Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women

Table 2 Association between the VDR genotypes and hand osteoarthritis (OA)

Genotype	Overall OA		Symmetrical OA		Osteophyte
	Yes/no	Odds ratio (95% CI)^a	Yes/no	Odds ratio (95% CI)^a	Yes/no	Odds ratio (95% CI)^a
ApaI^b
AA	51/123	1.0	29/145	1.0	18/156	1.0
Aa	77/191	0.98 (0.62–1.54)	56/212	1.43 (0.84–2.42)	14/254	0.46 (0.21–1.00)
aa	32/69	1.20 (0.67–2.15)	25/76	1.93 (1.00–3.70)	7/94	0.65 (0.24–1.75)
'A' allele carriage	128/303	0.82 (0.49–1.37)	85/357	0.65 (0.37–1.13)	32/410	1.01 (0.40–2.51)
'a' allele carriage	109/260	1.03 (0.67–1.59)	81/288	1.55 (0.94–2.56)	21/348	0.51 (0.25–1.03)
TaqI^c
tt	20/44	1.00	11/53	1.0	7/57	1.0
Tt	68/173	0.75 (0.39–1.44)	42/199	0.90 (0.41–1.97)	13/228	0.46 (0.16–1.26)
TT	71/164	0.92 (0.48–1.76)	57/178	1.53 (0.72–3.29)	19/216	0.73 (0.27–1.93)
't' allele carriage	88/217	0.87 (0.58–1.30)	53/252	0.60 (0.38–0.94)	20/285	0.77 (0.39–1.53)
'T' allele carriage	139/337	0.83 (0.45–1.54)	99/377	1.19 (0.57–2.47)	32/444	0.58 (0.23–1.46)

^aOdds ratio and 95% confidence interval (CI) adjusted for age (years), height (cm), occupation (1 = dentists, 2 = teachers [reference group]), hormone therapy (1 = ever used, 2 = never used [reference group]), current body mass index (1 = high, 2 = moderate, 3 = low [reference group]), daily calcium intake (1 = high [reference group], 2 = moderate, 3 = low), coffee consumption (number of cups per day), alcohol consumption (number of portion per week), and smoking history (1 = never smoked [reference group], 2 = ever smoked). ^bA, absence of a restriction site; a, presence of a restriction site. ^cT, absence of a restriction site; t, presence of a restriction site. For technical reasons, three samples were not genotyped for the TaqI VDR polymorphism.

ISSN: 1478-6362