Association of ENPP1gene polymorphisms with hand osteoarthritis in a Chuvasha population

Table 4 Reanalysis of M06NR1A 'allele' 4F

Allele	Freq.	P values of TDT			Combined P value for 3 tests^a		n inf.	Pedigree disequilibrium test
		FBAT	QTDT^b	EOT	A	B		P	Δ (years)
10	0.13	0.0051	0.0054	0.0083	0.0001	0.0016	59	0.0151	-2.6
10 + 11^c	0.15	0.0019	0.0015	0.0043	4.0e-6	0.0004	63	0.0060	-2.9
5 + 6^c	0.13	0.0622	0.0216	0.0490	0.0055	0.0181	49	0.1326	-1.6

The artificial 'allele' 4F combines all rare alleles but not the three most frequent alleles. ^aCombined P value using χ² (A) and simulated three-dimensional null distribution (B). ^bColumn presents orthogonal test, which uses parent trait values as covariates. ^cArtificial alleles including pairs of adjacent alleles. Δ, mean difference between the allele carriers and other individuals in age at onset of the disorder; EOT = extreme offspring design t-test; FBAT, family-based association test; Freq., frequency; n inf., number of informative families for TDT in the sample; QTDT = quantitative transmission disequilibrium test; TDT = transmission disequilibrium test.

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