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Figure 4 | Arthritis Res Ther

Figure 4

From: Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation

Figure 4

Chondrocyte death in the knee joints of mice with immune-complex-mediated arthritis (ICA). (a) At day 3 and 7 in arthritic knee joints injected with injected with AxCANI (adenovirus encoding no gene) or AxCAhIL-13 (adenovirus encoding interleukin-13) and (b) expression profiles of Fcγ receptor I (FcγRI), II, and III mRNA levels induced by IL-13 in synovium. IL-13 significantly decreased chondrocyte death, both at day 3 and at day 7 (a). Cycle threshold (Ct) values of FcγRI, II, and III in arthritic knee joints injected with AxCANI were subtracted from the Ct values for FcγRs after injection of AxCAhIL-13. Ct values were corrected for glyceraldehyde-3-phosphate dehydrogenase content for each individual sample. (b) FcγRI mRNA level was down-regulated by IL-13, whereas an up-regulation was observed for both FcγRII and III. Bars represent means ± SEM for 10 mice. Mann–Whitney U test. *P < 0.05. D, Δ.

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Arthritis Research & Therapy

ISSN: 1478-6362

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