Table 1 Histological and biochemical characteristics of baseline values of human osteoarthritic cartilage for different treatment groups
Parameter | Indomethacin (10 μmol/l) | Naproxen (300 μmol/l) | Aceclofenac (0.03 μmol/l) | Celecoxib (0.01 μmol/l) |
|---|---|---|---|---|
Age (years) | 70 ± 2 | 67 ± 3 | 63 ± 2 | 70 ± 3 |
Sex (female/male) | 4/1 | 3/2 | 4/1 | 4/1 |
Histological cartilage damage (Mankin grade) | 3 ± 1 | 4 ± 1 | 6 ± 2 | 5 ± 2 |
Prostaglandin synthesis rate (nmol/hour per g) | 6.8 ± 2.3 | 3.4 ± 1.9 | 4.8 ± 0.9 | 5.5 ± 1.8 |
% New prostaglandin release | 11 ± 2 | 13 ± 2 | 12 ± 2 | 11 ± 2 |
% Total release | 9 ± 2 | 7 ± 2 | 5 ± 1 | 6 ± 1 |
Prostaglandin content (mg/g) | 22 ± 2 | 19 ± 1 | 17 ± 6 | 19 ± 1 |