Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specimens

Table 2 Histological scores in patients with early (E) and long-standing (L) rheumatoid arthritis (RA)

	Group I										Group II
Histological feature	L-01	L-04	L-02	E-01	E-10	E-04	L-03	E-06	E-12	E-09	E-03	E-02	E-08	E-07	E-05	E-11
Proliferation of synovial cells	3	2	1	1	1	2	2	2	2	2	1	1	2	1	2	1
	1.80 ± 0.63 (1.67 ± 0.52)										1.33 ± 0.52
Typical palisading	3	3	3	2	2	2	2	1	2	3	1	1	2	2	2	0
	2.30 ± 0.68*(2.00 ± 0.63)										1.33 ± 0.82
Non-foreign-body giant cells	2	3	3	1	2	1	1	1	2	1	1	3	1	2	0	0
	1.70 ± 0.82 (1.33 ± 0.52)										1.17 ± 0.48
Lymphoid cell infiltration	3	1	3	0	2	1	2	1	1	2	0	0	0	0	0	0
	1.60 ± 0.97^† (1.17 ± 0.75*)										0.00 ± 0.00
Plasma cell infiltration	3	3	3	0	3	2	3	1	3	3	0	0	1	0	0	0
	2.40 ± 1.08^† (2.00 ± 1.27*)										0.17 ± 0.41
Neovascularization	2	2	2	2	2	2	3	2	2	3	3	3	2	2	1	3
	2.20 ± 0.42 (2.17 ± 0.41)										2.33 ± 0.82
Mesenchymoid transformation	1	1	2	0	0	0	1	0	0	3	0	0	0	0	0	0
	0.80 ± 1.03 (0.50 ± 1.23)										0.00 ± 0.00
Fibrinoid necrosis	1	3	2	0	0	0	1	0	1	2	0	0	1	0	1	0
	1.00 ± 1.05 (0.50 ± 0.84)										0.33 ± 0.52
Total	18	18	19	6	12	10	15	8	13	19	6	8	9	7	6	4
	13.80 ± 4.76^† (11.33 ± 4.37*)										6.67 ± 1.75

The value in the upper row is the histological score of each case. More than 6 samples were taken from each patient for the feature studied. The value in the lower row is the mean ± standard deviation for the group. Values in parentheses (group I) are those for only the patients with early RA. ^†P <0.01, *P <0.05 versus group II on the Mann–Whitney test. ACR, American College of Rheumatology.

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