From: The role and clinical implications of G6PI in experimental models of rheumatoid arthritis
 | Arthritis model | ||
---|---|---|---|
Characteristics | Collagen-induced arthritis | K/B×N arthritis | G6PI-induced arthritis |
Arthritogenic antigen | Cartilage specific (CII) | Systemic (G6PI) | Systemic (G6PI) |
Susceptible strain | DBA/1 | KRN TCR transgenic × NOD F1 mice | DBA/1 |
Arthritis induction | CII immunization and boost | Spontaneous | G6PI immunization |
Pathogenic cells and effector mechanisms | Â | Â | Â |
   T cells | ? | Induction phase | Induction and effector phases |
   Antibodies | Necessary and sufficient | Necessary and sufficient | Necessary |
   FcγRI or FcγRIII necessary | + | + | + |
   FcγRII | + | + or - in different studies | + |
   C5 | + | + | + |
   Mast cells | Uncertain | + | Unknown |
   Neutrophils | + | + | Unknown |
   Macrophages | Uncertain | Unknown | Unknown |
   TNF-α | + | (±) | + |
   IL-1 | + | + | Unknown |
   IL-6 | + | + | Unknown |
   Spontaneous remission | + | - | + |