From: A paragon of self-tolerance: CD25+CD4+regulatory T cells and the control of immune responses
Conventional naïve helper T cell | Natural regulatory T cell (TR) |
Foxp3 - | Foxp3 + |
CD5low, CD11alow, CD25low, CD38low, CD44low, CD45RBhigh, CD54low, CD103εlow, GITRlow | CD5high, CD11ahigh, CD25high, CD38high, CD44high, CD45RBlow, CD54high, CD103high, GITRhigh |
About 90–95% of splenic CD4+ T cells | About 5–10% of splenic CD4+ T cells |
Responsive to conventional T cell stimuli | Anergic to conventional T cell stimuli |
Non-suppressive | Suppressive |