Figure 2

Serum levels of (a) IgG₁ and (b) IgG_2a subtypes in tolerized and nontolerized collagen-induced arthritis (CIA) mice. When examined at 3, 5 and 7 weeks after primary immunization, mice that received oral type II collagen (CII) exhibited higher serum levels of IgG₁ than did nontolerized mice at all three time points, whereas the IgG_2a level was lower in the tolerized group. The data represent average values from 15 mice in each group.