Figure 2

Mast cells constitute a critical pathogenic link in K/BxN serum transfer arthritis. Compared with wild-type controls, mast-cell-deficient W/W^v mice injected with K/BxN arthritogenic serum are resistant to the development of arthritis. After reconstitution with cultured wild-type mast cells, but not sham reconstitution, normal susceptibility is restored. Error bars = SEM. (Adapted from reference [1], with permission.)