From: Association of ENPP1gene polymorphisms with hand osteoarthritis in a Chuvasha population
Marker | Allele/haplotype | Freq. | P values of TDT | Combined P values for 3 testsa | Bonferroni correction | n inf. | n test | Pedigree-based disequilibrium test | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FBAT | QTDTb | EOT | A | B | A | B | P | Δ (years) | |||||
M06NR1A | 4Fc | 0.27 | 0.0001 | 1.0e-5 | 0.0009 | <1.0e-6 | <5.0e-5 | <4.0e-6 | <2.0e-5 | 84 | 4 | 0.0002 | -3.5 |
K173Q | 1 | 0.11 | 0.0129 | 0.0347 | 0.0403 | 0.0020 | 0.0104 | 0.0020 | 0.0104 | 48 | 1 | 0.0196 | 1.9 |
_XXXd | _221 | 0.66 | 0.0147 | 0.0174 | 0.0043 | 0.0002 | 0.0033 | 0.0006 | 0.0099 | 88 | 3 | 0.3430 | -1.3 |
_XXX | _211 | 0.10 | 0.0148 | 0.0373 | 0.0096 | 0.0007 | 0.0074 | 0.0021 | 0.0220 | 39 | 3 | 0.0110 | 2.3 |
_XX_ | _22_ | 0.67 | 0.0046 | 0.0050 | 0.0030 | 1.8e-5 | 0.0006 | 0.0001 | 0.0018 | 89 | 3 | 0.1827 | -1.7 |
_XX_ | _21_ | 0.10 | 0.0114 | 0.0378 | 0.0091 | 0.0005 | 0.0062 | 0.0016 | 0.0185 | 40 | 3 | 0.0114 | 2.3 |
__XX | __11 | 0.12 | 0.0426 | 0.0509 | 0.0426 | 0.0074 | 0.0177 | 0.0147 | 0.0351 | 47 | 2 | 0.0278 | 2.1 |
__XX | __21 | 0.85 | 0.0362 | 0.0515 | 0.0576 | 0.0082 | 0.0205 | 0.0164 | 0.0406 | 58 | 2 | 0.1574 | -1.6 |