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Table 3 Autoantibodies as prognostic markers of poor outcomes

From: Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritis

Autoantibody

Measure

Outcomes at 30 months

  

Persistence

RA criteria

Severity

RF

Sensitivity

47.2

57.1

55.4

 

Specificity

91.7

62.8

63.0

 

Positive LR

5.69

1.53

1.50

Anti-Sa

Sensitivity

34.4

39.3

44.6

 

Specificity

95.8

72.7

79.3

 

Positive LR

8.26

1.44

2.16

Anti-CCP

Sensitivity

39.2

39.3

42.9

 

Specificity

91.7

66.9

70.7

 

Positive LR

4.70

1.19

1.46

  1. Combinations of antibodies (rheumatoid factor (RF) and/or anti-Sa and/or anti-cyclic citrullinated peptide (anti-CCP)) are not shown, because none brought any improvement over the detection of anti-Sa alone. LR, likelihood ratio; RA, rheumatoid arthritis.
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Arthritis Research & Therapy

ISSN: 1478-6362

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