From: Fibroblast biology Signals targeting the synovial fibroblast in arthritis
Cell type | Effect | Reference |
---|---|---|
Macrophage | Direct transfer (of FITC-dextran, mannose BSA gold) from macrophages to fibroblasts | |
Neutrophil | Neutrophil adhesion to fibroblasts is increased by PMA treatment of neutrophils and by IL-1α | [64] |
or TNF-α treatment of fibroblasts | ||
Fibroblasts provide directional guidance to adhering neutrophils | [65] | |
PAF and IL-8 enhance neutrophil adhesion to and motility of adhered neutrophils along | [66] | |
fibroblasts, respectively, in an integrin β2 dependent process | ||
Lymphocyte | Fibroblasts synthesize IL-1α, IL-1β, IL-6 and ICE | [67] |
Fibroblast mediated synthesis of collagen type I and type III is decreased | [68] | |
Eosinophil | Activated eosinophils adhere to fibroblasts: this adhesion is inhibited with RGDS | [69] |
Mast cell | Formation of mast pseudopods and their translocation to fibroblast surface | [70] |
Mast cell stimulates fibroblast proliferation after cell-cell contact in an IL-4 dependent manner | [71] | |
Gap junctions between the mast cell and fibroblast are possible | [72] | |
Osteoblast-like cells | Osteoblast-like cells stimulate fibroblast proliferation (regulation of osteoprogenitor cell | [73] |
proliferation?) |