Anti-α-fodrin antibodies do not add much to the diagnosis of Sjögren's syndrome

Table 1 Autoantibodies in Nijmegen sera from a cohort of patients with Sjögren's syndrome

	IgA^a		IgG^b
Pt no.	Nijmegen	Hanover^c	Nijmegen	Hanover^c	IB^d	IP^e	Ro60^f	La^g	LFS^h	Comorbidity
Primary Sjögren's syndrome
1	+	+	+	-	-	-	+	-	+
2	-	-	-	-	-	-	-	+	+
3	+	-	-	-	-	-	-	-	+
4	+	+	+	-	-	-	+	-	+
5	+	+	+	-	+	+	+	+	+
6	+	-	-	-	-	+	+	+	+
7	+	-	-	-	-	-	-	-	+
8	-	+	-	-	-	-	-	-	+
9	-	+	+	-	-	-	+	-	+
10	+	+	+	-	-	+	+	+	+
11	-	-	-	-	-	-	+	+	+
12	-	-	-	-	+	-	+	-	+
13	-	-	+	-	-	-	+	+	+
14	-	-	-	-	+	+	+	+	+
15	-	-	+	-	-	-	+	+	+
16	-	-	-	-	+	-	-	-	+
17	-	-	+	-	-	-	+	+	+
18	+	+	-	-	-	-	-	+	+
19	-	-	-	-	+	-	-	-	+
20	+	+	+	+	-	-	+	+	+
21	-	-	+	+	-	-	+	+	+
Secondary Sjögren's syndrome
22	+	+	+	-	+	+	+	+	+	SLE
23	+	+	+	+	+	+	+	+	+	SLE
24	-	-	-	-	-	-	+	-	+	SLE
25	+	+	+	+	+	+	-	-	+	SLE
26	+	+	+	-	+	-	+	+	+	SSc
27	-	-	+	-	-	-	+	-	+	DM

^aIgA, ELISA measuring presence of IgA antibodies directed against α-fodrin; ^bIgG, ELISA measuring presence of IgG antibodies directed against α-fodrin; ^cfindings in Hanover for the sera originally tested in Nijmegen; ^dIB, immunoblotting results (α-fodrin); ^eIP, protein immunoprecipitation results (α-fodrin); ^fRo60, ELISA measuring presence of antibodies directed against Ro60-antigen; ^gLa, ELISA measuring presence of antibodies directed against La-antigen; ^hLFS, lymphocytic focus score ≥ 1.0 in sublabial minor salivary glands biopsy. DM, dermatomyositis; Pt, patient; SSc, systemic sclerosis; SLE, systemic lupus erythematosus.

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