Skip to main content

Table 2 Genotype frequencies of PTPN22 1858 T/C SNP in RA patients, stratified by rheumatoid factor and anti-CCP antibody status

From: Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients

 

CT

CT and TT

OR for CT and TT (95% CI)

RF+ (n = 291)

34.7 (101)

38.8 (113)

2.67a (1.88–3.79)

RF- (n = 99)

29.3 (29)

35.4 (35)

2.3a (1.42–3.72)

CCP+ (n = 193)

34.7 (67)

38.3 (74)

2.62a (1.78–3.86)

CCP- (n = 65)

35.4 (23)

38.5 (25)

2.63a (1.52–4.56)

  1. Values are the frequency in percent with absolute number of genotypes given in parentheses. Rheumatoid arthritis (RA) patients (n = 390) were stratified by rheumatoid factor (RF) status (values ≥40 IU/ml were regarded as RF positive (RF+)). RA patients for whom anti-cyclic citrullinated peptide (CCP) antibody concentrations were available (n = 258) were stratified according to anti-CCP positivity (values ≥50 IU/ml were regarded as CCP positive (CCP+)). The odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated in the indicated patient subgroups in comparison to controls. Level of significance: ap = 0.001, power for all calculations α > 0.9.
Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us