Table 1 Distinct steps during leukocyte emigration into the arthritic synovium

Rolling

P-selectin

PSGL-1

E-selectin

ESL-1

L-selectin ligand ?

Sialyl Lewis-X,

CLA,

L-selectin

Activation

Chemokines (IL-8,

Cytokine and

MCP-1), PAF

chemokine receptors

PECAM-1

PECAM-1

E-selectin

PSGL-1, ESL-1

Firm adhesion

ICAM-1, VCAM-1

β₁, β₂ and β₇ integrins

Diapedesis

ICAM-1

β₁, β₂ and β₇ integrins

VCAM-1

PECAM-1

PECAM-1