Figure 1
From: Chemokine blockade: a new era in the treatment of rheumatoid arthritis?
Representative synovial tissue before and after specific CC chemokine receptor (CCR)1 blockade for 14 days in a patient with rheumatoid arthritis (haematoxylin–eosin staining; original magnification × 400). After active treatment there was a marked reduction in synovial cellularity, which was not observed in patients who received placebo. The reduction in cell infiltration was due to a specific decrease in CCR1-positive cells [29].