-Olivier Rouzaire, Barbara Tolusso, Edward M. Vital, Paul Emery, Gianfranco Ferracioli, Martin Soubrier, Bineta Ly, Houria Hendel Chavez, Yassine Taoufik, Maxime Dougados and Xavier Mariette

    Arthritis Research & Therapy 2017 19:11

    Published on: 23 January 2017

    The original article was published in Arthritis Research & Therapy 2016 18:294

  23. Research article

    Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

    To identify molecular alterations in skeletal muscle in rheumatoid arthritis (RA) that may contribute to ongoing disability in RA.

    Kim M. Huffman, Ryan Jessee, Brian Andonian, Brittany N. Davis, Rachel Narowski, Janet L. Huebner, Virginia B. Kraus, Julie McCracken, Brian F. Gilmore, K. Noelle Tune, Milton Campbell, Timothy R. Koves, Deborah M. Muoio, Monica J. Hubal and William E. Kraus

    Arthritis Research & Therapy 2017 19:12

    Published on: 23 January 2017

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