From: Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis
Gene bank | Name | Description | F-testa | Summary of function |
---|---|---|---|---|
U26173 | IL3BP1 | bZIP protein NF-IL3A (IL3BP1) | 4.5E-06 | Basic leucine zipper (bZIP) transcription factor; activates IL3 gene expression and can also repress transcription; binds to regulatory sequences in the promoters of the adenovirus E4, γ interferon (IFNG), and interleukin 3 (IL3) genes |
X87689 | G6 | Putative p64 CLCP protein | 0.00245 | Nuclear chloride channel-27; intracellular chloride channel |
Y00787 | IL-8 | IL-8 | 0.00307 | Interleukin 8; cytokine that plays a role in chemoattraction and activation of neutrophils; has similarity to several platelet-derived factors |
M62831 | ETR101 | Transcription factor ETR101 | 0.00336 | Immediate early gene product induced by TPA stimulation in promyelocytic leukemia cell line HL-60 and in other leukemia cell lines |
X83394 | HLA-C | HLA-Cw*0704 | 0.00553 | Heavy chain that associates with β2-microglobulin; forms MHC class I complex that binds peptides to present them to CTLs |
D88378 | PSMF1 | Proteasome inhibitor hPI31 subunit | 0.00556 | A protein inhibitor of the 20-S proteasome |
U08815 | SPA61 | Spliceosomal protein (SAP 61) | 0.0059 | Spliceosome-associated protein 3a, subunit 3; component of the essential heterotrimeric splicing factor SF3a; contains a zinc finger |
M55067 | NCF-1 | 47-kDa autosomal granulomatous disease protein | 0.0068 | Neutrophil cytosol factor 1; cytosolic component of NADPH oxidase, required for neutrophil superoxide production |
D42063 | RANBP2 | RanBP2 | 0.0073 | Ran binding protein 2; component of the nuclear pore complex; has leucine-rich and cyclophilin-like domains, and zinc finger motifs |
M80927 | YKL40 | Glycoprotein (GP-39 synovial protein) | 0.00793 | Cartilage glycoprotein-39; has similarity to chitinases |
X06272 | SRPR | Docking protein | 0.00826 | Signal recognition particle receptor (docking protein); binds the SRP complexed with the translating ribosome to prepare for translocation of the polypeptide across the rough endoplasmic reticulum membrane |
D44497 | Clabp | Actin-binding protein p57 | 0.00981 | Coronin 1A; binds actin, involved in mitosis, cell motility, formation of phagocytic vacuoles and phagocytosis; has five WD domains |
X86693 | HEVIN | Hevin-like protein | 0.01158 | Expressed in high endothelial venules, may have antiadhesive properties and a role in leukocyte extravasation. |
D86970 | MAJN | TGFβ 1-induced antiapoptotic factor | 0.01174 | Protects against tumor necrosis factor-α (TNF)-induced apoptosis |
X69391 | Â | Ribosomal protein L6 | 0.01251 | mRNA for ribosomal protein L6 |
X76105 | DAP | DAP-1 mRNA | 0.01319 | Death-associated protein; may mediate apoptosis induced by interferon-γ ; has proline-rich regions |
Y08110 | SORLA | Mosaic protein LR11 | 0.02155 | Sortilin-related receptor; may be involved in the uptake of lipoproteins and proteases |
D88153 | HYA22 | HYA22 | 0.02189 | Protein with similarity to Saccharomyces cerevisiae Psr1p and Psr2p |
D21267 | SNAP-25 | Synaptosomal-associated protein, 25 kDa | 0.02199 | Synaptosomal-associated protein, 25-kDa; involved in membrane fusion during exocytosis; member of the SNAP family of proteins |
M11233 | CPSD | Cathepsin D | 0.02328 | Cathepsin D; lysosomal aspartyl protease (acid protease) |
D88827 | ZNF# | Zinc finger protein FPM315 | 0.0244 | C2H2-type zinc finger protein 263; may act as a transcriptional repressor; contains C2H2-type zinc fingers, and KRAB-A and LeR domains |
U06452 | MART-1 | Melanoma antigen recognized by T cells | 0.02575 | Melan-A (melanoma antigen recognized by T cells 1) |
X13403 | OTF1 | Octamer-binding protein Oct-1 | 0.02722 | Ubiquitously expressed POU homeodomain transcription factor 1; binds to the octamer motif ATGCAAAT |
X56976 | UBE1X | Ubiquitin-activating enzyme E1 | 0.02928 | Ubiquitin-activating enzyme E1; activates ubiquitin to mark cellular proteins for degradation; very strongly similar to murine Ube1x, which may function in DNA repair |
X95325 | CSDA | DNA-binding protein A variant | 0.03421 | Member of a family of transcriptional regulators; binds and represses the promoter of the GM-CSF gene; contains a cold-shock domain |
X58536 | HLA-C | HLA class I locus C heavy chain | 0.035 | Heavy chain that associates with β2-microglobulin; forms MHC class I complex that binds peptides to present them to CTLs |
U16031 | IL-4-STAT | Transcription factor IL-4 Stat | 0.03632 | Signal transducer and activator of transcription 6, interleukin-4 induced; activates expression of the interleukin-4 receptor gene in response to interleukin-4 and mediates JAK kinase signal transduction; member of the STAT family |